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The map label for this gene is echA8 [H]

Identifier: 91783324

GI number: 91783324

Start: 2172104

End: 2173234

Strand: Direct

Name: echA8 [H]

Synonym: Bxe_A2495

Alternate gene names: 91783324

Gene position: 2172104-2173234 (Clockwise)

Preceding gene: 91783323

Following gene: 91783326

Centisome position: 44.37

GC content: 65.43

Gene sequence:

>1131_bases
ATGTCCATTTCCGCCTCGCCCGCCGTCAGCGACGAAGTCGCGACTTACGTAGCCAACCGCATCGGTTTCATCGAACTGGA
ACGGCCGAAAGCGCTCAACGCGCTGTCCACTGGCATGATTCGCGCCATCCACGCGGCGCTCGACCAGTGGCGTGAAAATC
CCGATGTGCTCGCCGTCGTGGTGCGCAGTCAGCACCCGCGCGCGTTTTGCGCGGGCGGCGACGTCCGCTTTCTGTATGAG
ACGGCGCAACGCGGCGAGCCCGACGCGCGCGACACGTTTTTCATCGAGGAATACCGGCTCAATCACGCGATCTTCACTTA
TCCGAAGCCGTATATCGCGTTGATGAACGGCGTCGTGATGGGCGGCGGCATGGGTATTTCGCAGGGCGCGCATCGCACCG
GCGGCCTGCGCGTCGTTACCGACTCGACCAGAATGGCCATGCCCGAAACCCGCATCGGACTCTTTCCCGATGTCGGCGCG
AGCTGGTTTCTGGCCCGCACGCCAGGCGCGATCGGGCGCTATCTGGCCGTGACCGGCGAGACGATCGACGCGGCCGACGC
GCTCTACGCGGGTCTGGCCGACACCTACATCGAGGACGCGGCATTGCCCGCGCTCGTCGATACGCTGCGCAGCGAGCTGT
TCGAGCGAGGCGCTGACGTGGTAGCGTGCATCGAACGTGAGGCGCTGGCGCACCAGGTCGTGCCGCGGCCCGAGGCGTCG
TTGCTGGCGAACGCGCGTGCGCTGATCGACCGCCACTTCGCGTTACCCGATGTCGCGCGGATTCTCGCCTCGCTCGAAAG
CGAGCGCAACGGCGAGGCCGCCGATTGGGCCGAACAGATGATCGCGATCTTGCGCGAACGTTCGCCGTTGTCGATGGCGG
TGTCGCTGGAAGTGGTGACGCGTGCCGAGGGTTCAATGGCGGACGTGCTGCGCTGCGACCTCGATCTGACACGTTCGAGC
TTTCTGCATGGCGACACGATCGAAGGCATTCGCGCGCGCATCATCGACAAGGACAACGCGCCGCGCTGGCGCTTTGCGCG
CATTGAAGACGTGAGCGCCGCCGAGGTCGGGAAGATGTTCGAGAGTCCGTGGCCGGCCAGCGAACACCCGTTGCGGGATT
TGCGCGGTTAG

Upstream 100 bases:

>100_bases
GCAACGGCCGGTGTCGACGCGCCCGCCGTCAGGCGCAAAGCCGCGAGTGCGTGATAACGTTCAATTCCACCTCACTTTGC
GCCGTTGCGCTTAGCTCCCC

Downstream 100 bases:

>100_bases
GCTCCAAGCCCGGCACAGCGGGAAACTGCGCCGGCTTGCGCGCGTTCATTCTTCCTCTTCGCTCGCCATGAACGCGCGCA
TGAACACCAGCGCGCCCCAG

Product: 3-hydroxyisobutyryl-CoA hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MSISASPAVSDEVATYVANRIGFIELERPKALNALSTGMIRAIHAALDQWRENPDVLAVVVRSQHPRAFCAGGDVRFLYE
TAQRGEPDARDTFFIEEYRLNHAIFTYPKPYIALMNGVVMGGGMGISQGAHRTGGLRVVTDSTRMAMPETRIGLFPDVGA
SWFLARTPGAIGRYLAVTGETIDAADALYAGLADTYIEDAALPALVDTLRSELFERGADVVACIEREALAHQVVPRPEAS
LLANARALIDRHFALPDVARILASLESERNGEAADWAEQMIAILRERSPLSMAVSLEVVTRAEGSMADVLRCDLDLTRSS
FLHGDTIEGIRARIIDKDNAPRWRFARIEDVSAAEVGKMFESPWPASEHPLRDLRG

Sequences:

>Translated_376_residues
MSISASPAVSDEVATYVANRIGFIELERPKALNALSTGMIRAIHAALDQWRENPDVLAVVVRSQHPRAFCAGGDVRFLYE
TAQRGEPDARDTFFIEEYRLNHAIFTYPKPYIALMNGVVMGGGMGISQGAHRTGGLRVVTDSTRMAMPETRIGLFPDVGA
SWFLARTPGAIGRYLAVTGETIDAADALYAGLADTYIEDAALPALVDTLRSELFERGADVVACIEREALAHQVVPRPEAS
LLANARALIDRHFALPDVARILASLESERNGEAADWAEQMIAILRERSPLSMAVSLEVVTRAEGSMADVLRCDLDLTRSS
FLHGDTIEGIRARIIDKDNAPRWRFARIEDVSAAEVGKMFESPWPASEHPLRDLRG
>Mature_375_residues
SISASPAVSDEVATYVANRIGFIELERPKALNALSTGMIRAIHAALDQWRENPDVLAVVVRSQHPRAFCAGGDVRFLYET
AQRGEPDARDTFFIEEYRLNHAIFTYPKPYIALMNGVVMGGGMGISQGAHRTGGLRVVTDSTRMAMPETRIGLFPDVGAS
WFLARTPGAIGRYLAVTGETIDAADALYAGLADTYIEDAALPALVDTLRSELFERGADVVACIEREALAHQVVPRPEASL
LANARALIDRHFALPDVARILASLESERNGEAADWAEQMIAILRERSPLSMAVSLEVVTRAEGSMADVLRCDLDLTRSSF
LHGDTIEGIRARIIDKDNAPRWRFARIEDVSAAEVGKMFESPWPASEHPLRDLRG

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=363, Percent_Identity=31.9559228650138, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI37594469, Length=323, Percent_Identity=31.2693498452012, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI194097323, Length=192, Percent_Identity=33.3333333333333, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1788682, Length=190, Percent_Identity=30, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI221142681, Length=181, Percent_Identity=29.8342541436464, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25144157, Length=373, Percent_Identity=38.3378016085791, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI25144160, Length=373, Percent_Identity=38.3378016085791, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17540714, Length=183, Percent_Identity=27.8688524590164, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320241, Length=378, Percent_Identity=28.5714285714286, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI28571729, Length=361, Percent_Identity=36.8421052631579, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI28571730, Length=361, Percent_Identity=36.8421052631579, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24653139, Length=182, Percent_Identity=30.2197802197802, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI20129971, Length=194, Percent_Identity=28.3505154639175, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24653477, Length=194, Percent_Identity=28.3505154639175, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 41156; Mature: 41025

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISASPAVSDEVATYVANRIGFIELERPKALNALSTGMIRAIHAALDQWRENPDVLAVV
CCCCCCCCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
VRSQHPRAFCAGGDVRFLYETAQRGEPDARDTFFIEEYRLNHAIFTYPKPYIALMNGVVM
EECCCCCEEECCCCEEEEEHHHHCCCCCCCCCEEEEEEECCCEEEECCCHHHHHHCCCCC
GGGMGISQGAHRTGGLRVVTDSTRMAMPETRIGLFPDVGASWFLARTPGAIGRYLAVTGE
CCCCCCCCCCCCCCCEEEEECCCHHCCCCCCCCCCCCCCCCEEEECCCCHHCCEEEEECC
TIDAADALYAGLADTYIEDAALPALVDTLRSELFERGADVVACIEREALAHQVVPRPEAS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHH
LLANARALIDRHFALPDVARILASLESERNGEAADWAEQMIAILRERSPLSMAVSLEVVT
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEE
RAEGSMADVLRCDLDLTRSSFLHGDTIEGIRARIIDKDNAPRWRFARIEDVSAAEVGKMF
CCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHEEECCCCCCCEEEEEECCCCHHHHHHHH
ESPWPASEHPLRDLRG
CCCCCCCCCCHHHHCC
>Mature Secondary Structure 
SISASPAVSDEVATYVANRIGFIELERPKALNALSTGMIRAIHAALDQWRENPDVLAVV
CCCCCCCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
VRSQHPRAFCAGGDVRFLYETAQRGEPDARDTFFIEEYRLNHAIFTYPKPYIALMNGVVM
EECCCCCEEECCCCEEEEEHHHHCCCCCCCCCEEEEEEECCCEEEECCCHHHHHHCCCCC
GGGMGISQGAHRTGGLRVVTDSTRMAMPETRIGLFPDVGASWFLARTPGAIGRYLAVTGE
CCCCCCCCCCCCCCCEEEEECCCHHCCCCCCCCCCCCCCCCEEEECCCCHHCCEEEEECC
TIDAADALYAGLADTYIEDAALPALVDTLRSELFERGADVVACIEREALAHQVVPRPEAS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHH
LLANARALIDRHFALPDVARILASLESERNGEAADWAEQMIAILRERSPLSMAVSLEVVT
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEE
RAEGSMADVLRCDLDLTRSSFLHGDTIEGIRARIIDKDNAPRWRFARIEDVSAAEVGKMF
CCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHEEECCCCCCCEEEEEECCCCHHHHHHHH
ESPWPASEHPLRDLRG
CCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]