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The map label for this gene is virB10 [H]

Identifier: 91784042

GI number: 91784042

Start: 2965845

End: 2967074

Strand: Reverse

Name: virB10 [H]

Synonym: Bxe_A1761

Alternate gene names: 91784042

Gene position: 2967074-2965845 (Counterclockwise)

Preceding gene: 91784043

Following gene: 91784041

Centisome position: 60.6

GC content: 67.56

Gene sequence:

>1230_bases
ATGAATGACGATACTGAACGCAACGTGATCGAGCCCGACGACTCCGCGGGCCAGCAGCCAGCGCGCAACCCGAATGGCGG
TGCTGTGCCGATGTCTGCCGATCGCGGCATGCCAGCGCTGGGCCAGTACCGTAGCACCCGTCCGCGGGCCTGGTGGCTGA
CGCCAATCGCAATCGTACTGGTCGTCGGCGCCGGTGCAGTCTGGACCGTGCATGGCTTCCTCGCCCGCCACGATGCTGAG
GCGAAGGCGCGGCGTGACTCGGTGGCCGACACGTCCACGCAAGGCCGCACTTTCAAGGATGCTCCCGCATCCGCGGTCAT
CGCTGCATCGGTACCGGTGCCCGCAAGTGCCGTTGTCGTTCGTCCTGTGCCGGCTTCGGGTGTGGCTGCCGCCCCGGTTA
GCACCCCGCATACGGCGGCACCCCGTAGCTATTACGACGCGCCCCTGCTGGCCACGGGAGGCGGGCAAGAGGCTGTGGCC
GGACTGCCTGGCGTGCTCGAGGCCGGCAGCGTGGCAGGTGCCGCTTCGTCGGTCGCGGCAGCCGTGACCGGTGGCGCCGG
GGCTCCGGTTGTGGGGCAGGCGGGCGGCGCGCTCGCCCAGGCACTGACGCCGACAGCGACGCCGCGCGTGCGCGCCGCCA
TGCTCGGCAATCGCAGCCTCACCCTCGCGCAGGGCGCCAAGATCGACTGCGTGGGCGACACCGCGTTCGATTCGACCGAG
GCCGGAATTTCGACCTGCACGGTCACGAAGAACGTGTACTCGGACGACGGGAACGTGCTGCTGATCGAGCGTGGTTCGCA
GATCAACAGCGAGTACCGCTCGAACCTGGCGCCAGGGCAGAAGCGCGTCTTCGTCCTGTCGGCCCGCATCAAGACCCCGA
ATGGCATCACGGTCGAGATCGACTCGCCGGCGGCCGATGCGCTCGGCCGGATGGGCGTCGATGGCTACGTGAACAACCAC
TGGGGCCAGCGCATTGGTGCGGCGATGCTGCTCGGTATCACGCAGGACGCGATCGGCTATCTGGCCACGCGCGGCGGCAA
CAGCAACGGGTCGGTGGTGTTCGAGAACACGCAGCAGCAGGGCAACGACATGGCCACGCGCGTGCTCGACAGCACTATCA
ATATCCCGCCGACCCTGGCGCAGAACCAGGGCGCAGAATTTACGATCGTCGTTGCACGCGATCTCGATTTCGGATCGGTC
TATGCCCTGAAGCCGGAGGGCACGCAATGA

Upstream 100 bases:

>100_bases
GTCGTCGGGATCTGGAACGACGCCTACGACATGGACGGCGTGCCGCCGCATGACGGCACCACGGTCAGCGGCGTGAAGCG
TGTCCTGCGGAGCCCCGGCG

Downstream 100 bases:

>100_bases
CGTTCCGCCCTGATACGTCGGATTCGCCCCACGATCCCATGCTGGCTCGTCTGCCCGACGATGCTTCCGTACGTGAGCTG
ATGCGTCCGTTCGCGCCGCT

Product: putative type IV secretion system protein VirB10

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MNDDTERNVIEPDDSAGQQPARNPNGGAVPMSADRGMPALGQYRSTRPRAWWLTPIAIVLVVGAGAVWTVHGFLARHDAE
AKARRDSVADTSTQGRTFKDAPASAVIAASVPVPASAVVVRPVPASGVAAAPVSTPHTAAPRSYYDAPLLATGGGQEAVA
GLPGVLEAGSVAGAASSVAAAVTGGAGAPVVGQAGGALAQALTPTATPRVRAAMLGNRSLTLAQGAKIDCVGDTAFDSTE
AGISTCTVTKNVYSDDGNVLLIERGSQINSEYRSNLAPGQKRVFVLSARIKTPNGITVEIDSPAADALGRMGVDGYVNNH
WGQRIGAAMLLGITQDAIGYLATRGGNSNGSVVFENTQQQGNDMATRVLDSTINIPPTLAQNQGAEFTIVVARDLDFGSV
YALKPEGTQ

Sequences:

>Translated_409_residues
MNDDTERNVIEPDDSAGQQPARNPNGGAVPMSADRGMPALGQYRSTRPRAWWLTPIAIVLVVGAGAVWTVHGFLARHDAE
AKARRDSVADTSTQGRTFKDAPASAVIAASVPVPASAVVVRPVPASGVAAAPVSTPHTAAPRSYYDAPLLATGGGQEAVA
GLPGVLEAGSVAGAASSVAAAVTGGAGAPVVGQAGGALAQALTPTATPRVRAAMLGNRSLTLAQGAKIDCVGDTAFDSTE
AGISTCTVTKNVYSDDGNVLLIERGSQINSEYRSNLAPGQKRVFVLSARIKTPNGITVEIDSPAADALGRMGVDGYVNNH
WGQRIGAAMLLGITQDAIGYLATRGGNSNGSVVFENTQQQGNDMATRVLDSTINIPPTLAQNQGAEFTIVVARDLDFGSV
YALKPEGTQ
>Mature_409_residues
MNDDTERNVIEPDDSAGQQPARNPNGGAVPMSADRGMPALGQYRSTRPRAWWLTPIAIVLVVGAGAVWTVHGFLARHDAE
AKARRDSVADTSTQGRTFKDAPASAVIAASVPVPASAVVVRPVPASGVAAAPVSTPHTAAPRSYYDAPLLATGGGQEAVA
GLPGVLEAGSVAGAASSVAAAVTGGAGAPVVGQAGGALAQALTPTATPRVRAAMLGNRSLTLAQGAKIDCVGDTAFDSTE
AGISTCTVTKNVYSDDGNVLLIERGSQINSEYRSNLAPGQKRVFVLSARIKTPNGITVEIDSPAADALGRMGVDGYVNNH
WGQRIGAAMLLGITQDAIGYLATRGGNSNGSVVFENTQQQGNDMATRVLDSTINIPPTLAQNQGAEFTIVVARDLDFGSV
YALKPEGTQ

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG2948

COG function: function code U; Type IV secretory pathway, VirB10 components

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trbI/virB10 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005498 [H]

Pfam domain/function: PF03743 TrbI [H]

EC number: NA

Molecular weight: Translated: 41789; Mature: 41789

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDDTERNVIEPDDSAGQQPARNPNGGAVPMSADRGMPALGQYRSTRPRAWWLTPIAIVL
CCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHCCCCCEEEHHHHHHHH
VVGAGAVWTVHGFLARHDAEAKARRDSVADTSTQGRTFKDAPASAVIAASVPVPASAVVV
HHCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCEECCCCCCEEEEECCCCCCCEEEE
RPVPASGVAAAPVSTPHTAAPRSYYDAPLLATGGGQEAVAGLPGVLEAGSVAGAASSVAA
ECCCCCCCEECCCCCCCCCCCCCCCCCCEEEECCCCHHHHCCCCHHCCCCCCCCHHHHHH
AVTGGAGAPVVGQAGGALAQALTPTATPRVRAAMLGNRSLTLAQGAKIDCVGDTAFDSTE
EEECCCCCCCCCCCCCHHHHHCCCCCCCCEEEEHHCCCEEEEECCCEEEEECCCCCCCCC
AGISTCTVTKNVYSDDGNVLLIERGSQINSEYRSNLAPGQKRVFVLSARIKTPNGITVEI
CCCEEEEEECCEECCCCCEEEEECCCCCCHHHHHCCCCCCCEEEEEEEEECCCCCEEEEE
DSPAADALGRMGVDGYVNNHWGQRIGAAMLLGITQDAIGYLATRGGNSNGSVVFENTQQQ
CCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHEEECCCCCCCCEEECCCHHC
GNDMATRVLDSTINIPPTLAQNQGAEFTIVVARDLDFGSVYALKPEGTQ
CHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCC
>Mature Secondary Structure
MNDDTERNVIEPDDSAGQQPARNPNGGAVPMSADRGMPALGQYRSTRPRAWWLTPIAIVL
CCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHCCCCCEEEHHHHHHHH
VVGAGAVWTVHGFLARHDAEAKARRDSVADTSTQGRTFKDAPASAVIAASVPVPASAVVV
HHCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCEECCCCCCEEEEECCCCCCCEEEE
RPVPASGVAAAPVSTPHTAAPRSYYDAPLLATGGGQEAVAGLPGVLEAGSVAGAASSVAA
ECCCCCCCEECCCCCCCCCCCCCCCCCCEEEECCCCHHHHCCCCHHCCCCCCCCHHHHHH
AVTGGAGAPVVGQAGGALAQALTPTATPRVRAAMLGNRSLTLAQGAKIDCVGDTAFDSTE
EEECCCCCCCCCCCCCHHHHHCCCCCCCCEEEEHHCCCEEEEECCCEEEEECCCCCCCCC
AGISTCTVTKNVYSDDGNVLLIERGSQINSEYRSNLAPGQKRVFVLSARIKTPNGITVEI
CCCEEEEEECCEECCCCCEEEEECCCCCCHHHHHCCCCCCCEEEEEEEEECCCCCEEEEE
DSPAADALGRMGVDGYVNNHWGQRIGAAMLLGITQDAIGYLATRGGNSNGSVVFENTQQQ
CCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHEEECCCCCCCCEEECCCHHC
GNDMATRVLDSTINIPPTLAQNQGAEFTIVVARDLDFGSVYALKPEGTQ
CHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]