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The map label for this gene is virB4 [H]

Identifier: 91784047

GI number: 91784047

Start: 2970689

End: 2973181

Strand: Reverse

Name: virB4 [H]

Synonym: Bxe_A1756

Alternate gene names: 91784047

Gene position: 2973181-2970689 (Counterclockwise)

Preceding gene: 91784048

Following gene: 91784046

Centisome position: 60.73

GC content: 64.66

Gene sequence:

>2493_bases
ATGCCGGCCTATCCGCAATTAGTAGCCGTCGCCAACCGGGAAGTACCGCTCTCAGGCTATATCCCGTACTCGACGCACGT
CACCGAGCACGTCATCAAGACGCGCGAAGGCGACTATCTGCAGGTCTGGAAGATCGCCGGCATTGCGTTCGAGGCGGCGG
ACCCGGCCGATATACTCGCGCGGCACGACGGGTTCAACCAGTTCGTACGGGGCCTGGCCGGCGGCCATGTGGCGTTGTGG
TCTCATCGCCTGCGCCGGCGCGTGTCGGATCGCTTCTCGACCGAGTACCGCAACCGCTTCTGCGAGGAACTGGCGACGCG
CTACTACGCGAGCTTCGCCGGCTACCGGATGATGGCCAACGAACTATATCTGACGGTGGTCTACCGGCCGAACCGGACGC
GGCTCGGGCGCGTTTTCAGTCGCGCCGCACGGCGCACGCGCGACGATATCCGGCGCGACCAGCTGGACGCGCTGAAGGTC
ATGGCCGAGCTGGCCGCGCAGGTCGAATCGAGCCTCAAGCCCTACGATCCGGTCGCGCTCGGCGTCTATACGCGGCAAAG
CCCCTTCACGCCACACCCGCGCCGCTATTCGTCGGCACTGGAACTGTTCGGTTATCTGGTGAACGGCGTCTGGGAGCGCG
AGCCCGTACCGTCCGGCCCGATTCGCGAGGCACTGCCGACCTCACGCCTGTTCGTCGGTGCCGAGAAGATCGAGATCCGT
ATGCCGGCCGCAACGCGCTTCGCCGCGATGCTCGACCTGAAGGATTACCCGGAAGACACCGAACCAGGGATGCTCAACGG
CCTGCTGTACGGTGACTTCGAGTACATCGAGACGCAGTCGTTTACGATTCTCGACCGGCCCAGCGCGAAAGAAGCGCTGG
AGCGGCAGCGCAACCAGCTGATCGCGGGAGAGGACGTCGCTGTGTCGCAGGTCGAGGCGATGGACCGTGCGCTCGACGAA
CTGGTCAACGGCGATTTTGTGCTTGGCGAATATCACTATTCGCTGGCCGTGCTCGGGGACACGCTGGATGAGGTGTCCGG
TAGCGTGGCGAAGGCCCGCACGCAACTCGCCGATGCTGGTTTCCAGACCGCGCTGATCGACCTCGTCGCCGATGCAGCCT
GGTTCGCTCAGCTACCGGGCAACTGGCGCTATCGGCCGCGCGAGGCGAAGCTTACCTCGCGCAACTTCTGCGGCCTGTCG
AGCCTGCACAATTTTGCGACGGGAAAACGCGACGGCAATCCGTGGGGCGAGGCGATCACCATCTTCAAGACGCCGAGCGG
CCAGCCGCTTTATCTGAACTTCCACGTCACGCCCGACAAGCAGGATTCGCTCGACGAGAAGGCGCTCGCCAATACGCAGA
TCATCGGCCGCGCCGGCGCGGGCAAGACCGTGCTCGAACTGTTCCTGCTCGCGATGGCGACGAAGTACGGCATCACGGCC
GTGCTGTTCGACAAGGACCGCGGCACCGAGATCGCTATCCGGGCGATGGGCGGCACCTATACGGTGTTCCGTCGCGGCGA
GCCGACCGGGCTGAACCCGTTCCAGATGGAACCGGGCGAACCCGTGATCGACTTCTGGGAGCGCCTGGTCCGCAAGCTCG
TCGATATCGGTGTGACGCTGTCCGCGAAGGACGAGCTCGACATTTCGCGCGCGGTGCGCGAAGTCGCGCGCATGGACAAG
CCACTGCGGCGTCTCTCGATGGTCCGGCAGCTCCTGCCGAACGTCGGCGAGAACAGCCTGCATGCGCGGCTCGCGAAATG
GTGCGCGGGCGGGCGCCTGGGCTGGGTGTTCGACAACCCGACCGACCGCATCGATCTCGCGCACGCGACGCTGTTCGGCT
TCGACGATACCGAGCTGCTCGACGACGCGGAGGTCGCCACGCCTGTCACGATGTACCTGCTGCACCGGACCGAAAACCTG
ATCGACGGCCGGCGTTTCGTGTACGTCATGACCGAATTCTGGAAGCGTCTCGGCGATCCGGTCTTCACCGATTTTGCCCA
GAACAAGCAGAAGACGATACGCAAGCAGAACGGGCTTGGGATCTTCGACACGCAGTCGCCGGCCGATGTGCTGCGCAGTC
CGATCGCCAGTGCGCTGATTGAGCAGAGCGCGACGTTCTTCTTCCTGCCGAACCCGCGCGCCGATTATGACGACTACGTG
CGCGGCTTCAAGCTGACCGAGGCCGAATTCAACATCGTGCGCAACCTTGGCGAGAACAGCCGCATGTTCCTCGTCAAGCA
GGGGCATCGGTCGGCCATCGGCCGGCTCGATCTCGCGGGTCTCGGCGACGTGCTCGACGTACTGTCCGGCACGATCGACA
ACGTGGAGTTGCTTGACACGATCCGCGCCCAGGTCGGCGACCTGCCGCAGAACTGGGTGCCCGCCTTTCACGAGCAGTTG
GCGAAGCGCCGAGCGGCGCAGTCAGAACAGGCCAGTGCGCGCCAGTCGAAGCAGTTGCCAGGGCCGGAGTCAGGGCAGGG
AGGTGTGCGATGA

Upstream 100 bases:

>100_bases
CAGTACCTGTTGCGTGTGCGCATGGTGCTGCGCCAGGGCAACCGCCGCTTCTGGGGCGGGCATGCCTATGTGCCGGTCCG
CCTCAAGAGGAGGGCGTGAC

Downstream 100 bases:

>100_bases
GCGGCCTCTTCACCGCTGTCGGCGGCACCCTCGAAAACGGCATGTCCACCTACGTCACGAACGTCTCGTCGGCGCTGTCC
GGCGCGCTTGTGCCTGTTGT

Product: putative Type IV secretion system protein VirB4/TraE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 830; Mature: 829

Protein sequence:

>830_residues
MPAYPQLVAVANREVPLSGYIPYSTHVTEHVIKTREGDYLQVWKIAGIAFEAADPADILARHDGFNQFVRGLAGGHVALW
SHRLRRRVSDRFSTEYRNRFCEELATRYYASFAGYRMMANELYLTVVYRPNRTRLGRVFSRAARRTRDDIRRDQLDALKV
MAELAAQVESSLKPYDPVALGVYTRQSPFTPHPRRYSSALELFGYLVNGVWEREPVPSGPIREALPTSRLFVGAEKIEIR
MPAATRFAAMLDLKDYPEDTEPGMLNGLLYGDFEYIETQSFTILDRPSAKEALERQRNQLIAGEDVAVSQVEAMDRALDE
LVNGDFVLGEYHYSLAVLGDTLDEVSGSVAKARTQLADAGFQTALIDLVADAAWFAQLPGNWRYRPREAKLTSRNFCGLS
SLHNFATGKRDGNPWGEAITIFKTPSGQPLYLNFHVTPDKQDSLDEKALANTQIIGRAGAGKTVLELFLLAMATKYGITA
VLFDKDRGTEIAIRAMGGTYTVFRRGEPTGLNPFQMEPGEPVIDFWERLVRKLVDIGVTLSAKDELDISRAVREVARMDK
PLRRLSMVRQLLPNVGENSLHARLAKWCAGGRLGWVFDNPTDRIDLAHATLFGFDDTELLDDAEVATPVTMYLLHRTENL
IDGRRFVYVMTEFWKRLGDPVFTDFAQNKQKTIRKQNGLGIFDTQSPADVLRSPIASALIEQSATFFFLPNPRADYDDYV
RGFKLTEAEFNIVRNLGENSRMFLVKQGHRSAIGRLDLAGLGDVLDVLSGTIDNVELLDTIRAQVGDLPQNWVPAFHEQL
AKRRAAQSEQASARQSKQLPGPESGQGGVR

Sequences:

>Translated_830_residues
MPAYPQLVAVANREVPLSGYIPYSTHVTEHVIKTREGDYLQVWKIAGIAFEAADPADILARHDGFNQFVRGLAGGHVALW
SHRLRRRVSDRFSTEYRNRFCEELATRYYASFAGYRMMANELYLTVVYRPNRTRLGRVFSRAARRTRDDIRRDQLDALKV
MAELAAQVESSLKPYDPVALGVYTRQSPFTPHPRRYSSALELFGYLVNGVWEREPVPSGPIREALPTSRLFVGAEKIEIR
MPAATRFAAMLDLKDYPEDTEPGMLNGLLYGDFEYIETQSFTILDRPSAKEALERQRNQLIAGEDVAVSQVEAMDRALDE
LVNGDFVLGEYHYSLAVLGDTLDEVSGSVAKARTQLADAGFQTALIDLVADAAWFAQLPGNWRYRPREAKLTSRNFCGLS
SLHNFATGKRDGNPWGEAITIFKTPSGQPLYLNFHVTPDKQDSLDEKALANTQIIGRAGAGKTVLELFLLAMATKYGITA
VLFDKDRGTEIAIRAMGGTYTVFRRGEPTGLNPFQMEPGEPVIDFWERLVRKLVDIGVTLSAKDELDISRAVREVARMDK
PLRRLSMVRQLLPNVGENSLHARLAKWCAGGRLGWVFDNPTDRIDLAHATLFGFDDTELLDDAEVATPVTMYLLHRTENL
IDGRRFVYVMTEFWKRLGDPVFTDFAQNKQKTIRKQNGLGIFDTQSPADVLRSPIASALIEQSATFFFLPNPRADYDDYV
RGFKLTEAEFNIVRNLGENSRMFLVKQGHRSAIGRLDLAGLGDVLDVLSGTIDNVELLDTIRAQVGDLPQNWVPAFHEQL
AKRRAAQSEQASARQSKQLPGPESGQGGVR
>Mature_829_residues
PAYPQLVAVANREVPLSGYIPYSTHVTEHVIKTREGDYLQVWKIAGIAFEAADPADILARHDGFNQFVRGLAGGHVALWS
HRLRRRVSDRFSTEYRNRFCEELATRYYASFAGYRMMANELYLTVVYRPNRTRLGRVFSRAARRTRDDIRRDQLDALKVM
AELAAQVESSLKPYDPVALGVYTRQSPFTPHPRRYSSALELFGYLVNGVWEREPVPSGPIREALPTSRLFVGAEKIEIRM
PAATRFAAMLDLKDYPEDTEPGMLNGLLYGDFEYIETQSFTILDRPSAKEALERQRNQLIAGEDVAVSQVEAMDRALDEL
VNGDFVLGEYHYSLAVLGDTLDEVSGSVAKARTQLADAGFQTALIDLVADAAWFAQLPGNWRYRPREAKLTSRNFCGLSS
LHNFATGKRDGNPWGEAITIFKTPSGQPLYLNFHVTPDKQDSLDEKALANTQIIGRAGAGKTVLELFLLAMATKYGITAV
LFDKDRGTEIAIRAMGGTYTVFRRGEPTGLNPFQMEPGEPVIDFWERLVRKLVDIGVTLSAKDELDISRAVREVARMDKP
LRRLSMVRQLLPNVGENSLHARLAKWCAGGRLGWVFDNPTDRIDLAHATLFGFDDTELLDDAEVATPVTMYLLHRTENLI
DGRRFVYVMTEFWKRLGDPVFTDFAQNKQKTIRKQNGLGIFDTQSPADVLRSPIASALIEQSATFFFLPNPRADYDDYVR
GFKLTEAEFNIVRNLGENSRMFLVKQGHRSAIGRLDLAGLGDVLDVLSGTIDNVELLDTIRAQVGDLPQNWVPAFHEQLA
KRRAAQSEQASARQSKQLPGPESGQGGVR

Specific function: The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice [H]

COG id: COG3451

COG function: function code U; Type IV secretory pathway, VirB4 components

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trbE/virB4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004346
- InterPro:   IPR018145 [H]

Pfam domain/function: PF03135 CagE_TrbE_VirB [H]

EC number: NA

Molecular weight: Translated: 93096; Mature: 92965

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAYPQLVAVANREVPLSGYIPYSTHVTEHVIKTREGDYLQVWKIAGIAFEAADPADILA
CCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCHHHHH
RHDGFNQFVRGLAGGHVALWSHRLRRRVSDRFSTEYRNRFCEELATRYYASFAGYRMMAN
HCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
ELYLTVVYRPNRTRLGRVFSRAARRTRDDIRRDQLDALKVMAELAAQVESSLKPYDPVAL
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
GVYTRQSPFTPHPRRYSSALELFGYLVNGVWEREPVPSGPIREALPTSRLFVGAEKIEIR
EEEECCCCCCCCCHHHHHHHHHHHHHHHCHHCCCCCCCCCHHHHCCCHHEEECCEEEEEE
MPAATRFAAMLDLKDYPEDTEPGMLNGLLYGDFEYIETQSFTILDRPSAKEALERQRNQL
CCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCEEEEECCCHHHHHHHHHHCE
IAGEDVAVSQVEAMDRALDELVNGDFVLGEYHYSLAVLGDTLDEVSGSVAKARTQLADAG
ECCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHEEEEEHHCHHHHHCCHHHHHHHHHHHCC
FQTALIDLVADAAWFAQLPGNWRYRPREAKLTSRNFCGLSSLHNFATGKRDGNPWGEAIT
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEE
IFKTPSGQPLYLNFHVTPDKQDSLDEKALANTQIIGRAGAGKTVLELFLLAMATKYGITA
EEECCCCCEEEEEEEECCCCCCCHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHCCEE
VLFDKDRGTEIAIRAMGGTYTVFRRGEPTGLNPFQMEPGEPVIDFWERLVRKLVDIGVTL
EEEECCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEE
SAKDELDISRAVREVARMDKPLRRLSMVRQLLPNVGENSLHARLAKWCAGGRLGWVFDNP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCC
TDRIDLAHATLFGFDDTELLDDAEVATPVTMYLLHRTENLIDGRRFVYVMTEFWKRLGDP
CCCEEEHHHEEECCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCH
VFTDFAQNKQKTIRKQNGLGIFDTQSPADVLRSPIASALIEQSATFFFLPNPRADYDDYV
HHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHH
RGFKLTEAEFNIVRNLGENSRMFLVKQGHRSAIGRLDLAGLGDVLDVLSGTIDNVELLDT
CCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHH
IRAQVGDLPQNWVPAFHEQLAKRRAAQSEQASARQSKQLPGPESGQGGVR
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PAYPQLVAVANREVPLSGYIPYSTHVTEHVIKTREGDYLQVWKIAGIAFEAADPADILA
CCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCHHHHH
RHDGFNQFVRGLAGGHVALWSHRLRRRVSDRFSTEYRNRFCEELATRYYASFAGYRMMAN
HCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
ELYLTVVYRPNRTRLGRVFSRAARRTRDDIRRDQLDALKVMAELAAQVESSLKPYDPVAL
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
GVYTRQSPFTPHPRRYSSALELFGYLVNGVWEREPVPSGPIREALPTSRLFVGAEKIEIR
EEEECCCCCCCCCHHHHHHHHHHHHHHHCHHCCCCCCCCCHHHHCCCHHEEECCEEEEEE
MPAATRFAAMLDLKDYPEDTEPGMLNGLLYGDFEYIETQSFTILDRPSAKEALERQRNQL
CCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCEEEEECCCHHHHHHHHHHCE
IAGEDVAVSQVEAMDRALDELVNGDFVLGEYHYSLAVLGDTLDEVSGSVAKARTQLADAG
ECCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHEEEEEHHCHHHHHCCHHHHHHHHHHHCC
FQTALIDLVADAAWFAQLPGNWRYRPREAKLTSRNFCGLSSLHNFATGKRDGNPWGEAIT
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEE
IFKTPSGQPLYLNFHVTPDKQDSLDEKALANTQIIGRAGAGKTVLELFLLAMATKYGITA
EEECCCCCEEEEEEEECCCCCCCHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHCCEE
VLFDKDRGTEIAIRAMGGTYTVFRRGEPTGLNPFQMEPGEPVIDFWERLVRKLVDIGVTL
EEEECCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEE
SAKDELDISRAVREVARMDKPLRRLSMVRQLLPNVGENSLHARLAKWCAGGRLGWVFDNP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCC
TDRIDLAHATLFGFDDTELLDDAEVATPVTMYLLHRTENLIDGRRFVYVMTEFWKRLGDP
CCCEEEHHHEEECCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCH
VFTDFAQNKQKTIRKQNGLGIFDTQSPADVLRSPIASALIEQSATFFFLPNPRADYDDYV
HHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHH
RGFKLTEAEFNIVRNLGENSRMFLVKQGHRSAIGRLDLAGLGDVLDVLSGTIDNVELLDT
CCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHH
IRAQVGDLPQNWVPAFHEQLAKRRAAQSEQASARQSKQLPGPESGQGGVR
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10940027 [H]