Click here to switch to the map view.

The map label for this gene is thiD [H]

Identifier: 91782030

GI number: 91782030

Start: 731091

End: 731951

Strand: Reverse

Name: thiD [H]

Synonym: Bxe_A3814

Alternate gene names: 91782030

Gene position: 731951-731091 (Counterclockwise)

Preceding gene: 91782039

Following gene: 91782026

Centisome position: 14.95

GC content: 67.6

Gene sequence:

>861_bases
ATGCCCAGCGACACGCCTCCGATCGTCCTCACCTTCGGCCTTTCCGATCCCACCGGCGGCTCCGGCCTGCAAGCCGACCT
GATGACCCTTGCCAGCATGGGCTGCCACGGCGTCTCCGTGCTCACGGGCTACACCGTGCGCGACTCGGCGAGCTGCGACG
AAGTCACCGGACTCGACCCCGAAGTGGTCGCGACCCAGGCCCGGATGCTGCTCGAAGACATGCCGATCGCCGCGTTCAAG
GTGGGCGCCTGCACGCGCGCGGAAGTCGTGAGCGCGATTGCCGAAGTCGTCGCCGATTACGACGACATTCCGCTGATTCT
CGCCCCCGACTTCACGCTCGACGACGAGCACGTGCTCTCCGCCGACGAACTGCGCGAAGCGATCGCCGATCTGCTCGCGC
CGCAAACCACCCTGCTGGTCGCCGACGCGACCACGCTGCTCGCGCTCGCTCAACCGGACGGCGACGCCGAAGCACCGAGC
CTCGACGCCGCGATCTCGCATCTGCTGTCGCAAGGCTGCGAATATATTCTGTCGACGGAAACCGGCACGCACCGGCATGT
CAACACGCTGTTCAGCGAAGACGGCCAGTTGCGCCAGGACATGTGGGACCGTGGCAGCCATCGGATCATGGGGCTGACGG
ATACGCTGGGGTCGGCCATCGCCGCGTTGCTGGCCAACGGCCAGGAGCCGGCTGAAGCCGTGCGCGAGGCGCAGGAGTAT
CTGTATCAGGCCGTGCGCAACGCGTTCCGGCCGGGCATGGGCGCGTATATGCCGGACCGGTTCTTCTGGGCGCGCAGCAG
CGATGACGAAACGCCGCCGGCCGCCGGCAAGGACGCAGCACCAGGCGAAGCGCGCCACTGA

Upstream 100 bases:

>100_bases
GGCGGGATGCGAAAAAACGCCCCGGCGGCGGTTTAGGCCGCATAATTGAGCCGATTGCGCACCCTCTGCGCCCAAATTCA
GCCTCTTTCAGCCAATCTTC

Downstream 100 bases:

>100_bases
GCGCTTGCGCGAGGTGCGCGCCGGCCACCCGAGCTGGGGCCGCGCCTTCTGATCCGGGCGCTTCAGCTTGCGGCGAGCGC
CCATAAAAAAACCCGCAGTG

Product: putative hydroxymethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MPSDTPPIVLTFGLSDPTGGSGLQADLMTLASMGCHGVSVLTGYTVRDSASCDEVTGLDPEVVATQARMLLEDMPIAAFK
VGACTRAEVVSAIAEVVADYDDIPLILAPDFTLDDEHVLSADELREAIADLLAPQTTLLVADATTLLALAQPDGDAEAPS
LDAAISHLLSQGCEYILSTETGTHRHVNTLFSEDGQLRQDMWDRGSHRIMGLTDTLGSAIAALLANGQEPAEAVREAQEY
LYQAVRNAFRPGMGAYMPDRFFWARSSDDETPPAAGKDAAPGEARH

Sequences:

>Translated_286_residues
MPSDTPPIVLTFGLSDPTGGSGLQADLMTLASMGCHGVSVLTGYTVRDSASCDEVTGLDPEVVATQARMLLEDMPIAAFK
VGACTRAEVVSAIAEVVADYDDIPLILAPDFTLDDEHVLSADELREAIADLLAPQTTLLVADATTLLALAQPDGDAEAPS
LDAAISHLLSQGCEYILSTETGTHRHVNTLFSEDGQLRQDMWDRGSHRIMGLTDTLGSAIAALLANGQEPAEAVREAQEY
LYQAVRNAFRPGMGAYMPDRFFWARSSDDETPPAAGKDAAPGEARH
>Mature_285_residues
PSDTPPIVLTFGLSDPTGGSGLQADLMTLASMGCHGVSVLTGYTVRDSASCDEVTGLDPEVVATQARMLLEDMPIAAFKV
GACTRAEVVSAIAEVVADYDDIPLILAPDFTLDDEHVLSADELREAIADLLAPQTTLLVADATTLLALAQPDGDAEAPSL
DAAISHLLSQGCEYILSTETGTHRHVNTLFSEDGQLRQDMWDRGSHRIMGLTDTLGSAIAALLANGQEPAEAVREAQEYL
YQAVRNAFRPGMGAYMPDRFFWARSSDDETPPAAGKDAAPGEARH

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=244, Percent_Identity=27.8688524590164, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 30343; Mature: 30212

Theoretical pI: Translated: 4.01; Mature: 4.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSDTPPIVLTFGLSDPTGGSGLQADLMTLASMGCHGVSVLTGYTVRDSASCDEVTGLDP
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCEECCCCCCCHHCCCCH
EVVATQARMLLEDMPIAAFKVGACTRAEVVSAIAEVVADYDDIPLILAPDFTLDDEHVLS
HHHHHHHHHHHHHCCHHHEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHCC
ADELREAIADLLAPQTTLLVADATTLLALAQPDGDAEAPSLDAAISHLLSQGCEYILSTE
HHHHHHHHHHHHCCCCEEEEECHHHEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEECC
TGTHRHVNTLFSEDGQLRQDMWDRGSHRIMGLTDTLGSAIAALLANGQEPAEAVREAQEY
CCCHHHHHHHHCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LYQAVRNAFRPGMGAYMPDRFFWARSSDDETPPAAGKDAAPGEARH
HHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PSDTPPIVLTFGLSDPTGGSGLQADLMTLASMGCHGVSVLTGYTVRDSASCDEVTGLDP
CCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCEECCCCCCCHHCCCCH
EVVATQARMLLEDMPIAAFKVGACTRAEVVSAIAEVVADYDDIPLILAPDFTLDDEHVLS
HHHHHHHHHHHHHCCHHHEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHCC
ADELREAIADLLAPQTTLLVADATTLLALAQPDGDAEAPSLDAAISHLLSQGCEYILSTE
HHHHHHHHHHHHCCCCEEEEECHHHEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEECC
TGTHRHVNTLFSEDGQLRQDMWDRGSHRIMGLTDTLGSAIAALLANGQEPAEAVREAQEY
CCCHHHHHHHHCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LYQAVRNAFRPGMGAYMPDRFFWARSSDDETPPAAGKDAAPGEARH
HHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10075431; 9097040; 9278503 [H]