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The map label for this gene is serA [H]

Identifier: 91783131

GI number: 91783131

Start: 1978660

End: 1979655

Strand: Direct

Name: serA [H]

Synonym: Bxe_A2676

Alternate gene names: 91783131

Gene position: 1978660-1979655 (Clockwise)

Preceding gene: 91783130

Following gene: 91783134

Centisome position: 40.42

GC content: 58.53

Gene sequence:

>996_bases
ATGAAATCTGGACACGTCCTTATCCTGAGCGAACCATCGTCGGTCAGACTGTTTCGGGAAATAGAAGAGGCTTTGAAGCA
GCATGTTTCCCGGGTCACGCATCTCCAGCACGACGATGAGATCGATCCGGCCGGCGAGCTTTGGCGATCAGCCGATGTAT
TGTTGGCATACGGCGGCTTTTCCTGCACCCGCGAGTTGATGTCTGCAGCTCCATCCCTTCGCGCCATCGTGAGCCCATGG
ACGGGGACGGAAGGGTTTGACGAAGCGGCGGCGACCGAGTTGGGCATCGTGGTGGCAAATGGCCAGGCGGAGGAAAATAC
GTTCAGCATGGCCGAGGCGACCGTCATGCTTATGCTCGCTTGCCTCTACAGCCTGCACGAAACGGAAGATGTGCTGCGGA
AGAACCAGGCCCGGCCGCCATATCCAATTGCCCGTATGCTGCGCGGGCGCAGGGTAGGTCTTGTCGGTTTCGGCGGCATT
GGTCGTCAGGTCGCCCGGCTGCTTGGGCCTTGGGGCGTTGAAATGGTGGCGTATAACCGCAGCGCCTTTACCGACGCGAA
CGTGAGCGCCGTCGGTCTTCCCACGCTGCTATCGACCAGTGACATCATTTCGCTGCACATCGGACTTAGCCCCGCTACCC
GTCACTTGTTGAACGCGGAAAATCTCAAACTCGTCAGGCCGGGAACGATCCTCGTGAATACCGCTCGTGGTGGCGTGATC
GATAAAGCGGCGCTCTATGAATGTGCTCGCGATGGCCGATTCGCCAAAATCGCACTGGACGTCTATGAGCAGGAGCCTTT
ATCTGAACTCAGCCCCTTGCGGAATCTGCCCAATGCGATATTGACTCCCCACATGGTGGGGCAGACACAGGAAGCGCGTG
CCGCTCTCATTGCGCTGGCGGTACAAAACGTCACGCGGGTGATGGAAGGCGAGCCGCCCGTATGCTTCCGTAATCCTGAA
GTTATTGCCAACTGGCGCGTGCGGCGAAAAATCTAG

Upstream 100 bases:

>100_bases
CGCGCCCCGCCGTTCACTATGCACTTATTGGCGATGACGGCCCTACGGGTGGTTTCTTCGGTGGCGACGGACCGATCGCC
TGGTGACGGGGGCATCCAAT

Downstream 100 bases:

>100_bases
AGAGAAGGAGTTTGTCAGGGCGCGAGAAACTAAGCAGGCCCGGATGAGACCGCAGCTGTTCGGGGCGATGACTGAGCACC
TTGCCGTCGCGGTTGTTATA

Product: putative D-3-phosphoglycerate dehydrogenase,NAD- binding

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MKSGHVLILSEPSSVRLFREIEEALKQHVSRVTHLQHDDEIDPAGELWRSADVLLAYGGFSCTRELMSAAPSLRAIVSPW
TGTEGFDEAAATELGIVVANGQAEENTFSMAEATVMLMLACLYSLHETEDVLRKNQARPPYPIARMLRGRRVGLVGFGGI
GRQVARLLGPWGVEMVAYNRSAFTDANVSAVGLPTLLSTSDIISLHIGLSPATRHLLNAENLKLVRPGTILVNTARGGVI
DKAALYECARDGRFAKIALDVYEQEPLSELSPLRNLPNAILTPHMVGQTQEARAALIALAVQNVTRVMEGEPPVCFRNPE
VIANWRVRRKI

Sequences:

>Translated_331_residues
MKSGHVLILSEPSSVRLFREIEEALKQHVSRVTHLQHDDEIDPAGELWRSADVLLAYGGFSCTRELMSAAPSLRAIVSPW
TGTEGFDEAAATELGIVVANGQAEENTFSMAEATVMLMLACLYSLHETEDVLRKNQARPPYPIARMLRGRRVGLVGFGGI
GRQVARLLGPWGVEMVAYNRSAFTDANVSAVGLPTLLSTSDIISLHIGLSPATRHLLNAENLKLVRPGTILVNTARGGVI
DKAALYECARDGRFAKIALDVYEQEPLSELSPLRNLPNAILTPHMVGQTQEARAALIALAVQNVTRVMEGEPPVCFRNPE
VIANWRVRRKI
>Mature_331_residues
MKSGHVLILSEPSSVRLFREIEEALKQHVSRVTHLQHDDEIDPAGELWRSADVLLAYGGFSCTRELMSAAPSLRAIVSPW
TGTEGFDEAAATELGIVVANGQAEENTFSMAEATVMLMLACLYSLHETEDVLRKNQARPPYPIARMLRGRRVGLVGFGGI
GRQVARLLGPWGVEMVAYNRSAFTDANVSAVGLPTLLSTSDIISLHIGLSPATRHLLNAENLKLVRPGTILVNTARGGVI
DKAALYECARDGRFAKIALDVYEQEPLSELSPLRNLPNAILTPHMVGQTQEARAALIALAVQNVTRVMEGEPPVCFRNPE
VIANWRVRRKI

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI145580578, Length=280, Percent_Identity=34.2857142857143, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI4557499, Length=280, Percent_Identity=34.2857142857143, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI61743967, Length=279, Percent_Identity=32.9749103942652, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI4557497, Length=279, Percent_Identity=32.9749103942652, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI145580575, Length=280, Percent_Identity=34.2857142857143, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI23308577, Length=236, Percent_Identity=29.6610169491525, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI6912396, Length=288, Percent_Identity=29.1666666666667, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1789279, Length=237, Percent_Identity=32.4894514767932, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082289, Length=265, Percent_Identity=29.4339622641509, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787645, Length=255, Percent_Identity=28.2352941176471, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788660, Length=106, Percent_Identity=33.9622641509434, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=265, Percent_Identity=26.7924528301887, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25147481, Length=274, Percent_Identity=26.6423357664234, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324055, Length=171, Percent_Identity=33.9181286549708, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=276, Percent_Identity=29.3478260869565, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=329, Percent_Identity=27.355623100304, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321253, Length=173, Percent_Identity=28.9017341040462, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646446, Length=272, Percent_Identity=33.0882352941176, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646448, Length=272, Percent_Identity=33.0882352941176, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646452, Length=272, Percent_Identity=33.0882352941176, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646450, Length=272, Percent_Identity=33.0882352941176, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI62472511, Length=272, Percent_Identity=33.0882352941176, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI45552429, Length=256, Percent_Identity=28.125, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24585514, Length=277, Percent_Identity=28.158844765343, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28574282, Length=277, Percent_Identity=28.158844765343, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28574284, Length=277, Percent_Identity=28.158844765343, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45551003, Length=277, Percent_Identity=28.158844765343, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28571528, Length=178, Percent_Identity=32.5842696629214, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24585516, Length=254, Percent_Identity=26.7716535433071, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI19921140, Length=279, Percent_Identity=28.673835125448, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574286, Length=276, Percent_Identity=28.6231884057971, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 36175; Mature: 36175

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSGHVLILSEPSSVRLFREIEEALKQHVSRVTHLQHDDEIDPAGELWRSADVLLAYGGF
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEECCH
SCTRELMSAAPSLRAIVSPWTGTEGFDEAAATELGIVVANGQAEENTFSMAEATVMLMLA
HHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHH
CLYSLHETEDVLRKNQARPPYPIARMLRGRRVGLVGFGGIGRQVARLLGPWGVEMVAYNR
HHHHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEEEECHHHHHHHHHHCCCCCEEEEECC
SAFTDANVSAVGLPTLLSTSDIISLHIGLSPATRHLLNAENLKLVRPGTILVNTARGGVI
CCCCCCCCCCCCCHHHHCCCCEEEEEECCCHHHHHHCCCCCEEEEECCEEEEECCCCCCC
DKAALYECARDGRFAKIALDVYEQEPLSELSPLRNLPNAILTPHMVGQTQEARAALIALA
HHHHHHHHHCCCCEEEEEEEHHHCCCHHHHHHHHHCCHHHCCCHHCCCCHHHHHHHHHHH
VQNVTRVMEGEPPVCFRNPEVIANWRVRRKI
HHHHHHHHCCCCCEEECCCCEEECCEEECCC
>Mature Secondary Structure
MKSGHVLILSEPSSVRLFREIEEALKQHVSRVTHLQHDDEIDPAGELWRSADVLLAYGGF
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEECCH
SCTRELMSAAPSLRAIVSPWTGTEGFDEAAATELGIVVANGQAEENTFSMAEATVMLMLA
HHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHH
CLYSLHETEDVLRKNQARPPYPIARMLRGRRVGLVGFGGIGRQVARLLGPWGVEMVAYNR
HHHHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEEEECHHHHHHHHHHCCCCCEEEEECC
SAFTDANVSAVGLPTLLSTSDIISLHIGLSPATRHLLNAENLKLVRPGTILVNTARGGVI
CCCCCCCCCCCCCHHHHCCCCEEEEEECCCHHHHHHCCCCCEEEEECCEEEEECCCCCCC
DKAALYECARDGRFAKIALDVYEQEPLSELSPLRNLPNAILTPHMVGQTQEARAALIALA
HHHHHHHHHCCCCEEEEEEEHHHCCCHHHHHHHHHCCHHHCCCHHCCCCHHHHHHHHHHH
VQNVTRVMEGEPPVCFRNPEVIANWRVRRKI
HHHHHHHHCCCCCEEECCCCEEECCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]