Click here to switch to the map view.

The map label for this gene is 91781944

Identifier: 91781944

GI number: 91781944

Start: 627244

End: 628554

Strand: Direct

Name: 91781944

Synonym: Bxe_A3899

Alternate gene names: NA

Gene position: 627244-628554 (Clockwise)

Preceding gene: 91781943

Following gene: 91781948

Centisome position: 12.81

GC content: 64.23

Gene sequence:

>1311_bases
ATGAACGCATCGAGCGATCTTCAGGCGACGCTCGATCCGTCGCGCAAAAGCTGGGTCGAGTCGGCCAACAATCCGACCGG
CGATTTTTCGATTCAGAATCTGCCGTTCGGCATTTTCAGCGACGGGCTGAATGCGACGCGCCGCGTGGGCGTGGCGATCG
GCGACAGCATCGTCGACCTGGCCGCGCTCGAAAGCGCGGGTCTGCTGAGCGTGCCGTCAACGGGCGCGGGCGACAGCGTG
TTCGTGCGCGACGCGTTGAACGATTTCATCGCCCTCGGCCGTGACGCATGGCGCAGTGTGCGTGTCCAGTTGAGCAGGCT
GTTGTCGCGCGACGACGCAACGCTGCGCGACGACGCCGAGCTGCGCGGCCGCGCGCTGATCCGTCAGGCCGACGCGCAAT
TGCATCTGCCGGTGCAGATTCCGGGCTACACCGATTTCTATTCGTCGAAGGAGCACGCAACGAATGTCGGCTCCATGTTC
CGCGATCCGAAGAATGCGCTGCTGCCGAACTGGTCGGAGATGCCGATTGGTTACAACGGACGCGCGTCGTCGGTGGTGGT
GAGCGGCACGCCCGTGCGTCGTCCTAACGGACAGCTGAAGCTGCCGGATCAGGAGCGTCCGGTGTTCGGCGCGTGCCGCA
AGCTGGATATCGAACTGGAAACGGGCTTCGTGATCGGTGCGGGCAATGCCCTGGGCGAGCCGGTTACATGCGCGGATGCC
GAAGCGCATATCTTCGGCATGGTGCTGCTGAACGACTGGAGCGCGCGCGATATCCAGCAGTGGGAATACGTGCCGCTCGG
GCCGTTCAACGCGAAGACCTTCGCGACCACGATCTCGCCCTGGATCGTGACGCTCGACGCGCTCGAACCGTTCCGCGTCG
CGCAGCCCGCGCAAGATCCGCAGCCGCTCGCTTATCTGCGGCACGACGGCGAACATGCTTTCGACATCACGCTGGAAGTG
ACGCTACGCCCGCAGCAGGCGAAAGAGGCGAGCACGATCACGCGGACCAACTTCAAACACATGTACTGGACGATGGCGCA
GCAACTCGCGCATCACACGGTATCGGGCTGCAACACGCGCGTGGGCGACCTGATGGGCTCCGGCACGATCAGCGGGCCGA
CGGAGGATTCCTTCGGCAGCCTGCTCGAATTGACGTGGAACGGCAAGAAGCCGCTGGAGTTGCGCGAAGGCGGCACGCGC
AGTTTCATCGAAGACGGCGACGAGTTGACGCTTGCCGGCTGGTGCCAGGGCGAGGGTTATCGGGTGGGCTTCGGCGTGTG
CGCCGGGGAGATTTTGCCGGCGTTGAAGTGA

Upstream 100 bases:

>100_bases
TGATCAAGCCGACCCGTTTCGCGCTCGAAACCGCGCAATTGCAGGCGCATTACTACGAGTGCTGGCAAGGCCTCAAGAAA
CATTTCAATCCGGAGCAACG

Downstream 100 bases:

>100_bases
CGCTGGCAACGCGCCGTTAGCGTGTGTACGGAAGGCGCGCGATAAAAAAACGGGGAAGCCATTTATCGTGGCTTTCCTGT
TTTTCTATTTGCGGATCGCC

Product: fumarylacetoacetate hydrolase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; Fumarylacetoacetase Hydrolase; 2-Hydroxyhepta-2 4-Diene-1 7-Dioate Isomerase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MNASSDLQATLDPSRKSWVESANNPTGDFSIQNLPFGIFSDGLNATRRVGVAIGDSIVDLAALESAGLLSVPSTGAGDSV
FVRDALNDFIALGRDAWRSVRVQLSRLLSRDDATLRDDAELRGRALIRQADAQLHLPVQIPGYTDFYSSKEHATNVGSMF
RDPKNALLPNWSEMPIGYNGRASSVVVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFVIGAGNALGEPVTCADA
EAHIFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATTISPWIVTLDALEPFRVAQPAQDPQPLAYLRHDGEHAFDITLEV
TLRPQQAKEASTITRTNFKHMYWTMAQQLAHHTVSGCNTRVGDLMGSGTISGPTEDSFGSLLELTWNGKKPLELREGGTR
SFIEDGDELTLAGWCQGEGYRVGFGVCAGEILPALK

Sequences:

>Translated_436_residues
MNASSDLQATLDPSRKSWVESANNPTGDFSIQNLPFGIFSDGLNATRRVGVAIGDSIVDLAALESAGLLSVPSTGAGDSV
FVRDALNDFIALGRDAWRSVRVQLSRLLSRDDATLRDDAELRGRALIRQADAQLHLPVQIPGYTDFYSSKEHATNVGSMF
RDPKNALLPNWSEMPIGYNGRASSVVVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFVIGAGNALGEPVTCADA
EAHIFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATTISPWIVTLDALEPFRVAQPAQDPQPLAYLRHDGEHAFDITLEV
TLRPQQAKEASTITRTNFKHMYWTMAQQLAHHTVSGCNTRVGDLMGSGTISGPTEDSFGSLLELTWNGKKPLELREGGTR
SFIEDGDELTLAGWCQGEGYRVGFGVCAGEILPALK
>Mature_436_residues
MNASSDLQATLDPSRKSWVESANNPTGDFSIQNLPFGIFSDGLNATRRVGVAIGDSIVDLAALESAGLLSVPSTGAGDSV
FVRDALNDFIALGRDAWRSVRVQLSRLLSRDDATLRDDAELRGRALIRQADAQLHLPVQIPGYTDFYSSKEHATNVGSMF
RDPKNALLPNWSEMPIGYNGRASSVVVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFVIGAGNALGEPVTCADA
EAHIFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATTISPWIVTLDALEPFRVAQPAQDPQPLAYLRHDGEHAFDITLEV
TLRPQQAKEASTITRTNFKHMYWTMAQQLAHHTVSGCNTRVGDLMGSGTISGPTEDSFGSLLELTWNGKKPLELREGGTR
SFIEDGDELTLAGWCQGEGYRVGFGVCAGEILPALK

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=408, Percent_Identity=58.578431372549, Blast_Score=517, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17568863, Length=420, Percent_Identity=55, Blast_Score=473, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24657182, Length=409, Percent_Identity=52.8117359413203, Blast_Score=437, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 47441; Mature: 47441

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNASSDLQATLDPSRKSWVESANNPTGDFSIQNLPFGIFSDGLNATRRVGVAIGDSIVDL
CCCCCCCEEECCCCHHHHHHHCCCCCCCEEECCCCCHHHHCCCCHHHEEEEEECCHHHHH
AALESAGLLSVPSTGAGDSVFVRDALNDFIALGRDAWRSVRVQLSRLLSRDDATLRDDAE
HHHCCCCEEECCCCCCCCCEEHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCHH
LRGRALIRQADAQLHLPVQIPGYTDFYSSKEHATNVGSMFRDPKNALLPNWSEMPIGYNG
HHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCC
RASSVVVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFVIGAGNALGEPVTCADA
CCCEEEEECCCCCCCCCCEECCCCCCCHHHCCEEEEEEEECCEEEECCCCCCCCEEECCC
EAHIFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATTISPWIVTLDALEPFRVAQPAQDP
CCEEEEEEEECCCCCCCCCCCCEEECCCCCCCHHEEECCCEEEEEECCCCHHHCCCCCCC
QPLAYLRHDGEHAFDITLEVTLRPQQAKEASTITRTNFKHMYWTMAQQLAHHTVSGCNTR
CCEEEEECCCCEEEEEEEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCH
VGDLMGSGTISGPTEDSFGSLLELTWNGKKPLELREGGTRSFIEDGDELTLAGWCQGEGY
HHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHCCCCEEEEEEEECCCCE
RVGFGVCAGEILPALK
EEEEEHHHHHHHCCCC
>Mature Secondary Structure
MNASSDLQATLDPSRKSWVESANNPTGDFSIQNLPFGIFSDGLNATRRVGVAIGDSIVDL
CCCCCCCEEECCCCHHHHHHHCCCCCCCEEECCCCCHHHHCCCCHHHEEEEEECCHHHHH
AALESAGLLSVPSTGAGDSVFVRDALNDFIALGRDAWRSVRVQLSRLLSRDDATLRDDAE
HHHCCCCEEECCCCCCCCCEEHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCHH
LRGRALIRQADAQLHLPVQIPGYTDFYSSKEHATNVGSMFRDPKNALLPNWSEMPIGYNG
HHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCC
RASSVVVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFVIGAGNALGEPVTCADA
CCCEEEEECCCCCCCCCCEECCCCCCCHHHCCEEEEEEEECCEEEECCCCCCCCEEECCC
EAHIFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATTISPWIVTLDALEPFRVAQPAQDP
CCEEEEEEEECCCCCCCCCCCCEEECCCCCCCHHEEECCCEEEEEECCCCHHHCCCCCCC
QPLAYLRHDGEHAFDITLEVTLRPQQAKEASTITRTNFKHMYWTMAQQLAHHTVSGCNTR
CCEEEEECCCCEEEEEEEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCH
VGDLMGSGTISGPTEDSFGSLLELTWNGKKPLELREGGTRSFIEDGDELTLAGWCQGEGY
HHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHCCCCEEEEEEEECCCCE
RVGFGVCAGEILPALK
EEEEEHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA