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The map label for this gene is maeB [H]

Identifier: 91782476

GI number: 91782476

Start: 1227005

End: 1229323

Strand: Direct

Name: maeB [H]

Synonym: Bxe_A3355

Alternate gene names: 91782476

Gene position: 1227005-1229323 (Clockwise)

Preceding gene: 91782475

Following gene: 91782479

Centisome position: 25.06

GC content: 65.16

Gene sequence:

>2319_bases
ATGACAAAGCAATCTGGCACGACGAGTTTTCGCGAAGCCGCCCTCGATTACCACGAGTTCCCCACCCCCGGGAAGATCGC
GATCGCCCCGACCAAGCAGATGATCAACCAGCGCGATCTGGCGCTGGCGTACTCGCCGGGCGTGGCGTTCGCGTGCGAGG
AAATCGTCGGGAACCCGCTGAACGCCGCGCGTTTCACCGCGCGCAGCAACCTGGTCGGCGTGGTCACCAACGGCACCGCG
GTGCTGGGTCTGGGCAACATCGGGCCGCTCGCCTCGAAGCCGGTCATGGAAGGCAAGGCCGTGCTGTTCAAGAAGTTCGC
CGGCATCGACGTGTTCGATATCGAGCTGAACGAGTCCGACCCGCACAAGCTGGTCGACGTGATCGCGGCGCTGGAGCCGA
CCTTCGGCGGCATCAATCTCGAAGACATCAAGGCACCGGACTGTTTCATCGTCGAGCGCGAATGCCGCAAGCGCATGAAG
ATTCCGGTCTTCCACGACGACCAGCACGGCACCGCGATCGTCGTCGCGGCGGCCATCACCAATGGTCTGAAGGTGGTCGG
CAAGGACATCAGGGAGGTCAAGCTGGTGTCCTCCGGCGCGGGCGCGGCGGCGCTGGCGTGTCTGGACCTGCTGGTCGACA
TCGGCCTGCCGCTGGAGAACATCACCGTCACCGATCTGGCCGGCGTGGTCTACAAGGGCCGCGTCGAACTGATGGACCCG
GACAAGGAGCGCTTCGCGCGTGAAACCGACGCCCGCACGCTTGCCGAAGCGATCGGCGGCGCGGACGTTTTTCTCGGCCT
CTCCGCCGGCGGCGTGCTCAAGCAGGACATGGTCAAACAGATGGCGGACAAGCCGCTGATTCTGGCGCTGGCCAACCCGA
CGCCGGAAATCCTGCCGGAACTGGCGCTCGAAGTGCGCCCGGATGCGGTGCTGTGCACGGGCCGCACCGATTACCCGAAC
CAGGTGAACAACGTGCTGGTGTTCCCGTTCCTGTTCCGCGGCGCGCTGGACGCGGGCGCGACCACGGTGACGCGGGAAAT
GGAAATCGCGGCGGTCAATGCGATCGCCGAACTGGCGCGCCAGGAGCAGAGCGATATCGTCGCGACGGCGTACGGCATCC
AGGATCTCTCGTTCGGCCCGGAGTATCTGATTCCGAAGCCGTTCGATCCGCGCCTGATCGTCAAGGTCGCGCCGGCGGTG
GCGCAGGCCGCGATGGATTCGGGCGTCGCCGAGCGGCCGATCGAGGACATGGACGCGTACGAACAGCATCTGCAGCAGTT
CGTGTATCACAGCGGCACGACCATGAAGCCGATTTTCCAGCTGGCGCGCAGCGTCGAGCCGGAGAAGAAGCGCATCGTGT
TCGCGGAAGGCGAGGAAGAGCGCGTGCTGCGCGCAATGCAGATCATCGTCGACGAGAAGCTGGCCAAACCGATCCTGATC
GGCCGCCCGGCGGTGATCGAGCAGCGCATTGCGCGCTACGGTCTGCGGCTGGTCGCGGGGCAGGACTACACGGTGGTGAA
CACCGACCACGACGAGCGTTACCGCGACTTCTGGCAGGAGTATCACCGGATGATGTCGCGCAAGGGCATCAGCGCGCAGA
TGGCGAAGCTCGAAATGCGCCGCCGCACCACGCTGATCGGCGCGATGCTGGTGGAAAAGGGCGAGGCGGACGGCATGATC
TGCGGCACGGTGTCGACCACGCACCGGCATCTGCACTTCATCGATCAGGTGATCGGCAGGAAGGCGGGCGCGAAGGTGTA
CGCGGCGATGAACGCGCTGGTGTTGCCGAACCGCCAGATCTTCCTGGTGGACACGCACGTGAACGTGGATCCGACGCCGG
AGCAACTGGCGGAAATCACGATCATGGCGGCCGAAGAAGTGCGCCGTTTCGGGATCGAGCCGAAGGTGGCGCTGCTGTCG
CATTCGAACTTCGGCACGAGCAACGCGCCGACCGCGCAGAAGATGCGCGACACGCTGGCGATTTTGCGCGAGCGCGCGCC
GGATCTGCAGGTGGACGGCGAAATGCACGGCGACATCGCACTCGACGCGAACCTGCGCCGCGAAGTGATGCCCGACTCGA
CGCTCGAAGGCGATGCGAACCTGCTGGTGCTGCCGAACATCGACGCGGCGAACATCTCGTACAACCTGCTGAAGACCGCC
GCGGGCAACAACATCGCGATCGGTCCGATACTGCTGGGCGCGGCCAGGCCGGTGCACGTGCTGACGGCTTCGGCGACGGT
GCGCCGGATCGTCAATATGACGGCGTTGCTGGTGGCGGATGTGATCGCGTTCCCGAAGCAGGCGAAGCCGGGAACATAG

Upstream 100 bases:

>100_bases
CCGTTGGAACGGCTCCGGCGAAAGAGACCGTTATTCGACCGAACACGCAACCCAACACGCACTGACCCCTTGGGTCATTT
CTATTCCAGACATCGCCACC

Downstream 100 bases:

>100_bases
AATCGCGCTATCCGGGCGGGCCTGCTACACGGCCCGCATCAACTGGTTGCGCCGGCAACTTTTTGCGCCAGCAGTCCCTT
CACGTGCGGAATCATGATTC

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 772; Mature: 771

Protein sequence:

>772_residues
MTKQSGTTSFREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSPGVAFACEEIVGNPLNAARFTARSNLVGVVTNGTA
VLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINLEDIKAPDCFIVERECRKRMK
IPVFHDDQHGTAIVVAAAITNGLKVVGKDIREVKLVSSGAGAAALACLDLLVDIGLPLENITVTDLAGVVYKGRVELMDP
DKERFARETDARTLAEAIGGADVFLGLSAGGVLKQDMVKQMADKPLILALANPTPEILPELALEVRPDAVLCTGRTDYPN
QVNNVLVFPFLFRGALDAGATTVTREMEIAAVNAIAELARQEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVKVAPAV
AQAAMDSGVAERPIEDMDAYEQHLQQFVYHSGTTMKPIFQLARSVEPEKKRIVFAEGEEERVLRAMQIIVDEKLAKPILI
GRPAVIEQRIARYGLRLVAGQDYTVVNTDHDERYRDFWQEYHRMMSRKGISAQMAKLEMRRRTTLIGAMLVEKGEADGMI
CGTVSTTHRHLHFIDQVIGRKAGAKVYAAMNALVLPNRQIFLVDTHVNVDPTPEQLAEITIMAAEEVRRFGIEPKVALLS
HSNFGTSNAPTAQKMRDTLAILRERAPDLQVDGEMHGDIALDANLRREVMPDSTLEGDANLLVLPNIDAANISYNLLKTA
AGNNIAIGPILLGAARPVHVLTASATVRRIVNMTALLVADVIAFPKQAKPGT

Sequences:

>Translated_772_residues
MTKQSGTTSFREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSPGVAFACEEIVGNPLNAARFTARSNLVGVVTNGTA
VLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINLEDIKAPDCFIVERECRKRMK
IPVFHDDQHGTAIVVAAAITNGLKVVGKDIREVKLVSSGAGAAALACLDLLVDIGLPLENITVTDLAGVVYKGRVELMDP
DKERFARETDARTLAEAIGGADVFLGLSAGGVLKQDMVKQMADKPLILALANPTPEILPELALEVRPDAVLCTGRTDYPN
QVNNVLVFPFLFRGALDAGATTVTREMEIAAVNAIAELARQEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVKVAPAV
AQAAMDSGVAERPIEDMDAYEQHLQQFVYHSGTTMKPIFQLARSVEPEKKRIVFAEGEEERVLRAMQIIVDEKLAKPILI
GRPAVIEQRIARYGLRLVAGQDYTVVNTDHDERYRDFWQEYHRMMSRKGISAQMAKLEMRRRTTLIGAMLVEKGEADGMI
CGTVSTTHRHLHFIDQVIGRKAGAKVYAAMNALVLPNRQIFLVDTHVNVDPTPEQLAEITIMAAEEVRRFGIEPKVALLS
HSNFGTSNAPTAQKMRDTLAILRERAPDLQVDGEMHGDIALDANLRREVMPDSTLEGDANLLVLPNIDAANISYNLLKTA
AGNNIAIGPILLGAARPVHVLTASATVRRIVNMTALLVADVIAFPKQAKPGT
>Mature_771_residues
TKQSGTTSFREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSPGVAFACEEIVGNPLNAARFTARSNLVGVVTNGTAV
LGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINLEDIKAPDCFIVERECRKRMKI
PVFHDDQHGTAIVVAAAITNGLKVVGKDIREVKLVSSGAGAAALACLDLLVDIGLPLENITVTDLAGVVYKGRVELMDPD
KERFARETDARTLAEAIGGADVFLGLSAGGVLKQDMVKQMADKPLILALANPTPEILPELALEVRPDAVLCTGRTDYPNQ
VNNVLVFPFLFRGALDAGATTVTREMEIAAVNAIAELARQEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVKVAPAVA
QAAMDSGVAERPIEDMDAYEQHLQQFVYHSGTTMKPIFQLARSVEPEKKRIVFAEGEEERVLRAMQIIVDEKLAKPILIG
RPAVIEQRIARYGLRLVAGQDYTVVNTDHDERYRDFWQEYHRMMSRKGISAQMAKLEMRRRTTLIGAMLVEKGEADGMIC
GTVSTTHRHLHFIDQVIGRKAGAKVYAAMNALVLPNRQIFLVDTHVNVDPTPEQLAEITIMAAEEVRRFGIEPKVALLSH
SNFGTSNAPTAQKMRDTLAILRERAPDLQVDGEMHGDIALDANLRREVMPDSTLEGDANLLVLPNIDAANISYNLLKTAA
GNNIAIGPILLGAARPVHVLTASATVRRIVNMTALLVADVIAFPKQAKPGT

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=343, Percent_Identity=26.530612244898, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI62420882, Length=352, Percent_Identity=27.5568181818182, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI62420880, Length=352, Percent_Identity=27.5568181818182, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI239049447, Length=352, Percent_Identity=27.5568181818182, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4505145, Length=317, Percent_Identity=29.0220820189274, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI270265879, Length=317, Percent_Identity=29.0220820189274, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1788806, Length=752, Percent_Identity=61.3031914893617, Blast_Score=956, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=319, Percent_Identity=32.2884012539185, Blast_Score=160, Evalue=3e-40,
Organism=Escherichia coli, GI1788800, Length=323, Percent_Identity=32.5077399380805, Blast_Score=150, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17537199, Length=411, Percent_Identity=24.330900243309, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322823, Length=239, Percent_Identity=27.6150627615063, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281362674, Length=474, Percent_Identity=25.7383966244726, Blast_Score=87, Evalue=5e-17,
Organism=Drosophila melanogaster, GI281362672, Length=474, Percent_Identity=25.7383966244726, Blast_Score=87, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21356279, Length=474, Percent_Identity=25.7383966244726, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24646388, Length=349, Percent_Identity=28.080229226361, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646386, Length=349, Percent_Identity=28.6532951289398, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI78707242, Length=415, Percent_Identity=24.8192771084337, Blast_Score=75, Evalue=3e-13,
Organism=Drosophila melanogaster, GI78707238, Length=415, Percent_Identity=24.8192771084337, Blast_Score=75, Evalue=3e-13,
Organism=Drosophila melanogaster, GI78707240, Length=349, Percent_Identity=25.7879656160458, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 83891; Mature: 83760

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKQSGTTSFREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSPGVAFACEEIVGNPL
CCCCCCCCHHHHHHHHHHCCCCCCEEEECCHHHHCCCCCEEEEECCCHHHHHHHHHCCCC
NAARFTARSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESD
CHHHEECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCC
PHKLVDVIAALEPTFGGINLEDIKAPDCFIVERECRKRMKIPVFHDDQHGTAIVVAAAIT
HHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEHHHHHCCCCCEEECCCCCCEEEEEEHHH
NGLKVVGKDIREVKLVSSGAGAAALACLDLLVDIGLPLENITVTDLAGVVYKGRVELMDP
CCHHHHCCCHHHEEEECCCCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHEECEEEEECC
DKERFARETDARTLAEAIGGADVFLGLSAGGVLKQDMVKQMADKPLILALANPTPEILPE
CHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHH
LALEVRPDAVLCTGRTDYPNQVNNVLVFPFLFRGALDAGATTVTREMEIAAVNAIAELAR
HHHEECCCEEEEECCCCCCCHHCCEEEEHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHH
QEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVKVAPAVAQAAMDSGVAERPIEDMDAY
HHHCCEEEEEECCEECCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHH
EQHLQQFVYHSGTTMKPIFQLARSVEPEKKRIVFAEGEEERVLRAMQIIVDEKLAKPILI
HHHHHHHHHHCCCCHHHHHHHHHCCCCCHHEEEEECCCHHHHHHHHHHHHHHHHCCCEEE
GRPAVIEQRIARYGLRLVAGQDYTVVNTDHDERYRDFWQEYHRMMSRKGISAQMAKLEMR
CCCHHHHHHHHHCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RRTTLIGAMLVEKGEADGMICGTVSTTHRHLHFIDQVIGRKAGAKVYAAMNALVLPNRQI
HHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCEEHHHEEEECCCEE
FLVDTHVNVDPTPEQLAEITIMAAEEVRRFGIEPKVALLSHSNFGTSNAPTAQKMRDTLA
EEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHH
ILRERAPDLQVDGEMHGDIALDANLRREVMPDSTLEGDANLLVLPNIDAANISYNLLKTA
HHHHCCCCCEECCCCCCCEEECCCCHHHCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHC
AGNNIAIGPILLGAARPVHVLTASATVRRIVNMTALLVADVIAFPKQAKPGT
CCCCEEECCEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TKQSGTTSFREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSPGVAFACEEIVGNPL
CCCCCCCHHHHHHHHHHCCCCCCEEEECCHHHHCCCCCEEEEECCCHHHHHHHHHCCCC
NAARFTARSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESD
CHHHEECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCC
PHKLVDVIAALEPTFGGINLEDIKAPDCFIVERECRKRMKIPVFHDDQHGTAIVVAAAIT
HHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEHHHHHCCCCCEEECCCCCCEEEEEEHHH
NGLKVVGKDIREVKLVSSGAGAAALACLDLLVDIGLPLENITVTDLAGVVYKGRVELMDP
CCHHHHCCCHHHEEEECCCCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHEECEEEEECC
DKERFARETDARTLAEAIGGADVFLGLSAGGVLKQDMVKQMADKPLILALANPTPEILPE
CHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHH
LALEVRPDAVLCTGRTDYPNQVNNVLVFPFLFRGALDAGATTVTREMEIAAVNAIAELAR
HHHEECCCEEEEECCCCCCCHHCCEEEEHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHH
QEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVKVAPAVAQAAMDSGVAERPIEDMDAY
HHHCCEEEEEECCEECCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHH
EQHLQQFVYHSGTTMKPIFQLARSVEPEKKRIVFAEGEEERVLRAMQIIVDEKLAKPILI
HHHHHHHHHHCCCCHHHHHHHHHCCCCCHHEEEEECCCHHHHHHHHHHHHHHHHCCCEEE
GRPAVIEQRIARYGLRLVAGQDYTVVNTDHDERYRDFWQEYHRMMSRKGISAQMAKLEMR
CCCHHHHHHHHHCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RRTTLIGAMLVEKGEADGMICGTVSTTHRHLHFIDQVIGRKAGAKVYAAMNALVLPNRQI
HHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCEEHHHEEEECCCEE
FLVDTHVNVDPTPEQLAEITIMAAEEVRRFGIEPKVALLSHSNFGTSNAPTAQKMRDTLA
EEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHH
ILRERAPDLQVDGEMHGDIALDANLRREVMPDSTLEGDANLLVLPNIDAANISYNLLKTA
HHHHCCCCCEECCCCCCCEEECCCCHHHCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHC
AGNNIAIGPILLGAARPVHVLTASATVRRIVNMTALLVADVIAFPKQAKPGT
CCCCEEECCEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]