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The map label for this gene is mntH [H]

Identifier: 91783862

GI number: 91783862

Start: 2779607

End: 2780953

Strand: Direct

Name: mntH [H]

Synonym: Bxe_A1949

Alternate gene names: 91783862

Gene position: 2779607-2780953 (Clockwise)

Preceding gene: 91783857

Following gene: 91783863

Centisome position: 56.77

GC content: 68.3

Gene sequence:

>1347_bases
ATGCGGCTTGCAAGAGGATGCAGTCTTGAACCTCAGGCACTGATGAACACCAATCCGTCCGCATTGCGACCCAACCGACG
CCGACGCCTGCCGGCCAGTGGACCGGCACGTCCGCCGCACTGGTTCTCGTTCGTCGGCGCGGGCGCACTGATCGCGGTCG
GCTATATCGATCCGGGCAACTGGGCGACGGCGCTCGGCGCCGGGGCCGGCTACGGCTACCGCCTGCTCAGCATGGTATTG
CTGGCGAGCCTGATGGCGATGCTGCTGCAATGGCTGTCGTCGCGCCTCGGCGTGGTGACCGGCCGCGACCTCGCGCAGAT
CTGCCGCGAGCGCACGAGCCGCCGCGGCACCCTGTTCCTGTGGCTGACGAGCGAGGTCGCGATCATCGCGTGCGACGTCG
CCGAGGTGGTCGGCAGCGCCGTCGCGTTGCAATTGCTACTTGGCGTGTCGCTCACGGTAGGCGTGTTGATGTCGGCCGTC
TGCACGTTCGCGCTGCTCGCGCTCCAGCAGAAAGGCGGCCGCAAGCTCGAAGCGGTGATCGCGGCGCTGATCGGCTTTGT
CGGCCTGTGCTTCGTGGTCCAGCTCGCGCTCGCGCGGCCGGACTGGCATGCAGCGCTTGCCGGCACCGTGCCGAGCGTCG
AACTGCTGCGCAATGCGGGCATGGTGTGGCTTGCGGCGGGCATCGTGGGCGCGACCGTGATGCCGCACAACCTCTATCTG
CACTCGGCGCTCGTCAAGCACCACGCGCCGGAGGGCAGCGACGCGCAGATCAAGGCCGCGCTGCACGTGGTCAATCTCGA
CACCTTCGGCTCGCTCTCGTTTGCGTTCGTGATCAATGCGGCGCTGCTGATCGTGGCCGCCGCCGTGTTCTACGTGAGCG
GGCATCGTGACGTGACCGATCTCGCGGATGCCCACCGGCTGATCGCGCCGCTCGTCGGCACGCACTGGGCCGGCATCCTG
TTCGCGGCCGCGCTGCTCGCCTGTGGGTTGAGCGCGACGGTTACCGGCACGCTGGCCGGCCAGGCGGTCATGGAAGGCTT
TCTGCGCATCCGCCTGCCGCGCTGGCAGCGCGCCCTGCTGACCCGCGCGCTGGCAATCGGGCCGGCGCTCCTCGCAGTCG
CGCTGTTCGGCCAGCATGGTTCCAACCAGTTGCTGGTGGCAAGTCAGGTAGTGCTGAGCCTGCAATTGCCGCTCGCGGTC
GTGCCTTTGATCCGTTACACCTCGGACGCCGGACTCATGCGCGGCTGGCGCGTGCGCGGCGTGCCGCTCGCGCTCGCCTG
GCTGTCCGCCGCGTTCATCGTGATGCTCAATGGCGCGCTGCTGTGGCAACTGGCGTTTGGCAATTGA

Upstream 100 bases:

>100_bases
AAGGCGCACCGCGTCACGTCCGACGGAGCACAATAGCTCTCACCAGCCCAAACGACACGGCCCGCCGCGAATCCCGCGGC
GCGCGCCACGCCCGGCGGGC

Downstream 100 bases:

>100_bases
AAGACCTTTTTCAGGCGGGCTGTAAATGATGTGACTTTGTAAGTATTCTCTGAGTATCTGGAAATGACCGGTGATCTTGC
CCGTAGCTGAAGCATGCCGG

Product: Mn2+/Fe2+ transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MRLARGCSLEPQALMNTNPSALRPNRRRRLPASGPARPPHWFSFVGAGALIAVGYIDPGNWATALGAGAGYGYRLLSMVL
LASLMAMLLQWLSSRLGVVTGRDLAQICRERTSRRGTLFLWLTSEVAIIACDVAEVVGSAVALQLLLGVSLTVGVLMSAV
CTFALLALQQKGGRKLEAVIAALIGFVGLCFVVQLALARPDWHAALAGTVPSVELLRNAGMVWLAAGIVGATVMPHNLYL
HSALVKHHAPEGSDAQIKAALHVVNLDTFGSLSFAFVINAALLIVAAAVFYVSGHRDVTDLADAHRLIAPLVGTHWAGIL
FAAALLACGLSATVTGTLAGQAVMEGFLRIRLPRWQRALLTRALAIGPALLAVALFGQHGSNQLLVASQVVLSLQLPLAV
VPLIRYTSDAGLMRGWRVRGVPLALAWLSAAFIVMLNGALLWQLAFGN

Sequences:

>Translated_448_residues
MRLARGCSLEPQALMNTNPSALRPNRRRRLPASGPARPPHWFSFVGAGALIAVGYIDPGNWATALGAGAGYGYRLLSMVL
LASLMAMLLQWLSSRLGVVTGRDLAQICRERTSRRGTLFLWLTSEVAIIACDVAEVVGSAVALQLLLGVSLTVGVLMSAV
CTFALLALQQKGGRKLEAVIAALIGFVGLCFVVQLALARPDWHAALAGTVPSVELLRNAGMVWLAAGIVGATVMPHNLYL
HSALVKHHAPEGSDAQIKAALHVVNLDTFGSLSFAFVINAALLIVAAAVFYVSGHRDVTDLADAHRLIAPLVGTHWAGIL
FAAALLACGLSATVTGTLAGQAVMEGFLRIRLPRWQRALLTRALAIGPALLAVALFGQHGSNQLLVASQVVLSLQLPLAV
VPLIRYTSDAGLMRGWRVRGVPLALAWLSAAFIVMLNGALLWQLAFGN
>Mature_448_residues
MRLARGCSLEPQALMNTNPSALRPNRRRRLPASGPARPPHWFSFVGAGALIAVGYIDPGNWATALGAGAGYGYRLLSMVL
LASLMAMLLQWLSSRLGVVTGRDLAQICRERTSRRGTLFLWLTSEVAIIACDVAEVVGSAVALQLLLGVSLTVGVLMSAV
CTFALLALQQKGGRKLEAVIAALIGFVGLCFVVQLALARPDWHAALAGTVPSVELLRNAGMVWLAAGIVGATVMPHNLYL
HSALVKHHAPEGSDAQIKAALHVVNLDTFGSLSFAFVINAALLIVAAAVFYVSGHRDVTDLADAHRLIAPLVGTHWAGIL
FAAALLACGLSATVTGTLAGQAVMEGFLRIRLPRWQRALLTRALAIGPALLAVALFGQHGSNQLLVASQVVLSLQLPLAV
VPLIRYTSDAGLMRGWRVRGVPLALAWLSAAFIVMLNGALLWQLAFGN

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=421, Percent_Identity=37.29216152019, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI295293167, Length=414, Percent_Identity=37.9227053140097, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI295293178, Length=466, Percent_Identity=35.8369098712446, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI295293171, Length=414, Percent_Identity=37.9227053140097, Blast_Score=198, Evalue=9e-51,
Organism=Homo sapiens, GI295293169, Length=414, Percent_Identity=37.9227053140097, Blast_Score=198, Evalue=9e-51,
Organism=Homo sapiens, GI295293175, Length=414, Percent_Identity=37.9227053140097, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI295293173, Length=414, Percent_Identity=37.9227053140097, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI10835169, Length=414, Percent_Identity=37.9227053140097, Blast_Score=198, Evalue=1e-50,
Organism=Escherichia coli, GI1788736, Length=436, Percent_Identity=40.3669724770642, Blast_Score=258, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI17569473, Length=376, Percent_Identity=37.2340425531915, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI193210616, Length=480, Percent_Identity=32.2916666666667, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI71999499, Length=473, Percent_Identity=31.2896405919662, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71993856, Length=250, Percent_Identity=35.2, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6323062, Length=402, Percent_Identity=37.0646766169154, Blast_Score=230, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6324450, Length=419, Percent_Identity=34.8448687350835, Blast_Score=219, Evalue=7e-58,
Organism=Saccharomyces cerevisiae, GI6321841, Length=402, Percent_Identity=37.3134328358209, Blast_Score=213, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24648607, Length=455, Percent_Identity=32.967032967033, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI281362176, Length=455, Percent_Identity=32.967032967033, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24648609, Length=455, Percent_Identity=32.967032967033, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI45553443, Length=455, Percent_Identity=32.967032967033, Blast_Score=205, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 47329; Mature: 47329

Theoretical pI: Translated: 10.88; Mature: 10.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLARGCSLEPQALMNTNPSALRPNRRRRLPASGPARPPHWFSFVGAGALIAVGYIDPGN
CCCCCCCCCCCHHHHCCCCCCCCCCHHCCCCCCCCCCCCHHHHHHCCCCEEEEEEECCCC
WATALGAGAGYGYRLLSMVLLASLMAMLLQWLSSRLGVVTGRDLAQICRERTSRRGTLFL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEE
WLTSEVAIIACDVAEVVGSAVALQLLLGVSLTVGVLMSAVCTFALLALQQKGGRKLEAVI
EEECCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AALIGFVGLCFVVQLALARPDWHAALAGTVPSVELLRNAGMVWLAAGIVGATVMPHNLYL
HHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHCCCCHHHH
HSALVKHHAPEGSDAQIKAALHVVNLDTFGSLSFAFVINAALLIVAAAVFYVSGHRDVTD
HHHHHHHCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LADAHRLIAPLVGTHWAGILFAAALLACGLSATVTGTLAGQAVMEGFLRIRLPRWQRALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
TRALAIGPALLAVALFGQHGSNQLLVASQVVLSLQLPLAVVPLIRYTSDAGLMRGWRVRG
HHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHCHHHHHHHHHHCCCCHHHCCCEECC
VPLALAWLSAAFIVMLNGALLWQLAFGN
HHHHHHHHHHHHHHHHCCHHEEEEECCC
>Mature Secondary Structure
MRLARGCSLEPQALMNTNPSALRPNRRRRLPASGPARPPHWFSFVGAGALIAVGYIDPGN
CCCCCCCCCCCHHHHCCCCCCCCCCHHCCCCCCCCCCCCHHHHHHCCCCEEEEEEECCCC
WATALGAGAGYGYRLLSMVLLASLMAMLLQWLSSRLGVVTGRDLAQICRERTSRRGTLFL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEE
WLTSEVAIIACDVAEVVGSAVALQLLLGVSLTVGVLMSAVCTFALLALQQKGGRKLEAVI
EEECCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AALIGFVGLCFVVQLALARPDWHAALAGTVPSVELLRNAGMVWLAAGIVGATVMPHNLYL
HHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHCCCCHHHH
HSALVKHHAPEGSDAQIKAALHVVNLDTFGSLSFAFVINAALLIVAAAVFYVSGHRDVTD
HHHHHHHCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LADAHRLIAPLVGTHWAGILFAAALLACGLSATVTGTLAGQAVMEGFLRIRLPRWQRALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
TRALAIGPALLAVALFGQHGSNQLLVASQVVLSLQLPLAVVPLIRYTSDAGLMRGWRVRG
HHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHCHHHHHHHHHHCCCCHHHCCCEECC
VPLALAWLSAAFIVMLNGALLWQLAFGN
HHHHHHHHHHHHHHHHCCHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]