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The map label for this gene is metC [H]

Identifier: 91783483

GI number: 91783483

Start: 2328819

End: 2330003

Strand: Direct

Name: metC [H]

Synonym: Bxe_A2333

Alternate gene names: 91783483

Gene position: 2328819-2330003 (Clockwise)

Preceding gene: 91783482

Following gene: 91783484

Centisome position: 47.57

GC content: 64.22

Gene sequence:

>1185_bases
ATGACCCAATCCAAACTCAAACGCGATCTGCAAACCCGTATCGTGCGTGCCGAGGACCAGCTCACGCCGGGCTTCGAGTC
GTTCTCGATGCCGGTCACGCGCGCTTCGACGGTCGTGTTCCCCGATCTCGCGACCATGCGCGCGCTCGACTGGAAAAACG
ACGCGCAATGGCGCTACGGCCTGCATGCCACGCCGACTTCGCTCGCGCTGGCGCAGCGTCTGGCCACCATCGAAGGCGGC
AATCATGCGTTGTTGCAGCCGTCGGGGTTGTCGTCGATTTCGAACGTGTATTTCGGCCTCGTCAAGGCGGGCGACGACGT
GCTGATTCCCGATAACGTCTATTCGCCGAACCGCGATCACGGCGACTGGCTGGCGCGCGACTTCGGCGTCTCCGTGCGCT
ATTACAATCCGATGATCGGCGCGGGCATTGCCGATCTGATCCGGCCGAATACGCGTCTCATCTGGCTCGAAGCACCCGGC
TCGGTGACGATGGAAGTGGCCGACGTGCCCGCCATTACCGCGGTCGCGCGCGCGCACAACGTCGTCACGGCAATCGACAA
TACGTGGTCCGCGGGGCTCGGTTTCCGTCCATTCGATCATGGCGTCGATATCTCGGTGCAGGCGTTGACCAAGTATCAGT
CGGGCGGCGGCGACGTGCTGATGGGCGCGACCATTACCGTCGATCGCGAACTGCATCTGAAGCTGAAGGCGGCGCGCATG
CGCATGGGCATCGGCGTCTCGTCGGACGACTGCTCGCTGATTCTGCGCAGCCTGCCGACCATGCAACTGCGCTTCGAGCA
GCATGACCGCGCGGCGCTCGGATTGGCCAGGTGGTTGAAGACGCGGCCGGAAATTGCCACCGTGTTGCACCCGGCGCTGC
CGGATTGTCCGGGCCATGAGTTTTTCGAGCGTGATTTCACGGGCGCGGGCGGGCTCTTTTCCGTCGTGTTCGACGGCCGT
TACAGCCCGGCGCAAATCGACACGTTCTGCGAGTCGCTCGAACTGTTCTCGCTCGGCTGGAGCTGGGGCGGCGCGCACAG
CCTCGCAATGCCGTACGACGTCGCGTCGATGCGCACGGCGGGGCAGTGGCCGCATCGCGGCACGTTGGTGCGGTTCTATA
TCGGTCTCGAAACCGAGGCGGATTTGCGTGCGGATATCGAGCAGTCGCTGGCGGCGCTGGGCTGA

Upstream 100 bases:

>100_bases
CATGAGCGCAATCCGACCGGCTCGGCTACTCTTGCGAATGCGGCGCGCGGCCTGAATCTGCGTCCCCTCCGTTTTCGTCC
GCTTTTCACCGACACTCACC

Downstream 100 bases:

>100_bases
AAAGTCCGGGCGACGTTTTTCCGCATGCGTAGGATGAGCAAGTCCATTGGGACACGTTTCCAATGGGCTTTTTTCCTGTC
TACGGTGTTTGCGAGGATAG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTQSKLKRDLQTRIVRAEDQLTPGFESFSMPVTRASTVVFPDLATMRALDWKNDAQWRYGLHATPTSLALAQRLATIEGG
NHALLQPSGLSSISNVYFGLVKAGDDVLIPDNVYSPNRDHGDWLARDFGVSVRYYNPMIGAGIADLIRPNTRLIWLEAPG
SVTMEVADVPAITAVARAHNVVTAIDNTWSAGLGFRPFDHGVDISVQALTKYQSGGGDVLMGATITVDRELHLKLKAARM
RMGIGVSSDDCSLILRSLPTMQLRFEQHDRAALGLARWLKTRPEIATVLHPALPDCPGHEFFERDFTGAGGLFSVVFDGR
YSPAQIDTFCESLELFSLGWSWGGAHSLAMPYDVASMRTAGQWPHRGTLVRFYIGLETEADLRADIEQSLAALG

Sequences:

>Translated_394_residues
MTQSKLKRDLQTRIVRAEDQLTPGFESFSMPVTRASTVVFPDLATMRALDWKNDAQWRYGLHATPTSLALAQRLATIEGG
NHALLQPSGLSSISNVYFGLVKAGDDVLIPDNVYSPNRDHGDWLARDFGVSVRYYNPMIGAGIADLIRPNTRLIWLEAPG
SVTMEVADVPAITAVARAHNVVTAIDNTWSAGLGFRPFDHGVDISVQALTKYQSGGGDVLMGATITVDRELHLKLKAARM
RMGIGVSSDDCSLILRSLPTMQLRFEQHDRAALGLARWLKTRPEIATVLHPALPDCPGHEFFERDFTGAGGLFSVVFDGR
YSPAQIDTFCESLELFSLGWSWGGAHSLAMPYDVASMRTAGQWPHRGTLVRFYIGLETEADLRADIEQSLAALG
>Mature_393_residues
TQSKLKRDLQTRIVRAEDQLTPGFESFSMPVTRASTVVFPDLATMRALDWKNDAQWRYGLHATPTSLALAQRLATIEGGN
HALLQPSGLSSISNVYFGLVKAGDDVLIPDNVYSPNRDHGDWLARDFGVSVRYYNPMIGAGIADLIRPNTRLIWLEAPGS
VTMEVADVPAITAVARAHNVVTAIDNTWSAGLGFRPFDHGVDISVQALTKYQSGGGDVLMGATITVDRELHLKLKAARMR
MGIGVSSDDCSLILRSLPTMQLRFEQHDRAALGLARWLKTRPEIATVLHPALPDCPGHEFFERDFTGAGGLFSVVFDGRY
SPAQIDTFCESLELFSLGWSWGGAHSLAMPYDVASMRTAGQWPHRGTLVRFYIGLETEADLRADIEQSLAALG

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=294, Percent_Identity=30.952380952381, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI299473759, Length=237, Percent_Identity=32.0675105485232, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI25453487, Length=293, Percent_Identity=28.3276450511945, Blast_Score=121, Evalue=1e-27,
Organism=Escherichia coli, GI1789383, Length=390, Percent_Identity=36.1538461538462, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI1790375, Length=369, Percent_Identity=29.2682926829268, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17538055, Length=343, Percent_Identity=31.4868804664723, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17560056, Length=346, Percent_Identity=31.2138728323699, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI71980708, Length=406, Percent_Identity=27.3399014778325, Blast_Score=144, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6321170, Length=314, Percent_Identity=41.0828025477707, Blast_Score=246, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6319307, Length=350, Percent_Identity=28.5714285714286, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323333, Length=430, Percent_Identity=24.4186046511628, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321254, Length=263, Percent_Identity=28.5171102661597, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321904, Length=343, Percent_Identity=23.6151603498542, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19922554, Length=355, Percent_Identity=32.6760563380282, Blast_Score=180, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43185; Mature: 43053

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSKLKRDLQTRIVRAEDQLTPGFESFSMPVTRASTVVFPDLATMRALDWKNDAQWRYG
CCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEEECCHHHHHHCCCCCCCCEEEC
LHATPTSLALAQRLATIEGGNHALLQPSGLSSISNVYFGLVKAGDDVLIPDNVYSPNRDH
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHEEEEECCCCEECCCCCCCCCCCC
GDWLARDFGVSVRYYNPMIGAGIADLIRPNTRLIWLEAPGSVTMEVADVPAITAVARAHN
CHHHHHHHCCEEEEECCHHHCCHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHCC
VVTAIDNTWSAGLGFRPFDHGVDISVQALTKYQSGGGDVLMGATITVDRELHLKLKAARM
EEEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEEEEEECCEEEEEEEEHHH
RMGIGVSSDDCSLILRSLPTMQLRFEQHDRAALGLARWLKTRPEIATVLHPALPDCPGHE
HHCCCCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCH
FFERDFTGAGGLFSVVFDGRYSPAQIDTFCESLELFSLGWSWGGAHSLAMPYDVASMRTA
HHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHHHC
GQWPHRGTLVRFYIGLETEADLRADIEQSLAALG
CCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQSKLKRDLQTRIVRAEDQLTPGFESFSMPVTRASTVVFPDLATMRALDWKNDAQWRYG
CHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEEECCHHHHHHCCCCCCCCEEEC
LHATPTSLALAQRLATIEGGNHALLQPSGLSSISNVYFGLVKAGDDVLIPDNVYSPNRDH
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHEEEEECCCCEECCCCCCCCCCCC
GDWLARDFGVSVRYYNPMIGAGIADLIRPNTRLIWLEAPGSVTMEVADVPAITAVARAHN
CHHHHHHHCCEEEEECCHHHCCHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHCC
VVTAIDNTWSAGLGFRPFDHGVDISVQALTKYQSGGGDVLMGATITVDRELHLKLKAARM
EEEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEEEEEECCEEEEEEEEHHH
RMGIGVSSDDCSLILRSLPTMQLRFEQHDRAALGLARWLKTRPEIATVLHPALPDCPGHE
HHCCCCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCH
FFERDFTGAGGLFSVVFDGRYSPAQIDTFCESLELFSLGWSWGGAHSLAMPYDVASMRTA
HHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHHHC
GQWPHRGTLVRFYIGLETEADLRADIEQSLAALG
CCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]