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The map label for this gene is groEL

Identifier: 91783188

GI number: 91783188

Start: 2033396

End: 2035018

Strand: Direct

Name: groEL

Synonym: Bxe_A4544

Alternate gene names: 91783188

Gene position: 2033396-2035018 (Clockwise)

Preceding gene: 91783187

Following gene: 91783189

Centisome position: 41.53

GC content: 62.05

Gene sequence:

>1623_bases
ATGAGTGCGAAAGATGTCAAGTTCCACGACAGCGCCCGCAGCCGGATCGTCAAGGGCGTGAACGTGCTGGCCGATGCAGT
GAAAGTGACGCTCGGCCCGAAGGGGCGAAATGTCCTGATTGAGCGCAGCTTCGGCGCGCCGACCATCACCAAGGACGGTG
TGTCTGTCGCTAAGGAAATCGAGCTGAAGGACCGCTTCGAAAACATGGGCGCCCAGGTTGTCAAGCAGGTCGCATCGAAG
ACCGCCGATGTCGCCGGCGACGGTACGACGACCGCCACGGTTCTCGCCCAGTCGATCGTGCAGGAAGGCATGAAGCACGT
CGCTGCTGGCATGAATCCGATGGACCTGAAGCGCGGCATCGACAAGGCGGTGGCGGCTGTGCTCGATGAACTGCACAGGC
TGTCCAAGCCGATAAAGACAAGCCGGGAAATCGCCCAGGTCGGCGCCATCTCGGCGAATGCGGACGAGGCGATCGGCAAG
ATCATTGCAGACGCGATGGACAAGGTCGGCAAGGAAGGGGTGATTACGGTCGAAGACGGCAAGTCGCTCGAGAACGAACT
GGAGGTCGTCGAAGGGATGCAGTTCGATCGGGGTTATCTGAGTCCATACTTCATCAATGACCCGGACAAACAGGTTGCGC
ATCTCGACGATCCGCTGATCCTGCTGCATGACAAGAAAATTTCCAGTATCCGCGACCTGCTGCCGGTCCTCGAGGCTGCT
GCCAAGGCAGGCAAGCCGCTCCTGATCATCGCCGAGGATGTCGAAGGCGAAGCGCTCACGACGCTGGTGGTCAATTCGAT
GCGCGGTGTGCTGAAGGTGGCGGCGGTGAAGGCCCCGGGCTTTGGCGATCGCCGCAAGGCCCTGCTCGAGGACATTGCGA
TTCTCACCGGTGCAACGGTCATTTCCGAAGAGACTGGCAAGCAGCTCGAGAAGGCAACGCTCGAAGAGCTGGGCCGCGCG
AAGCGTGTTGAGGTGCAGAAGGAAAACACCATCATCATCGATGGTGCAGGTGACCAGACGCGCATCGACGCACGCGTCAA
GGCGATCCGCGCGCAGATCGAAGAAGCGACGAGCGACTATGACCGTGAAAAACTGCAGGAGCGCGTGGCGAAGCTTGCCG
GTGGCGTTGCGGTGATCAAGGTGGGTGCGGCGACCGAGGTCGAAATGAAGGAAAAGAAAGACCGTGTCGACGATGCGCTG
CATGCGACCCGCGCCGCAGTCGAAGAGGGCATCGTGCCAGGCGGCGGCGTGGCGTTGCTGCGGGCGCGTTCGGCCATCTC
GAGTCTCACGGGCGCCAACGCCGACCAGGACGCCGGCATCAGGATTGTGCTGCGTGCGCTTGAGGCGCCGCTGCGCGTGA
TCGCAGCCAATGCGGGCGACGAGCCGTCGGTCGTCGTCGCGAAGGTGCTCAGCGGGAAAGGCAACTACGGCTACAACGCA
GCCACGGGCGAGTACGGCGATCTCGTCGAGACAGGTGTGGTCGACCCGACGAAGGTGACGCGTACGGCGCTGCAGAACGC
CGCTTCGATCGCCGGACTGATCCTGACCACGGACGCCACGGTAGCGGAAGCGCCAAAAGAAGAAAAAGCCGTGCCGGCAC
CTGCACCGGAACTGGAATACTAG

Upstream 100 bases:

>100_bases
ATGCGCGAGGAAGACGTCATGGGCGTCCTCGAGTCCGACGCAGGCGCCGCACGCAAGGCGGCCTGATTATCTCTTCAATG
GCTTATACCGGAGCAACAAG

Downstream 100 bases:

>100_bases
ACGTTGGCTGCCTTGTGCTGGACAGCCGGTCAGCGTGGCTGGGCCCGGCTCCATTTCCCCAGAGGCTTGGAGCCGTCATC
GGTGGCTGTAGCGCTGTCCG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MSAKDVKFHDSARSRIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTITKDGVSVAKEIELKDRFENMGAQVVKQVASK
TADVAGDGTTTATVLAQSIVQEGMKHVAAGMNPMDLKRGIDKAVAAVLDELHRLSKPIKTSREIAQVGAISANADEAIGK
IIADAMDKVGKEGVITVEDGKSLENELEVVEGMQFDRGYLSPYFINDPDKQVAHLDDPLILLHDKKISSIRDLLPVLEAA
AKAGKPLLIIAEDVEGEALTTLVVNSMRGVLKVAAVKAPGFGDRRKALLEDIAILTGATVISEETGKQLEKATLEELGRA
KRVEVQKENTIIIDGAGDQTRIDARVKAIRAQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDAL
HATRAAVEEGIVPGGGVALLRARSAISSLTGANADQDAGIRIVLRALEAPLRVIAANAGDEPSVVVAKVLSGKGNYGYNA
ATGEYGDLVETGVVDPTKVTRTALQNAASIAGLILTTDATVAEAPKEEKAVPAPAPELEY

Sequences:

>Translated_540_residues
MSAKDVKFHDSARSRIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTITKDGVSVAKEIELKDRFENMGAQVVKQVASK
TADVAGDGTTTATVLAQSIVQEGMKHVAAGMNPMDLKRGIDKAVAAVLDELHRLSKPIKTSREIAQVGAISANADEAIGK
IIADAMDKVGKEGVITVEDGKSLENELEVVEGMQFDRGYLSPYFINDPDKQVAHLDDPLILLHDKKISSIRDLLPVLEAA
AKAGKPLLIIAEDVEGEALTTLVVNSMRGVLKVAAVKAPGFGDRRKALLEDIAILTGATVISEETGKQLEKATLEELGRA
KRVEVQKENTIIIDGAGDQTRIDARVKAIRAQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDAL
HATRAAVEEGIVPGGGVALLRARSAISSLTGANADQDAGIRIVLRALEAPLRVIAANAGDEPSVVVAKVLSGKGNYGYNA
ATGEYGDLVETGVVDPTKVTRTALQNAASIAGLILTTDATVAEAPKEEKAVPAPAPELEY
>Mature_539_residues
SAKDVKFHDSARSRIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTITKDGVSVAKEIELKDRFENMGAQVVKQVASKT
ADVAGDGTTTATVLAQSIVQEGMKHVAAGMNPMDLKRGIDKAVAAVLDELHRLSKPIKTSREIAQVGAISANADEAIGKI
IADAMDKVGKEGVITVEDGKSLENELEVVEGMQFDRGYLSPYFINDPDKQVAHLDDPLILLHDKKISSIRDLLPVLEAAA
KAGKPLLIIAEDVEGEALTTLVVNSMRGVLKVAAVKAPGFGDRRKALLEDIAILTGATVISEETGKQLEKATLEELGRAK
RVEVQKENTIIIDGAGDQTRIDARVKAIRAQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDALH
ATRAAVEEGIVPGGGVALLRARSAISSLTGANADQDAGIRIVLRALEAPLRVIAANAGDEPSVVVAKVLSGKGNYGYNAA
TGEYGDLVETGVVDPTKVTRTALQNAASIAGLILTTDATVAEAPKEEKAVPAPAPELEY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=54.7348484848485, Blast_Score=561, Evalue=1e-160,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=54.7348484848485, Blast_Score=561, Evalue=1e-160,
Organism=Homo sapiens, GI5453607, Length=537, Percent_Identity=22.9050279329609, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=72.4528301886792, Blast_Score=773, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=53.4971644612476, Blast_Score=561, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=54.0284360189574, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17564182, Length=566, Percent_Identity=22.0848056537102, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=53.6121673003802, Blast_Score=559, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6322524, Length=534, Percent_Identity=23.0337078651685, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=54.26944971537, Blast_Score=570, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=54.26944971537, Blast_Score=570, Evalue=1e-162,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=53.1309297912713, Blast_Score=560, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=53.1309297912713, Blast_Score=560, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=53.1309297912713, Blast_Score=560, Evalue=1e-159,
Organism=Drosophila melanogaster, GI17864606, Length=530, Percent_Identity=44.7169811320755, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24584129, Length=531, Percent_Identity=39.924670433145, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19921262, Length=531, Percent_Identity=39.924670433145, Blast_Score=363, Evalue=1e-100,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_BURXL (Q13ZW7)

Other databases:

- EMBL:   CP000270
- EMBL:   CP000270
- RefSeq:   YP_558394.1
- RefSeq:   YP_558424.1
- ProteinModelPortal:   Q13ZW7
- SMR:   Q13ZW7
- GeneID:   4004527
- GeneID:   4005260
- GenomeReviews:   CP000270_GR
- GenomeReviews:   CP000270_GR
- KEGG:   bxe:Bxe_A2609
- KEGG:   bxe:Bxe_A4544
- HOGENOM:   HBG625289
- OMA:   DVKFHDS
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57019; Mature: 56888

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKDVKFHDSARSRIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTITKDGVSVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDRFENMGAQVVKQVASKTADVAGDGTTTATVLAQSIVQEGMKHVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVAAVLDELHRLSKPIKTSREIAQVGAISANADEAIGKIIADAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCC
KSLENELEVVEGMQFDRGYLSPYFINDPDKQVAHLDDPLILLHDKKISSIRDLLPVLEAA
CCHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHH
AKAGKPLLIIAEDVEGEALTTLVVNSMRGVLKVAAVKAPGFGDRRKALLEDIAILTGATV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHH
ISEETGKQLEKATLEELGRAKRVEVQKENTIIIDGAGDQTRIDARVKAIRAQIEEATSDY
HHHHHHHHHHHHHHHHHCCHHEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDALHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARSAISSLTGANADQDAGIRIVLRALEAPLRVIAANAGDEPSVVVAKVLSGKGNYGYNA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHEEEECCCCCCHHHHHHHHCCCCCCCCCC
ATGEYGDLVETGVVDPTKVTRTALQNAASIAGLILTTDATVAEAPKEEKAVPAPAPELEY
CCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SAKDVKFHDSARSRIVKGVNVLADAVKVTLGPKGRNVLIERSFGAPTITKDGVSVAKEI
CCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDRFENMGAQVVKQVASKTADVAGDGTTTATVLAQSIVQEGMKHVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVAAVLDELHRLSKPIKTSREIAQVGAISANADEAIGKIIADAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCC
KSLENELEVVEGMQFDRGYLSPYFINDPDKQVAHLDDPLILLHDKKISSIRDLLPVLEAA
CCHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHH
AKAGKPLLIIAEDVEGEALTTLVVNSMRGVLKVAAVKAPGFGDRRKALLEDIAILTGATV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHH
ISEETGKQLEKATLEELGRAKRVEVQKENTIIIDGAGDQTRIDARVKAIRAQIEEATSDY
HHHHHHHHHHHHHHHHHCCHHEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDALHATRAAVEEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARSAISSLTGANADQDAGIRIVLRALEAPLRVIAANAGDEPSVVVAKVLSGKGNYGYNA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHEEEECCCCCCHHHHHHHHCCCCCCCCCC
ATGEYGDLVETGVVDPTKVTRTALQNAASIAGLILTTDATVAEAPKEEKAVPAPAPELEY
CCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA