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The map label for this gene is guaB [H]

Identifier: 91784095

GI number: 91784095

Start: 3021222

End: 3022682

Strand: Reverse

Name: guaB [H]

Synonym: Bxe_A1706

Alternate gene names: 91784095

Gene position: 3022682-3021222 (Counterclockwise)

Preceding gene: 91784097

Following gene: 91784094

Centisome position: 61.74

GC content: 65.02

Gene sequence:

>1461_bases
ATGCGTCTGATCCAAACAGCACTCACGTTCGATGACGTGCTCCTCGTCCCGGCTTTCTCCGATGTTCTGCCGCGCGACAC
CAGCCTCAAGACCCGGCTGACCCGCAACATCTCCCTGAATATGCCGCTCGTGTCCGCCGCAATGGACACGGTCACGGAAG
CCCGTCTCGCCATCGCAATGGCGCAAATGGGTGGCGTGGGCATCATCCACAAGAACCTCACGCCGGCCGAACAGGCGCGT
GAAGTCGCCAAGGTGAAGCGCTTCGAATCGGGCGTCGTACGTGATCCGATCACCGTGCCGCCGCAAATGAAGGTGCGCGA
CGTGATCGCACTGTCGCGCCAGCATGGCATTTCGGGCTTCCCGGTTGTCGAAGGCGCGCAACTGGTGGGTATCGTCACGA
ACCGCGACCTGCGCTTCGAAGAGCGTCTGGACGAGCCGGTGCGCAACATCATGACGCCGCGCGAGCGCCTCGTCACAGTC
AAGGAAGGCACGCCGCTCGCCGAAGCCAAGGCGCTGATGCACAGCCACCGCCTCGAACGCGTGCTGGTGATCAACGACGC
ATTCGAACTGCGCGGCCTGATGACGGTCAAGGACATCACCAAGCAGACCGAACACCCGGACGCGTGTAAAGACGAGCACG
GCAAGCTGCGCGCAGGCGCGGCGGTCGGCGTGGGCGAAGACAACGAAGAGCGCGTGGAACTGCTGGTGCAGGCGGGCGTG
GACGTGATCGTGGTCGACACCGCGCATGGCCATAGCAAAGGCGTGCTCGAGCGCGTCAAGTGGGTCAAGCAGAACTTCCC
GCGGGTCGAAGTGATCGGCGGCAACATCGCCACCGCGGCGGCCGCCAAGGCGCTCGTCGAATATGGCGCGGACGGCGTGA
AGGTCGGTATCGGCCCGGGCTCGATCTGCACGACGCGGATCGTCGCCGGCGTGGGCGTGCCGCAGGTCACCGCGATCTCG
AACGTTTCCGAAGCGCTGAAGGGCTCGGGCGTACCGGTCATCGCCGACGGCGGCGTGCGGTTCTCCGGCGACGTCAGCAA
GGCGCTGGCCGCCGGCGCGAACGCCGTGATGATGGGCAGCATGTTTGCCGGCACCGAAGAAGCGCCGGGCGACGTGTTCC
TGTTCCAGGGCCGCCAGTACAAGTCGTACCGTGGCATGGGCTCGGTCGGCGCGATGAAGGACGGCGCCGCGGACCGCTAC
TTCCAGGACAACTCCGCGAATATCGACAAGCTGGTGCCCGAAGGTATCGAAGGCCGCGTCGCCTACAAGGGCTCGGTCAA
CGCGATCCTGTTCCAGCTGATCGGCGGCGTGCGCGCCAGCATGGGCTACTGTGGCTGCCGCACCATCGCCGAGATGAACG
ACAAGGCGGAGTTCGTGCAGATCACGGGCGCCGGTTTGCGCGAGTCGCACGTGCATGATGTGCAGATCACCAAGGAAGCA
CCCAACTACCACGTGGACTAA

Upstream 100 bases:

>100_bases
GATGCGAAAAAACTACCCGAAATTCGCTAAGCTGCTGTTAGTGCAGTGAAAACCAGGGAGGTATCGCGTATAATTCGCTT
TTGCGCCTATAGGATTTGCC

Downstream 100 bases:

>100_bases
ACGCTAATGAAGCCATTGCTGCGCGGTGTACTCATCCTCGATGCCTTGCTGTTGCTTGCGTTCGGCCTGCTTTTTCTGCT
GACGCCGTGGACTTCGTTGT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MRLIQTALTFDDVLLVPAFSDVLPRDTSLKTRLTRNISLNMPLVSAAMDTVTEARLAIAMAQMGGVGIIHKNLTPAEQAR
EVAKVKRFESGVVRDPITVPPQMKVRDVIALSRQHGISGFPVVEGAQLVGIVTNRDLRFEERLDEPVRNIMTPRERLVTV
KEGTPLAEAKALMHSHRLERVLVINDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGEDNEERVELLVQAGV
DVIVVDTAHGHSKGVLERVKWVKQNFPRVEVIGGNIATAAAAKALVEYGADGVKVGIGPGSICTTRIVAGVGVPQVTAIS
NVSEALKGSGVPVIADGGVRFSGDVSKALAAGANAVMMGSMFAGTEEAPGDVFLFQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVNAILFQLIGGVRASMGYCGCRTIAEMNDKAEFVQITGAGLRESHVHDVQITKEA
PNYHVD

Sequences:

>Translated_486_residues
MRLIQTALTFDDVLLVPAFSDVLPRDTSLKTRLTRNISLNMPLVSAAMDTVTEARLAIAMAQMGGVGIIHKNLTPAEQAR
EVAKVKRFESGVVRDPITVPPQMKVRDVIALSRQHGISGFPVVEGAQLVGIVTNRDLRFEERLDEPVRNIMTPRERLVTV
KEGTPLAEAKALMHSHRLERVLVINDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGEDNEERVELLVQAGV
DVIVVDTAHGHSKGVLERVKWVKQNFPRVEVIGGNIATAAAAKALVEYGADGVKVGIGPGSICTTRIVAGVGVPQVTAIS
NVSEALKGSGVPVIADGGVRFSGDVSKALAAGANAVMMGSMFAGTEEAPGDVFLFQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVNAILFQLIGGVRASMGYCGCRTIAEMNDKAEFVQITGAGLRESHVHDVQITKEA
PNYHVD
>Mature_486_residues
MRLIQTALTFDDVLLVPAFSDVLPRDTSLKTRLTRNISLNMPLVSAAMDTVTEARLAIAMAQMGGVGIIHKNLTPAEQAR
EVAKVKRFESGVVRDPITVPPQMKVRDVIALSRQHGISGFPVVEGAQLVGIVTNRDLRFEERLDEPVRNIMTPRERLVTV
KEGTPLAEAKALMHSHRLERVLVINDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGEDNEERVELLVQAGV
DVIVVDTAHGHSKGVLERVKWVKQNFPRVEVIGGNIATAAAAKALVEYGADGVKVGIGPGSICTTRIVAGVGVPQVTAIS
NVSEALKGSGVPVIADGGVRFSGDVSKALAAGANAVMMGSMFAGTEEAPGDVFLFQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVNAILFQLIGGVRASMGYCGCRTIAEMNDKAEFVQITGAGLRESHVHDVQITKEA
PNYHVD

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=452, Percent_Identity=44.0265486725664, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI34328928, Length=452, Percent_Identity=44.0265486725664, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI156616279, Length=452, Percent_Identity=44.0265486725664, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI34328930, Length=452, Percent_Identity=44.0265486725664, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI217035152, Length=448, Percent_Identity=43.9732142857143, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=41.2863070539419, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI217035148, Length=452, Percent_Identity=43.141592920354, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI217035150, Length=452, Percent_Identity=40.4867256637168, Blast_Score=331, Evalue=7e-91,
Organism=Homo sapiens, GI156104880, Length=262, Percent_Identity=34.7328244274809, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI50541956, Length=245, Percent_Identity=36.3265306122449, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI50541954, Length=245, Percent_Identity=36.3265306122449, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI50541952, Length=245, Percent_Identity=36.3265306122449, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI50541948, Length=245, Percent_Identity=36.3265306122449, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=61.3963039014374, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1786293, Length=238, Percent_Identity=32.3529411764706, Blast_Score=135, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI71994385, Length=480, Percent_Identity=36.875, Blast_Score=305, Evalue=5e-83,
Organism=Caenorhabditis elegans, GI71994389, Length=424, Percent_Identity=38.4433962264151, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17560440, Length=239, Percent_Identity=34.7280334728033, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=39.1393442622951, Blast_Score=357, Evalue=2e-99,
Organism=Saccharomyces cerevisiae, GI6323585, Length=484, Percent_Identity=39.8760330578512, Blast_Score=353, Evalue=3e-98,
Organism=Saccharomyces cerevisiae, GI6323464, Length=484, Percent_Identity=38.8429752066116, Blast_Score=342, Evalue=6e-95,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=39.766081871345, Blast_Score=270, Evalue=5e-73,
Organism=Saccharomyces cerevisiae, GI6319353, Length=119, Percent_Identity=36.1344537815126, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641071, Length=481, Percent_Identity=41.3721413721414, Blast_Score=359, Evalue=3e-99,
Organism=Drosophila melanogaster, GI24641073, Length=481, Percent_Identity=41.3721413721414, Blast_Score=359, Evalue=3e-99,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=41.9501133786848, Blast_Score=325, Evalue=6e-89,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52020; Mature: 52020

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIQTALTFDDVLLVPAFSDVLPRDTSLKTRLTRNISLNMPLVSAAMDTVTEARLAIAM
CCHHHHHHCCCCEEEECCHHHHCCCCCCHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
AQMGGVGIIHKNLTPAEQAREVAKVKRFESGVVRDPITVPPQMKVRDVIALSRQHGISGF
HHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
PVVEGAQLVGIVTNRDLRFEERLDEPVRNIMTPRERLVTVKEGTPLAEAKALMHSHRLER
CEECCCEEEEEEECCCCCHHHHHHHHHHHHCCCHHHEEEEECCCCHHHHHHHHHHHHCCE
VLVINDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGEDNEERVELLVQAGV
EEEEECHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEECEEECCCCCCHHHHHHHHHCCC
DVIVVDTAHGHSKGVLERVKWVKQNFPRVEVIGGNIATAAAAKALVEYGADGVKVGIGPG
CEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCC
SICTTRIVAGVGVPQVTAISNVSEALKGSGVPVIADGGVRFSGDVSKALAAGANAVMMGS
CHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCEEECCCHHHHHHCCCCEEEECH
MFAGTEEAPGDVFLFQGRQYKSYRGMGSVGAMKDGAADRYFQDNSANIDKLVPEGIEGRV
HHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEE
AYKGSVNAILFQLIGGVRASMGYCGCRTIAEMNDKAEFVQITGAGLRESHVHDVQITKEA
EECCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEECC
PNYHVD
CCCCCC
>Mature Secondary Structure
MRLIQTALTFDDVLLVPAFSDVLPRDTSLKTRLTRNISLNMPLVSAAMDTVTEARLAIAM
CCHHHHHHCCCCEEEECCHHHHCCCCCCHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
AQMGGVGIIHKNLTPAEQAREVAKVKRFESGVVRDPITVPPQMKVRDVIALSRQHGISGF
HHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
PVVEGAQLVGIVTNRDLRFEERLDEPVRNIMTPRERLVTVKEGTPLAEAKALMHSHRLER
CEECCCEEEEEEECCCCCHHHHHHHHHHHHCCCHHHEEEEECCCCHHHHHHHHHHHHCCE
VLVINDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGEDNEERVELLVQAGV
EEEEECHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEECEEECCCCCCHHHHHHHHHCCC
DVIVVDTAHGHSKGVLERVKWVKQNFPRVEVIGGNIATAAAAKALVEYGADGVKVGIGPG
CEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCC
SICTTRIVAGVGVPQVTAISNVSEALKGSGVPVIADGGVRFSGDVSKALAAGANAVMMGS
CHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCEEECCCHHHHHHCCCCEEEECH
MFAGTEEAPGDVFLFQGRQYKSYRGMGSVGAMKDGAADRYFQDNSANIDKLVPEGIEGRV
HHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEE
AYKGSVNAILFQLIGGVRASMGYCGCRTIAEMNDKAEFVQITGAGLRESHVHDVQITKEA
EECCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEECC
PNYHVD
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA