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The map label for this gene is hemH [H]

Identifier: 91781880

GI number: 91781880

Start: 561861

End: 562931

Strand: Direct

Name: hemH [H]

Synonym: Bxe_A3965

Alternate gene names: 91781880

Gene position: 561861-562931 (Clockwise)

Preceding gene: 91781879

Following gene: 91781881

Centisome position: 11.48

GC content: 63.87

Gene sequence:

>1071_bases
ATGCGCTTCGACCTCGAGCGGCCTTCACAGAACGCCACGTCACACCGTGTCGCCGTGCTGCTGATCAATCTCGGCACGCC
CGACGCGCCGACGCCGCGCGCGGTCCGCCGCTATCTCGCGCAGTTTCTGTCCGATCCGCGCGTGGTCGAAATTCCGGCGC
TGCTCTGGCAGATCATCTTGCGTCTGCTGATCCTGCCGTTCCGGGGCAGTGCCTCGGCCAAGAAGTACGCTGCGGTGTGG
ATGCCCGAAGGCTCGCCGCTGCGCGTGTATACAGAGAAGCAGGTGGAGGGCTTGCGCCATCTGCTGCAACTGAACGACTA
CACGGTGCTGGTCGATTACGCGATGCGCTACGGTACGCCGGGTATTCCGGCCATGCTGAACCAGCTCAAGCTGGCAGGCG
CCGAACGCGTGCTGCTCATGCCCATGTATCCGCAGTATTCGTCGTCCACCACCGCCACCGCTTTCGACGACGCCTTTTCG
GCGCTCAAGCGCATGCGCAATCAGCCGGAAATTCGCACGGTGCGCCAGTACGCCGATCATCCGGCCTACATTGCGGCGCT
TGCCGCACAGGTGCATCAATATTGGCATCAGCATGGCCGGCCGGATTTCGCCGCGGGCGACAAGCTGGTGCTGAGTTTTC
ACGGCGTGCCCAAACGCACGCTGGATCTCGGCGACCCATACCATGAGCAATGCCAGCAAACGGGCGCGCTGCTGATGCAG
GCGCTCGAACTGACGCCGGTGGAGTGCCGCATTACGTTCCAGTCGCGTTTCGGCAAGGCCGAGTGGCTGCAGCCGTATAC
GGCGCCCACGCTCAAGGAACTGGGCGCGGCGGGCGTGCGGCGCGCCGATGTGTTCTGTCCGGGCTTTACTGCCGACTGCC
TTGAGACCATCGAGGAAATCGGCATGGAAGTGCGCGATGAATTCCTGCACGCGGGCGGCAAGGATTTTCATCGGATTCCC
TGCCTGAATGCGTCGCAGGCCTGGATTGCCGCGCTGGGCGAAATCGTCGCGCAGAATCTCCAGGGCTGGCCGGTGCAGGC
GCTGCCGGTGCCGCATACGACAGGAGCTTGA

Upstream 100 bases:

>100_bases
AATGGCCAGGGGTGTCCGGCGGACCGGTGCATGCACCACGCCGCTATAATGGTTCTCACCTGAACCGACACTCCGCCTGA
GCGGGTTACCTCTGCTGCCT

Downstream 100 bases:

>100_bases
ACAGGCTCATGAATTACGGGATCTCAACCGAAGCGGGCGCGAAACTGCGCATCGACAAATGGCTTTGGGCCGCGCGCTTT
TTCAAGACGCGTTCGCTCGC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MRFDLERPSQNATSHRVAVLLINLGTPDAPTPRAVRRYLAQFLSDPRVVEIPALLWQIILRLLILPFRGSASAKKYAAVW
MPEGSPLRVYTEKQVEGLRHLLQLNDYTVLVDYAMRYGTPGIPAMLNQLKLAGAERVLLMPMYPQYSSSTTATAFDDAFS
ALKRMRNQPEIRTVRQYADHPAYIAALAAQVHQYWHQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHEQCQQTGALLMQ
ALELTPVECRITFQSRFGKAEWLQPYTAPTLKELGAAGVRRADVFCPGFTADCLETIEEIGMEVRDEFLHAGGKDFHRIP
CLNASQAWIAALGEIVAQNLQGWPVQALPVPHTTGA

Sequences:

>Translated_356_residues
MRFDLERPSQNATSHRVAVLLINLGTPDAPTPRAVRRYLAQFLSDPRVVEIPALLWQIILRLLILPFRGSASAKKYAAVW
MPEGSPLRVYTEKQVEGLRHLLQLNDYTVLVDYAMRYGTPGIPAMLNQLKLAGAERVLLMPMYPQYSSSTTATAFDDAFS
ALKRMRNQPEIRTVRQYADHPAYIAALAAQVHQYWHQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHEQCQQTGALLMQ
ALELTPVECRITFQSRFGKAEWLQPYTAPTLKELGAAGVRRADVFCPGFTADCLETIEEIGMEVRDEFLHAGGKDFHRIP
CLNASQAWIAALGEIVAQNLQGWPVQALPVPHTTGA
>Mature_356_residues
MRFDLERPSQNATSHRVAVLLINLGTPDAPTPRAVRRYLAQFLSDPRVVEIPALLWQIILRLLILPFRGSASAKKYAAVW
MPEGSPLRVYTEKQVEGLRHLLQLNDYTVLVDYAMRYGTPGIPAMLNQLKLAGAERVLLMPMYPQYSSSTTATAFDDAFS
ALKRMRNQPEIRTVRQYADHPAYIAALAAQVHQYWHQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHEQCQQTGALLMQ
ALELTPVECRITFQSRFGKAEWLQPYTAPTLKELGAAGVRRADVFCPGFTADCLETIEEIGMEVRDEFLHAGGKDFHRIP
CLNASQAWIAALGEIVAQNLQGWPVQALPVPHTTGA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=266, Percent_Identity=26.6917293233083, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI60499021, Length=266, Percent_Identity=26.6917293233083, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI1786681, Length=322, Percent_Identity=45.9627329192547, Blast_Score=273, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6324750, Length=354, Percent_Identity=25.4237288135593, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17864156, Length=337, Percent_Identity=24.3323442136499, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24651774, Length=265, Percent_Identity=24.5283018867925, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 39782; Mature: 39782

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFDLERPSQNATSHRVAVLLINLGTPDAPTPRAVRRYLAQFLSDPRVVEIPALLWQIIL
CCCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
RLLILPFRGSASAKKYAAVWMPEGSPLRVYTEKQVEGLRHLLQLNDYTVLVDYAMRYGTP
HHHHCCCCCCCCCCCEEEEECCCCCCEEEEEHHHHHHHHHHHHHCCCCEEEHHHHHCCCC
GIPAMLNQLKLAGAERVLLMPMYPQYSSSTTATAFDDAFSALKRMRNQPEIRTVRQYADH
CHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PAYIAALAAQVHQYWHQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHEQCQQTGALLMQ
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
ALELTPVECRITFQSRFGKAEWLQPYTAPTLKELGAAGVRRADVFCPGFTADCLETIEEI
HHHCCCEEEEEEEHHHCCCHHHCCCCCCHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHH
GMEVRDEFLHAGGKDFHRIPCLNASQAWIAALGEIVAQNLQGWPVQALPVPHTTGA
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCC
>Mature Secondary Structure
MRFDLERPSQNATSHRVAVLLINLGTPDAPTPRAVRRYLAQFLSDPRVVEIPALLWQIIL
CCCCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
RLLILPFRGSASAKKYAAVWMPEGSPLRVYTEKQVEGLRHLLQLNDYTVLVDYAMRYGTP
HHHHCCCCCCCCCCCEEEEECCCCCCEEEEEHHHHHHHHHHHHHCCCCEEEHHHHHCCCC
GIPAMLNQLKLAGAERVLLMPMYPQYSSSTTATAFDDAFSALKRMRNQPEIRTVRQYADH
CHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PAYIAALAAQVHQYWHQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHEQCQQTGALLMQ
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
ALELTPVECRITFQSRFGKAEWLQPYTAPTLKELGAAGVRRADVFCPGFTADCLETIEEI
HHHCCCEEEEEEEHHHCCCHHHCCCCCCHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHH
GMEVRDEFLHAGGKDFHRIPCLNASQAWIAALGEIVAQNLQGWPVQALPVPHTTGA
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA