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The map label for this gene is thrC [H]

Identifier: 91783436

GI number: 91783436

Start: 2276786

End: 2278237

Strand: Direct

Name: thrC [H]

Synonym: Bxe_A2380

Alternate gene names: 91783436

Gene position: 2276786-2278237 (Clockwise)

Preceding gene: 91783435

Following gene: 91783437

Centisome position: 46.5

GC content: 63.15

Gene sequence:

>1452_bases
ATGAACTACCTCTCCACGCGCGGCGCCGGAGCCGGCGAGCACCATACCTTTTCCGACATCCTGCTGGGCGGTCTCGCGAA
AGACGGCGGCCTGTACCTGCCCGCCGAATATCCGCGCATCACCGGCGACGAACTGACGCGCTGGCGCACGCTGCCGTACG
CGGACCTGGCCTTCGAGATCCTGTCCCGATTCAGCGACGACATTCCCGCCGAAGACCTGCGCGCGCTCACACGCAAAACG
TACACCGCGGCCACCTACTGCAACGTGCGCGACGACGAAAGCGCCGCGCAGATCACGCCGCTGAAGACGCTCGGCGTCGA
GAACGGCGCGCCGCTGTCGCTGCTGGAACTCTCGAACGGACCGACGCTCGCATTCAAGGACATGGCGATGCAGTTGATCG
GCAACCTGTTCGAATACACGCTGGCAAAGCACGGTCAAACGCTGAACATTCTCGGCGCGACCTCGGGCGACACCGGCAGC
GCCGCGGAATACGCGATGCGCGGCAAGAAAGGCATCAGCGTGTTCATGCTCTCGCCGCACAGGAAGATGAGCGCGTTCCA
GACCGCGCAGATGTACAGCCTGCAGGATCCGAACATCTTCAACATCGCGGTGGAAGGCGTGTTCGACGACGCGCAGGACA
TCGTCAAGGCCGTCTCGAACGATCACGCATTCAAGGCGAAGTACAGGATCGGCACGGTCAACTCGATCAACTGGGCGCGC
GTCGTCGCGCAGGTCGTGTATTACTTCAAGGGCTACTTTGCGGCCACGAAGTCGAACGACGAGCGCGTGTCGTTCACGGT
GCCGTCGGGCAACTTCGGCAACGTGTGCGCGGGTCACATCGCGCGCATGATGGGTTTGCCGATCGAAAAGCTGGTCGTGG
CGACGAACGAAAACGACGTGCTCGACGAGTTTTTCCGCACCGGTATTTACCGCGTGCGCAAGGCGGCCGAGACGTATCAC
ACCAGCAGCCCGAGCATGGACATTTCGAAGGCTTCGAACTTCGAGCGTTTCGTGTTCGATCTGCTCGGCCGCGATCCGGC
GCGCGTGCTGCAACTGTTCCGCGACGTCGAAGAGAAGGGCGGTTTCGACCTCGCCGCGAGCGGGGACTTTGCGCGCGTGC
AGCAATTCGGTTTCGTGTCGGGCCGCAGCAGCCACGAATCGCGCGTGGAGACCATCCGCGACGTGTTCGAGCGTTACGAC
ACGATGATCGACACGCACACGGCCGACGGACTGAAGGTCGCGCGCGAATATCTGCAGCCGGGCATTCCGATGATCGTGCT
GGAGACCGCGCAACCGATCAAATTCGGCGAGACGATCCGCGAAGCGCTGCTGCGCGAACCGGAGCGGCCGGCGGCTTTCT
CGGGCCTCGAATCCCTGCCGCAGCGCTTCGAAGTGCTGCCCGCGGACGTTCAGCGCGTGAAGGACTTTATCGCGGCGAAC
GTGGACGCGTAA

Upstream 100 bases:

>100_bases
AGAAGAACGTCAACGCCGCGATCAAGACGATCGAAGCGCTGAAGACCGTTGTTTCGCAAGTCACGAAGCTGCGCATGGAA
GCGCTGAACTAGGCCGAACT

Downstream 100 bases:

>100_bases
GCGAGTCTCACGTTGCCGTAAAGCGTAACCGGATCCGCGGCCCACGCACCGTCCGGCACGCTCGCTGCACCCCGTGCGCT
CCATGTTTAACGACGCTTGC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MNYLSTRGAGAGEHHTFSDILLGGLAKDGGLYLPAEYPRITGDELTRWRTLPYADLAFEILSRFSDDIPAEDLRALTRKT
YTAATYCNVRDDESAAQITPLKTLGVENGAPLSLLELSNGPTLAFKDMAMQLIGNLFEYTLAKHGQTLNILGATSGDTGS
AAEYAMRGKKGISVFMLSPHRKMSAFQTAQMYSLQDPNIFNIAVEGVFDDAQDIVKAVSNDHAFKAKYRIGTVNSINWAR
VVAQVVYYFKGYFAATKSNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDVLDEFFRTGIYRVRKAAETYH
TSSPSMDISKASNFERFVFDLLGRDPARVLQLFRDVEEKGGFDLAASGDFARVQQFGFVSGRSSHESRVETIRDVFERYD
TMIDTHTADGLKVAREYLQPGIPMIVLETAQPIKFGETIREALLREPERPAAFSGLESLPQRFEVLPADVQRVKDFIAAN
VDA

Sequences:

>Translated_483_residues
MNYLSTRGAGAGEHHTFSDILLGGLAKDGGLYLPAEYPRITGDELTRWRTLPYADLAFEILSRFSDDIPAEDLRALTRKT
YTAATYCNVRDDESAAQITPLKTLGVENGAPLSLLELSNGPTLAFKDMAMQLIGNLFEYTLAKHGQTLNILGATSGDTGS
AAEYAMRGKKGISVFMLSPHRKMSAFQTAQMYSLQDPNIFNIAVEGVFDDAQDIVKAVSNDHAFKAKYRIGTVNSINWAR
VVAQVVYYFKGYFAATKSNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDVLDEFFRTGIYRVRKAAETYH
TSSPSMDISKASNFERFVFDLLGRDPARVLQLFRDVEEKGGFDLAASGDFARVQQFGFVSGRSSHESRVETIRDVFERYD
TMIDTHTADGLKVAREYLQPGIPMIVLETAQPIKFGETIREALLREPERPAAFSGLESLPQRFEVLPADVQRVKDFIAAN
VDA
>Mature_483_residues
MNYLSTRGAGAGEHHTFSDILLGGLAKDGGLYLPAEYPRITGDELTRWRTLPYADLAFEILSRFSDDIPAEDLRALTRKT
YTAATYCNVRDDESAAQITPLKTLGVENGAPLSLLELSNGPTLAFKDMAMQLIGNLFEYTLAKHGQTLNILGATSGDTGS
AAEYAMRGKKGISVFMLSPHRKMSAFQTAQMYSLQDPNIFNIAVEGVFDDAQDIVKAVSNDHAFKAKYRIGTVNSINWAR
VVAQVVYYFKGYFAATKSNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDVLDEFFRTGIYRVRKAAETYH
TSSPSMDISKASNFERFVFDLLGRDPARVLQLFRDVEEKGGFDLAASGDFARVQQFGFVSGRSSHESRVETIRDVFERYD
TMIDTHTADGLKVAREYLQPGIPMIVLETAQPIKFGETIREALLREPERPAAFSGLESLPQRFEVLPADVQRVKDFIAAN
VDA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=450, Percent_Identity=34, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI149193323, Length=475, Percent_Identity=31.1578947368421, Blast_Score=206, Evalue=4e-53,
Organism=Escherichia coli, GI1786185, Length=467, Percent_Identity=28.4796573875803, Blast_Score=181, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6319901, Length=472, Percent_Identity=40.6779661016949, Blast_Score=315, Evalue=9e-87,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 53449; Mature: 53449

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYLSTRGAGAGEHHTFSDILLGGLAKDGGLYLPAEYPRITGDELTRWRTLPYADLAFEI
CCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEECCCCCCCCCCHHHHHHCCCCHHHHHHHH
LSRFSDDIPAEDLRALTRKTYTAATYCNVRDDESAAQITPLKTLGVENGAPLSLLELSNG
HHHHCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCHHCCCHHHHCCCCCCCEEEEEECCC
PTLAFKDMAMQLIGNLFEYTLAKHGQTLNILGATSGDTGSAAEYAMRGKKGISVFMLSPH
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHCCCCCCEEEEECCC
RKMSAFQTAQMYSLQDPNIFNIAVEGVFDDAQDIVKAVSNDHAFKAKYRIGTVNSINWAR
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHH
VVAQVVYYFKGYFAATKSNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDV
HHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHH
LDEFFRTGIYRVRKAAETYHTSSPSMDISKASNFERFVFDLLGRDPARVLQLFRDVEEKG
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHC
GFDLAASGDFARVQQFGFVSGRSSHESRVETIRDVFERYDTMIDTHTADGLKVAREYLQP
CEEEECCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
GIPMIVLETAQPIKFGETIREALLREPERPAAFSGLESLPQRFEVLPADVQRVKDFIAAN
CCCEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
VDA
CCC
>Mature Secondary Structure
MNYLSTRGAGAGEHHTFSDILLGGLAKDGGLYLPAEYPRITGDELTRWRTLPYADLAFEI
CCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEECCCCCCCCCCHHHHHHCCCCHHHHHHHH
LSRFSDDIPAEDLRALTRKTYTAATYCNVRDDESAAQITPLKTLGVENGAPLSLLELSNG
HHHHCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCHHCCCHHHHCCCCCCCEEEEEECCC
PTLAFKDMAMQLIGNLFEYTLAKHGQTLNILGATSGDTGSAAEYAMRGKKGISVFMLSPH
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHCCCCCCEEEEECCC
RKMSAFQTAQMYSLQDPNIFNIAVEGVFDDAQDIVKAVSNDHAFKAKYRIGTVNSINWAR
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHH
VVAQVVYYFKGYFAATKSNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDV
HHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHH
LDEFFRTGIYRVRKAAETYHTSSPSMDISKASNFERFVFDLLGRDPARVLQLFRDVEEKG
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHC
GFDLAASGDFARVQQFGFVSGRSSHESRVETIRDVFERYDTMIDTHTADGLKVAREYLQP
CEEEECCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
GIPMIVLETAQPIKFGETIREALLREPERPAAFSGLESLPQRFEVLPADVQRVKDFIAAN
CCCEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
VDA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8117070 [H]