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The map label for this gene is yeiA [H]

Identifier: 91784371

GI number: 91784371

Start: 3338099

End: 3339433

Strand: Reverse

Name: yeiA [H]

Synonym: Bxe_A1429

Alternate gene names: 91784371

Gene position: 3339433-3338099 (Counterclockwise)

Preceding gene: 91784372

Following gene: 91784370

Centisome position: 68.21

GC content: 63.45

Gene sequence:

>1335_bases
ATGGCCGATCTGCGCTGTACGATTGCCGGCATCACTTCGCCGAATCCCTTCTGGCTCGCCTCCGCGCCGCCGACCGACAA
AGCCTATAACGTGAACCGCGCCTTCGAGGCGGGCTGGGGCGGCGTGGTGTGGAAGACGCTCGGCCTCGACCCGCACGTGG
TGAACGTCAGCTCGCGCTACGGCGCGGTGCAATGGAACGGCCAGCGTATCGCGGGCCTGAACAATATCGAGCTGATCACC
GACCGTCCGCTCGACGTCAATCTGAAGGAAATCGCGCAAGTCAAACGCGACTGGCCAGACCGCGCGATGATCGTCTCGCT
GATGGTGCCGTGCAACGAACGCGACTGGAAATGGATTCTGCCGCTTGTCGAAGACACCGGCGCGGATGCGGTCGAACTGA
ATTTCGGCTGCCCGCATGGCATGAGCGAACGCGGCATGGGCGCGGCGGTGGGCCAGGTGCCCGAGTACGTGGAGATGGTC
ACGCGCTGGGTCAAGGAGGGCACGAAACTGCCGTGCCTCGTCAAACTGACGCCGAACATCAGCGACATTCGTCTGGGTTC
GCGCGCGGCCTATAAAGGCGGCGCGGACGGCGTGTCGCTGATCAACACGATCAACTCGATCGTGGCGGTCGATCTCGACG
CAATGTCGCCGTTGCCGATGGTCGACGGCAAAGGCACGCACGGCGGCTACTGCGGCCCGGCCGTGAAGCCGATCGCGCTG
AACATGGTCGCGGAAATCGCGCGCGACGCGGAAACGCCGAACCTGCCGATTTCCGGCATCGGCGGAATCTCCTCATGGCG
CGACGCCGCCGAATTCATGGTGCTCGGCGCGGGCAGCGTGCAGGTCTGCACGGCGGCGATGCACTACGGATTCCGTATCG
TTTCCGATCTCGCCGACGGCCTCTCCAACTGGATGGACGAAAAAGGCTACGCGACGCTCGACGACATTCGCGGCCGCGCC
GTGCCGAACGTGACCGACTGGAAATACCTGAACCTCAAATACGACATCAAGGCGCGCATCGACCAGGACAAGTGCATTCA
GTGCGGCCTGTGCCATATCGCCTGCGAAGACACGGCTCACCAGGCCATCATGAAAGAAAAAGATGGCGTCCGGCATTTTG
AAGTGATGGACTCCGAATGTGTCGGCTGCAATCTGTGCATGCATGTGTGTCCGGTCGAGCAGTGCATCACGATGGAACGC
GTGGACAACGGCGAGTACGCGAACTGGACCACGCATCCGAACAACCCGGCGCGAGTGGGGGCCGGACAAAGCGCCACGGC
GGACGCCGCTGAAACCGCCGAGCCCGCGCATGCCCACGCGGCCAAAGCCGCCTGA

Upstream 100 bases:

>100_bases
AAACAGACAAAAAACAGCAGTCCCCAAGGAGCCGAAAGCGAATCGAGCCAAATCACGTAACGAAAACAGACAAAAAACAG
CAGTCCCCAAGGAGCCGAAC

Downstream 100 bases:

>100_bases
AACATGGGTTGTTGGCAGCAAACGCAGCGCTAGTACTGAACCTGTCATTCCCCAAGGCCCGACGCGCCGTGAGAGCCGCG
CGGGCCGCAACGATCGAGTG

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MADLRCTIAGITSPNPFWLASAPPTDKAYNVNRAFEAGWGGVVWKTLGLDPHVVNVSSRYGAVQWNGQRIAGLNNIELIT
DRPLDVNLKEIAQVKRDWPDRAMIVSLMVPCNERDWKWILPLVEDTGADAVELNFGCPHGMSERGMGAAVGQVPEYVEMV
TRWVKEGTKLPCLVKLTPNISDIRLGSRAAYKGGADGVSLINTINSIVAVDLDAMSPLPMVDGKGTHGGYCGPAVKPIAL
NMVAEIARDAETPNLPISGIGGISSWRDAAEFMVLGAGSVQVCTAAMHYGFRIVSDLADGLSNWMDEKGYATLDDIRGRA
VPNVTDWKYLNLKYDIKARIDQDKCIQCGLCHIACEDTAHQAIMKEKDGVRHFEVMDSECVGCNLCMHVCPVEQCITMER
VDNGEYANWTTHPNNPARVGAGQSATADAAETAEPAHAHAAKAA

Sequences:

>Translated_444_residues
MADLRCTIAGITSPNPFWLASAPPTDKAYNVNRAFEAGWGGVVWKTLGLDPHVVNVSSRYGAVQWNGQRIAGLNNIELIT
DRPLDVNLKEIAQVKRDWPDRAMIVSLMVPCNERDWKWILPLVEDTGADAVELNFGCPHGMSERGMGAAVGQVPEYVEMV
TRWVKEGTKLPCLVKLTPNISDIRLGSRAAYKGGADGVSLINTINSIVAVDLDAMSPLPMVDGKGTHGGYCGPAVKPIAL
NMVAEIARDAETPNLPISGIGGISSWRDAAEFMVLGAGSVQVCTAAMHYGFRIVSDLADGLSNWMDEKGYATLDDIRGRA
VPNVTDWKYLNLKYDIKARIDQDKCIQCGLCHIACEDTAHQAIMKEKDGVRHFEVMDSECVGCNLCMHVCPVEQCITMER
VDNGEYANWTTHPNNPARVGAGQSATADAAETAEPAHAHAAKAA
>Mature_443_residues
ADLRCTIAGITSPNPFWLASAPPTDKAYNVNRAFEAGWGGVVWKTLGLDPHVVNVSSRYGAVQWNGQRIAGLNNIELITD
RPLDVNLKEIAQVKRDWPDRAMIVSLMVPCNERDWKWILPLVEDTGADAVELNFGCPHGMSERGMGAAVGQVPEYVEMVT
RWVKEGTKLPCLVKLTPNISDIRLGSRAAYKGGADGVSLINTINSIVAVDLDAMSPLPMVDGKGTHGGYCGPAVKPIALN
MVAEIARDAETPNLPISGIGGISSWRDAAEFMVLGAGSVQVCTAAMHYGFRIVSDLADGLSNWMDEKGYATLDDIRGRAV
PNVTDWKYLNLKYDIKARIDQDKCIQCGLCHIACEDTAHQAIMKEKDGVRHFEVMDSECVGCNLCMHVCPVEQCITMERV
DNGEYANWTTHPNNPARVGAGQSATADAAETAEPAHAHAAKAA

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=337, Percent_Identity=39.4658753709199, Blast_Score=231, Evalue=1e-60,
Organism=Escherichia coli, GI87082059, Length=400, Percent_Identity=43.25, Blast_Score=332, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI71984108, Length=326, Percent_Identity=39.2638036809816, Blast_Score=222, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6322633, Length=323, Percent_Identity=25.3869969040248, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24640763, Length=309, Percent_Identity=42.7184466019417, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI18858217, Length=309, Percent_Identity=42.7184466019417, Blast_Score=242, Evalue=4e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 48030; Mature: 47899

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLRCTIAGITSPNPFWLASAPPTDKAYNVNRAFEAGWGGVVWKTLGLDPHVVNVSSRY
CCCCEEEEEECCCCCCEEEECCCCCCCCEECCCHHHCCCCCEEEEECCCCCEEEEECCCC
GAVQWNGQRIAGLNNIELITDRPLDVNLKEIAQVKRDWPDRAMIVSLMVPCNERDWKWIL
CEEEECCEEEECCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEE
PLVEDTGADAVELNFGCPHGMSERGMGAAVGQVPEYVEMVTRWVKEGTKLPCLVKLTPNI
EEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
SDIRLGSRAAYKGGADGVSLINTINSIVAVDLDAMSPLPMVDGKGTHGGYCGPAVKPIAL
CCEECCCCCCCCCCCCHHHHHHHHHHHEEEEHHCCCCCCCCCCCCCCCCCCCCCCCHHHH
NMVAEIARDAETPNLPISGIGGISSWRDAAEFMVLGAGSVQVCTAAMHYGFRIVSDLADG
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
LSNWMDEKGYATLDDIRGRAVPNVTDWKYLNLKYDIKARIDQDKCIQCGLCHIACEDTAH
HHHHHHCCCCEEHHHHCCCCCCCCCCEEEEEEEEEEEECCCCCHHHCCCEEEEEECHHHH
QAIMKEKDGVRHFEVMDSECVGCNLCMHVCPVEQCITMERVDNGEYANWTTHPNNPARVG
HHHHHHCCCCEEEEECCCCCCCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
AGQSATADAAETAEPAHAHAAKAA
CCCCCCCCHHHCCCCHHHHHCCCC
>Mature Secondary Structure 
ADLRCTIAGITSPNPFWLASAPPTDKAYNVNRAFEAGWGGVVWKTLGLDPHVVNVSSRY
CCCEEEEEECCCCCCEEEECCCCCCCCEECCCHHHCCCCCEEEEECCCCCEEEEECCCC
GAVQWNGQRIAGLNNIELITDRPLDVNLKEIAQVKRDWPDRAMIVSLMVPCNERDWKWIL
CEEEECCEEEECCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEE
PLVEDTGADAVELNFGCPHGMSERGMGAAVGQVPEYVEMVTRWVKEGTKLPCLVKLTPNI
EEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
SDIRLGSRAAYKGGADGVSLINTINSIVAVDLDAMSPLPMVDGKGTHGGYCGPAVKPIAL
CCEECCCCCCCCCCCCHHHHHHHHHHHEEEEHHCCCCCCCCCCCCCCCCCCCCCCCHHHH
NMVAEIARDAETPNLPISGIGGISSWRDAAEFMVLGAGSVQVCTAAMHYGFRIVSDLADG
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
LSNWMDEKGYATLDDIRGRAVPNVTDWKYLNLKYDIKARIDQDKCIQCGLCHIACEDTAH
HHHHHHCCCCEEHHHHCCCCCCCCCCEEEEEEEEEEEECCCCCHHHCCCEEEEEECHHHH
QAIMKEKDGVRHFEVMDSECVGCNLCMHVCPVEQCITMERVDNGEYANWTTHPNNPARVG
HHHHHHCCCCEEEEECCCCCCCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
AGQSATADAAETAEPAHAHAAKAA
CCCCCCCCHHHCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]