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The map label for this gene is uvrD [H]

Identifier: 91784462

GI number: 91784462

Start: 3440789

End: 3443140

Strand: Reverse

Name: uvrD [H]

Synonym: Bxe_A1337

Alternate gene names: 91784462

Gene position: 3443140-3440789 (Counterclockwise)

Preceding gene: 91784463

Following gene: 91784461

Centisome position: 70.33

GC content: 64.41

Gene sequence:

>2352_bases
ATGCCCGACCTGCTAGCCAATCTCAACCCCGAACAACACGCCGCCGTCACGCTCCCCAACGAGCCGGCGCTCATTCTCGC
CGGCGCGGGCAGCGGCAAGACCCGCGTTCTGATCACGCGTATTGCCTGGCTGATCCAGCATGGGCTGGCCTCGCCCGCCA
CGATTCTGGCGGTGACTTTCACCAACAAGGCCGCCCGCGAAATGATGTCGCGCCTCTCGGCGCTCCTGCCGATCGACACG
CGCGGCATGTGGATCGGCACCTTCCACGGTCTGTGCAACCGCATGCTGCGCGCGCATCACCGCGACGCGGGCCTGCCGGC
CACCTTCCAGATTCTCGACACCGCGGACCAGCTTTCCGCGATCAAGCGTCTGATGAAGGGCCTCAATATCGACGACGAAA
AGTACCCGGCGAAAAATCTCCAGTACTTCATCAACAACGCGAAAGAACAAGGCCTGCGGCCGAAAGACGTCGACGCCACG
GACAACTTCAACCGCAAATTCGTCGAACTCTACGAAGCCTACGACCAGCAATGCCAGCGCGAAGGCGTGGTCGACTTTCC
GGAACTGCTGCTGCGCTGCTACGAGCTGCTCGCGCACAATCCGCCGCTGCGCGCGCACTACCAGGCGCGCTTCAGGCACA
TTCTGGTCGACGAGTTCCAGGACACCAACAAGCTGCAATATGCGTGGCTCAAGCTGCTGGCGGGCGAGGCCAACTCGATC
TTCGCGGTCGGCGACGACGACCAGTCGATCTACGCGTTTCGCGGCGCGAACGTCGGCAACATGCGCGACTTCGAACACGA
GTTCAACGTTCGCCACCTGATCAAGCTCGAACAGAACTACCGCTCGCACGGCCATATTCTCGACGCCGCCAATCAGCTGA
TCGCCAACAACTCGCGGCGTCTGGGCAAGAATCTGCGTACCGACGCGGGTCACGGCGAACCGGTGCGCGTGTATGAATCC
GCCACCGACTCGCAGGAAGCCGGCTGGATCGTCGAGGAAATCAAGGCGCTGATCAGCACCGGCACGTCGCGCAGCGAAAT
CGCGATTCTTTATCGCAGCAACGCGCAGTCGCGCACGATCGAACACACGCTGGTCAATGCGGGTATCGCGTACCGCGTGT
ACGGCGGCTTGCGCTTTTTCGAGCGTCAGGAAGTCAAGCACGCGCTCGCCTATCTGCGCCTGATCGACAATCCGAACGAC
GACACCGCGTTCGCGCGCGTCGTCAATTTCCCGACGCGCGGCATCGGCGCTCGCTCGATCGAGCAACTCGCGGACGCGGC
GCGTCAGTACAACTGCTCGATGGCCGCGGCGATTCCGTACGTGGCGGGCAAGGCGGGGTCGAGCCTCGCGGGCTTCGCGA
ACCTGATCGGCAAGATGCGCGCCGAAACGCAGCAGATGAGCCTGCCGGAAACCGTCGAATACGTGGTGCGCGCAAGTGGT
CTGTCGGAGTTCTATCAGAACGAACGCGAAGGCCAGGACCGCCTGGAGAACTTGCAGGAACTGGTCAACGCGGCCGCGGC
GTTCGTCAGCGAAGAGGGCTACGGCATGGACACGCCGGCGCGCTCCATTCCGCTGCGTCCGGGTGCGACCGCCGCGCCCG
AACTGGCGGTCGCCACCGACGATCCGAATACCATCGTGTTCGACGCGCCCGGCATCGCCGATCCGGCGCAAAACCCGGAC
ACGATGACACCGCTCGCCGGCTTCCTGTCGCACGCGTCGCTGGAGGCGGGCGACAACCAGGCGCAAGCGGGCCAGGAAGC
CGTGCAACTGATGACGGTGCACGCGGCCAAGGGCCTTGAGTTCACGGCGGTGTTCATCACCGGTCTCGAAGAAGGGCTGT
TCCCGCACGAGAACAGCGCGATGGAATCGGACGGTCTGGAAGAAGAGCGCCGCCTGATGTACGTGGCGATCACGCGGGCC
AAGGAGCGGCTGTATCTGTCGTTCGCCCAGAGCCGCATGCTGCACGGCCAGACGCGTTACAACATCCGCTCGCGTTTCTT
CGACGAACTGCCGCAGGAAACGCTCAAGTGGCTCACGCCGAAGATCGAGCCGGGCGCGCGCTGGGGTGGCCGTTCGGACA
ACGCGGGTTATGGGCGCGACTGGTTCGCGCGGCCGGGTTACACGGGCGCCGCGTCGTCGACGCCCGCGCCGCTGCCAGCG
TTCGCGAACGAACAGCGTGCAGCGGAAACGGGTTTCCGCGTGGGCCAGCAGGTGTTCCACACCAAATTCGGCGAAGGCAC
GATCACCGCGCTCGAAGGCGGCGGCACCGACGCAAAGGCGCAGGTCAAATTCAAGCGGCACGGCGAGAAGTGGCTGGCGC
TCGCGGTCGCCAAACTGCAGGCGGTGGAATGA

Upstream 100 bases:

>100_bases
GGCACACCCGAACCCGCACGTTCAACAGCGCCGCGACGACAAAAAAGCCATTCCTCCCAGGGGCATATAATGTCGGACGA
CCTGCCGCCCCTCCAGACAA

Downstream 100 bases:

>100_bases
GCGCGGCGGGGGTAGCCATGCAGATTGGCGCGCCCGGGGGAGGGGCGGCTGACGCAGCGGCGGCTGACGCAGGCGCGGCC
GGCACACGAGTGGCCGGAGC

Product: ATP-dependent DNA helicase UvrD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 783; Mature: 782

Protein sequence:

>783_residues
MPDLLANLNPEQHAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQHGLASPATILAVTFTNKAAREMMSRLSALLPIDT
RGMWIGTFHGLCNRMLRAHHRDAGLPATFQILDTADQLSAIKRLMKGLNIDDEKYPAKNLQYFINNAKEQGLRPKDVDAT
DNFNRKFVELYEAYDQQCQREGVVDFPELLLRCYELLAHNPPLRAHYQARFRHILVDEFQDTNKLQYAWLKLLAGEANSI
FAVGDDDQSIYAFRGANVGNMRDFEHEFNVRHLIKLEQNYRSHGHILDAANQLIANNSRRLGKNLRTDAGHGEPVRVYES
ATDSQEAGWIVEEIKALISTGTSRSEIAILYRSNAQSRTIEHTLVNAGIAYRVYGGLRFFERQEVKHALAYLRLIDNPND
DTAFARVVNFPTRGIGARSIEQLADAARQYNCSMAAAIPYVAGKAGSSLAGFANLIGKMRAETQQMSLPETVEYVVRASG
LSEFYQNEREGQDRLENLQELVNAAAAFVSEEGYGMDTPARSIPLRPGATAAPELAVATDDPNTIVFDAPGIADPAQNPD
TMTPLAGFLSHASLEAGDNQAQAGQEAVQLMTVHAAKGLEFTAVFITGLEEGLFPHENSAMESDGLEEERRLMYVAITRA
KERLYLSFAQSRMLHGQTRYNIRSRFFDELPQETLKWLTPKIEPGARWGGRSDNAGYGRDWFARPGYTGAASSTPAPLPA
FANEQRAAETGFRVGQQVFHTKFGEGTITALEGGGTDAKAQVKFKRHGEKWLALAVAKLQAVE

Sequences:

>Translated_783_residues
MPDLLANLNPEQHAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQHGLASPATILAVTFTNKAAREMMSRLSALLPIDT
RGMWIGTFHGLCNRMLRAHHRDAGLPATFQILDTADQLSAIKRLMKGLNIDDEKYPAKNLQYFINNAKEQGLRPKDVDAT
DNFNRKFVELYEAYDQQCQREGVVDFPELLLRCYELLAHNPPLRAHYQARFRHILVDEFQDTNKLQYAWLKLLAGEANSI
FAVGDDDQSIYAFRGANVGNMRDFEHEFNVRHLIKLEQNYRSHGHILDAANQLIANNSRRLGKNLRTDAGHGEPVRVYES
ATDSQEAGWIVEEIKALISTGTSRSEIAILYRSNAQSRTIEHTLVNAGIAYRVYGGLRFFERQEVKHALAYLRLIDNPND
DTAFARVVNFPTRGIGARSIEQLADAARQYNCSMAAAIPYVAGKAGSSLAGFANLIGKMRAETQQMSLPETVEYVVRASG
LSEFYQNEREGQDRLENLQELVNAAAAFVSEEGYGMDTPARSIPLRPGATAAPELAVATDDPNTIVFDAPGIADPAQNPD
TMTPLAGFLSHASLEAGDNQAQAGQEAVQLMTVHAAKGLEFTAVFITGLEEGLFPHENSAMESDGLEEERRLMYVAITRA
KERLYLSFAQSRMLHGQTRYNIRSRFFDELPQETLKWLTPKIEPGARWGGRSDNAGYGRDWFARPGYTGAASSTPAPLPA
FANEQRAAETGFRVGQQVFHTKFGEGTITALEGGGTDAKAQVKFKRHGEKWLALAVAKLQAVE
>Mature_782_residues
PDLLANLNPEQHAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQHGLASPATILAVTFTNKAAREMMSRLSALLPIDTR
GMWIGTFHGLCNRMLRAHHRDAGLPATFQILDTADQLSAIKRLMKGLNIDDEKYPAKNLQYFINNAKEQGLRPKDVDATD
NFNRKFVELYEAYDQQCQREGVVDFPELLLRCYELLAHNPPLRAHYQARFRHILVDEFQDTNKLQYAWLKLLAGEANSIF
AVGDDDQSIYAFRGANVGNMRDFEHEFNVRHLIKLEQNYRSHGHILDAANQLIANNSRRLGKNLRTDAGHGEPVRVYESA
TDSQEAGWIVEEIKALISTGTSRSEIAILYRSNAQSRTIEHTLVNAGIAYRVYGGLRFFERQEVKHALAYLRLIDNPNDD
TAFARVVNFPTRGIGARSIEQLADAARQYNCSMAAAIPYVAGKAGSSLAGFANLIGKMRAETQQMSLPETVEYVVRASGL
SEFYQNEREGQDRLENLQELVNAAAAFVSEEGYGMDTPARSIPLRPGATAAPELAVATDDPNTIVFDAPGIADPAQNPDT
MTPLAGFLSHASLEAGDNQAQAGQEAVQLMTVHAAKGLEFTAVFITGLEEGLFPHENSAMESDGLEEERRLMYVAITRAK
ERLYLSFAQSRMLHGQTRYNIRSRFFDELPQETLKWLTPKIEPGARWGGRSDNAGYGRDWFARPGYTGAASSTPAPLPAF
ANEQRAAETGFRVGQQVFHTKFGEGTITALEGGGTDAKAQVKFKRHGEKWLALAVAKLQAVE

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=788, Percent_Identity=44.6700507614213, Blast_Score=652, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=688, Percent_Identity=36.4825581395349, Blast_Score=367, Evalue=1e-102,
Organism=Escherichia coli, GI1787196, Length=340, Percent_Identity=29.7058823529412, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322369, Length=762, Percent_Identity=28.6089238845144, Blast_Score=214, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6324477, Length=725, Percent_Identity=24, Blast_Score=114, Evalue=8e-26,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 86632; Mature: 86501

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDLLANLNPEQHAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQHGLASPATILAVTF
CCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEE
TNKAAREMMSRLSALLPIDTRGMWIGTFHGLCNRMLRAHHRDAGLPATFQILDTADQLSA
CCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHH
IKRLMKGLNIDDEKYPAKNLQYFINNAKEQGLRPKDVDATDNFNRKFVELYEAYDQQCQR
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EGVVDFPELLLRCYELLAHNPPLRAHYQARFRHILVDEFQDTNKLQYAWLKLLAGEANSI
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCE
FAVGDDDQSIYAFRGANVGNMRDFEHEFNVRHLIKLEQNYRSHGHILDAANQLIANNSRR
EEECCCCCCEEEEECCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHH
LGKNLRTDAGHGEPVRVYESATDSQEAGWIVEEIKALISTGTSRSEIAILYRSNAQSRTI
HHCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHH
EHTLVNAGIAYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFARVVNFPTRGIGARSI
HHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
EQLADAARQYNCSMAAAIPYVAGKAGSSLAGFANLIGKMRAETQQMSLPETVEYVVRASG
HHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LSEFYQNEREGQDRLENLQELVNAAAAFVSEEGYGMDTPARSIPLRPGATAAPELAVATD
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEC
DPNTIVFDAPGIADPAQNPDTMTPLAGFLSHASLEAGDNQAQAGQEAVQLMTVHAAKGLE
CCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCE
FTAVFITGLEEGLFPHENSAMESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRY
EEEEEEEHHHHCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCHHH
NIRSRFFDELPQETLKWLTPKIEPGARWGGRSDNAGYGRDWFARPGYTGAASSTPAPLPA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
FANEQRAAETGFRVGQQVFHTKFGEGTITALEGGGTDAKAQVKFKRHGEKWLALAVAKLQ
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEHHHCCHHHHHHHHHHHH
AVE
HCC
>Mature Secondary Structure 
PDLLANLNPEQHAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQHGLASPATILAVTF
CCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEE
TNKAAREMMSRLSALLPIDTRGMWIGTFHGLCNRMLRAHHRDAGLPATFQILDTADQLSA
CCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHH
IKRLMKGLNIDDEKYPAKNLQYFINNAKEQGLRPKDVDATDNFNRKFVELYEAYDQQCQR
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EGVVDFPELLLRCYELLAHNPPLRAHYQARFRHILVDEFQDTNKLQYAWLKLLAGEANSI
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCE
FAVGDDDQSIYAFRGANVGNMRDFEHEFNVRHLIKLEQNYRSHGHILDAANQLIANNSRR
EEECCCCCCEEEEECCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHH
LGKNLRTDAGHGEPVRVYESATDSQEAGWIVEEIKALISTGTSRSEIAILYRSNAQSRTI
HHCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHH
EHTLVNAGIAYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFARVVNFPTRGIGARSI
HHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
EQLADAARQYNCSMAAAIPYVAGKAGSSLAGFANLIGKMRAETQQMSLPETVEYVVRASG
HHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LSEFYQNEREGQDRLENLQELVNAAAAFVSEEGYGMDTPARSIPLRPGATAAPELAVATD
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEC
DPNTIVFDAPGIADPAQNPDTMTPLAGFLSHASLEAGDNQAQAGQEAVQLMTVHAAKGLE
CCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCE
FTAVFITGLEEGLFPHENSAMESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRY
EEEEEEEHHHHCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCHHH
NIRSRFFDELPQETLKWLTPKIEPGARWGGRSDNAGYGRDWFARPGYTGAASSTPAPLPA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
FANEQRAAETGFRVGQQVFHTKFGEGTITALEGGGTDAKAQVKFKRHGEKWLALAVAKLQ
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEHHHCCHHHHHHHHHHHH
AVE
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]