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The map label for this gene is lpd [H]

Identifier: 91784258

GI number: 91784258

Start: 3205001

End: 3206812

Strand: Reverse

Name: lpd [H]

Synonym: Bxe_A1543

Alternate gene names: 91784258

Gene position: 3206812-3205001 (Counterclockwise)

Preceding gene: 91784259

Following gene: 91784256

Centisome position: 65.5

GC content: 62.2

Gene sequence:

>1812_bases
ATGAGTCTCGTCGAAGTAAAAGTGCCGGATATCGGCGACTTCAAAGATGTCGATGTCATTGAAGTCAACATCAAACCGGG
CGATGTCATCGAGAACGAACAGGCGCTGATGACGCTCGAATCCGATAAGGCTTCCATCGAAGTGCCGAGCGACACCGCCG
GCACCGTCAGGGAAGTGCGCGTCAAAGCCGGCGATAAGGTTTCGCAAGGCACAGTGATCGCGCTCGTCGAAACATCGGGG
GAGGCGGCGCCCGCGAAAGATGCACCGAAGGCGCCGGCCAAGGAAGCTGAGAAAGCGCCCGCTCAGGCAGAAGCCAAGCC
GCAGGCAGCCGAGGCTCCGGCTGCCGCTCCGGCCAAGGCGGCGGCGCCCGCGCCGCAAGCCGGCAGCTATTCGGGCAGCG
CGGATATCGAGTGCGACATGCTCGTGCTCGGATCCGGCCCCGGCGGCTACTCGGCAGCGTTCCGCTCGGCCGACCTCGGC
ATGAAGACGGTGCTGGTCGAGCGTTATTCGACGCTCGGCGGCGTGTGTCTGAATGTCGGCTGTATTCCGTCGAAAGCGCT
GTTGCATACGGCTCTCGTGATCGACGAAGCCGAAGCGCTCGGCGCACACGGCATTACGTTCGCCAAGCCGCAAATCGATC
TCGACAAGCTGCGTGATTTCAAGTCGGGCGTCGTCAGGAAGCTGACCGGCGGTCTCGCCGGCATGGCGAAGATGCGCAAG
GTCGAAGTGGTGACGGGTAACGGCGCGTTTGTCGATCCGTATCACATGGAAGTGCAGACCGAAGGCGGCAAGAAAGTCGT
CAAGTTCAAGCAGGCGATCATCGCCGCCGGCTCGGAAGCGGTGAAGCTGCCGTTCATTCCGGAAGATCCGCGCGTGGTCG
ATTCGACCGGTGCGCTCGAACTGCGGCAGATTCCGCAACGCATGCTGGTGATCGGCGGCGGCATCATCGGTCTGGAAATG
GCCACGGTGTATGCCACGCTCGGCGCGAAGATCGACGTGGTCGAAATGCTCGACGGCCTGATGGCCGGCGCGGACCGCGA
TCTGGTCAAGGTCTGGGAGAAGTACAACAGCAAGCGTTTCGCAAACGTCATGCTGAAGACCAAAACCACCGCAGCCGAAG
CGAAAGACGACGGCATCCATGTCTCGTTCGAAGGCGAAAAAGCCCCGGCCGAAGCGCAACGCTACGACCTCGTGCTGGTG
GCAGTCGGCCGTACGCCGAATGGCAAGAAAATCGGCGCGGACAAGGCCGGCGTCGCGGTGACGGATCGCGGCTTTATCGA
CGTCGACAAGCAGATGCGTACCAACGTGCCGCACATCTTCGCGATCGGCGATATCGTCGGTCAGCCGATGCTCGCGCATA
AAGCGGTGCACGAAGGCCACGTTGCCGCCGAAGCCGCGCATGGTGAGAAGGCGTACTTCGACGCGCTGCAGATTCCGTCG
GTGGCTTACACCGATCCGGAAGTGGCGTGGGCCGGCAAGACCGAAGACCAGTTGAAGGCGGCGGGCATCAAGTACGGCAA
GGCGGTGTTCCCGTGGGCCGCTTCGGGCCGCGCGATTGCCAACGGTCGCGACGAAGGCTTCACGAAGCTGTTGTTCGACG
AGGAAACGCATCGCGTGATCGGCGGCGGGATCGTCGGCCTGAATGCGGGCGACCTGATCAGCGAAGTGTGTCTCGCAGTC
GAGATGGGTGCGGACGCAACGGATATCGGTAAGACGATTCATCCGCATCCGACGCTCGGTGAATCGATCGGCATGGCCGC
CGAGTTGTATGAAGGCGTGTGCACCGACTTGCCGCCGCAGAAAAAGAAGTAG

Upstream 100 bases:

>100_bases
CGGACAGCAAAGAATGTTTCTGTTCGCCGCGCTGCCAGCTTTTTGGACTTATGGGTGTGAGTTCTCCGTTCATCACGATC
AATAAGAGAAGGGGACACTA

Downstream 100 bases:

>100_bases
CGCGGTTTGGCCCGTCCGCATTCATATGCAGGCGGGCCAAGAAAGCAAAAAAAACGGCGCGTTCCGTAAAGGACGCGCCA
TTTTTTTTGAGCAGCAGAGC

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex [H]

Number of amino acids: Translated: 603; Mature: 602

Protein sequence:

>603_residues
MSLVEVKVPDIGDFKDVDVIEVNIKPGDVIENEQALMTLESDKASIEVPSDTAGTVREVRVKAGDKVSQGTVIALVETSG
EAAPAKDAPKAPAKEAEKAPAQAEAKPQAAEAPAAAPAKAAAPAPQAGSYSGSADIECDMLVLGSGPGGYSAAFRSADLG
MKTVLVERYSTLGGVCLNVGCIPSKALLHTALVIDEAEALGAHGITFAKPQIDLDKLRDFKSGVVRKLTGGLAGMAKMRK
VEVVTGNGAFVDPYHMEVQTEGGKKVVKFKQAIIAAGSEAVKLPFIPEDPRVVDSTGALELRQIPQRMLVIGGGIIGLEM
ATVYATLGAKIDVVEMLDGLMAGADRDLVKVWEKYNSKRFANVMLKTKTTAAEAKDDGIHVSFEGEKAPAEAQRYDLVLV
AVGRTPNGKKIGADKAGVAVTDRGFIDVDKQMRTNVPHIFAIGDIVGQPMLAHKAVHEGHVAAEAAHGEKAYFDALQIPS
VAYTDPEVAWAGKTEDQLKAAGIKYGKAVFPWAASGRAIANGRDEGFTKLLFDEETHRVIGGGIVGLNAGDLISEVCLAV
EMGADATDIGKTIHPHPTLGESIGMAAELYEGVCTDLPPQKKK

Sequences:

>Translated_603_residues
MSLVEVKVPDIGDFKDVDVIEVNIKPGDVIENEQALMTLESDKASIEVPSDTAGTVREVRVKAGDKVSQGTVIALVETSG
EAAPAKDAPKAPAKEAEKAPAQAEAKPQAAEAPAAAPAKAAAPAPQAGSYSGSADIECDMLVLGSGPGGYSAAFRSADLG
MKTVLVERYSTLGGVCLNVGCIPSKALLHTALVIDEAEALGAHGITFAKPQIDLDKLRDFKSGVVRKLTGGLAGMAKMRK
VEVVTGNGAFVDPYHMEVQTEGGKKVVKFKQAIIAAGSEAVKLPFIPEDPRVVDSTGALELRQIPQRMLVIGGGIIGLEM
ATVYATLGAKIDVVEMLDGLMAGADRDLVKVWEKYNSKRFANVMLKTKTTAAEAKDDGIHVSFEGEKAPAEAQRYDLVLV
AVGRTPNGKKIGADKAGVAVTDRGFIDVDKQMRTNVPHIFAIGDIVGQPMLAHKAVHEGHVAAEAAHGEKAYFDALQIPS
VAYTDPEVAWAGKTEDQLKAAGIKYGKAVFPWAASGRAIANGRDEGFTKLLFDEETHRVIGGGIVGLNAGDLISEVCLAV
EMGADATDIGKTIHPHPTLGESIGMAAELYEGVCTDLPPQKKK
>Mature_602_residues
SLVEVKVPDIGDFKDVDVIEVNIKPGDVIENEQALMTLESDKASIEVPSDTAGTVREVRVKAGDKVSQGTVIALVETSGE
AAPAKDAPKAPAKEAEKAPAQAEAKPQAAEAPAAAPAKAAAPAPQAGSYSGSADIECDMLVLGSGPGGYSAAFRSADLGM
KTVLVERYSTLGGVCLNVGCIPSKALLHTALVIDEAEALGAHGITFAKPQIDLDKLRDFKSGVVRKLTGGLAGMAKMRKV
EVVTGNGAFVDPYHMEVQTEGGKKVVKFKQAIIAAGSEAVKLPFIPEDPRVVDSTGALELRQIPQRMLVIGGGIIGLEMA
TVYATLGAKIDVVEMLDGLMAGADRDLVKVWEKYNSKRFANVMLKTKTTAAEAKDDGIHVSFEGEKAPAEAQRYDLVLVA
VGRTPNGKKIGADKAGVAVTDRGFIDVDKQMRTNVPHIFAIGDIVGQPMLAHKAVHEGHVAAEAAHGEKAYFDALQIPSV
AYTDPEVAWAGKTEDQLKAAGIKYGKAVFPWAASGRAIANGRDEGFTKLLFDEETHRVIGGGIVGLNAGDLISEVCLAVE
MGADATDIGKTIHPHPTLGESIGMAAELYEGVCTDLPPQKKK

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransfer

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=455, Percent_Identity=42.4175824175824, Blast_Score=343, Evalue=3e-94,
Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=25.7019438444924, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI291045266, Length=434, Percent_Identity=26.9585253456221, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI148277071, Length=426, Percent_Identity=25.3521126760563, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI22035672, Length=455, Percent_Identity=26.1538461538462, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI33519430, Length=426, Percent_Identity=25.3521126760563, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI33519428, Length=426, Percent_Identity=25.3521126760563, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI33519426, Length=426, Percent_Identity=25.3521126760563, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI148277065, Length=426, Percent_Identity=25.3521126760563, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI291045268, Length=427, Percent_Identity=25.7611241217799, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI1786307, Length=473, Percent_Identity=65.7505285412262, Blast_Score=629, Evalue=0.0,
Organism=Escherichia coli, GI87082354, Length=472, Percent_Identity=29.6610169491525, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI87081717, Length=450, Percent_Identity=25.3333333333333, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1789915, Length=440, Percent_Identity=27.2727272727273, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI1786305, Length=73, Percent_Identity=53.4246575342466, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32565766, Length=462, Percent_Identity=41.7748917748918, Blast_Score=342, Evalue=4e-94,
Organism=Caenorhabditis elegans, GI17557007, Length=483, Percent_Identity=26.7080745341615, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71983429, Length=462, Percent_Identity=26.4069264069264, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71983419, Length=462, Percent_Identity=26.4069264069264, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71982272, Length=445, Percent_Identity=26.0674157303371, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321091, Length=458, Percent_Identity=41.4847161572052, Blast_Score=312, Evalue=9e-86,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=28.7846481876333, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6325166, Length=468, Percent_Identity=26.9230769230769, Blast_Score=133, Evalue=8e-32,
Organism=Drosophila melanogaster, GI21358499, Length=466, Percent_Identity=43.5622317596566, Blast_Score=359, Evalue=4e-99,
Organism=Drosophila melanogaster, GI24640553, Length=486, Percent_Identity=27.7777777777778, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24640549, Length=484, Percent_Identity=27.8925619834711, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24640551, Length=490, Percent_Identity=27.7551020408163, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17737741, Length=480, Percent_Identity=25.8333333333333, Blast_Score=102, Evalue=1e-21,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 63210; Mature: 63079

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00076 PYRIDINE_REDOX_1 ; PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVEVKVPDIGDFKDVDVIEVNIKPGDVIENEQALMTLESDKASIEVPSDTAGTVREVR
CCEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEECCCCEEECCCCCCCCHHEEE
VKAGDKVSQGTVIALVETSGEAAPAKDAPKAPAKEAEKAPAQAEAKPQAAEAPAAAPAKA
ECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCC
AAPAPQAGSYSGSADIECDMLVLGSGPGGYSAAFRSADLGMKTVLVERYSTLGGVCLNVG
CCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEC
CIPSKALLHTALVIDEAEALGAHGITFAKPQIDLDKLRDFKSGVVRKLTGGLAGMAKMRK
CCCCHHHHHHHHHEECHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCEE
VEVVTGNGAFVDPYHMEVQTEGGKKVVKFKQAIIAAGSEAVKLPFIPEDPRVVDSTGALE
EEEEECCCCEECCEEEEEEECCCHHHHHHHHHHHHCCCCEEECCCCCCCCCEECCCCCHH
LRQIPQRMLVIGGGIIGLEMATVYATLGAKIDVVEMLDGLMAGADRDLVKVWEKYNSKRF
HHHHCHHEEEECCCCHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCHHHHHHHHHHCCCEE
ANVMLKTKTTAAEAKDDGIHVSFEGEKAPAEAQRYDLVLVAVGRTPNGKKIGADKAGVAV
EEEEEEECCCCCCCCCCCEEEEECCCCCCCCHHHEEEEEEEECCCCCCCEECCCCCCEEE
TDRGFIDVDKQMRTNVPHIFAIGDIVGQPMLAHKAVHEGHVAAEAAHGEKAYFDALQIPS
ECCCCEEECHHHHCCCCEEEEEHHHHCCCHHHHHHHHCCCCEEECCCCCHHHHHHHCCCC
VAYTDPEVAWAGKTEDQLKAAGIKYGKAVFPWAASGRAIANGRDEGFTKLLFDEETHRVI
EEECCCCEEECCCCHHHHHHHCCCCCCEECCCCCCCCEEECCCCCCCEEEEECCCCCEEE
GGGIVGLNAGDLISEVCLAVEMGADATDIGKTIHPHPTLGESIGMAAELYEGVCTDLPPQ
CCCEEECCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
KKK
CCC
>Mature Secondary Structure 
SLVEVKVPDIGDFKDVDVIEVNIKPGDVIENEQALMTLESDKASIEVPSDTAGTVREVR
CEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEECCCCEEECCCCCCCCHHEEE
VKAGDKVSQGTVIALVETSGEAAPAKDAPKAPAKEAEKAPAQAEAKPQAAEAPAAAPAKA
ECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCC
AAPAPQAGSYSGSADIECDMLVLGSGPGGYSAAFRSADLGMKTVLVERYSTLGGVCLNVG
CCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEC
CIPSKALLHTALVIDEAEALGAHGITFAKPQIDLDKLRDFKSGVVRKLTGGLAGMAKMRK
CCCCHHHHHHHHHEECHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCEE
VEVVTGNGAFVDPYHMEVQTEGGKKVVKFKQAIIAAGSEAVKLPFIPEDPRVVDSTGALE
EEEEECCCCEECCEEEEEEECCCHHHHHHHHHHHHCCCCEEECCCCCCCCCEECCCCCHH
LRQIPQRMLVIGGGIIGLEMATVYATLGAKIDVVEMLDGLMAGADRDLVKVWEKYNSKRF
HHHHCHHEEEECCCCHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCHHHHHHHHHHCCCEE
ANVMLKTKTTAAEAKDDGIHVSFEGEKAPAEAQRYDLVLVAVGRTPNGKKIGADKAGVAV
EEEEEEECCCCCCCCCCCEEEEECCCCCCCCHHHEEEEEEEECCCCCCCEECCCCCCEEE
TDRGFIDVDKQMRTNVPHIFAIGDIVGQPMLAHKAVHEGHVAAEAAHGEKAYFDALQIPS
ECCCCEEECHHHHCCCCEEEEEHHHHCCCHHHHHHHHCCCCEEECCCCCHHHHHHHCCCC
VAYTDPEVAWAGKTEDQLKAAGIKYGKAVFPWAASGRAIANGRDEGFTKLLFDEETHRVI
EEECCCCEEECCCCHHHHHHHCCCCCCEECCCCCCCCEEECCCCCCCEEEEECCCCCEEE
GGGIVGLNAGDLISEVCLAVEMGADATDIGKTIHPHPTLGESIGMAAELYEGVCTDLPPQ
CCCEEECCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
KKK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]