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The map label for this gene is guaA [H]

Identifier: 91784093

GI number: 91784093

Start: 3018699

End: 3020282

Strand: Reverse

Name: guaA [H]

Synonym: Bxe_A1708

Alternate gene names: 91784093

Gene position: 3020282-3018699 (Counterclockwise)

Preceding gene: 91784094

Following gene: 91784092

Centisome position: 61.69

GC content: 62.69

Gene sequence:

>1584_bases
ATGCACGACAAGATTCTGATCCTCGACTTCGGTTCGCAAGTCACCCAACTGATTGCACGTCGCGTTCGCGAAGCCAACGT
GTATTCGGAAATTCATCCGTACGACGTCGATGCGTCGTTCATTCGCGACTTCGCGCCGAAGGGCGTGATCCTTTCCGGCG
GCCCGAGCTCGGTCACTGAAACGGACACGCCGCGCGTGCCGCAGGCCGTGTTCGAACTCGGCGTGCCGGTGCTCGGCATC
TGCTACGGCATGCAGGCGATGGCCGAGCAGCTGGGCGGCAAGGTCGATATCGGCCACCTGCGCGAGTTCGGTTATGCCGA
GGTGCGCGCGCGCAACCACACGAGCCTGCTCGAAGGCATCAGCGACTTCACCACGCCGGAAGGCCACGGCATGTTGAAGG
TGTGGATGAGCCACGGCGACAAGGTGCTGGAAATGCCGCCGGGCTTCGCGCTGATGGCGTCGACGGAATCGTGCCCGATC
GCCGCGATGGCCGACGAAACGCGCCATTTCTACGGCCTGCAATGGCACCCGGAAGTCACGCACACCGTGCAGGGCCGCGC
CATGCTCGAACGCTTCGTGCTGAAGATCTGCGGCGCGCAGCCGGATTGGGAAATGGGCCACTATATCGACGAAGCCGTCG
CGAAGATCCGCGAGCAGGTCGGTCAGGAACATGTGATCCTGGGACTCTCGGGCGGCGTGGATTCGTCGGTGGCGGCGGCG
CTGCTGCATCGCGCGATTGGCGATCAGCTGACCTGCGTGTTCGTCGATCATGGCCTGTTGCGCCTGAACGAAGCCGAGCA
GGTAATGGCGACCTTCGCGGATCACCTGGGCGTGAAGGTGATTCACGTCGACGCGAGCGAGGTGTTCCTGCGCAAGCTGG
CCGGTGTGACCGATCCGGAAGCGAAGCGCAAGATCATCGGCGCGGAATTCGTCGAGGTGTTCCAGACCGAAGCCGGCAAG
CTGACCGATGCGAAGTGGCTGGCGCAAGGCACGATCTATCCGGACGTGATCGAATCGGCCGGCAAGGGCAAGAAAGCCAC
GCAGACGATCAAGAGCCATCACAACGTGGGCGGCCTGCCAGAGACGCTGAACCTGAAGCTGCTCGAGCCGCTGCGCGAAC
TGTTCAAGGACGAAGTGCGCGAACTCGGCGTCAAGCTCGGTTTGCCGCCGGCCATGGTGTACCGCCATCCGTTCCCGGGC
CCGGGTCTGGGCGTGCGGATTCTCGGCGAAGTGAAGCGCGATTTCGCGGACCTGCTGCGCCGCGCGGACGCGATTTTCAT
CGAGACGTTGCGGACTTTCATCGACAAGGAAACCGGCAAGTCCTGGTACGATCTGACGAGCCAGGCGTTCGCGGTGTTTC
TGCCGGTGAAGAGCGTGGGCGTGATGGGTGACGGGCGGACTTATGAGTATGTTGTCGCGCTGCGCGCCGTGCAGACGCTG
GACTTCATGACCGCGCATTGGGCGCATCTGCCGCATGAGTTGCTGGGGCATGTGTCGAACCGGATTATTAATGAAGTGCG
CGGGATTAACCGGGTGGTGTATGACATTTCGGGGAAGCCGCCGGCGACAATCGAGTGGGAATGA

Upstream 100 bases:

>100_bases
CTTCACGCTCCAATGTCCCCACGTGGACCGCTTTGAATTCAACGCCGCGCGCTGTGCGCGGCATTCCGTATCCGCTTACT
CTTTGACTCCGTCCGCTGCC

Downstream 100 bases:

>100_bases
CCTAGACTGTTCCCAAGTCGTTCCGGGAGCTCCGGTTTTTCGTGTTTTCCCTTTTAAAAACATGAGGTTATTGTCCGCTC
TGATCCGTGGTGATCCGGGC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MHDKILILDFGSQVTQLIARRVREANVYSEIHPYDVDASFIRDFAPKGVILSGGPSSVTETDTPRVPQAVFELGVPVLGI
CYGMQAMAEQLGGKVDIGHLREFGYAEVRARNHTSLLEGISDFTTPEGHGMLKVWMSHGDKVLEMPPGFALMASTESCPI
AAMADETRHFYGLQWHPEVTHTVQGRAMLERFVLKICGAQPDWEMGHYIDEAVAKIREQVGQEHVILGLSGGVDSSVAAA
LLHRAIGDQLTCVFVDHGLLRLNEAEQVMATFADHLGVKVIHVDASEVFLRKLAGVTDPEAKRKIIGAEFVEVFQTEAGK
LTDAKWLAQGTIYPDVIESAGKGKKATQTIKSHHNVGGLPETLNLKLLEPLRELFKDEVRELGVKLGLPPAMVYRHPFPG
PGLGVRILGEVKRDFADLLRRADAIFIETLRTFIDKETGKSWYDLTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTL
DFMTAHWAHLPHELLGHVSNRIINEVRGINRVVYDISGKPPATIEWE

Sequences:

>Translated_527_residues
MHDKILILDFGSQVTQLIARRVREANVYSEIHPYDVDASFIRDFAPKGVILSGGPSSVTETDTPRVPQAVFELGVPVLGI
CYGMQAMAEQLGGKVDIGHLREFGYAEVRARNHTSLLEGISDFTTPEGHGMLKVWMSHGDKVLEMPPGFALMASTESCPI
AAMADETRHFYGLQWHPEVTHTVQGRAMLERFVLKICGAQPDWEMGHYIDEAVAKIREQVGQEHVILGLSGGVDSSVAAA
LLHRAIGDQLTCVFVDHGLLRLNEAEQVMATFADHLGVKVIHVDASEVFLRKLAGVTDPEAKRKIIGAEFVEVFQTEAGK
LTDAKWLAQGTIYPDVIESAGKGKKATQTIKSHHNVGGLPETLNLKLLEPLRELFKDEVRELGVKLGLPPAMVYRHPFPG
PGLGVRILGEVKRDFADLLRRADAIFIETLRTFIDKETGKSWYDLTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTL
DFMTAHWAHLPHELLGHVSNRIINEVRGINRVVYDISGKPPATIEWE
>Mature_527_residues
MHDKILILDFGSQVTQLIARRVREANVYSEIHPYDVDASFIRDFAPKGVILSGGPSSVTETDTPRVPQAVFELGVPVLGI
CYGMQAMAEQLGGKVDIGHLREFGYAEVRARNHTSLLEGISDFTTPEGHGMLKVWMSHGDKVLEMPPGFALMASTESCPI
AAMADETRHFYGLQWHPEVTHTVQGRAMLERFVLKICGAQPDWEMGHYIDEAVAKIREQVGQEHVILGLSGGVDSSVAAA
LLHRAIGDQLTCVFVDHGLLRLNEAEQVMATFADHLGVKVIHVDASEVFLRKLAGVTDPEAKRKIIGAEFVEVFQTEAGK
LTDAKWLAQGTIYPDVIESAGKGKKATQTIKSHHNVGGLPETLNLKLLEPLRELFKDEVRELGVKLGLPPAMVYRHPFPG
PGLGVRILGEVKRDFADLLRRADAIFIETLRTFIDKETGKSWYDLTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTL
DFMTAHWAHLPHELLGHVSNRIINEVRGINRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=564, Percent_Identity=34.7517730496454, Blast_Score=290, Evalue=2e-78,
Organism=Escherichia coli, GI1788854, Length=524, Percent_Identity=66.6030534351145, Blast_Score=716, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992710, Length=581, Percent_Identity=35.6282271944923, Blast_Score=298, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI71992717, Length=581, Percent_Identity=35.6282271944923, Blast_Score=298, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI133901714, Length=581, Percent_Identity=35.6282271944923, Blast_Score=298, Evalue=5e-81,
Organism=Saccharomyces cerevisiae, GI6323873, Length=534, Percent_Identity=50.749063670412, Blast_Score=532, Evalue=1e-152,
Organism=Drosophila melanogaster, GI281365319, Length=561, Percent_Identity=36.541889483066, Blast_Score=305, Evalue=4e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58217; Mature: 58217

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDKILILDFGSQVTQLIARRVREANVYSEIHPYDVDASFIRDFAPKGVILSGGPSSVTE
CCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEEECCCCCCCC
TDTPRVPQAVFELGVPVLGICYGMQAMAEQLGGKVDIGHLREFGYAEVRARNHTSLLEGI
CCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHCCCHHHHHHHH
SDFTTPEGHGMLKVWMSHGDKVLEMPPGFALMASTESCPIAAMADETRHFYGLQWHPEVT
HHCCCCCCCCEEEEEECCCCEEEECCCCEEEEECCCCCCEEHEHHCCHHEECEEECCCHH
HTVQGRAMLERFVLKICGAQPDWEMGHYIDEAVAKIREQVGQEHVILGLSGGVDSSVAAA
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LLHRAIGDQLTCVFVDHGLLRLNEAEQVMATFADHLGVKVIHVDASEVFLRKLAGVTDPE
HHHHHHCCCEEEEEECCCCCEECHHHHHHHHHHHHCCEEEEEECHHHHHHHHHCCCCCCH
AKRKIIGAEFVEVFQTEAGKLTDAKWLAQGTIYPDVIESAGKGKKATQTIKSHHNVGGLP
HHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCC
ETLNLKLLEPLRELFKDEVRELGVKLGLPPAMVYRHPFPGPGLGVRILGEVKRDFADLLR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIETLRTFIDKETGKSWYDLTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHEEEEEEHHHHCCCCCCCCHHHHHHHHHHHHH
DFMTAHWAHLPHELLGHVSNRIINEVRGINRVVYDISGKPPATIEWE
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MHDKILILDFGSQVTQLIARRVREANVYSEIHPYDVDASFIRDFAPKGVILSGGPSSVTE
CCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEEECCCCCCCC
TDTPRVPQAVFELGVPVLGICYGMQAMAEQLGGKVDIGHLREFGYAEVRARNHTSLLEGI
CCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHCCCHHHHHHHH
SDFTTPEGHGMLKVWMSHGDKVLEMPPGFALMASTESCPIAAMADETRHFYGLQWHPEVT
HHCCCCCCCCEEEEEECCCCEEEECCCCEEEEECCCCCCEEHEHHCCHHEECEEECCCHH
HTVQGRAMLERFVLKICGAQPDWEMGHYIDEAVAKIREQVGQEHVILGLSGGVDSSVAAA
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LLHRAIGDQLTCVFVDHGLLRLNEAEQVMATFADHLGVKVIHVDASEVFLRKLAGVTDPE
HHHHHHCCCEEEEEECCCCCEECHHHHHHHHHHHHCCEEEEEECHHHHHHHHHCCCCCCH
AKRKIIGAEFVEVFQTEAGKLTDAKWLAQGTIYPDVIESAGKGKKATQTIKSHHNVGGLP
HHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCC
ETLNLKLLEPLRELFKDEVRELGVKLGLPPAMVYRHPFPGPGLGVRILGEVKRDFADLLR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIETLRTFIDKETGKSWYDLTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHEEEEEEHHHHCCCCCCCCHHHHHHHHHHHHH
DFMTAHWAHLPHELLGHVSNRIINEVRGINRVVYDISGKPPATIEWE
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA