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The map label for this gene is aroP [H]

Identifier: 91784938

GI number: 91784938

Start: 3947854

End: 3949239

Strand: Reverse

Name: aroP [H]

Synonym: Bxe_A0842

Alternate gene names: 91784938

Gene position: 3949239-3947854 (Counterclockwise)

Preceding gene: 91784940

Following gene: 91784937

Centisome position: 80.67

GC content: 62.48

Gene sequence:

>1386_bases
TTGAATAGTGCACAGCAGCAAGACGGCCTGAAGCGGGGGCTCAAGAATCGCCACATCCAGCTCATCGCGCTGGGCGGCGC
GATCGGCACGGGGCTCTTTCTCGGCTCCGCCAGCGTGTTGCAGGCAGCCGGCCCGTCGATGATTCTCGGCTACGCGATCG
GCGGCGTCATCGCCTTCATGATCATGCGGCAGTTGGGCGAAATGGTGGCGCAGGAGCCGGTGGCCGGTTCGTTCAGCCAC
TTCGCGTACAAGTATTGGGGCGACTTTCCGGGCTTTCTGTCGGGCTGGAATTACTGGGTGCTGTATGTGCTCGTGAGCAT
GGCCGAGCTGACTGCTGTCGGCACGTATGTTCATTACTGGTGGCCCGGCGTGCCGACGTGGGTGTCGGCGCTGGTGTGCT
TTGCCGCCATCAACGCGATCAATCTCGCCAACGTCAAGGCCTATGGCGAAACGGAGTTCTGGTTCGCGATCATCAAGGTT
GCGGCGGTGATCGGCATGATCGTGTTCGGCGGCTATCTGCTGATTAGCGGCCACGGCGGCCCGCAAGCGTCGATCTCCAA
CCTCTGGGCTCACGGCGGTTTTTTCCCGCACGGGTTTCATGGTCTGTTCATGATGCTCGCGGTCATCATGTTCTCGTTCG
GCGGGCTGGAGTTGATCGGTATTACGGCGGCGGAGGCCGACGAGCCGCAGAAGAGCATTCCGAAGGCCGTGAATCAGGTG
ATCTACCGGATTCTGATTTTCTACATCTGCTCGCTGACGGTGCTGCTGTCGTTGTACCCGTGGAACGAGGTCGCGGCCGG
CGGCAGTCCGTTCGTGATGATCTTTTCGCAGATTGGTTCGACGCTGACCGCGAACGTCCTCAACGTGGTGGTGTTGACCG
CGGCGCTGTCGGTGTACAACAGCGGCGTCTATGCGAACAGCCGCATGCTCTACGGTCTCGCGGAGCAGGGTAACGCCCCG
CGCGCGCTGATGAAGGTCGACCGGCGCGGCGTGCCGTATATGGCGATCGGTTTGTCGGCGCTCGCCACGTTCACGTGCGT
GATCGTCAACTACCTGATTCCGGCCGAAGCGCTCGGCTTGCTGATGGCGCTGGTGGTGGCGGCGCTCGTGCTCAACTGGG
CGCTGATCAGCATCACGCATCTCAAGTCGCGCAAGGCGATGGTCGCGGCAGGCGAGACGCTCGTGTTCAAGTCGTTCTGG
TTCCCGGTCAGCAACTGGATCTGCCTCGCGTTCATGGCATTGATCCTCGTGATTCTGGCAATGACGCCCGGTCTGTCCGT
TTCAGTGTGGCTGGTGCCGGCGTGGCTGGTGGTGATGTGGGCCGGCTATGTGTTCAAGCGCCGGCGCGCGGCCGTGCAGG
GCGGGGCGCGGGTGGTGGGGCGGTAA

Upstream 100 bases:

>100_bases
CCAGTATTTAGGTAATATCGGCCACGGTAAAATTTCAGGTTCGGCCGGCCCGGACCATAAGTCCGATCGGGTGATCGATA
TCCATACACTGGGGCGCAAT

Downstream 100 bases:

>100_bases
GGGTAGTGATGCTGTGATGGTGGCTGTGAGGCCGGCCTCGCGCATGCGCCTGTGCCAATGGTTTTTGCCGAAAACGGGCT
GCAACGGCTGGCACTCCGGG

Product: aromatic amino acid/H+ symporter

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MNSAQQQDGLKRGLKNRHIQLIALGGAIGTGLFLGSASVLQAAGPSMILGYAIGGVIAFMIMRQLGEMVAQEPVAGSFSH
FAYKYWGDFPGFLSGWNYWVLYVLVSMAELTAVGTYVHYWWPGVPTWVSALVCFAAINAINLANVKAYGETEFWFAIIKV
AAVIGMIVFGGYLLISGHGGPQASISNLWAHGGFFPHGFHGLFMMLAVIMFSFGGLELIGITAAEADEPQKSIPKAVNQV
IYRILIFYICSLTVLLSLYPWNEVAAGGSPFVMIFSQIGSTLTANVLNVVVLTAALSVYNSGVYANSRMLYGLAEQGNAP
RALMKVDRRGVPYMAIGLSALATFTCVIVNYLIPAEALGLLMALVVAALVLNWALISITHLKSRKAMVAAGETLVFKSFW
FPVSNWICLAFMALILVILAMTPGLSVSVWLVPAWLVVMWAGYVFKRRRAAVQGGARVVGR

Sequences:

>Translated_461_residues
MNSAQQQDGLKRGLKNRHIQLIALGGAIGTGLFLGSASVLQAAGPSMILGYAIGGVIAFMIMRQLGEMVAQEPVAGSFSH
FAYKYWGDFPGFLSGWNYWVLYVLVSMAELTAVGTYVHYWWPGVPTWVSALVCFAAINAINLANVKAYGETEFWFAIIKV
AAVIGMIVFGGYLLISGHGGPQASISNLWAHGGFFPHGFHGLFMMLAVIMFSFGGLELIGITAAEADEPQKSIPKAVNQV
IYRILIFYICSLTVLLSLYPWNEVAAGGSPFVMIFSQIGSTLTANVLNVVVLTAALSVYNSGVYANSRMLYGLAEQGNAP
RALMKVDRRGVPYMAIGLSALATFTCVIVNYLIPAEALGLLMALVVAALVLNWALISITHLKSRKAMVAAGETLVFKSFW
FPVSNWICLAFMALILVILAMTPGLSVSVWLVPAWLVVMWAGYVFKRRRAAVQGGARVVGR
>Mature_461_residues
MNSAQQQDGLKRGLKNRHIQLIALGGAIGTGLFLGSASVLQAAGPSMILGYAIGGVIAFMIMRQLGEMVAQEPVAGSFSH
FAYKYWGDFPGFLSGWNYWVLYVLVSMAELTAVGTYVHYWWPGVPTWVSALVCFAAINAINLANVKAYGETEFWFAIIKV
AAVIGMIVFGGYLLISGHGGPQASISNLWAHGGFFPHGFHGLFMMLAVIMFSFGGLELIGITAAEADEPQKSIPKAVNQV
IYRILIFYICSLTVLLSLYPWNEVAAGGSPFVMIFSQIGSTLTANVLNVVVLTAALSVYNSGVYANSRMLYGLAEQGNAP
RALMKVDRRGVPYMAIGLSALATFTCVIVNYLIPAEALGLLMALVVAALVLNWALISITHLKSRKAMVAAGETLVFKSFW
FPVSNWICLAFMALILVILAMTPGLSVSVWLVPAWLVVMWAGYVFKRRRAAVQGGARVVGR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=339, Percent_Identity=25.9587020648968, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI258645169, Length=412, Percent_Identity=23.7864077669903, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI114326544, Length=489, Percent_Identity=21.2678936605317, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI114326550, Length=489, Percent_Identity=21.2678936605317, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI4507047, Length=376, Percent_Identity=22.8723404255319, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786302, Length=450, Percent_Identity=69.5555555555556, Blast_Score=647, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=448, Percent_Identity=60.9375, Blast_Score=562, Evalue=1e-161,
Organism=Escherichia coli, GI48994972, Length=418, Percent_Identity=44.4976076555024, Blast_Score=345, Evalue=3e-96,
Organism=Escherichia coli, GI1786602, Length=448, Percent_Identity=43.3035714285714, Blast_Score=343, Evalue=1e-95,
Organism=Escherichia coli, GI1790653, Length=460, Percent_Identity=38.0434782608696, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI87081915, Length=463, Percent_Identity=36.9330453563715, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1789017, Length=434, Percent_Identity=38.0184331797235, Blast_Score=291, Evalue=4e-80,
Organism=Escherichia coli, GI87081708, Length=466, Percent_Identity=32.618025751073, Blast_Score=268, Evalue=7e-73,
Organism=Escherichia coli, GI1788480, Length=431, Percent_Identity=34.5707656612529, Blast_Score=243, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6322892, Length=416, Percent_Identity=35.5769230769231, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6324924, Length=453, Percent_Identity=32.6710816777042, Blast_Score=220, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6320772, Length=440, Percent_Identity=33.6363636363636, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6324061, Length=433, Percent_Identity=32.7944572748268, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6321053, Length=426, Percent_Identity=32.3943661971831, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6319824, Length=410, Percent_Identity=31.9512195121951, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6324059, Length=445, Percent_Identity=33.9325842696629, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6324553, Length=444, Percent_Identity=32.2072072072072, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6320717, Length=409, Percent_Identity=30.3178484107579, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6324990, Length=419, Percent_Identity=32.2195704057279, Blast_Score=189, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6321629, Length=412, Percent_Identity=29.8543689320388, Blast_Score=186, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6319543, Length=405, Percent_Identity=30.1234567901235, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6320251, Length=408, Percent_Identity=30.1470588235294, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6319608, Length=410, Percent_Identity=29.0243902439024, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319542, Length=417, Percent_Identity=28.2973621103118, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6322967, Length=410, Percent_Identity=28.780487804878, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324981, Length=398, Percent_Identity=28.894472361809, Blast_Score=142, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6320364, Length=475, Percent_Identity=24.6315789473684, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI161077963, Length=392, Percent_Identity=25, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24666159, Length=279, Percent_Identity=24.7311827956989, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221512776, Length=279, Percent_Identity=24.7311827956989, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24667468, Length=332, Percent_Identity=23.4939759036145, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49758; Mature: 49758

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSAQQQDGLKRGLKNRHIQLIALGGAIGTGLFLGSASVLQAAGPSMILGYAIGGVIAFM
CCCCHHHHHHHHCCCCCCEEEEEECCHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHH
IMRQLGEMVAQEPVAGSFSHFAYKYWGDFPGFLSGWNYWVLYVLVSMAELTAVGTYVHYW
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHEEE
WPGVPTWVSALVCFAAINAINLANVKAYGETEFWFAIIKVAAVIGMIVFGGYLLISGHGG
CCCHHHHHHHHHHHHHHHHHHECCEEECCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
PQASISNLWAHGGFFPHGFHGLFMMLAVIMFSFGGLELIGITAAEADEPQKSIPKAVNQV
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHH
IYRILIFYICSLTVLLSLYPWNEVAAGGSPFVMIFSQIGSTLTANVLNVVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
SGVYANSRMLYGLAEQGNAPRALMKVDRRGVPYMAIGLSALATFTCVIVNYLIPAEALGL
CCCEECCCEEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMALVVAALVLNWALISITHLKSRKAMVAAGETLVFKSFWFPVSNWICLAFMALILVILA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTPGLSVSVWLVPAWLVVMWAGYVFKRRRAAVQGGARVVGR
HCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNSAQQQDGLKRGLKNRHIQLIALGGAIGTGLFLGSASVLQAAGPSMILGYAIGGVIAFM
CCCCHHHHHHHHCCCCCCEEEEEECCHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHH
IMRQLGEMVAQEPVAGSFSHFAYKYWGDFPGFLSGWNYWVLYVLVSMAELTAVGTYVHYW
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHEEE
WPGVPTWVSALVCFAAINAINLANVKAYGETEFWFAIIKVAAVIGMIVFGGYLLISGHGG
CCCHHHHHHHHHHHHHHHHHHECCEEECCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
PQASISNLWAHGGFFPHGFHGLFMMLAVIMFSFGGLELIGITAAEADEPQKSIPKAVNQV
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHH
IYRILIFYICSLTVLLSLYPWNEVAAGGSPFVMIFSQIGSTLTANVLNVVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
SGVYANSRMLYGLAEQGNAPRALMKVDRRGVPYMAIGLSALATFTCVIVNYLIPAEALGL
CCCEECCCEEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMALVVAALVLNWALISITHLKSRKAMVAAGETLVFKSFWFPVSNWICLAFMALILVILA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTPGLSVSVWLVPAWLVVMWAGYVFKRRRAAVQGGARVVGR
HCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]