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The map label for this gene is hutH [H]

Identifier: 91784318

GI number: 91784318

Start: 3278969

End: 3280501

Strand: Reverse

Name: hutH [H]

Synonym: Bxe_A1482

Alternate gene names: 91784318

Gene position: 3280501-3278969 (Counterclockwise)

Preceding gene: 91784319

Following gene: 91784317

Centisome position: 67.01

GC content: 61.45

Gene sequence:

>1533_bases
ATGAACAAACCAGATGAAGTTCTGACTCTCGTGCCGGGCCAGGTAACGCTCGGTCAGTTGCGCCGCATCATTGAAGCGCG
GCCGATGGTGCAGATCGAGCGCGCGTCGCTCGAGCGGGTCGAAAAATCGAAGGACATCGTGAGCCGGATCGTCGCGGACG
GCAAGATCGTCTATGGCGTGAACACGGGCTTCGGCCGGCTGGCAAACACGACGATCCCCGCTGGGCGGATCGCGGAGTTG
CAAAAGAATCTCGTGCTCTCGCACAGCGTGGGCACGGGCGAACTGATGGAAGACCGGGTCGTCGGCCTGATCATGGCGCT
CAAGGCGATCAGTCTCGCGCGCGGTCACTCGGGCGTGCGTCCGCAAGTTGTGCTCGCCATCATCTCGATGCTCAATGCCG
GCGTCTATCCGTGCATTCCCAGCAAGGGGTCGGTCGGCGCGTCGGGCGATCTCGCGCCGCTCGCGCATCTGGCGGCCGCG
ATGTTGGGCGTGGGCCACGTGCGCATCGACGGCAAGCGCGTGCCGGCCGCTGAAGGCTTGAGCGTCGCCGGACTCGAAGC
ACTTAAACTAGGTCCGAAGGAAGGGCTCGCGCTGCTCAACGGAACGCAGGCGTCGACTGCGCTCGCGCTCTCAGGGCTTT
TCGCCGCGGAACGCGTGTTCGCTTCGGCGATGGTTACCGGTGCGTTGTCGCTCGAAGCGGTGAAAGGCTCGACCGTGCCT
TTCGATCCGCGTATTCATGTTGCGCGCGGCCAGCGCGGGCAAATCGACGTGGCGGGGCGTCTCGCGGCACTGCTCGATGG
CAGCGGCATCATCGCGTCGCATGGAAACGGGACTCGCGTGCAGGACCCGTATTCGATTCGCTGTCAGCCGCAGGTCATGG
GGGCGTGCCTCGACCACATCCGCTACGTTGCGGGCATTCTGACCATCGAGGCCAATGCTGCGTCGGACAATCCGCTCGTT
TTCGACAATGGCGATGTGCTGTCTGGCGGTAATTTCCATGCGGAACCGGTTGCGCTGGCAGCAGACGCGCTAGCAGTGGC
TATCTCTGAGATTGGCGCTATTTCCGAACGACGTACGGCATTGTTGCTTGATAGCCATATGTCGGGCCTGCCGGCGTTTC
TCGTGAAAGAAAGCGGAATCAATTCCGGCTTCATGATTGCGCAGGTAACGAGCGCCGCGCTGGCTTCGGAGAACAAGTCG
CTTGCACATCCCGCGAGCGTGGACAGTTTGCCGACGTCGGCGAATCAGGAGGATCACGTTTCAATGGCCACGTTTGCTGC
GAGACGGCTCAAGGATATGGCCGACAACACGGCCGTTATCGTGGGCATAGAAGGGATGGCCGCGGCGCAGGGCATGGACT
TTCATCGTCCGCTGCGTTCGAGCGAACTGCTGGAGGAACAGCATGTGCAGATTCGCGCGCGCGTTTCCTTTTATACGAAA
GACCGCTACCTCGCCGACGACATCGAGACAATGAAAAACTGGGCATTGGAGAGTTCCAGGCCGGGCATTGTCAACACGCT
ATTCGATATCTGA

Upstream 100 bases:

>100_bases
ACAACAAGCAGTTGATCTGGATGACGGTCGAACTGGCCTGACGGCTGTTTGAACGATATTCGAGCGGCGCGCGTCGCAAG
CAAGGTGAAATGGTATCTCT

Downstream 100 bases:

>100_bases
CCGACAGCTTCCATCGGGGAGAGAAAATGAACGATGCTCGATCGAACGCGAATGAAGGCCATATCGCTCCTTCGGCGGAG
GCGAACGCATTGGCGCTTGA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MNKPDEVLTLVPGQVTLGQLRRIIEARPMVQIERASLERVEKSKDIVSRIVADGKIVYGVNTGFGRLANTTIPAGRIAEL
QKNLVLSHSVGTGELMEDRVVGLIMALKAISLARGHSGVRPQVVLAIISMLNAGVYPCIPSKGSVGASGDLAPLAHLAAA
MLGVGHVRIDGKRVPAAEGLSVAGLEALKLGPKEGLALLNGTQASTALALSGLFAAERVFASAMVTGALSLEAVKGSTVP
FDPRIHVARGQRGQIDVAGRLAALLDGSGIIASHGNGTRVQDPYSIRCQPQVMGACLDHIRYVAGILTIEANAASDNPLV
FDNGDVLSGGNFHAEPVALAADALAVAISEIGAISERRTALLLDSHMSGLPAFLVKESGINSGFMIAQVTSAALASENKS
LAHPASVDSLPTSANQEDHVSMATFAARRLKDMADNTAVIVGIEGMAAAQGMDFHRPLRSSELLEEQHVQIRARVSFYTK
DRYLADDIETMKNWALESSRPGIVNTLFDI

Sequences:

>Translated_510_residues
MNKPDEVLTLVPGQVTLGQLRRIIEARPMVQIERASLERVEKSKDIVSRIVADGKIVYGVNTGFGRLANTTIPAGRIAEL
QKNLVLSHSVGTGELMEDRVVGLIMALKAISLARGHSGVRPQVVLAIISMLNAGVYPCIPSKGSVGASGDLAPLAHLAAA
MLGVGHVRIDGKRVPAAEGLSVAGLEALKLGPKEGLALLNGTQASTALALSGLFAAERVFASAMVTGALSLEAVKGSTVP
FDPRIHVARGQRGQIDVAGRLAALLDGSGIIASHGNGTRVQDPYSIRCQPQVMGACLDHIRYVAGILTIEANAASDNPLV
FDNGDVLSGGNFHAEPVALAADALAVAISEIGAISERRTALLLDSHMSGLPAFLVKESGINSGFMIAQVTSAALASENKS
LAHPASVDSLPTSANQEDHVSMATFAARRLKDMADNTAVIVGIEGMAAAQGMDFHRPLRSSELLEEQHVQIRARVSFYTK
DRYLADDIETMKNWALESSRPGIVNTLFDI
>Mature_510_residues
MNKPDEVLTLVPGQVTLGQLRRIIEARPMVQIERASLERVEKSKDIVSRIVADGKIVYGVNTGFGRLANTTIPAGRIAEL
QKNLVLSHSVGTGELMEDRVVGLIMALKAISLARGHSGVRPQVVLAIISMLNAGVYPCIPSKGSVGASGDLAPLAHLAAA
MLGVGHVRIDGKRVPAAEGLSVAGLEALKLGPKEGLALLNGTQASTALALSGLFAAERVFASAMVTGALSLEAVKGSTVP
FDPRIHVARGQRGQIDVAGRLAALLDGSGIIASHGNGTRVQDPYSIRCQPQVMGACLDHIRYVAGILTIEANAASDNPLV
FDNGDVLSGGNFHAEPVALAADALAVAISEIGAISERRTALLLDSHMSGLPAFLVKESGINSGFMIAQVTSAALASENKS
LAHPASVDSLPTSANQEDHVSMATFAARRLKDMADNTAVIVGIEGMAAAQGMDFHRPLRSSELLEEQHVQIRARVSFYTK
DRYLADDIETMKNWALESSRPGIVNTLFDI

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=508, Percent_Identity=44.0944881889764, Blast_Score=407, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17567831, Length=493, Percent_Identity=43.2048681541582, Blast_Score=359, Evalue=2e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53577; Mature: 53577

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPDEVLTLVPGQVTLGQLRRIIEARPMVQIERASLERVEKSKDIVSRIVADGKIVYGV
CCCCCCEEEECCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEE
NTGFGRLANTTIPAGRIAELQKNLVLSHSVGTGELMEDRVVGLIMALKAISLARGHSGVR
CCCCCHHCCCCCCCHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
PQVVLAIISMLNAGVYPCIPSKGSVGASGDLAPLAHLAAAMLGVGHVRIDGKRVPAAEGL
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCC
SVAGLEALKLGPKEGLALLNGTQASTALALSGLFAAERVFASAMVTGALSLEAVKGSTVP
CCCCCHHHHCCCHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC
FDPRIHVARGQRGQIDVAGRLAALLDGSGIIASHGNGTRVQDPYSIRCQPQVMGACLDHI
CCCCEEEECCCCCCEEHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEECHHHHHHHHHHH
RYVAGILTIEANAASDNPLVFDNGDVLSGGNFHAEPVALAADALAVAISEIGAISERRTA
HHHHHEEEEEECCCCCCCEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCHHHCCEE
LLLDSHMSGLPAFLVKESGINSGFMIAQVTSAALASENKSLAHPASVDSLPTSANQEDHV
EEEHHHCCCCCEEEEECCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHH
SMATFAARRLKDMADNTAVIVGIEGMAAAQGMDFHRPLRSSELLEEQHVQIRARVSFYTK
HHHHHHHHHHHHHCCCCEEEEEECCHHHHCCCCHHCCCCHHHHHHHHHHEEEEEEEEEEC
DRYLADDIETMKNWALESSRPGIVNTLFDI
CCHHHHHHHHHHHHCCCCCCCCHHHHHHCC
>Mature Secondary Structure
MNKPDEVLTLVPGQVTLGQLRRIIEARPMVQIERASLERVEKSKDIVSRIVADGKIVYGV
CCCCCCEEEECCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEE
NTGFGRLANTTIPAGRIAELQKNLVLSHSVGTGELMEDRVVGLIMALKAISLARGHSGVR
CCCCCHHCCCCCCCHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
PQVVLAIISMLNAGVYPCIPSKGSVGASGDLAPLAHLAAAMLGVGHVRIDGKRVPAAEGL
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCC
SVAGLEALKLGPKEGLALLNGTQASTALALSGLFAAERVFASAMVTGALSLEAVKGSTVP
CCCCCHHHHCCCHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC
FDPRIHVARGQRGQIDVAGRLAALLDGSGIIASHGNGTRVQDPYSIRCQPQVMGACLDHI
CCCCEEEECCCCCCEEHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEECHHHHHHHHHHH
RYVAGILTIEANAASDNPLVFDNGDVLSGGNFHAEPVALAADALAVAISEIGAISERRTA
HHHHHEEEEEECCCCCCCEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCHHHCCEE
LLLDSHMSGLPAFLVKESGINSGFMIAQVTSAALASENKSLAHPASVDSLPTSANQEDHV
EEEHHHCCCCCEEEEECCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHH
SMATFAARRLKDMADNTAVIVGIEGMAAAQGMDFHRPLRSSELLEEQHVQIRARVSFYTK
HHHHHHHHHHHHHCCCCEEEEEECCHHHHCCCCHHCCCCHHHHHHHHHHEEEEEEEEEEC
DRYLADDIETMKNWALESSRPGIVNTLFDI
CCHHHHHHHHHHHHCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]