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The map label for this gene is hmgA [H]

Identifier: 91781943

GI number: 91781943

Start: 625901

End: 627247

Strand: Direct

Name: hmgA [H]

Synonym: Bxe_A3900

Alternate gene names: 91781943

Gene position: 625901-627247 (Clockwise)

Preceding gene: 91781942

Following gene: 91781944

Centisome position: 12.78

GC content: 63.92

Gene sequence:

>1347_bases
ATGGATACCCAAACACGTACGCCGAACACTGTCAGTTCGCGGCTCGAGATCGAGCCCGGCTATCAGTCGGGTTTCGCGAA
CGAATTCGCGACAGAGGCGTTGCCGGGCGCGTTGCCGGAAGGCCGCAACTCGCCGCAACGCGTGGCCTATGGTCTGTACG
CCGAACAGGTGTCGGGCACGGCGTTTACTGCGCCGCGCGCCCACAATCGCCGTTCGTGGCTGTACCGGATTCGTCCGGCG
GCGGTGCACAAGCCGTTCACGCCGCTGCCCTCGGAGCGGCTCGTCGCCAACTTCGCCGAGGTGCCGCCCACACCGCCGAA
CCAGTTGCGCTGGGACCCGCTGCCGATGCCGGCCGAGCCGACCGATTTCATCGACGGCTGGGTGACGATGGCGGGCAACG
GCGCGGCGGAATCGATGAGCGGTTGCGCGATTCACCTGTACGCGGCGAACCGCTCGATGCAAGACCGCTTCTTCTATAGC
GCCGACGGCGAATTGCTGATCGTGCCGCAGGAAGGGCGTCTCGACATTGCCACCGAAATGGGCCGGCTCGAAGTCGAACC
GTTCGAGATCGTGGTGATTCCGCGCGGCGTACGCTTCGCGGTGAGCCTGCCGGACGGCGCGGCGCGCGGCTACATCTGCG
AGAATTTCGGGGCGTTGCTGCGTTTGCCGGACCTCGGACCGATCGGCTCGAATGGGCTCGCCAATCCGCGCGATTTCCTC
ACGCCGCATGCGGCCTACGAGGATCGTGAGGGCGACTTCGAACTCGTCGCCAAGCTGAACGGCAACCTGTGGCGCGCGGA
TATCGGCCATTCGCCGCTCGACGTGGTGGCGTGGCACGGCAACTATGCCCCATACAAATACGACCTGCGCCGCTTCAACA
CGATCGGCTCGATCAGCTTCGACCATCCGGACCCGTCGATTTTTCTGGTGCTGCAATCGCAAAGCGATACGCCGGGCGTC
GATGCGATCGACTTCGTGATCTTCCCGCCGCGCTGGCTGGCGGCCGAAGATACGTTCCGGCCACCCTGGTTCCATCGCAA
CGTCGCGAGCGAGTTCATGGGCCTCGTGCACGGCGTGTACGACGCGAAGGCCGAGGGCTTCGTGCCGGGCGGAGGGAGTC
TGCATAACTGCATGTCGGGTCACGGCCCGGATGCGGACACGTTCGAAAAGGCTTCGCATATCGATACGTCGAAGCCGGCG
AAAGTCGGCGACACGATGGCCTTTATGTTCGAGACGCGCACGCTGATCAAGCCGACCCGTTTCGCGCTCGAAACCGCGCA
ATTGCAGGCGCATTACTACGAGTGCTGGCAAGGCCTCAAGAAACATTTCAATCCGGAGCAACGATGA

Upstream 100 bases:

>100_bases
CTGGTGATCGGACTGGCCGCCGCGACGCGCCAGCGCGGCCGGCCGTCCGAGCCGCGCACCGCCTGAGATGACGAGATCGA
GTATCAACGGAGAACCTTGC

Downstream 100 bases:

>100_bases
ACGCATCGAGCGATCTTCAGGCGACGCTCGATCCGTCGCGCAAAAGCTGGGTCGAGTCGGCCAACAATCCGACCGGCGAT
TTTTCGATTCAGAATCTGCC

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MDTQTRTPNTVSSRLEIEPGYQSGFANEFATEALPGALPEGRNSPQRVAYGLYAEQVSGTAFTAPRAHNRRSWLYRIRPA
AVHKPFTPLPSERLVANFAEVPPTPPNQLRWDPLPMPAEPTDFIDGWVTMAGNGAAESMSGCAIHLYAANRSMQDRFFYS
ADGELLIVPQEGRLDIATEMGRLEVEPFEIVVIPRGVRFAVSLPDGAARGYICENFGALLRLPDLGPIGSNGLANPRDFL
TPHAAYEDREGDFELVAKLNGNLWRADIGHSPLDVVAWHGNYAPYKYDLRRFNTIGSISFDHPDPSIFLVLQSQSDTPGV
DAIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGVYDAKAEGFVPGGGSLHNCMSGHGPDADTFEKASHIDTSKPA
KVGDTMAFMFETRTLIKPTRFALETAQLQAHYYECWQGLKKHFNPEQR

Sequences:

>Translated_448_residues
MDTQTRTPNTVSSRLEIEPGYQSGFANEFATEALPGALPEGRNSPQRVAYGLYAEQVSGTAFTAPRAHNRRSWLYRIRPA
AVHKPFTPLPSERLVANFAEVPPTPPNQLRWDPLPMPAEPTDFIDGWVTMAGNGAAESMSGCAIHLYAANRSMQDRFFYS
ADGELLIVPQEGRLDIATEMGRLEVEPFEIVVIPRGVRFAVSLPDGAARGYICENFGALLRLPDLGPIGSNGLANPRDFL
TPHAAYEDREGDFELVAKLNGNLWRADIGHSPLDVVAWHGNYAPYKYDLRRFNTIGSISFDHPDPSIFLVLQSQSDTPGV
DAIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGVYDAKAEGFVPGGGSLHNCMSGHGPDADTFEKASHIDTSKPA
KVGDTMAFMFETRTLIKPTRFALETAQLQAHYYECWQGLKKHFNPEQR
>Mature_448_residues
MDTQTRTPNTVSSRLEIEPGYQSGFANEFATEALPGALPEGRNSPQRVAYGLYAEQVSGTAFTAPRAHNRRSWLYRIRPA
AVHKPFTPLPSERLVANFAEVPPTPPNQLRWDPLPMPAEPTDFIDGWVTMAGNGAAESMSGCAIHLYAANRSMQDRFFYS
ADGELLIVPQEGRLDIATEMGRLEVEPFEIVVIPRGVRFAVSLPDGAARGYICENFGALLRLPDLGPIGSNGLANPRDFL
TPHAAYEDREGDFELVAKLNGNLWRADIGHSPLDVVAWHGNYAPYKYDLRRFNTIGSISFDHPDPSIFLVLQSQSDTPGV
DAIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGVYDAKAEGFVPGGGSLHNCMSGHGPDADTFEKASHIDTSKPA
KVGDTMAFMFETRTLIKPTRFALETAQLQAHYYECWQGLKKHFNPEQR

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=440, Percent_Identity=52.7272727272727, Blast_Score=462, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17507969, Length=432, Percent_Identity=53.0092592592593, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24583650, Length=434, Percent_Identity=52.073732718894, Blast_Score=437, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 49705; Mature: 49705

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTQTRTPNTVSSRLEIEPGYQSGFANEFATEALPGALPEGRNSPQRVAYGLYAEQVSGT
CCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCC
AFTAPRAHNRRSWLYRIRPAAVHKPFTPLPSERLVANFAEVPPTPPNQLRWDPLPMPAEP
EEECCCCCCCCCEEEEECHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
TDFIDGWVTMAGNGAAESMSGCAIHLYAANRSMQDRFFYSADGELLIVPQEGRLDIATEM
HHHHCCEEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCCEEEEECCCCEEEEECC
GRLEVEPFEIVVIPRGVRFAVSLPDGAARGYICENFGALLRLPDLGPIGSNGLANPRDFL
CCEEECCEEEEEECCCEEEEEECCCCCCCCCCHHCCCCEEECCCCCCCCCCCCCCCHHHC
TPHAAYEDREGDFELVAKLNGNLWRADIGHSPLDVVAWHGNYAPYKYDLRRFNTIGSISF
CCCCCCCCCCCCEEEEEEECCCEEEECCCCCCCEEEEECCCCCCEEHHHHHHCCCCCEEE
DHPDPSIFLVLQSQSDTPGVDAIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGVY
CCCCCEEEEEEECCCCCCCCCEEEEEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHHHH
DAKAEGFVPGGGSLHNCMSGHGPDADTFEKASHIDTSKPAKVGDTMAFMFETRTLIKPTR
HCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHCCCHH
FALETAQLQAHYYECWQGLKKHFNPEQR
HHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDTQTRTPNTVSSRLEIEPGYQSGFANEFATEALPGALPEGRNSPQRVAYGLYAEQVSGT
CCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCC
AFTAPRAHNRRSWLYRIRPAAVHKPFTPLPSERLVANFAEVPPTPPNQLRWDPLPMPAEP
EEECCCCCCCCCEEEEECHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
TDFIDGWVTMAGNGAAESMSGCAIHLYAANRSMQDRFFYSADGELLIVPQEGRLDIATEM
HHHHCCEEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCCEEEEECCCCEEEEECC
GRLEVEPFEIVVIPRGVRFAVSLPDGAARGYICENFGALLRLPDLGPIGSNGLANPRDFL
CCEEECCEEEEEECCCEEEEEECCCCCCCCCCHHCCCCEEECCCCCCCCCCCCCCCHHHC
TPHAAYEDREGDFELVAKLNGNLWRADIGHSPLDVVAWHGNYAPYKYDLRRFNTIGSISF
CCCCCCCCCCCCEEEEEEECCCEEEECCCCCCCEEEEECCCCCCEEHHHHHHCCCCCEEE
DHPDPSIFLVLQSQSDTPGVDAIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGVY
CCCCCEEEEEEECCCCCCCCCEEEEEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHHHH
DAKAEGFVPGGGSLHNCMSGHGPDADTFEKASHIDTSKPAKVGDTMAFMFETRTLIKPTR
HCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHCCCHH
FALETAQLQAHYYECWQGLKKHFNPEQR
HHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA