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The map label for this gene is groEL [H]

Identifier: 91782029

GI number: 91782029

Start: 729263

End: 730903

Strand: Direct

Name: groEL [H]

Synonym: Bxe_A3815

Alternate gene names: 91782029

Gene position: 729263-730903 (Clockwise)

Preceding gene: 91782028

Following gene: 91782031

Centisome position: 14.9

GC content: 60.15

Gene sequence:

>1641_bases
ATGGCAGCTAAAGACGTCGTATTCGGTGATTCCGCCCGTGCCAAGATGGTTGAAGGCGTGAACATCCTCGCGAACGCTGT
GAAGGTCACGCTGGGCCCGAAGGGTCGCAACGTTGTCCTGGAACGCAGCTTCGGCGGCCCCACGGTCACGAAAGACGGTG
TGTCGGTCGCGAAAGAGATCGAACTGAAAGACAAGCTCCAGAACATGGGCGCGCAAATGGTCAAGGAAGTGGCTTCCAAG
ACCAGCGACAACGCAGGTGACGGCACCACGACCGCAACGGTCCTGGCACAGTCCATCGTTCGCGAAGGCATGAAGTACGT
TGCATCGGGCATGAACCCGATGGACCTGAAGCGCGGTATCGACAAGGCTGTGTTCGCAGCGATCGAAGAACTGCGCAAGA
TCAGCAAGCCGTGCACGACCAACAAGGAAATTGCACAAGTCGGCGCGATCTCGGCAAACAGCGACTCGTCGATCGGCGAT
CGTATCGCTGAAGCAATGGACAAGGTCGGCAAGGAAGGCGTCATCACCGTCGAAGACGGCAAGTCGCTGCAAGACGAGTT
GGACGTTGTCGAAGGTATGCAGTTCGACCGCGGCTACCTGTCGCCGTACTTCATCAACAACCCGGACAAGCAGGTTGCCG
TGTTGGAGAACCCGTTCGTGCTGCTGCACGACAAGAAGGTGTCGAACATCCGTGATCTGCTGCCGATTCTGGAACAGGTC
GCCAAGGCTGGCCGTCCGCTGCTGATCATCGCGGAAGACGTTGAAGGCGAAGCACTGGCTACGCTGGTGGTGAACAACAT
CCGCGGCATTCTGAAGACCGTTGCTGTCAAGGCTCCGGGCTTCGGCGATCGTCGTAAGGCCATGCTGGAAGACATCGCGA
TCCTGACCGGTGGTCAGGTCATCGCTGAAGAAACCGGCCTGACGCTCGAAAAGGCAACGCTGGCCGAACTGGGTCAGGCG
AAGCGTATCGAAGTGGCGAAGGAAAACACCACGATCATCGACGGCGCAGGCGAAGCGGCCAACATCGAAGCACGTGTGAA
GCAGGTTCGCACGCAAATCGAAGAAGCTACGTCGGACTACGACCGTGAAAAGCTGCAGGAACGCGTTGCCAAGCTGGCAG
GCGGCGTTGCAGTAATCAAGGTCGGCGCTGCGACCGAAGTCGAAATGAAGGAAAAGAAGGCACGTGTCGAAGACGCACTG
CACGCAACGCGCGCAGCTGTGGAAGAAGGCATCGTCGCTGGCGGCGGCGTCGCGCTGATCCGCGCACGTACGGCTATCGC
TGGCCTGAAGGGCGCTAACGCCGATCAGGACGCAGGTATCAAGATCGTGCTGCGCGCGATGGAAGAGCCGCTGCGTCAGA
TCGTCACGAACGGTGGCGAAGAAGCCAGCGTCGTGGTGGCGGCAGTTGCTGCTGGCACGGGCAACTACGGCTACAACGCT
GCAACCGGCGAGTACGTCGACCTGGTCGACGCTGGTGTTGTCGACCCGACGAAGGTAACGCGCACGGCGCTGCAGAACGC
AGCTTCGGTGGCAGGTCTCCTGCTGACCACCGACGCAGCTGTTTGCGAACTGCCGAAGGAAGATGCACCGATGGCCGGCG
GCATGCCCGGCGGCATGGGCGGCATGGGCATGGACATGTAA

Upstream 100 bases:

>100_bases
GCTCGTGATGCGCGAAGAAGACATCATGGCCGTGGTGCAGAAGTAAGCGCAAGCCGCTACTTTTCCCGGTTATATCCCAG
AGAATTCAAGGAGTTAGAAG

Downstream 100 bases:

>100_bases
TTCCGGGTTGGGCCTCATTGCGAGGCTCACCAGGAAGACATGGGGAAGCGCGCTGAAAGGCGTGCTTCCCATAAAAAAAC
CCGCAGACACTGCGGGTTTT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MAAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASK
TSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVFAAIEELRKISKPCTTNKEIAQVGAISANSDSSIGD
RIAEAMDKVGKEGVITVEDGKSLQDELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPILEQV
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLAELGQA
KRIEVAKENTTIIDGAGEAANIEARVKQVRTQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVAGGGVALIRARTAIAGLKGANADQDAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGTGNYGYNA
ATGEYVDLVDAGVVDPTKVTRTALQNAASVAGLLLTTDAAVCELPKEDAPMAGGMPGGMGGMGMDM

Sequences:

>Translated_546_residues
MAAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASK
TSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVFAAIEELRKISKPCTTNKEIAQVGAISANSDSSIGD
RIAEAMDKVGKEGVITVEDGKSLQDELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPILEQV
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLAELGQA
KRIEVAKENTTIIDGAGEAANIEARVKQVRTQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVAGGGVALIRARTAIAGLKGANADQDAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGTGNYGYNA
ATGEYVDLVDAGVVDPTKVTRTALQNAASVAGLLLTTDAAVCELPKEDAPMAGGMPGGMGGMGMDM
>Mature_545_residues
AAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASKT
SDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVFAAIEELRKISKPCTTNKEIAQVGAISANSDSSIGDR
IAEAMDKVGKEGVITVEDGKSLQDELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPILEQVA
KAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLAELGQAK
RIEVAKENTTIIDGAGEAANIEARVKQVRTQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVEEGIVAGGGVALIRARTAIAGLKGANADQDAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGTGNYGYNAA
TGEYVDLVDAGVVDPTKVTRTALQNAASVAGLLLTTDAAVCELPKEDAPMAGGMPGGMGGMGMDM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=53.4090909090909, Blast_Score=546, Evalue=1e-155,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=53.4090909090909, Blast_Score=546, Evalue=1e-155,
Organism=Homo sapiens, GI24307939, Length=350, Percent_Identity=24, Blast_Score=78, Evalue=3e-14,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=75.6143667296786, Blast_Score=800, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=52.1739130434783, Blast_Score=548, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI193210679, Length=218, Percent_Identity=50.9174311926605, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI25144674, Length=293, Percent_Identity=23.8907849829352, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=52.0912547528517, Blast_Score=533, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6322524, Length=375, Percent_Identity=24, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6322446, Length=555, Percent_Identity=21.2612612612613, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6322350, Length=565, Percent_Identity=22.6548672566372, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=51.8026565464896, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=51.8026565464896, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=50.6641366223909, Blast_Score=533, Evalue=1e-151,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=50.6641366223909, Blast_Score=533, Evalue=1e-151,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=50.6641366223909, Blast_Score=533, Evalue=1e-151,
Organism=Drosophila melanogaster, GI17864606, Length=550, Percent_Identity=43.6363636363636, Blast_Score=458, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24584129, Length=526, Percent_Identity=37.2623574144487, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI19921262, Length=526, Percent_Identity=37.2623574144487, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI17647245, Length=473, Percent_Identity=23.6786469344609, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24652903, Length=446, Percent_Identity=24.2152466367713, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57198; Mature: 57067

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEI
CCCCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHH
ELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVFAAIEELRKISKPCTTNKEIAQVGAISANSDSSIGDRIAEAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KSLQDELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPILEQV
CCHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEE
IAEETGLTLEKATLAELGQAKRIEVAKENTTIIDGAGEAANIEARVKQVRTQIEEATSDY
EECCCCCEEHHHHHHHCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALI
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARTAIAGLKGANADQDAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGTGNYGYNA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
ATGEYVDLVDAGVVDPTKVTRTALQNAASVAGLLLTTDAAVCELPKEDAPMAGGMPGGMG
CCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCC
GMGMDM
CCCCCC
>Mature Secondary Structure 
AAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEI
CCCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHH
ELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVFAAIEELRKISKPCTTNKEIAQVGAISANSDSSIGDRIAEAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KSLQDELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPILEQV
CCHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEE
IAEETGLTLEKATLAELGQAKRIEVAKENTTIIDGAGEAANIEARVKQVRTQIEEATSDY
EECCCCCEEHHHHHHHCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALI
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARTAIAGLKGANADQDAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGTGNYGYNA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
ATGEYVDLVDAGVVDPTKVTRTALQNAASVAGLLLTTDAAVCELPKEDAPMAGGMPGGMG
CCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCC
GMGMDM
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA