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The map label for this gene is hom [H]

Identifier: 91783435

GI number: 91783435

Start: 2275446

End: 2276777

Strand: Direct

Name: hom [H]

Synonym: Bxe_A2381

Alternate gene names: 91783435

Gene position: 2275446-2276777 (Clockwise)

Preceding gene: 91783434

Following gene: 91783436

Centisome position: 46.48

GC content: 64.41

Gene sequence:

>1332_bases
ATGGAACCGATCAAAGTTGGACTGCTGGGCTTCGGCACGGTAGGCAGCGGCACCTTCACGGTACTGCGCCGCAATCAGGA
AGAAATCAAACGCCGCGCGGGCCGCGGCATCGAGATCGCGCGCATTGCCGTGCGCAATCCCGCCAAAGCGACGGCGGTGC
TCGGCGCCGAGGCAGGCACCGTGGCGCTGACCGATGACTTCAACGCGGTGGTCGACGACCCGTCGATCGATATCGTGGCC
GAAATGATCGGCGGCACGGGCGTGGCGCGCGACCTCGTGCTGCGCGCGATCCGCAACCGCAAGCATGTGGTGACCGCCAA
CAAGGCGCTGCTCGCGGTGCACGGCACGGAGATTTTCGAAGCGGCGCGCGCCAACGGCGTGATGGTGTCGTTCGAGGCGG
CGGTGGCGGGCGGGATTCCGATCATCAAGGCGCTGCGCGAAGGGCTCACGGCCAATCGCATCCAGTACATTGCGGGCATC
ATCAACGGCACCACGAACTACATTCTCTCGGAAATGCGCGACCGCGGGCTCGACTTCGCGACCGCGCTGAAAGCGGCGCA
GGACCTCGGTTATGCCGAAGCCGACCCGACCTTCGACATCGAAGGCGTGGACGCCGCGCACAAGGCGACCATCATGAGCG
CGATCGCGTTCGGCGTGCCGGTGCAGTTCGACAAGGCCTACGTCGAAGGCATCAGCAAGCTCGCGGCGATCGACATCAGA
TATGCCGAGGAACTCGGCTACCGTATCAAGCTGCTCGGCATTGCGCGCCGCACAGATAAAGGCATCGAATTGCGCGTGCA
TCCCACGCTGATTCCGGAAAAGCGCCTGCTGGCGAACGTGGAAGGCGCGATGAACGCAGTCGTCGTGCACGGCGACGCGG
TCGGCACCACGCTGTACTACGGCAAGGGCGCGGGCGCCGAGCCCACGGCTTCCGCGGTGGTGGCCGATCTGGTCGACGTG
ACGCGTCTGCACACGGCGGACCCGGAGCACCGCGTGCCGCATCTGGCGTTCCAGCCGGACAGCCTGTCGAACACCCCGAT
CCTGCCGATCGACGAAGTGACGAGCGGCTACTACCTGCGTCTGCGGGTGGCGGACGTGACCGGCGTGCTGGCTGACATCA
CGCGCATTCTGGCCGATACCGGCATTTCGATCGACGCGCTGCTGCAGAAGGAATCGGAGCAGGTCGACGCGAACGGCAAG
GGCGAAACCGACATCATCCTGATTACGCACGAAACGGTTGAGAAGAACGTCAACGCCGCGATCAAGACGATCGAAGCGCT
GAAGACCGTTGTTTCGCAAGTCACGAAGCTGCGCATGGAAGCGCTGAACTAG

Upstream 100 bases:

>100_bases
GCCTCACAGCAAATACGTCTGGGCGCATGCCGCGCCGCGCGGACCGCGCCGGACCCGAAGCCCGTTTACTTTTAATCATC
TACTCGAAAACACACGCTGC

Downstream 100 bases:

>100_bases
GCCGAACTATGAACTACCTCTCCACGCGCGGCGCCGGAGCCGGCGAGCACCATACCTTTTCCGACATCCTGCTGGGCGGT
CTCGCGAAAGACGGCGGCCT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MEPIKVGLLGFGTVGSGTFTVLRRNQEEIKRRAGRGIEIARIAVRNPAKATAVLGAEAGTVALTDDFNAVVDDPSIDIVA
EMIGGTGVARDLVLRAIRNRKHVVTANKALLAVHGTEIFEAARANGVMVSFEAAVAGGIPIIKALREGLTANRIQYIAGI
INGTTNYILSEMRDRGLDFATALKAAQDLGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDKAYVEGISKLAAIDIR
YAEELGYRIKLLGIARRTDKGIELRVHPTLIPEKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDSLSNTPILPIDEVTSGYYLRLRVADVTGVLADITRILADTGISIDALLQKESEQVDANGK
GETDIILITHETVEKNVNAAIKTIEALKTVVSQVTKLRMEALN

Sequences:

>Translated_443_residues
MEPIKVGLLGFGTVGSGTFTVLRRNQEEIKRRAGRGIEIARIAVRNPAKATAVLGAEAGTVALTDDFNAVVDDPSIDIVA
EMIGGTGVARDLVLRAIRNRKHVVTANKALLAVHGTEIFEAARANGVMVSFEAAVAGGIPIIKALREGLTANRIQYIAGI
INGTTNYILSEMRDRGLDFATALKAAQDLGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDKAYVEGISKLAAIDIR
YAEELGYRIKLLGIARRTDKGIELRVHPTLIPEKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDSLSNTPILPIDEVTSGYYLRLRVADVTGVLADITRILADTGISIDALLQKESEQVDANGK
GETDIILITHETVEKNVNAAIKTIEALKTVVSQVTKLRMEALN
>Mature_443_residues
MEPIKVGLLGFGTVGSGTFTVLRRNQEEIKRRAGRGIEIARIAVRNPAKATAVLGAEAGTVALTDDFNAVVDDPSIDIVA
EMIGGTGVARDLVLRAIRNRKHVVTANKALLAVHGTEIFEAARANGVMVSFEAAVAGGIPIIKALREGLTANRIQYIAGI
INGTTNYILSEMRDRGLDFATALKAAQDLGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDKAYVEGISKLAAIDIR
YAEELGYRIKLLGIARRTDKGIELRVHPTLIPEKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDSLSNTPILPIDEVTSGYYLRLRVADVTGVLADITRILADTGISIDALLQKESEQVDANGK
GETDIILITHETVEKNVNAAIKTIEALKTVVSQVTKLRMEALN

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=256, Percent_Identity=26.171875, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=135, Percent_Identity=34.8148148148148, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47236; Mature: 47236

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPIKVGLLGFGTVGSGTFTVLRRNQEEIKRRAGRGIEIARIAVRNPAKATAVLGAEAGT
CCCEEEEEEEECCCCCCEEEEEECCHHHHHHHCCCCCEEEEEEECCCCCCEEEEECCCCE
VALTDDFNAVVDDPSIDIVAEMIGGTGVARDLVLRAIRNRKHVVTANKALLAVHGTEIFE
EEEECCCCEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCEEEEEECHHHHH
AARANGVMVSFEAAVAGGIPIIKALREGLTANRIQYIAGIINGTTNYILSEMRDRGLDFA
HHCCCCEEEEEEHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHH
TALKAAQDLGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDKAYVEGISKLAAIDIR
HHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHH
YAEELGYRIKLLGIARRTDKGIELRVHPTLIPEKRLLANVEGAMNAVVVHGDAVGTTLYY
HHHHCCCEEEEEEEEECCCCCCEEEECCCCCCCHHHHHHHCCCCEEEEEECCCCCCEEEE
GKGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPDSLSNTPILPIDEVTSGYYLR
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHCCCCEEEE
LRVADVTGVLADITRILADTGISIDALLQKESEQVDANGKGETDIILITHETVEKNVNAA
EEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECHHHHHHHHHH
IKTIEALKTVVSQVTKLRMEALN
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEPIKVGLLGFGTVGSGTFTVLRRNQEEIKRRAGRGIEIARIAVRNPAKATAVLGAEAGT
CCCEEEEEEEECCCCCCEEEEEECCHHHHHHHCCCCCEEEEEEECCCCCCEEEEECCCCE
VALTDDFNAVVDDPSIDIVAEMIGGTGVARDLVLRAIRNRKHVVTANKALLAVHGTEIFE
EEEECCCCEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCEEEEEECHHHHH
AARANGVMVSFEAAVAGGIPIIKALREGLTANRIQYIAGIINGTTNYILSEMRDRGLDFA
HHCCCCEEEEEEHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHH
TALKAAQDLGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDKAYVEGISKLAAIDIR
HHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHH
YAEELGYRIKLLGIARRTDKGIELRVHPTLIPEKRLLANVEGAMNAVVVHGDAVGTTLYY
HHHHCCCEEEEEEEEECCCCCCEEEECCCCCCCHHHHHHHCCCCEEEEEECCCCCCEEEE
GKGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPDSLSNTPILPIDEVTSGYYLR
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHCCCCEEEE
LRVADVTGVLADITRILADTGISIDALLQKESEQVDANGKGETDIILITHETVEKNVNAA
EEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECHHHHHHHHHH
IKTIEALKTVVSQVTKLRMEALN
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]