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The map label for this gene is dmlR [H]

Identifier: 91784152

GI number: 91784152

Start: 3087762

End: 3088664

Strand: Reverse

Name: dmlR [H]

Synonym: Bxe_A1649

Alternate gene names: 91784152

Gene position: 3088664-3087762 (Counterclockwise)

Preceding gene: 91784155

Following gene: 91784151

Centisome position: 63.09

GC content: 66.22

Gene sequence:

>903_bases
ATGGACCGTTTCAAGCAGATCGAGACTTTCGTGACCGTCGCGGCCAAAGGCAGCCTGTCCGCTGCGGCTTCGGCCGAAGG
CGTGGCGCCGGCCATCATCGGGCGACGCATCGACGCGCTCGAAGAGCGTCTCGGCGTCAAATTGCTGGTGCGCACCACGC
GCAAGCTCACGCTGACCTTCGAAGGCTCGGCCTTTCTCGAAGACTGTCAGCGCATCATTCACGAGATGCAGAATGCGGAA
GCCAGCGTGTCGGCGGGCGGCGTCAAGGCGAGCGGCCATCTGCGGCTCTCCGCGCCCGCGGGCTTCGGACGCCGGCACGT
CGCGCCACTGGTGCCGGCGTTCACGGTCGCGCATCCGGACGTGTCGATCACGCTCGACCTGTCCGACCGGCTCGTCGATC
TGGTCAACGAGGGTTTCGACTGCGCCGTGCGTCTCGGCGAATTGCCGGATTCGTCGCTGGTGTCGCTCAGGCTCGGCGAG
AACCGCCGGGTTTGCGTCGCGTCGCCCGCGTATCTGAGCCGGCGCGGTGCGCCGCACAGCCTCGCCGATCTCGCGCATCA
CAACTGCCTCGCGCTCGGCGCGAGCGCCAACCAGCAGCGTGGCTGGATGTTCCAGCAGGACGACAAGGTGGTTTCGATCA
AGGTGTCCGGCACGATGGAATGCTCGGACGGCGCGGTGCTGCACGACTGGTGTCTCGAAGGCTATGGTCTCGCGTGGCGC
TCGTGGTGGGAGGTCGGTACGGACATTGCGGCGGGGCGGCTCGTCAGCGTGCTCGACGAATTCGCCGCGCCGCCCATCGG
CATTCATGCGGTGTTTCCGCAGCGCCGCCATCTGCCGCTGCGCGTGAGACTGTTTCTGGACTTTCTCAAGCATACCTATG
GACATCCCGGCTATTGGGGCTGA

Upstream 100 bases:

>100_bases
TCTTTTACTTTCATGCACCTAATCTGACGCGCACTGACCACCTTCCACGCGTCGCGTCTCAAGGAAAATGCCTTGATGGG
ACGGCGCGGCCCCCTCGCTT

Downstream 100 bases:

>100_bases
CGCCGCGCGATCTCGCCCGCCGATTTGCGCCGCGCCGAACAAGGGGTTTCCGATATGCGGACAGACCCTCGGCGGATCCT
TCGGCCCGATTCCGCGACCT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: D-malate degradation protein R [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MDRFKQIETFVTVAAKGSLSAAASAEGVAPAIIGRRIDALEERLGVKLLVRTTRKLTLTFEGSAFLEDCQRIIHEMQNAE
ASVSAGGVKASGHLRLSAPAGFGRRHVAPLVPAFTVAHPDVSITLDLSDRLVDLVNEGFDCAVRLGELPDSSLVSLRLGE
NRRVCVASPAYLSRRGAPHSLADLAHHNCLALGASANQQRGWMFQQDDKVVSIKVSGTMECSDGAVLHDWCLEGYGLAWR
SWWEVGTDIAAGRLVSVLDEFAAPPIGIHAVFPQRRHLPLRVRLFLDFLKHTYGHPGYWG

Sequences:

>Translated_300_residues
MDRFKQIETFVTVAAKGSLSAAASAEGVAPAIIGRRIDALEERLGVKLLVRTTRKLTLTFEGSAFLEDCQRIIHEMQNAE
ASVSAGGVKASGHLRLSAPAGFGRRHVAPLVPAFTVAHPDVSITLDLSDRLVDLVNEGFDCAVRLGELPDSSLVSLRLGE
NRRVCVASPAYLSRRGAPHSLADLAHHNCLALGASANQQRGWMFQQDDKVVSIKVSGTMECSDGAVLHDWCLEGYGLAWR
SWWEVGTDIAAGRLVSVLDEFAAPPIGIHAVFPQRRHLPLRVRLFLDFLKHTYGHPGYWG
>Mature_300_residues
MDRFKQIETFVTVAAKGSLSAAASAEGVAPAIIGRRIDALEERLGVKLLVRTTRKLTLTFEGSAFLEDCQRIIHEMQNAE
ASVSAGGVKASGHLRLSAPAGFGRRHVAPLVPAFTVAHPDVSITLDLSDRLVDLVNEGFDCAVRLGELPDSSLVSLRLGE
NRRVCVASPAYLSRRGAPHSLADLAHHNCLALGASANQQRGWMFQQDDKVVSIKVSGTMECSDGAVLHDWCLEGYGLAWR
SWWEVGTDIAAGRLVSVLDEFAAPPIGIHAVFPQRRHLPLRVRLFLDFLKHTYGHPGYWG

Specific function: Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081978, Length=297, Percent_Identity=36.026936026936, Blast_Score=192, Evalue=2e-50,
Organism=Escherichia coli, GI1789440, Length=286, Percent_Identity=32.1678321678322, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI1786401, Length=295, Percent_Identity=33.2203389830508, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI145693193, Length=290, Percent_Identity=31.3793103448276, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI1787589, Length=287, Percent_Identity=31.0104529616725, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1787128, Length=283, Percent_Identity=29.3286219081272, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1789639, Length=297, Percent_Identity=28.6195286195286, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1786448, Length=274, Percent_Identity=27.3722627737226, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788706, Length=191, Percent_Identity=27.2251308900524, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790011, Length=298, Percent_Identity=23.489932885906, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789173, Length=255, Percent_Identity=25.8823529411765, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787601, Length=146, Percent_Identity=26.7123287671233, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32651; Mature: 32651

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRFKQIETFVTVAAKGSLSAAASAEGVAPAIIGRRIDALEERLGVKLLVRTTRKLTLTF
CCHHHHHHHHHEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEEEECEEEEEEE
EGSAFLEDCQRIIHEMQNAEASVSAGGVKASGHLRLSAPAGFGRRHVAPLVPAFTVAHPD
CCCHHHHHHHHHHHHHHCCCCEECCCCEEECCEEEEECCCCCCCCCCCHHCCEEEEECCC
VSITLDLSDRLVDLVNEGFDCAVRLGELPDSSLVSLRLGENRRVCVASPAYLSRRGAPHS
EEEEEECHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCEEEEECCHHHHHCCCCHH
LADLAHHNCLALGASANQQRGWMFQQDDKVVSIKVSGTMECSDGAVLHDWCLEGYGLAWR
HHHHHCCCEEEECCCCCCCCCCEEECCCCEEEEEEECEEECCCCCEEHHHHHCCCCCHHH
SWWEVGTDIAAGRLVSVLDEFAAPPIGIHAVFPQRRHLPLRVRLFLDFLKHTYGHPGYWG
HHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDRFKQIETFVTVAAKGSLSAAASAEGVAPAIIGRRIDALEERLGVKLLVRTTRKLTLTF
CCHHHHHHHHHEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEEEECEEEEEEE
EGSAFLEDCQRIIHEMQNAEASVSAGGVKASGHLRLSAPAGFGRRHVAPLVPAFTVAHPD
CCCHHHHHHHHHHHHHHCCCCEECCCCEEECCEEEEECCCCCCCCCCCHHCCEEEEECCC
VSITLDLSDRLVDLVNEGFDCAVRLGELPDSSLVSLRLGENRRVCVASPAYLSRRGAPHS
EEEEEECHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCEEEEECCHHHHHCCCCHH
LADLAHHNCLALGASANQQRGWMFQQDDKVVSIKVSGTMECSDGAVLHDWCLEGYGLAWR
HHHHHCCCEEEECCCCCCCCCCEEECCCCEEEEEEECEEECCCCCEEHHHHHCCCCCHHH
SWWEVGTDIAAGRLVSVLDEFAAPPIGIHAVFPQRRHLPLRVRLFLDFLKHTYGHPGYWG
HHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]