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The map label for this gene is qor [C]

Identifier: 91783491

GI number: 91783491

Start: 2339127

End: 2340149

Strand: Direct

Name: qor [C]

Synonym: Bxe_A2325

Alternate gene names: 91783491

Gene position: 2339127-2340149 (Clockwise)

Preceding gene: 91783489

Following gene: 91783492

Centisome position: 47.78

GC content: 63.34

Gene sequence:

>1023_bases
ATGAAAGCCGTCGGTCTCTATCGTTATTTGCCGATCGATCAAGCCGAAGCCTTGGTCGATGTGGATATCCCCAAACCCGA
AGCCAGCGGTCGTGATCTGCTGGTGAAGGTGGAGGCCATTTCCGTCAATCCGGTCGACACCAAAGTGCGCGCCCCGAAAG
ACACGGTCGAAAAATCGCCGCGCATACTCGGCTGGGATGTCGCCGGCACCGTGGCGGCGGTCGGGCCGGAGGTCACGCTG
TTCAAGGTCGGCGATCCGGTGTTCTACGCGGGCAGCATCACGCGGCCCGGCGCCAACAGCGAGTTCCATCTGGTGGACGA
GCGGATCGTCGGGCGCAAGCCGGCGTCGCTCGACTTCACCCACGCGGCCGCGCTGCCGCTGACCGCGATCACCGCCTGGG
AAGCCCTGTTCGACCGGCTCGGCGTATCGCCGCAAGGCGCGGACGAAGGCCGCACGGTGTTGATCATCGGTGGAGCGGGC
GGGGTCGGCTCGATCGGGATTCAACTGGCAAAGCAGCTTGCGAAGCTGAAGGTGATCGCAACCGCATCGCGGCCCGCATC
GGCGAAGTGGGCCACGGAGCTGGGCGCGGATCACATCGTCGATCATTTCGGCGACATGCCCGCGCAATTGAAAAAGCTCG
GGATCGACGAGGTCGATTACGTGCTGATGTTCAATGATACCGACAGGAACTTCCCGGCGGCAGCCGAAGTCATCAAGCCG
CAAGGCGGCATCTGCACGATCGTGGAAAACAGCCAGCCGGTGCCGGTCGAACTGTTGAAGGCGAAGAGCGCCGCGTTCCA
CTGGGAATTCATGTTCACGCGTTCCATGTTCGGCACGCCTGACATGATCGAGCAGCACAAGCTGCTGACCGAAGTGGCGC
GTCTGGTCGACTCGGGCACGTTGCGCACCACCGTCGGCCAGGATCTCGGCACCATCAACGCCGCGAATCTGCGCCGCGCG
CATCAACTGCTCGAAGAAGGACGGGCAATCGGCAAGCTGGTGCTGACCGGCTTCGAGGCCTAG

Upstream 100 bases:

>100_bases
TATCGCGGTTTTATAAGAATAAGAACCGTCTTACGATACCGCCACCGGGATCGCCAGGTATCGCGATCCTCCAACCGCAT
GTGAACGAACAGGAGCATGT

Downstream 100 bases:

>100_bases
GCAGCACCGCGCTCGCAGCAGTCAGACTGAACCGGCATGGCCGGCGTCGCAGCAATGCGCGCCGGCCGTTTTCATTTGAT
GCGCATCGAGCGGCGCGACC

Product: alginate lyase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MKAVGLYRYLPIDQAEALVDVDIPKPEASGRDLLVKVEAISVNPVDTKVRAPKDTVEKSPRILGWDVAGTVAAVGPEVTL
FKVGDPVFYAGSITRPGANSEFHLVDERIVGRKPASLDFTHAAALPLTAITAWEALFDRLGVSPQGADEGRTVLIIGGAG
GVGSIGIQLAKQLAKLKVIATASRPASAKWATELGADHIVDHFGDMPAQLKKLGIDEVDYVLMFNDTDRNFPAAAEVIKP
QGGICTIVENSQPVPVELLKAKSAAFHWEFMFTRSMFGTPDMIEQHKLLTEVARLVDSGTLRTTVGQDLGTINAANLRRA
HQLLEEGRAIGKLVLTGFEA

Sequences:

>Translated_340_residues
MKAVGLYRYLPIDQAEALVDVDIPKPEASGRDLLVKVEAISVNPVDTKVRAPKDTVEKSPRILGWDVAGTVAAVGPEVTL
FKVGDPVFYAGSITRPGANSEFHLVDERIVGRKPASLDFTHAAALPLTAITAWEALFDRLGVSPQGADEGRTVLIIGGAG
GVGSIGIQLAKQLAKLKVIATASRPASAKWATELGADHIVDHFGDMPAQLKKLGIDEVDYVLMFNDTDRNFPAAAEVIKP
QGGICTIVENSQPVPVELLKAKSAAFHWEFMFTRSMFGTPDMIEQHKLLTEVARLVDSGTLRTTVGQDLGTINAANLRRA
HQLLEEGRAIGKLVLTGFEA
>Mature_340_residues
MKAVGLYRYLPIDQAEALVDVDIPKPEASGRDLLVKVEAISVNPVDTKVRAPKDTVEKSPRILGWDVAGTVAAVGPEVTL
FKVGDPVFYAGSITRPGANSEFHLVDERIVGRKPASLDFTHAAALPLTAITAWEALFDRLGVSPQGADEGRTVLIIGGAG
GVGSIGIQLAKQLAKLKVIATASRPASAKWATELGADHIVDHFGDMPAQLKKLGIDEVDYVLMFNDTDRNFPAAAEVIKP
QGGICTIVENSQPVPVELLKAKSAAFHWEFMFTRSMFGTPDMIEQHKLLTEVARLVDSGTLRTTVGQDLGTINAANLRRA
HQLLEEGRAIGKLVLTGFEA

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=337, Percent_Identity=30.8605341246291, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI194239674, Length=205, Percent_Identity=32.1951219512195, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI13236495, Length=205, Percent_Identity=32.1951219512195, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI194239676, Length=205, Percent_Identity=32.1951219512195, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI24308257, Length=327, Percent_Identity=25.6880733944954, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI18379349, Length=220, Percent_Identity=32.2727272727273, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1790485, Length=199, Percent_Identity=31.6582914572864, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71987554, Length=354, Percent_Identity=26.5536723163842, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17507255, Length=203, Percent_Identity=32.512315270936, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324195, Length=229, Percent_Identity=31.4410480349345, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319945, Length=232, Percent_Identity=30.1724137931034, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323493, Length=227, Percent_Identity=30.3964757709251, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36447; Mature: 36447

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVGLYRYLPIDQAEALVDVDIPKPEASGRDLLVKVEAISVNPVDTKVRAPKDTVEKSP
CCCCCEEEECCCCCCCEEEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCCCHHHHHCCC
RILGWDVAGTVAAVGPEVTLFKVGDPVFYAGSITRPGANSEFHLVDERIVGRKPASLDFT
CEEEEECCCHHHHCCCCEEEEEECCCEEEECCCCCCCCCCCEEEEHHHHHCCCCCCCCCC
HAAALPLTAITAWEALFDRLGVSPQGADEGRTVLIIGGAGGVGSIGIQLAKQLAKLKVIA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHEEEEE
TASRPASAKWATELGADHIVDHFGDMPAQLKKLGIDEVDYVLMFNDTDRNFPAAAEVIKP
ECCCCCCCHHHHHCCHHHHHHHHCCCHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHCCC
QGGICTIVENSQPVPVELLKAKSAAFHWEFMFTRSMFGTPDMIEQHKLLTEVARLVDSGT
CCCEEEEEECCCCCCHHHHHCCCCEEEEEEEEEHHHCCCHHHHHHHHHHHHHHHHHCCCC
LRTTVGQDLGTINAANLRRAHQLLEEGRAIGKLVLTGFEA
EEEHHCCCCCCCCHHHHHHHHHHHHHCHHHEEHHEEECCC
>Mature Secondary Structure
MKAVGLYRYLPIDQAEALVDVDIPKPEASGRDLLVKVEAISVNPVDTKVRAPKDTVEKSP
CCCCCEEEECCCCCCCEEEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCCCHHHHHCCC
RILGWDVAGTVAAVGPEVTLFKVGDPVFYAGSITRPGANSEFHLVDERIVGRKPASLDFT
CEEEEECCCHHHHCCCCEEEEEECCCEEEECCCCCCCCCCCEEEEHHHHHCCCCCCCCCC
HAAALPLTAITAWEALFDRLGVSPQGADEGRTVLIIGGAGGVGSIGIQLAKQLAKLKVIA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHEEEEE
TASRPASAKWATELGADHIVDHFGDMPAQLKKLGIDEVDYVLMFNDTDRNFPAAAEVIKP
ECCCCCCCHHHHHCCHHHHHHHHCCCHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHCCC
QGGICTIVENSQPVPVELLKAKSAAFHWEFMFTRSMFGTPDMIEQHKLLTEVARLVDSGT
CCCEEEEEECCCCCCHHHHHCCCCEEEEEEEEEHHHCCCHHHHHHHHHHHHHHHHHCCCC
LRTTVGQDLGTINAANLRRAHQLLEEGRAIGKLVLTGFEA
EEEHHCCCCCCCCHHHHHHHHHHHHHCHHHEEHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA