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The map label for this gene is map [H]

Identifier: 91782404

GI number: 91782404

Start: 1145907

End: 1146692

Strand: Direct

Name: map [H]

Synonym: Bxe_A3427

Alternate gene names: 91782404

Gene position: 1145907-1146692 (Clockwise)

Preceding gene: 91782401

Following gene: 91782405

Centisome position: 23.41

GC content: 63.36

Gene sequence:

>786_bases
ATGGCCATTACCTACAAGACTCCCGACGACATCGCCAGGCTGCGCATTTCGGGCCGCCTCGCGGCCGACGTGCTGGCGAT
GATCGGCGAGCACATCAAGGCCGGTGTCTCCACTGAAGAGCTGGACGCACTGTGCAACGACTACATCGTCAATACGCAAA
AGTCGATTCCGGCAAATGTCGGCTATCTGGGATTTCCGAAGACTATCTGCACGTCGGTCAACTCGGTGGTGTGCCACGGC
ATCCCCAATCGCGGCGAAGTCCTGAAAGACGGCGACATCATCAATATCGACGTGGCGATCATCAAGGACGGCTACTTCGG
CGACACGAGCCGCATGTATTGCGTCGGCCAGCCGAGTACGGTGGCGCGCCAGCTGATCGACACGACCTATGAAGCGATGC
TCGCCGGCATCCGCGAAGTGAAGCCAGGCGCAACGCTCGGCGACGTGGGCCATGCGATCCAGAAGATCGCGCAGCGCGAC
GGCTTCTCGATCGTGCGCGACTATTGCGGGCACGGTATCGGCAAGGTCTACCACGAAGAGCCGCAGGTGCTGCATTACGG
CCAGCCGGGGCAGGGCGTGCGCCTGAAGCCGGGCATGGTCTTCACGATCGAGCCGATGATCAACGCCGGCCGCGCCGGCA
CCACGGTGCTGCGCGACGGCTGGACCGTGGTCACCAAAGACCGCTCGCTGTCGGCGCAATGGGAACACATGGTCGCCGTC
ACCGACGAGGGCTATGAGCTGCTGACGCCGTGGCCGGACGGCACCGGCCGCTACGAAGCGCCTTGA

Upstream 100 bases:

>100_bases
AAGAATGGCGCGGTTTGCGCAAGCCTCGCGGCGATCCTCTGTACAATTGGCCGATCGATTGAACATCGACTTTCCTATTC
GACCCACATCGACCGAATTC

Downstream 100 bases:

>100_bases
GCGTGCAAAGGGCGCGCTGCCCGCGGCTGCATCTGCCGCCCGGCGGGCGCGCGAAATGCTGCTGAGTCTGCGTGCGCTCC
GTGCGTGGTTCCACAATCCG

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MAITYKTPDDIARLRISGRLAADVLAMIGEHIKAGVSTEELDALCNDYIVNTQKSIPANVGYLGFPKTICTSVNSVVCHG
IPNRGEVLKDGDIINIDVAIIKDGYFGDTSRMYCVGQPSTVARQLIDTTYEAMLAGIREVKPGATLGDVGHAIQKIAQRD
GFSIVRDYCGHGIGKVYHEEPQVLHYGQPGQGVRLKPGMVFTIEPMINAGRAGTTVLRDGWTVVTKDRSLSAQWEHMVAV
TDEGYELLTPWPDGTGRYEAP

Sequences:

>Translated_261_residues
MAITYKTPDDIARLRISGRLAADVLAMIGEHIKAGVSTEELDALCNDYIVNTQKSIPANVGYLGFPKTICTSVNSVVCHG
IPNRGEVLKDGDIINIDVAIIKDGYFGDTSRMYCVGQPSTVARQLIDTTYEAMLAGIREVKPGATLGDVGHAIQKIAQRD
GFSIVRDYCGHGIGKVYHEEPQVLHYGQPGQGVRLKPGMVFTIEPMINAGRAGTTVLRDGWTVVTKDRSLSAQWEHMVAV
TDEGYELLTPWPDGTGRYEAP
>Mature_260_residues
AITYKTPDDIARLRISGRLAADVLAMIGEHIKAGVSTEELDALCNDYIVNTQKSIPANVGYLGFPKTICTSVNSVVCHGI
PNRGEVLKDGDIINIDVAIIKDGYFGDTSRMYCVGQPSTVARQLIDTTYEAMLAGIREVKPGATLGDVGHAIQKIAQRDG
FSIVRDYCGHGIGKVYHEEPQVLHYGQPGQGVRLKPGMVFTIEPMINAGRAGTTVLRDGWTVVTKDRSLSAQWEHMVAVT
DEGYELLTPWPDGTGRYEAP

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=247, Percent_Identity=44.9392712550607, Blast_Score=215, Evalue=3e-56,
Organism=Homo sapiens, GI40385867, Length=251, Percent_Identity=39.4422310756972, Blast_Score=194, Evalue=1e-49,
Organism=Escherichia coli, GI1786364, Length=255, Percent_Identity=57.6470588235294, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI1788728, Length=257, Percent_Identity=24.9027237354086, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=245, Percent_Identity=39.5918367346939, Blast_Score=186, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6323273, Length=242, Percent_Identity=40.9090909090909, Blast_Score=201, Evalue=8e-53,
Organism=Drosophila melanogaster, GI21355531, Length=249, Percent_Identity=39.3574297188755, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24583427, Length=244, Percent_Identity=38.9344262295082, Blast_Score=186, Evalue=1e-47,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28364; Mature: 28233

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITYKTPDDIARLRISGRLAADVLAMIGEHIKAGVSTEELDALCNDYIVNTQKSIPANV
CEEECCCCHHHHHEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEECCCCCCCCCC
GYLGFPKTICTSVNSVVCHGIPNRGEVLKDGDIINIDVAIIKDGYFGDTSRMYCVGQPST
CCCCCCHHHHHHHHHHEECCCCCCCCEECCCCEEEEEEEEEECCCCCCCCCEEEECCCHH
VARQLIDTTYEAMLAGIREVKPGATLGDVGHAIQKIAQRDGFSIVRDYCGHGIGKVYHEE
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHCCCC
PQVLHYGQPGQGVRLKPGMVFTIEPMINAGRAGTTVLRDGWTVVTKDRSLSAQWEHMVAV
CCEEECCCCCCCEEECCCEEEEEECCCCCCCCCCEEEECCCEEEEECCCCCCCEEEEEEE
TDEGYELLTPWPDGTGRYEAP
ECCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure 
AITYKTPDDIARLRISGRLAADVLAMIGEHIKAGVSTEELDALCNDYIVNTQKSIPANV
EEECCCCHHHHHEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEECCCCCCCCCC
GYLGFPKTICTSVNSVVCHGIPNRGEVLKDGDIINIDVAIIKDGYFGDTSRMYCVGQPST
CCCCCCHHHHHHHHHHEECCCCCCCCEECCCCEEEEEEEEEECCCCCCCCCEEEECCCHH
VARQLIDTTYEAMLAGIREVKPGATLGDVGHAIQKIAQRDGFSIVRDYCGHGIGKVYHEE
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHCCCC
PQVLHYGQPGQGVRLKPGMVFTIEPMINAGRAGTTVLRDGWTVVTKDRSLSAQWEHMVAV
CCEEECCCCCCCEEECCCEEEEEECCCCCCCCCCEEEECCCEEEEECCCCCCCEEEEEEE
TDEGYELLTPWPDGTGRYEAP
ECCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]