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The map label for this gene is lon [H]

Identifier: 91783522

GI number: 91783522

Start: 2375717

End: 2378140

Strand: Direct

Name: lon [H]

Synonym: Bxe_A2293

Alternate gene names: 91783522

Gene position: 2375717-2378140 (Clockwise)

Preceding gene: 91783521

Following gene: 91783523

Centisome position: 48.53

GC content: 60.4

Gene sequence:

>2424_bases
ATGTCAGGAACCCAACTCCTTCCGCCGGAACGCATTACGCTCCCGCTGCTCCCGCTGCGTGACGTAGTCGTTTTCCCGCA
CATGGTGATTCCGCTCTTCGTAGGCCGCCCGAAGTCGATCAAGGCTCTCGAAGCAGCGATGGAAGGCGGCAAGCACATCA
TGCTCGTCGCCCAGAAAACGGCTGCGAAAGATGAGCCGACCGAAAAGGACATGTACGAAGTAGGATGCGTTGCTAACATC
CTGCAAATGCTCAAGCTGCCCGATGGCACCGTCAAGGTGCTCGTCGAAGGCTTGCAGCGCGCGAAAACGCTTTCCATCGA
AGAACAGGAAACGCAGTTCTCGTGCGAAGTCATGCCGCTCGAACCCGACCACGCCGACAGCGCTGAAACCGAAGCGCTGC
GCCGCGCGATCGTGTCGCAGTTCGACCAGTATGTGAAGCTGAACAAGAAGATCCCGCCGGAGATCCTGACGTCGCTGTCG
GGGATCGACGAGGCCGGGCGTCTGGCCGACACGATCGCGGCGCATCTGCCGCTCAAGCTCGACCAGAAGCAGCACATCCT
CGAAATGTTCCCGGTCATCGAGCGGCTCGAGCATCTGCTCGCGCAACTCGAAGCCGAGATCGACATCCTGCAGGTCGAAA
AGCGCATCCGCGGGCGTGTCAAACGCCAGATGGAGAAGAGCCAGCGCGAGTACTACCTGAACGAACAGGTCAAGGCGATT
CAGAAGGAACTCGGCGAAGGCGAGGAAGGTGCGGATCTCGAAGAACTCGAGAAGCGCATCACGGCTGCCCGCATGCCGAA
GGAAGCCAAGAAGAAGGCCGACGCCGAGCTGAAAAAGCTCAAGCTGATGTCGCCGATGTCGGCTGAAGCCACCGTCGTGC
GCAACTATATCGACACGCTGATCGGCTTGCCGTGGCGCAAGAAGAGCAAGGTCAACAACGACCTCTCGAATGCGGAACGC
GTACTCGACGAAGACCACTTCGGTCTCGAGAAAGTGAAGGAACGCATTCTCGAGTATCTCGCGGTCCAGCAACGTGTCGA
CAAGGTCAAGGCGCCGATCCTGTGCCTCGTTGGGCCTCCGGGTGTCGGTAAGACGTCGCTGGGTCAGTCGATCGCTCGCG
CCACGAATCGCAAGTTCGTGCGTATGGCGCTTGGTGGCGTGCGCGACGAAGCCGAGATTCGCGGTCACCGTCGTACGTAC
ATTGGTTCGATGCCCGGCAAGATTCTGCAAAGCCTGACCAAGGTCGGCGTGCGCAATCCGCTCTTCCTGCTCGACGAAGT
CGACAAGATGGGCCAGGATTTCCGCGGCGATCCGTCTTCGGCTCTGCTGGAAGTGCTCGATCCGGAACAGAACCATACGT
TCGCCGATCACTACGTCGAAGTCGACTTCGATCTCTCGGACGTGATGTTCGTGGCGACGTCGAACTCGCTGAACATTCCG
CCGCCGTTGCTCGACCGGATGGAAGTGATCCGTCTGTCGGGTTACACGGAAGACGAGAAGGTCAGCATCGCGCAACGTTA
TCTTTTGCCCAAACAGAAGAAGAACAACGGCCTCAAGGATGGCGAGGTCGATGTGACGGAAACCGCGATCCGCGACATCA
TTCGCTACTACACGCGTGAAGCGGGCGTGCGTTCGCTCGAGCGTGAAATTTCGAAGATCTGCCGCAAGGTCGTGAAGATG
CTTCTGCTGAAGAAGGCGGAAGGCGCGGTGAAGGTGGACGGCAGCAACCTCGACACGTTCCTCGGCGTGCGCAAGTACGA
CTTCGGTCTGGCTGCGAAGGAAAATCAGGTTGGCCAGGTCACGGGTCTCGCGTGGACGGAAGTGGGCGGCGATCTGCTGA
CCATTGAAGCCGCGGTGATGCCGGGCAAGGGCAACGTGATCCGCACGGGTTCGCTCGGCGACGTGATGAAGGAATCGGTC
GAGGCAGCACGCTCGGTGGTCCGTTCGCGCTCGCGTCGTCTCGGCATCAAGGACGAAGCGTTCGAGAAGCAGGACATTCA
CATCCACGTGCCGGAAGGCGCGACGCCGAAAGACGGCCCGTCTGCCGGTATCGCGATGACGACCGCGCTGGTGTCGGTGC
TGACCGGCATTCCGGTGCGTGCCGACGTCGCGATGACGGGCGAAATCACGTTGCGTGGCGAAGTTCTGCCGATCGGCGGC
CTGAAGGAAAAGCTGCTGGCGGCGCATCGCGGCGGCATCAAGCTGGTGCTGATTCCGGAAGAAAACGTCAAGGACTTGAC
GGAGATTCCGGACAACGTGAAGAACGCCATCGAAATCGTGCCGGTCCGCTGGGTCGACAAGGTGCTCGAACTCGCGCTCG
AACGTGTGCCGTCGGCGTTGCCGGATGAAGAGCCGAAGCCTGCTGCGCCGGTTGCAGCGGAGCCGGGCAAAGACGCCGCA
GCAACAGAGGTGGTGAAGCACTAG

Upstream 100 bases:

>100_bases
ACCTTCGGAGTCACTGAACTTTTCCCACACGCGGAGGCTTGCAATCTTTTCTGCTGGCCTCACCTATCGAACGAACTGAT
TCCACTCATGGGGAAATGAA

Downstream 100 bases:

>100_bases
GACGGTCAGCAACGAAGCTGTTTGCTGCAAAGAACCCGCGGTCACGGCCGCGGGTTTTTTCTTGTCCGCTCTCCATTTCC
GCAAAGCGTCCGCGAGGCAC

Product: Lon-A peptidase

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 807; Mature: 806

Protein sequence:

>807_residues
MSGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKTAAKDEPTEKDMYEVGCVANI
LQMLKLPDGTVKVLVEGLQRAKTLSIEEQETQFSCEVMPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEAGRLADTIAAHLPLKLDQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELEKRITAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIGLPWRKKSKVNNDLSNAER
VLDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLTKVGVRNPLFLLDEVDKMGQDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIP
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEVDVTETAIRDIIRYYTREAGVRSLEREISKICRKVVKM
LLLKKAEGAVKVDGSNLDTFLGVRKYDFGLAAKENQVGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESV
EAARSVVRSRSRRLGIKDEAFEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLVLIPEENVKDLTEIPDNVKNAIEIVPVRWVDKVLELALERVPSALPDEEPKPAAPVAAEPGKDAA
ATEVVKH

Sequences:

>Translated_807_residues
MSGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKTAAKDEPTEKDMYEVGCVANI
LQMLKLPDGTVKVLVEGLQRAKTLSIEEQETQFSCEVMPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEAGRLADTIAAHLPLKLDQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELEKRITAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIGLPWRKKSKVNNDLSNAER
VLDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLTKVGVRNPLFLLDEVDKMGQDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIP
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEVDVTETAIRDIIRYYTREAGVRSLEREISKICRKVVKM
LLLKKAEGAVKVDGSNLDTFLGVRKYDFGLAAKENQVGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESV
EAARSVVRSRSRRLGIKDEAFEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLVLIPEENVKDLTEIPDNVKNAIEIVPVRWVDKVLELALERVPSALPDEEPKPAAPVAAEPGKDAA
ATEVVKH
>Mature_806_residues
SGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKTAAKDEPTEKDMYEVGCVANIL
QMLKLPDGTVKVLVEGLQRAKTLSIEEQETQFSCEVMPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSG
IDEAGRLADTIAAHLPLKLDQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
KELGEGEEGADLEELEKRITAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIGLPWRKKSKVNNDLSNAERV
LDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYI
GSMPGKILQSLTKVGVRNPLFLLDEVDKMGQDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIPP
PLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEVDVTETAIRDIIRYYTREAGVRSLEREISKICRKVVKML
LLKKAEGAVKVDGSNLDTFLGVRKYDFGLAAKENQVGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVE
AARSVVRSRSRRLGIKDEAFEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGGL
KEKLLAAHRGGIKLVLIPEENVKDLTEIPDNVKNAIEIVPVRWVDKVLELALERVPSALPDEEPKPAAPVAAEPGKDAAA
TEVVKH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=568, Percent_Identity=46.4788732394366, Blast_Score=520, Evalue=1e-147,
Organism=Homo sapiens, GI21396489, Length=683, Percent_Identity=40.2635431918009, Blast_Score=501, Evalue=1e-141,
Organism=Escherichia coli, GI1786643, Length=772, Percent_Identity=70.3367875647668, Blast_Score=1088, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=692, Percent_Identity=39.3063583815029, Blast_Score=473, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17556486, Length=540, Percent_Identity=40.5555555555556, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319449, Length=720, Percent_Identity=41.5277777777778, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI221513036, Length=677, Percent_Identity=42.0974889217134, Blast_Score=514, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24666867, Length=677, Percent_Identity=42.0974889217134, Blast_Score=513, Evalue=1e-145,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89242; Mature: 89111

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKT
CCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECC
AAKDEPTEKDMYEVGCVANILQMLKLPDGTVKVLVEGLQRAKTLSIEEQETQFSCEVMPL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCEEEEEEEC
EPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADTIAAHLPLKL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC
DQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELEKRITAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IGLPWRKKSKVNNDLSNAERVLDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP
HCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLTKVGVRNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCC
LFLLDEVDKMGQDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIP
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEECCEEEEEECCCCEEEEEECCCCCCC
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEVDVTETAIRDIIRYYTRE
CHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
AGVRSLEREISKICRKVVKMLLLKKAEGAVKVDGSNLDTFLGVRKYDFGLAAKENQVGQV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHCCHHHCCCCCCCCCCCCCE
TGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVEAARSVVRSRSRRLGIKDEA
ECEEHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
FEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
CCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIKLVLIPEENVKDLTEIPDNVKNAIEIVPVRWVDKVLELALERVPSAL
HHHHHHHHHCCCEEEEEECCCCHHHHHHCCHHHHHHHEEECHHHHHHHHHHHHHHCCCCC
PDEEPKPAAPVAAEPGKDAAATEVVKH
CCCCCCCCCCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
SGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKT
CCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECC
AAKDEPTEKDMYEVGCVANILQMLKLPDGTVKVLVEGLQRAKTLSIEEQETQFSCEVMPL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCEEEEEEEC
EPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADTIAAHLPLKL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC
DQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELEKRITAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IGLPWRKKSKVNNDLSNAERVLDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP
HCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLTKVGVRNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCC
LFLLDEVDKMGQDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIP
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEECCEEEEEECCCCEEEEEECCCCCCC
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEVDVTETAIRDIIRYYTRE
CHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
AGVRSLEREISKICRKVVKMLLLKKAEGAVKVDGSNLDTFLGVRKYDFGLAAKENQVGQV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHCCHHHCCCCCCCCCCCCCE
TGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVEAARSVVRSRSRRLGIKDEA
ECEEHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
FEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
CCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIKLVLIPEENVKDLTEIPDNVKNAIEIVPVRWVDKVLELALERVPSAL
HHHHHHHHHCCCEEEEEECCCCHHHHHHCCHHHHHHHEEECHHHHHHHHHHHHHHCCCCC
PDEEPKPAAPVAAEPGKDAAATEVVKH
CCCCCCCCCCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]