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The map label for this gene is rfbB [H]

Identifier: 91782041

GI number: 91782041

Start: 742012

End: 743064

Strand: Direct

Name: rfbB [H]

Synonym: Bxe_A3803

Alternate gene names: 91782041

Gene position: 742012-743064 (Clockwise)

Preceding gene: 91782040

Following gene: 91782042

Centisome position: 15.16

GC content: 62.39

Gene sequence:

>1053_bases
ATGATTCTGGTAACGGGCGGCGCCGGTTTTATCGGCGCCAATTTCGTGCTCGACTGGCTCAATGCCTCGGACGAAGCGGT
ACTGAACGTGGACAAGCTGACGTATGCCGGCAATCTGGGTACGCTCAAGTCACAACAGGGCAACCCGAAACACGTTTTCG
TGCGCGCGGATATCTGCGATCGCAGCGCACTCGACGCGTTGTTTGCCGAGCACAAGCCGCGTGCCGTGCTGCACTTTGCC
GCGGAAAGCCACGTGGACCGTTCGATTCATGGACCGGCCGATTTCGTGCAGACGAACGTGGTCGGCACCTTCACGCTGCT
CGAAGCAACCCGCCAGTACTGGAACGCGCTCGGCGAAGCCGGCAAGGCCGCGTTCCGCTTCCTGCACGTTTCGACCGACG
AAGTTTTCGGCTCGCTGTCCGCTACCGATCCGCAGTTCTCCGAAACCACGCCGTATGCGCCGAACAGTCCTTACTCGGCC
ACCAAGGCCGGTTCCGACCACCTCGTGCGCGCCTACCATCATACGTATGGGCTGCCGGTGCTGACCACGAACTGCTCGAA
CAACTACGGTCCGTACCAGTTCCCCGAAAAGCTGATTCCGCTGATGATCGCCAATGCGCTCGCCGGCAAGGCGCTGCCGG
TCTACGGCGACGGCCAGAACGTGCGCGACTGGCTGTACGTGGGCGACCACTGCAGCGCGATCCGCGAGGTGCTCGCGCGC
GGCACACCCGGCGAGACGTACAACGTGGGCGGCTGGAACGAGAAGAAGAACCTCGAAGTGGTCCACACGCTGTGCGACCT
GCTCGACCAGTTGCGTCCGAAGGCGGGCGGGTCGTACCACGACCAGATCACGTATGTGAAAGATCGTCCGGGCCACGACC
GCCGTTATGCGATCGACGCGCGCAAGCTCGAACGTGAGCTTGGGTGGAAGCCCGCGGAAACGTTCGAAACGGGTCTCGCG
AAGACGGTCCAGTGGTATCTGGACAATCAGGCGTGGTCGGACGAAGTCGCCTCGGGCGAGTACCGCAAGTGGGTGGCCAA
GCAATATGCGTGA

Upstream 100 bases:

>100_bases
AAGGCGGTGGCGGCGGGCGTCGACAAGATTCCGCACCACAACGCGCGGTGGCAGATCTGCCAACCATCCGATCTGCGGCC
AACATCTAGAAGGGAATTTC

Downstream 100 bases:

>100_bases
TAAGGCCAGTTCGGTGCCCATCCTCCTTGTTACCGGAAGTCGAGGCCAAGTTGGCTTTGAGTTGCGCCGGAGTTTGGCTT
CGCTCGGCAACGTGGTAGCG

Product: dTDP-glucose 4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MILVTGGAGFIGANFVLDWLNASDEAVLNVDKLTYAGNLGTLKSQQGNPKHVFVRADICDRSALDALFAEHKPRAVLHFA
AESHVDRSIHGPADFVQTNVVGTFTLLEATRQYWNALGEAGKAAFRFLHVSTDEVFGSLSATDPQFSETTPYAPNSPYSA
TKAGSDHLVRAYHHTYGLPVLTTNCSNNYGPYQFPEKLIPLMIANALAGKALPVYGDGQNVRDWLYVGDHCSAIREVLAR
GTPGETYNVGGWNEKKNLEVVHTLCDLLDQLRPKAGGSYHDQITYVKDRPGHDRRYAIDARKLERELGWKPAETFETGLA
KTVQWYLDNQAWSDEVASGEYRKWVAKQYA

Sequences:

>Translated_350_residues
MILVTGGAGFIGANFVLDWLNASDEAVLNVDKLTYAGNLGTLKSQQGNPKHVFVRADICDRSALDALFAEHKPRAVLHFA
AESHVDRSIHGPADFVQTNVVGTFTLLEATRQYWNALGEAGKAAFRFLHVSTDEVFGSLSATDPQFSETTPYAPNSPYSA
TKAGSDHLVRAYHHTYGLPVLTTNCSNNYGPYQFPEKLIPLMIANALAGKALPVYGDGQNVRDWLYVGDHCSAIREVLAR
GTPGETYNVGGWNEKKNLEVVHTLCDLLDQLRPKAGGSYHDQITYVKDRPGHDRRYAIDARKLERELGWKPAETFETGLA
KTVQWYLDNQAWSDEVASGEYRKWVAKQYA
>Mature_350_residues
MILVTGGAGFIGANFVLDWLNASDEAVLNVDKLTYAGNLGTLKSQQGNPKHVFVRADICDRSALDALFAEHKPRAVLHFA
AESHVDRSIHGPADFVQTNVVGTFTLLEATRQYWNALGEAGKAAFRFLHVSTDEVFGSLSATDPQFSETTPYAPNSPYSA
TKAGSDHLVRAYHHTYGLPVLTTNCSNNYGPYQFPEKLIPLMIANALAGKALPVYGDGQNVRDWLYVGDHCSAIREVLAR
GTPGETYNVGGWNEKKNLEVVHTLCDLLDQLRPKAGGSYHDQITYVKDRPGHDRRYAIDARKLERELGWKPAETFETGLA
KTVQWYLDNQAWSDEVASGEYRKWVAKQYA

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=329, Percent_Identity=34.6504559270517, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI42516563, Length=333, Percent_Identity=24.6246246246246, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI56237023, Length=362, Percent_Identity=26.7955801104972, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI56118217, Length=362, Percent_Identity=26.7955801104972, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI189083684, Length=362, Percent_Identity=26.7955801104972, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI4504031, Length=344, Percent_Identity=25, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1788353, Length=356, Percent_Identity=61.2359550561798, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI48994969, Length=344, Percent_Identity=63.0813953488372, Blast_Score=456, Evalue=1e-129,
Organism=Escherichia coli, GI1786974, Length=352, Percent_Identity=25.5681818181818, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788366, Length=301, Percent_Identity=28.2392026578073, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17568069, Length=332, Percent_Identity=36.4457831325301, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI115532424, Length=330, Percent_Identity=33.6363636363636, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71982035, Length=359, Percent_Identity=27.0194986072423, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71982038, Length=361, Percent_Identity=26.8698060941828, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17539532, Length=331, Percent_Identity=23.8670694864048, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17507723, Length=339, Percent_Identity=24.7787610619469, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539422, Length=277, Percent_Identity=26.7148014440433, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI133901790, Length=277, Percent_Identity=26.7148014440433, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17539424, Length=277, Percent_Identity=26.7148014440433, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI133901788, Length=277, Percent_Identity=26.7148014440433, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI133901786, Length=277, Percent_Identity=26.7148014440433, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=361, Percent_Identity=25.207756232687, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI19923002, Length=364, Percent_Identity=29.3956043956044, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI21356223, Length=339, Percent_Identity=26.2536873156342, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24158427, Length=339, Percent_Identity=25.6637168141593, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 38765; Mature: 38765

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILVTGGAGFIGANFVLDWLNASDEAVLNVDKLTYAGNLGTLKSQQGNPKHVFVRADICD
CEEEECCCCHHHHHHHHHHCCCCCCEEEEEHHEEECCCCCCCCCCCCCCCEEEEECCCCC
RSALDALFAEHKPRAVLHFAAESHVDRSIHGPADFVQTNVVGTFTLLEATRQYWNALGEA
HHHHHHHHHCCCCCEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GKAAFRFLHVSTDEVFGSLSATDPQFSETTPYAPNSPYSATKAGSDHLVRAYHHTYGLPV
HHHHEEEEEEEHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCE
LTTNCSNNYGPYQFPEKLIPLMIANALAGKALPVYGDGQNVRDWLYVGDHCSAIREVLAR
EEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCHHEEECHHHHHHHHHHHC
GTPGETYNVGGWNEKKNLEVVHTLCDLLDQLRPKAGGSYHDQITYVKDRPGHDRRYAIDA
CCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCEEEHHH
RKLERELGWKPAETFETGLAKTVQWYLDNQAWSDEVASGEYRKWVAKQYA
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHCC
>Mature Secondary Structure
MILVTGGAGFIGANFVLDWLNASDEAVLNVDKLTYAGNLGTLKSQQGNPKHVFVRADICD
CEEEECCCCHHHHHHHHHHCCCCCCEEEEEHHEEECCCCCCCCCCCCCCCEEEEECCCCC
RSALDALFAEHKPRAVLHFAAESHVDRSIHGPADFVQTNVVGTFTLLEATRQYWNALGEA
HHHHHHHHHCCCCCEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GKAAFRFLHVSTDEVFGSLSATDPQFSETTPYAPNSPYSATKAGSDHLVRAYHHTYGLPV
HHHHEEEEEEEHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCE
LTTNCSNNYGPYQFPEKLIPLMIANALAGKALPVYGDGQNVRDWLYVGDHCSAIREVLAR
EEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCHHEEECHHHHHHHHHHHC
GTPGETYNVGGWNEKKNLEVVHTLCDLLDQLRPKAGGSYHDQITYVKDRPGHDRRYAIDA
CCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCEEEHHH
RKLERELGWKPAETFETGLAKTVQWYLDNQAWSDEVASGEYRKWVAKQYA
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8253667 [H]