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The map label for this gene is icd [H]

Identifier: 91784983

GI number: 91784983

Start: 3997477

End: 3998733

Strand: Reverse

Name: icd [H]

Synonym: Bxe_A0797

Alternate gene names: 91784983

Gene position: 3998733-3997477 (Counterclockwise)

Preceding gene: 91784996

Following gene: 91784981

Centisome position: 81.68

GC content: 58.63

Gene sequence:

>1257_bases
ATGCCGTATCAGCACATCAAGGTTCCGACCGGTGGTGACAAGATCACCGTCAATCCCGATTTCTCGCTCAACGTGTCGGA
CCAGCCGATCATTCCGTACATCGAAGGCGACGGCACCGGCATCGACATCACGCCGGTCATGATCAAGGTCGTGGATGCCG
CTGTGGAAAAAGCGTATGCAGGCAAGCGAAAAATCCACTGGATGGAAATCTACGCCGGCGAGAAATCCACCAAGGTGTAC
GGCCCGGATGTGTGGCTGCCCGAAGAGACGCTGCAGGTGCTCAAGGAATATGTCGTCTCGATCAAGGGCCCGCTCACCAC
GCCGGTGGGCGGCGGCATCCGTTCGCTGAACGTCGCGTTGCGCCAGGAACTGGATCTGTATGTGTGCTTGCGGCCGGTGC
AGTATTTCAAGGGCGTGCCTTCGCCGGTGCGCGAGCCGGAGAAAACCAACATGGTGATCTTCCGCGAGAACTCGGAAGAC
ATCTACGCGGGTATCGAGTGGCCGGCCGAATCGGAGCAGGCGAAAAAAATCATCAGGTTCCTGCGCGAAGAAATGGGCGT
GAAGAAGATCCGTTTCCCGGAAACGTCGGGGATCGGCATCAAGCCGGTGTCGCGTGAAGGAACGGAGCGTCTGGTGCGCA
AGGCGATCCAGTACGCGATCGACCACGATCGCCGTTCGGTCACGCTGGTGCACAAGGGCAACATCATGAAGTTCACCGAA
GGCGCGTTCCGCGACTACGGTTACGCGCTGGCGCAAAAGGAATTCGCCGCGGAACTGATCGACGGCGGCCCGTGGATGAA
GATCAAGAATCCGAAAACGGGCGGCGACGTCGTCCTCAAGGACGTGATCGCCGACGCGTTCCTGCAGCAGATCCTGCTGC
GTCCGGCTGAATACGACGTGATCGCCACGCTGAACCTGAATGGCGACTACGTATCGGATGCGTTGGCCGCGCAGGTCGGC
GGTATTGGTATCGCACCGGGCGCGAATATGTCGGATTCAGTCGCGATGTTCGAAGCCACGCACGGCACCGCGCCGAAATA
CGCCGGCAAGGACTACGTGAATCCGGGCTCGGAAATTCTCTCGGCAGAAATGATGCTGCGCCATCTCGGCTGGACCGAGG
CGGCGGATCTGATCATCAAGTCGATGGAAAAATCGATTCTGCAAAAACGCGTCACATACGATTTCGCGCGCTTGATGGAA
GGCGCGACTCAGGTGTCGTGTTCCGGATTTGGTCAGGTGCTGATCGAAAATCTGTAA

Upstream 100 bases:

>100_bases
CAGGCCGCTTGCCGGCGTGCGGCATTGCGCGTAGCGAGGAGCGCCCCCGTTTTCGCAGTCTCCCATCAGCTTTCAGCACA
GCCTTCACTGGAGTCCGACC

Downstream 100 bases:

>100_bases
GCGGCTCGCGTTGGGCTGACCGGTTCGCATGTGTAACCCCGGCGCCGCGAGGCGGCCGGGGTTTTTTGTTTCTGGCTTCA
CGCGATGTTCACGCAACGCG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MPYQHIKVPTGGDKITVNPDFSLNVSDQPIIPYIEGDGTGIDITPVMIKVVDAAVEKAYAGKRKIHWMEIYAGEKSTKVY
GPDVWLPEETLQVLKEYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVQYFKGVPSPVREPEKTNMVIFRENSED
IYAGIEWPAESEQAKKIIRFLREEMGVKKIRFPETSGIGIKPVSREGTERLVRKAIQYAIDHDRRSVTLVHKGNIMKFTE
GAFRDYGYALAQKEFAAELIDGGPWMKIKNPKTGGDVVLKDVIADAFLQQILLRPAEYDVIATLNLNGDYVSDALAAQVG
GIGIAPGANMSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTEAADLIIKSMEKSILQKRVTYDFARLME
GATQVSCSGFGQVLIENL

Sequences:

>Translated_418_residues
MPYQHIKVPTGGDKITVNPDFSLNVSDQPIIPYIEGDGTGIDITPVMIKVVDAAVEKAYAGKRKIHWMEIYAGEKSTKVY
GPDVWLPEETLQVLKEYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVQYFKGVPSPVREPEKTNMVIFRENSED
IYAGIEWPAESEQAKKIIRFLREEMGVKKIRFPETSGIGIKPVSREGTERLVRKAIQYAIDHDRRSVTLVHKGNIMKFTE
GAFRDYGYALAQKEFAAELIDGGPWMKIKNPKTGGDVVLKDVIADAFLQQILLRPAEYDVIATLNLNGDYVSDALAAQVG
GIGIAPGANMSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTEAADLIIKSMEKSILQKRVTYDFARLME
GATQVSCSGFGQVLIENL
>Mature_417_residues
PYQHIKVPTGGDKITVNPDFSLNVSDQPIIPYIEGDGTGIDITPVMIKVVDAAVEKAYAGKRKIHWMEIYAGEKSTKVYG
PDVWLPEETLQVLKEYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVQYFKGVPSPVREPEKTNMVIFRENSEDI
YAGIEWPAESEQAKKIIRFLREEMGVKKIRFPETSGIGIKPVSREGTERLVRKAIQYAIDHDRRSVTLVHKGNIMKFTEG
AFRDYGYALAQKEFAAELIDGGPWMKIKNPKTGGDVVLKDVIADAFLQQILLRPAEYDVIATLNLNGDYVSDALAAQVGG
IGIAPGANMSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTEAADLIIKSMEKSILQKRVTYDFARLMEG
ATQVSCSGFGQVLIENL

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=351, Percent_Identity=31.3390313390313, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI28178816, Length=352, Percent_Identity=28.6931818181818, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI28178821, Length=352, Percent_Identity=28.6931818181818, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI28178838, Length=281, Percent_Identity=28.8256227758007, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI4758582, Length=274, Percent_Identity=29.1970802919708, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI28178819, Length=181, Percent_Identity=34.2541436464088, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1787381, Length=411, Percent_Identity=75.669099756691, Blast_Score=653, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=376, Percent_Identity=27.1276595744681, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI87081683, Length=398, Percent_Identity=24.3718592964824, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71986051, Length=397, Percent_Identity=29.2191435768262, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI25144293, Length=305, Percent_Identity=30.1639344262295, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17505779, Length=301, Percent_Identity=29.9003322259136, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17550882, Length=260, Percent_Identity=26.9230769230769, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324709, Length=393, Percent_Identity=29.0076335877863, Blast_Score=152, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6324291, Length=370, Percent_Identity=29.4594594594595, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6322097, Length=363, Percent_Identity=29.2011019283747, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319830, Length=361, Percent_Identity=22.9916897506925, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24643270, Length=392, Percent_Identity=32.1428571428571, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24643268, Length=392, Percent_Identity=32.1428571428571, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24661184, Length=389, Percent_Identity=30.8483290488432, Blast_Score=168, Evalue=8e-42,
Organism=Drosophila melanogaster, GI161078635, Length=278, Percent_Identity=29.4964028776978, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI161078637, Length=300, Percent_Identity=29, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI161078639, Length=300, Percent_Identity=29, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI161078633, Length=278, Percent_Identity=29.4964028776978, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24650122, Length=278, Percent_Identity=29.4964028776978, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI20130355, Length=354, Percent_Identity=25.4237288135593, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI281362242, Length=336, Percent_Identity=26.7857142857143, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24648872, Length=336, Percent_Identity=26.7857142857143, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46200; Mature: 46069

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYQHIKVPTGGDKITVNPDFSLNVSDQPIIPYIEGDGTGIDITPVMIKVVDAAVEKAYA
CCCCEEECCCCCCEEEECCCCEECCCCCCCEEEECCCCCCEEHHHHHHHHHHHHHHHHHC
GKRKIHWMEIYAGEKSTKVYGPDVWLPEETLQVLKEYVVSIKGPLTTPVGGGIRSLNVAL
CCCCEEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
RQELDLYVCLRPVQYFKGVPSPVREPEKTNMVIFRENSEDIYAGIEWPAESEQAKKIIRF
HHCCCCEEEEHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHH
LREEMGVKKIRFPETSGIGIKPVSREGTERLVRKAIQYAIDHDRRSVTLVHKGNIMKFTE
HHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECC
GAFRDYGYALAQKEFAAELIDGGPWMKIKNPKTGGDVVLKDVIADAFLQQILLRPAEYDV
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCE
IATLNLNGDYVSDALAAQVGGIGIAPGANMSDSVAMFEATHGTAPKYAGKDYVNPGSEIL
EEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHH
SAEMMLRHLGWTEAADLIIKSMEKSILQKRVTYDFARLMEGATQVSCSGFGQVLIENL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHCCC
>Mature Secondary Structure 
PYQHIKVPTGGDKITVNPDFSLNVSDQPIIPYIEGDGTGIDITPVMIKVVDAAVEKAYA
CCCEEECCCCCCEEEECCCCEECCCCCCCEEEECCCCCCEEHHHHHHHHHHHHHHHHHC
GKRKIHWMEIYAGEKSTKVYGPDVWLPEETLQVLKEYVVSIKGPLTTPVGGGIRSLNVAL
CCCCEEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
RQELDLYVCLRPVQYFKGVPSPVREPEKTNMVIFRENSEDIYAGIEWPAESEQAKKIIRF
HHCCCCEEEEHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHH
LREEMGVKKIRFPETSGIGIKPVSREGTERLVRKAIQYAIDHDRRSVTLVHKGNIMKFTE
HHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECC
GAFRDYGYALAQKEFAAELIDGGPWMKIKNPKTGGDVVLKDVIADAFLQQILLRPAEYDV
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCE
IATLNLNGDYVSDALAAQVGGIGIAPGANMSDSVAMFEATHGTAPKYAGKDYVNPGSEIL
EEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHH
SAEMMLRHLGWTEAADLIIKSMEKSILQKRVTYDFARLMEGATQVSCSGFGQVLIENL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361714; 10556719; 12704232 [H]