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The map label for this gene is glyA [H]

Identifier: 91781929

GI number: 91781929

Start: 613720

End: 614967

Strand: Direct

Name: glyA [H]

Synonym: Bxe_A3914

Alternate gene names: 91781929

Gene position: 613720-614967 (Clockwise)

Preceding gene: 91781920

Following gene: 91781930

Centisome position: 12.54

GC content: 62.34

Gene sequence:

>1248_bases
ATGTTTGACAGAGCCCAAAGCACCATCGCCAACGTCGATCCTGAACTCTGGAAGGTCATCGAGCAGGAAAACCGCCGTCA
GGAAGAGCACATCGAACTGATCGCGTCGGAAAACTACACGAGCCCGGCTGTCATGGCTGCGCAAGGCTCGCAACTCACGA
ACAAGTACGCCGAAGGGTATCCGGGCAAGCGCTATTACGGCGGTTGCGAGTACGTGGACATCGCCGAGCAGCTGGCGATC
GACCGTGTGAAGCAACTGTTCGGCGCCGAAGCCGCCAACGTGCAGCCGAACTCCGGCTCGCAGGCCAACCAGGGCGTGTT
CTTCGCCGTGCTCAAGCCGGGCGATACGATCATGGGCATGAGCCTCGCGCACGGAGGCCACCTGACTCACGGTTCGCCGG
TCAACATGTCGGGCAAGTGGTTCAACGTGGTGAGCTACGGCCTGAACGAAGCCGAAGACATCGACTACGAAGCCGCGGAG
AAGCTCGCTCAGGAACACAAGCCGAAGCTGATCGTGGCGGGCGCCTCCGCGTTCTCGCTGCGTATCGATTTCGAACGCAT
GTCGAAGATCGCCAGGTCGGTCGGCGCGTATTTCATGGTCGACATGGCGCATTACGCCGGTCTGATCGCCGCGGGCGTCT
ATCCGAATCCGGTGCCGCACGCCGATTTCGTCACCACCACCACGCACAAGAGCCTGCGCGGCCCGCGCGGCGGCGTGATC
CTGATGAAGGCGGAGTTCGAAAAGCAGATCAACTCGGCCATCTTCCCGGGCATTCAAGGTGGACCGTTGATGCACGTGAT
CGCCGGCAAGGCCGTCGCGTTCAAGGAAGCGCTCTCGCCGGAGTTCAAGGCGTATCAGCAGCAGGTCGTCGAAAACGCGC
GTGTGCTGGCGGAAACGCTGGTCAAGCGCGGTCTGCGCATCGTGTCGGGCCGCACTGAAAGCCATGTGATGCTCGTCGAC
CTGCGTGCAAAGAAGATTACCGGCAAGGCTGCGGAAGCAGCGCTGGGCACGGCTCACATCACGGTCAACAAGAACGCGAT
TCCGAACGATCCGGAAAAGCCGTTCGTGACGAGCGGCGTGCGTCTCGGCTCGCCGGCCATGACCACGCGCGGCTTCGGCG
TCAAGGAAGCCGAGCAGGTGGGTAACCTGATCGCCGACGTGCTGGACAACCCGGAAGACGCCGCCACGATCGAACGTGTG
CGCGCGCAGGTCGCCGAGCTGACCCAGCGCTTCCCGGTTTACCGTTAA

Upstream 100 bases:

>100_bases
GCCACGTCAGGGCTGGCCCAGCCGCCAGCAGCGCTGCGTACCCTCTACGCAAGATTCGGCACACGATCCGGTCAACCTGA
ACCCATTCAACGGAATCCGT

Downstream 100 bases:

>100_bases
GCCGCCATGCACTGCCCCTTCTGCCGTCACGCCGATACGCAGGTTGTCGACTCGCGCGTATCCGAAGACGGCGCAACGAT
TCGCCGGCGCCGCCGCTGCC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MFDRAQSTIANVDPELWKVIEQENRRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDIAEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAVLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNEAEDIDYEAAE
KLAQEHKPKLIVAGASAFSLRIDFERMSKIARSVGAYFMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEFEKQINSAIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQQQVVENARVLAETLVKRGLRIVSGRTESHVMLVD
LRAKKITGKAAEAALGTAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGVKEAEQVGNLIADVLDNPEDAATIERV
RAQVAELTQRFPVYR

Sequences:

>Translated_415_residues
MFDRAQSTIANVDPELWKVIEQENRRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDIAEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAVLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNEAEDIDYEAAE
KLAQEHKPKLIVAGASAFSLRIDFERMSKIARSVGAYFMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEFEKQINSAIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQQQVVENARVLAETLVKRGLRIVSGRTESHVMLVD
LRAKKITGKAAEAALGTAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGVKEAEQVGNLIADVLDNPEDAATIERV
RAQVAELTQRFPVYR
>Mature_415_residues
MFDRAQSTIANVDPELWKVIEQENRRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDIAEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAVLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNEAEDIDYEAAE
KLAQEHKPKLIVAGASAFSLRIDFERMSKIARSVGAYFMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEFEKQINSAIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQQQVVENARVLAETLVKRGLRIVSGRTESHVMLVD
LRAKKITGKAAEAALGTAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGVKEAEQVGNLIADVLDNPEDAATIERV
RAQVAELTQRFPVYR

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=454, Percent_Identity=40.9691629955947, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI261862350, Length=454, Percent_Identity=40.9691629955947, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI261862348, Length=454, Percent_Identity=40.9691629955947, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI19923315, Length=454, Percent_Identity=40.9691629955947, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI261862346, Length=453, Percent_Identity=40.6181015452539, Blast_Score=334, Evalue=8e-92,
Organism=Homo sapiens, GI22547186, Length=428, Percent_Identity=42.9906542056075, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI22547189, Length=413, Percent_Identity=40.9200968523002, Blast_Score=286, Evalue=4e-77,
Organism=Escherichia coli, GI1788902, Length=414, Percent_Identity=64.7342995169082, Blast_Score=554, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI25144732, Length=400, Percent_Identity=45.75, Blast_Score=351, Evalue=4e-97,
Organism=Caenorhabditis elegans, GI25144729, Length=400, Percent_Identity=45.75, Blast_Score=351, Evalue=5e-97,
Organism=Saccharomyces cerevisiae, GI6319739, Length=411, Percent_Identity=45.4987834549878, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6323087, Length=433, Percent_Identity=43.4180138568129, Blast_Score=336, Evalue=3e-93,
Organism=Drosophila melanogaster, GI24640005, Length=455, Percent_Identity=43.0769230769231, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI221329721, Length=455, Percent_Identity=43.0769230769231, Blast_Score=365, Evalue=1e-101,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45110; Mature: 45110

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDRAQSTIANVDPELWKVIEQENRRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHCCC
PGKRYYGGCEYVDIAEQLAIDRVKQLFGAEAANVQPNSGSQANQGVFFAVLKPGDTIMGM
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAHGGHLTHGSPVNMSGKWFNVVSYGLNEAEDIDYEAAEKLAQEHKPKLIVAGASAFSL
EECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEEECCCEEEE
RIDFERMSKIARSVGAYFMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKAEFEKQINSAIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQQQVVENARVLAETL
EEEHHHHHHHHHHHCCCCCCCCEEEEHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VKRGLRIVSGRTESHVMLVDLRAKKITGKAAEAALGTAHITVNKNAIPNDPEKPFVTSGV
HHCCCEEECCCCCCEEEEEEECHHHHCCHHHHHHCCEEEEEECCCCCCCCCCCCCEECCE
RLGSPAMTTRGFGVKEAEQVGNLIADVLDNPEDAATIERVRAQVAELTQRFPVYR
ECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFDRAQSTIANVDPELWKVIEQENRRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHCCC
PGKRYYGGCEYVDIAEQLAIDRVKQLFGAEAANVQPNSGSQANQGVFFAVLKPGDTIMGM
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAHGGHLTHGSPVNMSGKWFNVVSYGLNEAEDIDYEAAEKLAQEHKPKLIVAGASAFSL
EECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEEECCCEEEE
RIDFERMSKIARSVGAYFMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKAEFEKQINSAIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQQQVVENARVLAETL
EEEHHHHHHHHHHHCCCCCCCCEEEEHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VKRGLRIVSGRTESHVMLVDLRAKKITGKAAEAALGTAHITVNKNAIPNDPEKPFVTSGV
HHCCCEEECCCCCCEEEEEEECHHHHCCHHHHHHCCEEEEEECCCCCCCCCCCCCEECCE
RLGSPAMTTRGFGVKEAEQVGNLIADVLDNPEDAATIERVRAQVAELTQRFPVYR
ECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA