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The map label for this gene is pyrC [H]

Identifier: 91785177

GI number: 91785177

Start: 4211146

End: 4212207

Strand: Reverse

Name: pyrC [H]

Synonym: Bxe_A0602

Alternate gene names: 91785177

Gene position: 4212207-4211146 (Counterclockwise)

Preceding gene: 91785179

Following gene: 91785176

Centisome position: 86.04

GC content: 65.44

Gene sequence:

>1062_bases
ATGACCGCTTCCAACGCTTCCCTCGACTCCATCACGCTCGCCCGGCCGGACGACTGGCACCTGCACGTCCGCGACGGCGC
GATGCTGGCCGCCGTGCTGCCGGACACCGCGCGCCAGTTCGGCCGCGCGATCATCATGCCGAACCTGAAGCCGCCGGTCA
CGACCACCGCAATGGCGCAGGCTTATCGCGAGCGGATCGTCACCGCGATTCCCGAAGGCGCGAAGTTCGAACCGCTGATG
ACGCTGTACCTGACCGACAACACGCCGCCCGACGAAATCCGCCGCGCGCGCGAAAGCGGCTTCGTGCACGGTGTGAAGCT
GTACCCGGCGGGCGCGACGACCAATTCGGACGCGGGCGTCACCGACATCATGAAGTGCGCGAAAACGCTCGAAGTGATGC
AGGAACTGGGCATGCCGCTGCTGGTGCACGGCGAAGTGACGGATGCGTCGATCGATCTGTTCGACCGCGAGAAGGTGTTC
ATCGACCGGGTCATGACGCCGCTGCGCCGCGCGTTTCCGGCGCTGAAGGTGGTGTTCGAGCACATCACCACGAAAGACGC
GGTCGACTATATCCGCGAAGCCGGCGTGGCGCCGGAAGTGCTGGGCGCGACGATCACCGCGCATCATCTGCTGTACAACC
GCAACGCGATCTTCCAGGGCGGTATTCGCCCGCATTACTACTGCTTGCCCGTGTTGAAGCGGGAGACGCATCGGGTGGCG
CTGGTCGAGGCGGCGACGTCGGGCAATCCGCGCTTTTTCCTCGGAACGGACAGCGCGCCGCACCCGAAGGGGCTGAAAGA
GCATGCGTGCGGCTGCGCGGGCTGCTACACGGCGCTGCACGCTTTGGAGCTCTATACGGAAGCATTCGACAAGGCCGGCG
CGCTGGACAAGCTCGAAGGTTTCGCGAGCTTTTTCGGCGCGGATTTCTATGGTCTGCCGCGTAACGAAGAGAAGGTCACG
TTGCGTCGCGAGGAATGGACGCTGCCGGCCGAACTGCCGGTCGGCGATACGCCGGTCGTGCCGCTGCGCGGCGGCGAGTC
GATCGGCTGGCGCCTGGTTTAA

Upstream 100 bases:

>100_bases
AGAAACGCCAAATAGCAAAATTGACGTGTGTTCATGCCGCAACGGCGCGGTTTGACCGCATAGATTGGCTTTTGTCGCCG
AACTCGTCCCCCTTTTCGCC

Downstream 100 bases:

>100_bases
GGCATCAGCACGATGCAGGCGCGTGAGGCGGAGCCGCCGGGCTTCGCTGCCATCGACTGGTCGAAGCCGTGGTTCGCGCC
GTTCGCCGAACGCGGCAAGC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MTASNASLDSITLARPDDWHLHVRDGAMLAAVLPDTARQFGRAIIMPNLKPPVTTTAMAQAYRERIVTAIPEGAKFEPLM
TLYLTDNTPPDEIRRARESGFVHGVKLYPAGATTNSDAGVTDIMKCAKTLEVMQELGMPLLVHGEVTDASIDLFDREKVF
IDRVMTPLRRAFPALKVVFEHITTKDAVDYIREAGVAPEVLGATITAHHLLYNRNAIFQGGIRPHYYCLPVLKRETHRVA
LVEAATSGNPRFFLGTDSAPHPKGLKEHACGCAGCYTALHALELYTEAFDKAGALDKLEGFASFFGADFYGLPRNEEKVT
LRREEWTLPAELPVGDTPVVPLRGGESIGWRLV

Sequences:

>Translated_353_residues
MTASNASLDSITLARPDDWHLHVRDGAMLAAVLPDTARQFGRAIIMPNLKPPVTTTAMAQAYRERIVTAIPEGAKFEPLM
TLYLTDNTPPDEIRRARESGFVHGVKLYPAGATTNSDAGVTDIMKCAKTLEVMQELGMPLLVHGEVTDASIDLFDREKVF
IDRVMTPLRRAFPALKVVFEHITTKDAVDYIREAGVAPEVLGATITAHHLLYNRNAIFQGGIRPHYYCLPVLKRETHRVA
LVEAATSGNPRFFLGTDSAPHPKGLKEHACGCAGCYTALHALELYTEAFDKAGALDKLEGFASFFGADFYGLPRNEEKVT
LRREEWTLPAELPVGDTPVVPLRGGESIGWRLV
>Mature_352_residues
TASNASLDSITLARPDDWHLHVRDGAMLAAVLPDTARQFGRAIIMPNLKPPVTTTAMAQAYRERIVTAIPEGAKFEPLMT
LYLTDNTPPDEIRRARESGFVHGVKLYPAGATTNSDAGVTDIMKCAKTLEVMQELGMPLLVHGEVTDASIDLFDREKVFI
DRVMTPLRRAFPALKVVFEHITTKDAVDYIREAGVAPEVLGATITAHHLLYNRNAIFQGGIRPHYYCLPVLKRETHRVAL
VEAATSGNPRFFLGTDSAPHPKGLKEHACGCAGCYTALHALELYTEAFDKAGALDKLEGFASFFGADFYGLPRNEEKVTL
RREEWTLPAELPVGDTPVVPLRGGESIGWRLV

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=342, Percent_Identity=53.8011695906433, Blast_Score=375, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6323452, Length=366, Percent_Identity=36.0655737704918, Blast_Score=194, Evalue=2e-50,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 38807; Mature: 38676

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASNASLDSITLARPDDWHLHVRDGAMLAAVLPDTARQFGRAIIMPNLKPPVTTTAMAQ
CCCCCCCCCEEEEECCCCCEEEEECCEEEEEECCHHHHHHCCEEECCCCCCCCHHHHHHH
AYRERIVTAIPEGAKFEPLMTLYLTDNTPPDEIRRARESGFVHGVKLYPAGATTNSDAGV
HHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCH
TDIMKCAKTLEVMQELGMPLLVHGEVTDASIDLFDREKVFIDRVMTPLRRAFPALKVVFE
HHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHH
HITTKDAVDYIREAGVAPEVLGATITAHHLLYNRNAIFQGGIRPHYYCLPVLKRETHRVA
HHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEHHHHCCCCEEE
LVEAATSGNPRFFLGTDSAPHPKGLKEHACGCAGCYTALHALELYTEAFDKAGALDKLEG
EEEEECCCCCEEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
FASFFGADFYGLPRNEEKVTLRREEWTLPAELPVGDTPVVPLRGGESIGWRLV
HHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCEEC
>Mature Secondary Structure 
TASNASLDSITLARPDDWHLHVRDGAMLAAVLPDTARQFGRAIIMPNLKPPVTTTAMAQ
CCCCCCCCEEEEECCCCCEEEEECCEEEEEECCHHHHHHCCEEECCCCCCCCHHHHHHH
AYRERIVTAIPEGAKFEPLMTLYLTDNTPPDEIRRARESGFVHGVKLYPAGATTNSDAGV
HHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCH
TDIMKCAKTLEVMQELGMPLLVHGEVTDASIDLFDREKVFIDRVMTPLRRAFPALKVVFE
HHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHH
HITTKDAVDYIREAGVAPEVLGATITAHHLLYNRNAIFQGGIRPHYYCLPVLKRETHRVA
HHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEHHHHCCCCEEE
LVEAATSGNPRFFLGTDSAPHPKGLKEHACGCAGCYTALHALELYTEAFDKAGALDKLEG
EEEEECCCCCEEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
FASFFGADFYGLPRNEEKVTLRREEWTLPAELPVGDTPVVPLRGGESIGWRLV
HHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA