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The map label for this gene is alkK [H]

Identifier: 91783540

GI number: 91783540

Start: 2400457

End: 2402145

Strand: Direct

Name: alkK [H]

Synonym: Bxe_A2275

Alternate gene names: 91783540

Gene position: 2400457-2402145 (Clockwise)

Preceding gene: 91783534

Following gene: 91783541

Centisome position: 49.03

GC content: 64.24

Gene sequence:

>1689_bases
ATGACGACGCCGCTCGCTGGCCAGATGATGGACGTGCCGCTCACCGTGCCTTCGCTGCTCGCGCATGCCGCGCGGCATTT
CGGCAGCACTGAAATCGTGTCGCGCCGCATTGAAGGCGACCTGCATCGTTATACCTATCGCGATTGCGAAAAGCGCGCGA
AGCAGCTCGCGCAGGCTTTGATCGCGCTCGGCGTCGAACCCGGCGAACGGGTCGCGACGCTGGCATGGAACGGCTACCGG
CATCTGGAAGCGTATTACGGCACGACCGGCTTCGGCGCTGTCTGCCACACGATCAATCCGCGTCTCTTTCCCGATCAGAT
CGCCTACATCATCAATCACGCGGACGACGCTTACGTGCTGTTCGACACCACGTTCGCCCCGCTCGTCGACGTGCTCGCGC
CGCAGTGCCCGAAAGTGCGCGGCTGGATCGCGCTCGCCGACGAAGCGCACCTGCCTGCCATGCAGACACCCGTGCTCAGC
TACGAGACGCTCGTCACCGCGCAGGACGGCAATTACGAATGGCCGCCGCTCGACGAGCGCCAGGCTTCATACCTTTGCTA
TACGTCCGGCACCACCGGTAATCCGAAGGGCGCGCTGTATTCGCATCGCTCGACGGTGCTGCATGCGTTCGGCGCCGCGT
TGCCCGACGCCATGAGCTTGTCCGCGCGCGACTGCGTGCTGCCCGTCGTGCCGATGTTTCATGTGAACGCGTGGGGCATT
CCGCACTCGGCGCCGCTGACCGGCGCGAAGCTGGTGTTCCCCGGCAAGGATCTCGACGGCAAGTCGCTGTACGAATTGAT
GGAAAGCGAACGCGTCACGTATTCGGCCGGCGTGCCGACCGTGTGGCTCGGTCTGCTCAACTATCTGCGCGAGGCGAAGG
TGCGGTTTTCGTCGCTCAATCGCACGGTGATCGGCGGCTCGGCGTGTCCGCCGGCCATGCTGCGCACGTTCGAGGACGAC
TACGGCGTGCAGGTGATCCATGCATGGGGCATGACCGAGATGTCGCCGCTCGGCACGCTGTCCAGGCTGACATGGGAGCA
AAGCCAGCGTCCGCTGGAAGAGCAGCGCAAGTTGCTGGAGAAGCAGGGGCACGTGCTCTATGGCGTCGATATGAAGATCG
TCGGCGAAGACGGCCGCGAGCTGCCGTGGGACGGCGTGGCGTTCGGCGATCTGCACGTGCGCGGGCCGTGGGTGATCGAC
CGGTATTTCCGCAAGGACGACTCGCCGCTGGTGGACGGCTGGTTTCCCACCGGCGACGTCGCCACTATCGACCGCGACAG
CTTTCTGCATATCACGGACCGCTCGAAAGACGTGATCAAGTCCGGCGGCGAATGGATCAGTTCGATCGACATCGAGAACG
TGGCGATCGCGCATCCGGCCGTGGCCGAAGCGGCGTGCATCGCGTGTGCGCATCCGAAATGGACCGAGCGGCCGCTGCTG
GTGGTCGTCAAGCGTCCCGGCTTCGAGGTGACGCGAGATGAGCTGATCGCCTTCTACGAAGGCAAGGTCGCCAGATGGTG
GATTCCCGACGACGTCGCCTTTGTCGACGAACTGCCGCACACGGCAACCGGCAAGCTGCAAAAACTCAAGCTGCGCGACA
TTTTCCGCGACCATGTGCTGCCGTCCGCGCTGGAGGATGAAAAGGACTGCCCGCTCACGCCGCTTGCCAGGGGAAACCCC
GTCTCCTGA

Upstream 100 bases:

>100_bases
GCCGGACTTCCGCCGGTTTCGCTGACGGCGCGTCGAGGCTGAGGCGCGCCCCCCGAGCTGCCAACCGATTGAAACAATCA
AGCCGAGGAGACCCCTTCTT

Downstream 100 bases:

>100_bases
TAAATTGAACGAGCGTGCTTTTCTGTGTATTCTGCCTGCTGACCCCGGCGTCAAACGACAATTCGTCCGACAATGAGTCG
GACCGATAGTCCGACCTGAT

Product: long-chain-fatty-acid--CoA ligase

Products: NA

Alternate protein names: Medium-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 562; Mature: 561

Protein sequence:

>562_residues
MTTPLAGQMMDVPLTVPSLLAHAARHFGSTEIVSRRIEGDLHRYTYRDCEKRAKQLAQALIALGVEPGERVATLAWNGYR
HLEAYYGTTGFGAVCHTINPRLFPDQIAYIINHADDAYVLFDTTFAPLVDVLAPQCPKVRGWIALADEAHLPAMQTPVLS
YETLVTAQDGNYEWPPLDERQASYLCYTSGTTGNPKGALYSHRSTVLHAFGAALPDAMSLSARDCVLPVVPMFHVNAWGI
PHSAPLTGAKLVFPGKDLDGKSLYELMESERVTYSAGVPTVWLGLLNYLREAKVRFSSLNRTVIGGSACPPAMLRTFEDD
YGVQVIHAWGMTEMSPLGTLSRLTWEQSQRPLEEQRKLLEKQGHVLYGVDMKIVGEDGRELPWDGVAFGDLHVRGPWVID
RYFRKDDSPLVDGWFPTGDVATIDRDSFLHITDRSKDVIKSGGEWISSIDIENVAIAHPAVAEAACIACAHPKWTERPLL
VVVKRPGFEVTRDELIAFYEGKVARWWIPDDVAFVDELPHTATGKLQKLKLRDIFRDHVLPSALEDEKDCPLTPLARGNP
VS

Sequences:

>Translated_562_residues
MTTPLAGQMMDVPLTVPSLLAHAARHFGSTEIVSRRIEGDLHRYTYRDCEKRAKQLAQALIALGVEPGERVATLAWNGYR
HLEAYYGTTGFGAVCHTINPRLFPDQIAYIINHADDAYVLFDTTFAPLVDVLAPQCPKVRGWIALADEAHLPAMQTPVLS
YETLVTAQDGNYEWPPLDERQASYLCYTSGTTGNPKGALYSHRSTVLHAFGAALPDAMSLSARDCVLPVVPMFHVNAWGI
PHSAPLTGAKLVFPGKDLDGKSLYELMESERVTYSAGVPTVWLGLLNYLREAKVRFSSLNRTVIGGSACPPAMLRTFEDD
YGVQVIHAWGMTEMSPLGTLSRLTWEQSQRPLEEQRKLLEKQGHVLYGVDMKIVGEDGRELPWDGVAFGDLHVRGPWVID
RYFRKDDSPLVDGWFPTGDVATIDRDSFLHITDRSKDVIKSGGEWISSIDIENVAIAHPAVAEAACIACAHPKWTERPLL
VVVKRPGFEVTRDELIAFYEGKVARWWIPDDVAFVDELPHTATGKLQKLKLRDIFRDHVLPSALEDEKDCPLTPLARGNP
VS
>Mature_561_residues
TTPLAGQMMDVPLTVPSLLAHAARHFGSTEIVSRRIEGDLHRYTYRDCEKRAKQLAQALIALGVEPGERVATLAWNGYRH
LEAYYGTTGFGAVCHTINPRLFPDQIAYIINHADDAYVLFDTTFAPLVDVLAPQCPKVRGWIALADEAHLPAMQTPVLSY
ETLVTAQDGNYEWPPLDERQASYLCYTSGTTGNPKGALYSHRSTVLHAFGAALPDAMSLSARDCVLPVVPMFHVNAWGIP
HSAPLTGAKLVFPGKDLDGKSLYELMESERVTYSAGVPTVWLGLLNYLREAKVRFSSLNRTVIGGSACPPAMLRTFEDDY
GVQVIHAWGMTEMSPLGTLSRLTWEQSQRPLEEQRKLLEKQGHVLYGVDMKIVGEDGRELPWDGVAFGDLHVRGPWVIDR
YFRKDDSPLVDGWFPTGDVATIDRDSFLHITDRSKDVIKSGGEWISSIDIENVAIAHPAVAEAACIACAHPKWTERPLLV
VVKRPGFEVTRDELIAFYEGKVARWWIPDDVAFVDELPHTATGKLQKLKLRDIFRDHVLPSALEDEKDCPLTPLARGNPV
S

Specific function: Unknown

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=527, Percent_Identity=26.1859582542694, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI187761345, Length=535, Percent_Identity=25.2336448598131, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI187761343, Length=535, Percent_Identity=25.2336448598131, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI38505220, Length=508, Percent_Identity=23.4251968503937, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI28416953, Length=577, Percent_Identity=24.263431542461, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI157311624, Length=513, Percent_Identity=23.1968810916179, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI157311622, Length=513, Percent_Identity=23.1968810916179, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI58082049, Length=518, Percent_Identity=23.1660231660232, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI115511026, Length=511, Percent_Identity=20.7436399217221, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI122937307, Length=511, Percent_Identity=22.7005870841487, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI83745141, Length=517, Percent_Identity=20.3094777562863, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI145693145, Length=505, Percent_Identity=26.7326732673267, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1788107, Length=528, Percent_Identity=26.3257575757576, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI221142682, Length=512, Percent_Identity=23.4375, Blast_Score=140, Evalue=3e-34,
Organism=Escherichia coli, GI1786810, Length=561, Percent_Identity=26.0249554367201, Blast_Score=112, Evalue=9e-26,
Organism=Escherichia coli, GI1789201, Length=411, Percent_Identity=23.8442822384428, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17558820, Length=512, Percent_Identity=26.5625, Blast_Score=139, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI71994690, Length=562, Percent_Identity=24.9110320284698, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71994703, Length=561, Percent_Identity=24.777183600713, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71994694, Length=561, Percent_Identity=24.777183600713, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17557194, Length=558, Percent_Identity=26.1648745519713, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI32563687, Length=511, Percent_Identity=26.614481409002, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17531443, Length=509, Percent_Identity=24.3614931237721, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17560308, Length=536, Percent_Identity=24.8134328358209, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17538037, Length=519, Percent_Identity=24.2774566473988, Blast_Score=122, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17559526, Length=529, Percent_Identity=24.952741020794, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17560140, Length=493, Percent_Identity=22.920892494929, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71996755, Length=504, Percent_Identity=22.4206349206349, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71985884, Length=357, Percent_Identity=24.0896358543417, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319699, Length=360, Percent_Identity=27.7777777777778, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24581924, Length=557, Percent_Identity=27.1095152603232, Blast_Score=162, Evalue=7e-40,
Organism=Drosophila melanogaster, GI18859661, Length=474, Percent_Identity=27.0042194092827, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI21355181, Length=524, Percent_Identity=23.2824427480916, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17933690, Length=547, Percent_Identity=23.0347349177331, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24648260, Length=506, Percent_Identity=24.3083003952569, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19922652, Length=496, Percent_Identity=21.9758064516129, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24648253, Length=497, Percent_Identity=21.327967806841, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21355225, Length=577, Percent_Identity=23.2235701906412, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648255, Length=512, Percent_Identity=21.2890625, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI62471681, Length=522, Percent_Identity=21.6475095785441, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI62471687, Length=522, Percent_Identity=21.6475095785441, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24586634, Length=522, Percent_Identity=21.6475095785441, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI22026970, Length=522, Percent_Identity=21.6475095785441, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI62471689, Length=522, Percent_Identity=21.6475095785441, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI62471679, Length=522, Percent_Identity=21.6475095785441, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI62471683, Length=522, Percent_Identity=21.6475095785441, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI62471685, Length=522, Percent_Identity=21.6475095785441, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24586636, Length=522, Percent_Identity=21.6475095785441, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21356441, Length=508, Percent_Identity=21.4566929133858, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356947, Length=390, Percent_Identity=23.5897435897436, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24648257, Length=365, Percent_Identity=21.9178082191781, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281365686, Length=247, Percent_Identity=21.4574898785425, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24653035, Length=372, Percent_Identity=22.5806451612903, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20130357, Length=364, Percent_Identity=21.4285714285714, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 62419; Mature: 62288

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPLAGQMMDVPLTVPSLLAHAARHFGSTEIVSRRIEGDLHRYTYRDCEKRAKQLAQAL
CCCCCCCCEEECCCCHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
IALGVEPGERVATLAWNGYRHLEAYYGTTGFGAVCHTINPRLFPDQIAYIINHADDAYVL
HHHCCCCCCEEEEEEECCEEEEEEECCCCCHHHHHHCCCCCCCHHHHHHHHCCCCCEEEE
FDTTFAPLVDVLAPQCPKVRGWIALADEAHLPAMQTPVLSYETLVTAQDGNYEWPPLDER
EECCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCC
QASYLCYTSGTTGNPKGALYSHRSTVLHAFGAALPDAMSLSARDCVLPVVPMFHVNAWGI
CCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHCCCHHHCCCCCCCCEECCCEEEEEECCC
PHSAPLTGAKLVFPGKDLDGKSLYELMESERVTYSAGVPTVWLGLLNYLREAKVRFSSLN
CCCCCCCCCEEEECCCCCCHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHCC
RTVIGGSACPPAMLRTFEDDYGVQVIHAWGMTEMSPLGTLSRLTWEQSQRPLEEQRKLLE
CEEECCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
KQGHVLYGVDMKIVGEDGRELPWDGVAFGDLHVRGPWVIDRYFRKDDSPLVDGWFPTGDV
HCCCEEEEEEEEEECCCCCCCCCCCEEECCEEECCCHHHHHHHCCCCCCCCCCCCCCCCE
ATIDRDSFLHITDRSKDVIKSGGEWISSIDIENVAIAHPAVAEAACIACAHPKWTERPLL
EEECCCCEEEEECCCHHHHHCCCCEEHHCCCCCEEECCCHHHHHHHHEECCCCCCCCCEE
VVVKRPGFEVTRDELIAFYEGKVARWWIPDDVAFVDELPHTATGKLQKLKLRDIFRDHVL
EEEECCCCCCCHHHEEEEECCCEEEEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
PSALEDEKDCPLTPLARGNPVS
CCHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTPLAGQMMDVPLTVPSLLAHAARHFGSTEIVSRRIEGDLHRYTYRDCEKRAKQLAQAL
CCCCCCCEEECCCCHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
IALGVEPGERVATLAWNGYRHLEAYYGTTGFGAVCHTINPRLFPDQIAYIINHADDAYVL
HHHCCCCCCEEEEEEECCEEEEEEECCCCCHHHHHHCCCCCCCHHHHHHHHCCCCCEEEE
FDTTFAPLVDVLAPQCPKVRGWIALADEAHLPAMQTPVLSYETLVTAQDGNYEWPPLDER
EECCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCC
QASYLCYTSGTTGNPKGALYSHRSTVLHAFGAALPDAMSLSARDCVLPVVPMFHVNAWGI
CCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHCCCHHHCCCCCCCCEECCCEEEEEECCC
PHSAPLTGAKLVFPGKDLDGKSLYELMESERVTYSAGVPTVWLGLLNYLREAKVRFSSLN
CCCCCCCCCEEEECCCCCCHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHCC
RTVIGGSACPPAMLRTFEDDYGVQVIHAWGMTEMSPLGTLSRLTWEQSQRPLEEQRKLLE
CEEECCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
KQGHVLYGVDMKIVGEDGRELPWDGVAFGDLHVRGPWVIDRYFRKDDSPLVDGWFPTGDV
HCCCEEEEEEEEEECCCCCCCCCCCEEECCEEECCCHHHHHHHCCCCCCCCCCCCCCCCE
ATIDRDSFLHITDRSKDVIKSGGEWISSIDIENVAIAHPAVAEAACIACAHPKWTERPLL
EEECCCCEEEEECCCHHHHHCCCCEEHHCCCCCEEECCCHHHHHHHHEECCCCCCCCCEE
VVVKRPGFEVTRDELIAFYEGKVARWWIPDDVAFVDELPHTATGKLQKLKLRDIFRDHVL
EEEECCCCCCCHHHEEEEECCCEEEEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
PSALEDEKDCPLTPLARGNPVS
CCHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]