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The map label for this gene is gca [H]

Identifier: 91782040

GI number: 91782040

Start: 740635

End: 741546

Strand: Direct

Name: gca [H]

Synonym: Bxe_A3804

Alternate gene names: 91782040

Gene position: 740635-741546 (Clockwise)

Preceding gene: 91782038

Following gene: 91782041

Centisome position: 15.13

GC content: 62.61

Gene sequence:

>912_bases
ATGTCGTCTCTTCATGCAAAGCAGCCTATCCGTACGCTCGTTACCGGCGCAAGCGGCTTTACCGGCCGCTACCTGGTCGA
TAACCTGCTCGGCCGGGGCCACACTGTGATCGAAACGGTCGCCGGGCGCGATGAGCCTGAAACGCCAACCCGCGTGAGGC
TCGACATCACGTCGCCGGACGCCTGCCGGCGCGCGATCGAAATCGCGCGCCCCGACTATATTGTCCATCTGGCTGCGATC
AGTTTCGTGGGGCATAACGACCCGCTCGACTTTTACCGCGTCAACGTGATCGGCACGCTGAATCTGCTGGAGGCCTGTGC
CGCCGTCGGGCATACGCCGCGCAAGCTGCTGATCGCGAGCAGCGCGAACGTCTACGGCAACGTGACGAGCGAGGCTATCG
ACGAGAGCTTTCCGGTCACGCCGGTCAATCACTACGCCGCCAGCAAGGCGGCGATGGAAACGATGGTGCGGACCTGGTTC
GACCGGCTGCCGATCCTGATTGTGCGGCCGTTCAACTATACCGGGCGCGGCCAGGCGTCGAACTTCCTCGTGCCGAAGAT
CGTCGGGCACTTCGCGCGTCGCGAAGCGTCGATCGAACTCGGCAATATCGATGTCGCGCGCGATTTCTCCGACGTACGGT
ATGTGGCAAGCGCTTATGAAGCGCTGCTCGACTCGGAGGCCGCGGCCGAAACCGTCAATGTCTGCACCGGCACGCCTTTT
ACGCTGCGCGAAATTCTCGCGGCGGCAAGCGATCTGACCGGACATGAGTTGGAGATTCAGATCAATCCCGCCTTCGTGCG
GCAAACCGACGTGAAAATGCTGGCCGGTTCGCCCGCCAGACTGCGCACGCTCGTGCCGACCGTCGAGGCGATTCCGTTCA
TGGATACGCTGCGCTGGATGCTTGCGGCATAA

Upstream 100 bases:

>100_bases
ATCGCGTCAGGCGGCGTAAGGCGCCGCTGGCAAGCGTCACGGCGAACGGCGCGCGTGATAGTGCGGCACAACACGACGAC
CCTCGTGAACGGAGAAAAGC

Downstream 100 bases:

>100_bases
ACCCGCATCGGCGCTGATCGGCGGTTCTTTTTGAGTCGTGATGACGCGCGACTTTCGTTCGCGTATAAACAATCGTAGTG
CGCCGCGCGGACGCTGCGGG

Product: putative UDP-glucose 4-epimerase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MSSLHAKQPIRTLVTGASGFTGRYLVDNLLGRGHTVIETVAGRDEPETPTRVRLDITSPDACRRAIEIARPDYIVHLAAI
SFVGHNDPLDFYRVNVIGTLNLLEACAAVGHTPRKLLIASSANVYGNVTSEAIDESFPVTPVNHYAASKAAMETMVRTWF
DRLPILIVRPFNYTGRGQASNFLVPKIVGHFARREASIELGNIDVARDFSDVRYVASAYEALLDSEAAAETVNVCTGTPF
TLREILAAASDLTGHELEIQINPAFVRQTDVKMLAGSPARLRTLVPTVEAIPFMDTLRWMLAA

Sequences:

>Translated_303_residues
MSSLHAKQPIRTLVTGASGFTGRYLVDNLLGRGHTVIETVAGRDEPETPTRVRLDITSPDACRRAIEIARPDYIVHLAAI
SFVGHNDPLDFYRVNVIGTLNLLEACAAVGHTPRKLLIASSANVYGNVTSEAIDESFPVTPVNHYAASKAAMETMVRTWF
DRLPILIVRPFNYTGRGQASNFLVPKIVGHFARREASIELGNIDVARDFSDVRYVASAYEALLDSEAAAETVNVCTGTPF
TLREILAAASDLTGHELEIQINPAFVRQTDVKMLAGSPARLRTLVPTVEAIPFMDTLRWMLAA
>Mature_302_residues
SSLHAKQPIRTLVTGASGFTGRYLVDNLLGRGHTVIETVAGRDEPETPTRVRLDITSPDACRRAIEIARPDYIVHLAAIS
FVGHNDPLDFYRVNVIGTLNLLEACAAVGHTPRKLLIASSANVYGNVTSEAIDESFPVTPVNHYAASKAAMETMVRTWFD
RLPILIVRPFNYTGRGQASNFLVPKIVGHFARREASIELGNIDVARDFSDVRYVASAYEALLDSEAAAETVNVCTGTPFT
LREILAAASDLTGHELEIQINPAFVRQTDVKMLAGSPARLRTLVPTVEAIPFMDTLRWMLAA

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=342, Percent_Identity=27.4853801169591, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI56118217, Length=342, Percent_Identity=27.4853801169591, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI189083684, Length=342, Percent_Identity=27.4853801169591, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI7657641, Length=257, Percent_Identity=27.2373540856031, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1786974, Length=188, Percent_Identity=31.3829787234043, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI48994969, Length=250, Percent_Identity=28.8, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788366, Length=323, Percent_Identity=22.9102167182663, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17507723, Length=337, Percent_Identity=24.9258160237389, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17539422, Length=337, Percent_Identity=24.0356083086053, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI133901788, Length=337, Percent_Identity=24.0356083086053, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI133901786, Length=337, Percent_Identity=24.0356083086053, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17539424, Length=337, Percent_Identity=24.0356083086053, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI133901790, Length=337, Percent_Identity=24.0356083086053, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71982035, Length=311, Percent_Identity=22.8295819935691, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=316, Percent_Identity=25.6329113924051, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24158427, Length=336, Percent_Identity=24.1071428571429, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 33116; Mature: 32985

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLHAKQPIRTLVTGASGFTGRYLVDNLLGRGHTVIETVAGRDEPETPTRVRLDITSPD
CCCCCHHCCHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEEEECCCH
ACRRAIEIARPDYIVHLAAISFVGHNDPLDFYRVNVIGTLNLLEACAAVGHTPRKLLIAS
HHHHHHHHCCCCCEEEEEHHHHHCCCCCCCEEEEEEEEHHHHHHHHHHCCCCCCEEEEEE
SANVYGNVTSEAIDESFPVTPVNHYAASKAAMETMVRTWFDRLPILIVRPFNYTGRGQAS
CCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCC
NFLVPKIVGHFARREASIELGNIDVARDFSDVRYVASAYEALLDSEAAAETVNVCTGTPF
CCHHHHHHHHHHHHHCCEEECCEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCH
TLREILAAASDLTGHELEIQINPAFVRQTDVKMLAGSPARLRTLVPTVEAIPFMDTLRWM
HHHHHHHHHCCCCCCEEEEEECHHEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LAA
HCC
>Mature Secondary Structure 
SSLHAKQPIRTLVTGASGFTGRYLVDNLLGRGHTVIETVAGRDEPETPTRVRLDITSPD
CCCCHHCCHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEEEECCCH
ACRRAIEIARPDYIVHLAAISFVGHNDPLDFYRVNVIGTLNLLEACAAVGHTPRKLLIAS
HHHHHHHHCCCCCEEEEEHHHHHCCCCCCCEEEEEEEEHHHHHHHHHHCCCCCCEEEEEE
SANVYGNVTSEAIDESFPVTPVNHYAASKAAMETMVRTWFDRLPILIVRPFNYTGRGQAS
CCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCC
NFLVPKIVGHFARREASIELGNIDVARDFSDVRYVASAYEALLDSEAAAETVNVCTGTPF
CCHHHHHHHHHHHHHCCEEECCEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCH
TLREILAAASDLTGHELEIQINPAFVRQTDVKMLAGSPARLRTLVPTVEAIPFMDTLRWM
HHHHHHHHHCCCCCCEEEEEECHHEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LAA
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8548534; 10984043 [H]