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The map label for this gene is moeA [H]

Identifier: 91783437

GI number: 91783437

Start: 2278453

End: 2279709

Strand: Direct

Name: moeA [H]

Synonym: Bxe_A2379

Alternate gene names: 91783437

Gene position: 2278453-2279709 (Clockwise)

Preceding gene: 91783436

Following gene: 91783438

Centisome position: 46.54

GC content: 67.46

Gene sequence:

>1257_bases
ATGTCCACACCCACGCCCCGCGCGCCGATGCTCGCCACCGCCGAAGCGCTGGCGACCCTGCTCAGCGCCGCGAGCCCGAT
TGCCGGCACAGAGTCGATTCCCACGCTGGATGCGCTGAACCGTGTTCTCGCGGCCAACGTCACTTCACCGCTCGATGTCC
CGCCAATGAACACCAGTTCAATGGACGGCTATGCGATCCGCACGGCGGACCTGACGGTTCGGGACTACAGCCGCTTGCCG
GTTTCGCAGCGCATTCCGGCCGGCCACGCGCCAGAGCCGCTCAAGCCCGGCACGGCGGCGCGCATCTTCACCGGCGCCAC
GGTGCCGCCCGGCGCCGACGCGATCGTGATGCAGGAGCAAACCGAAGCCGCCGACGCAGACGTCGTGATCCTGCACAGTC
CGGAACCGGGCGAATGGATTACAGCGCAGGGCGCGGATATCCGCAGCGGTTCGGTCATCCTGCCGGCGGGCACGCGGCTT
ACGCCGCAGGCATTGGGGCTCGCCGCGTCGGTTGGTTGCGCCGAGCTCGTGGTGCGGCGGCGCGTCAAGGTTGCCGTATT
CTTCACCGGCGACGAGCTGACCATGCCGGGCGAGCCGCTGAAGCCTGGCGCGATCTACAACTCGAACCGTTTCACGCTGC
GTGGCCTGCTGGAAAAACTCGGCTGCGAAGTGACCGACTACGGCATCGTCGCCGACAGGCTCGATGCGACCCGCGCGACC
TTGCGCGAAGCCGCCGGGGCACACGACCTCATCCTGACGTGCGGCGGCGTGTCGGTGGGCGAGGAGGATCATGTGAAGCC
GGCTGTGGAAGCAGAAGGGCGGCTCGCCATGTGGCAGATCGCGATGAAGCCCGGCAAGCCGCTCGCCTTCGGCGCGGTGC
GCCGTGCAGCGCGGCATGGCGAGACCTCGTCGGCGGAGACCTTCTTTATCGGTCTGCCGGGCAATCCGGTGTCCAGCTTC
GCAACCTTCCTGCTGTTCGTGCGTCCGTTCATCCTGAGTCTGGCCGGCGTGCAGGCGGTCGCGCCGCGCGCGCTGTCGCT
GCGCGCGGACTTCACGCAGAGCAAGGCCGACCGCCGCAACGAATTCCTGCGCGCGCGTATCAATCCGGCTGGCGGGCTCG
ATCTGTTTCCGAACCAGAGCTCGGCAGTGCTGACCTCGACCGTCTGGGGCGACGGCCTGATCGACAATCCGCCGAACCAC
GCGATCAGCGCTGGCGAGACCGTGCGCTTCATTCCTTTTTCCGAACTGTTGAACTGA

Upstream 100 bases:

>100_bases
CAAGCGCCAACCACCAGAAACCTCCCGTAACGCCACGCAGCCCAGGCTTCCTGCTTCGACCGCTACAATATTCTTTTAAC
CTGCGGCTTCGAGACCAGAG

Downstream 100 bases:

>100_bases
GGCCGGCAACCGCCGGCGCCATCCCGATGAAGATCCAACTCCGATATTTTGCGAGCGTGCGCGAAGCGCTCGAATTGGCC
GACGAAACCGTCGATCTGCC

Product: molybdenum cofactor biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MSTPTPRAPMLATAEALATLLSAASPIAGTESIPTLDALNRVLAANVTSPLDVPPMNTSSMDGYAIRTADLTVRDYSRLP
VSQRIPAGHAPEPLKPGTAARIFTGATVPPGADAIVMQEQTEAADADVVILHSPEPGEWITAQGADIRSGSVILPAGTRL
TPQALGLAASVGCAELVVRRRVKVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRGLLEKLGCEVTDYGIVADRLDATRAT
LREAAGAHDLILTCGGVSVGEEDHVKPAVEAEGRLAMWQIAMKPGKPLAFGAVRRAARHGETSSAETFFIGLPGNPVSSF
ATFLLFVRPFILSLAGVQAVAPRALSLRADFTQSKADRRNEFLRARINPAGGLDLFPNQSSAVLTSTVWGDGLIDNPPNH
AISAGETVRFIPFSELLN

Sequences:

>Translated_418_residues
MSTPTPRAPMLATAEALATLLSAASPIAGTESIPTLDALNRVLAANVTSPLDVPPMNTSSMDGYAIRTADLTVRDYSRLP
VSQRIPAGHAPEPLKPGTAARIFTGATVPPGADAIVMQEQTEAADADVVILHSPEPGEWITAQGADIRSGSVILPAGTRL
TPQALGLAASVGCAELVVRRRVKVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRGLLEKLGCEVTDYGIVADRLDATRAT
LREAAGAHDLILTCGGVSVGEEDHVKPAVEAEGRLAMWQIAMKPGKPLAFGAVRRAARHGETSSAETFFIGLPGNPVSSF
ATFLLFVRPFILSLAGVQAVAPRALSLRADFTQSKADRRNEFLRARINPAGGLDLFPNQSSAVLTSTVWGDGLIDNPPNH
AISAGETVRFIPFSELLN
>Mature_417_residues
STPTPRAPMLATAEALATLLSAASPIAGTESIPTLDALNRVLAANVTSPLDVPPMNTSSMDGYAIRTADLTVRDYSRLPV
SQRIPAGHAPEPLKPGTAARIFTGATVPPGADAIVMQEQTEAADADVVILHSPEPGEWITAQGADIRSGSVILPAGTRLT
PQALGLAASVGCAELVVRRRVKVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRGLLEKLGCEVTDYGIVADRLDATRATL
REAAGAHDLILTCGGVSVGEEDHVKPAVEAEGRLAMWQIAMKPGKPLAFGAVRRAARHGETSSAETFFIGLPGNPVSSFA
TFLLFVRPFILSLAGVQAVAPRALSLRADFTQSKADRRNEFLRARINPAGGLDLFPNQSSAVLTSTVWGDGLIDNPPNHA
ISAGETVRFIPFSELLN

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=408, Percent_Identity=34.3137254901961, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI66932975, Length=408, Percent_Identity=34.3137254901961, Blast_Score=186, Evalue=4e-47,
Organism=Escherichia coli, GI1787049, Length=391, Percent_Identity=40.920716112532, Blast_Score=268, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI25147659, Length=347, Percent_Identity=30.835734870317, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17562606, Length=379, Percent_Identity=24.802110817942, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17136978, Length=410, Percent_Identity=31.9512195121951, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24638841, Length=410, Percent_Identity=31.9512195121951, Blast_Score=154, Evalue=9e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44010; Mature: 43879

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPTPRAPMLATAEALATLLSAASPIAGTESIPTLDALNRVLAANVTSPLDVPPMNTSS
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
MDGYAIRTADLTVRDYSRLPVSQRIPAGHAPEPLKPGTAARIFTGATVPPGADAIVMQEQ
CCCEEEEEEEEEEEHHHCCCHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECC
TEAADADVVILHSPEPGEWITAQGADIRSGSVILPAGTRLTPQALGLAASVGCAELVVRR
CCCCCCCEEEEECCCCCCEEEECCCCCCCCCEEECCCCCCCHHHHHHHHHCCHHHHHHHC
RVKVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRGLLEKLGCEVTDYGIVADRLDATRAT
CEEEEEEEECCEEECCCCCCCCCEEECCCCHHHHHHHHHHCCCEECCCCCHHHHHHHHHH
LREAAGAHDLILTCGGVSVGEEDHVKPAVEAEGRLAMWQIAMKPGKPLAFGAVRRAARHG
HHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCC
ETSSAETFFIGLPGNPVSSFATFLLFVRPFILSLAGVQAVAPRALSLRADFTQSKADRRN
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHH
EFLRARINPAGGLDLFPNQSSAVLTSTVWGDGLIDNPPNHAISAGETVRFIPFSELLN
HHHEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEHHHHCC
>Mature Secondary Structure 
STPTPRAPMLATAEALATLLSAASPIAGTESIPTLDALNRVLAANVTSPLDVPPMNTSS
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
MDGYAIRTADLTVRDYSRLPVSQRIPAGHAPEPLKPGTAARIFTGATVPPGADAIVMQEQ
CCCEEEEEEEEEEEHHHCCCHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECC
TEAADADVVILHSPEPGEWITAQGADIRSGSVILPAGTRLTPQALGLAASVGCAELVVRR
CCCCCCCEEEEECCCCCCEEEECCCCCCCCCEEECCCCCCCHHHHHHHHHCCHHHHHHHC
RVKVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRGLLEKLGCEVTDYGIVADRLDATRAT
CEEEEEEEECCEEECCCCCCCCCEEECCCCHHHHHHHHHHCCCEECCCCCHHHHHHHHHH
LREAAGAHDLILTCGGVSVGEEDHVKPAVEAEGRLAMWQIAMKPGKPLAFGAVRRAARHG
HHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCC
ETSSAETFFIGLPGNPVSSFATFLLFVRPFILSLAGVQAVAPRALSLRADFTQSKADRRN
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHH
EFLRARINPAGGLDLFPNQSSAVLTSTVWGDGLIDNPPNHAISAGETVRFIPFSELLN
HHHEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]