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The map label for this gene is apt [H]

Identifier: 91781731

GI number: 91781731

Start: 381657

End: 382223

Strand: Direct

Name: apt [H]

Synonym: Bxe_A4115

Alternate gene names: 91781731

Gene position: 381657-382223 (Clockwise)

Preceding gene: 91781730

Following gene: 91781732

Centisome position: 7.8

GC content: 63.84

Gene sequence:

>567_bases
ATGTCCAACGCGCTTCCGAGCGCGCCGCTCGATGCGGCCGATTACATCAAAAGCCACATCCGCACGGTGCCCGACTGGCC
GGAGCCGGGCGTGCAGTTCCGCGATATCACGCCGCTGCTGCAGGAGCCGAAGTCGCTGCGCGTGCTGATCGATCTGTTCG
TGCAGCGCTATATCGACGCGAAGCTCGACTACATTGCCGGGCTGGACGCGCGCGGGTTCATCATCGGGCCGATTCTCGCG
TATGAGCTGAACCTCGGCTTCATTCCGATCCGCAAGGCGGGCAAGCTGCCCTACAACCGGCTCGCGCAATCTTATGAACT
CGAATACGGCTGCGCAACCGTCGAGATTCACGAAGACGCCTGCAAGCCCGGCGACCGCGTGGTCATCATCGACGACCTGA
TCGCCACGGGCGGCACGATGATGGCCGGCAAGATCCTGCTCGAACGGCTCGGCGCGGTCGTGGTGGAAGGCGCGGCGATC
ATCGATCTGCCCGAACTCGGCGGTTCGAAGCTGCTGCGCGACAGTGGGCTGGCGCTCTATACGGTGACCGGATTCGAGGG
TCACTGA

Upstream 100 bases:

>100_bases
GCGCCGCCGCCTAGCGCCTGTACCCCGGCTGCGCGCGTTCCCGCCGCGGCATCCTGGTTTGGTTTTTCATCGGACCTGTC
GAGGTCCATCCGGAGACATC

Downstream 100 bases:

>100_bases
TCACCGGCAGCCAACCCGCTGCGAACTTCTTCTTTCTGTCCATCGAGAAGGTCAAAAGCATGCCTGACTTCCTGCTGTTT
CTCGCTACCTCGATTGCGAT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MSNALPSAPLDAADYIKSHIRTVPDWPEPGVQFRDITPLLQEPKSLRVLIDLFVQRYIDAKLDYIAGLDARGFIIGPILA
YELNLGFIPIRKAGKLPYNRLAQSYELEYGCATVEIHEDACKPGDRVVIIDDLIATGGTMMAGKILLERLGAVVVEGAAI
IDLPELGGSKLLRDSGLALYTVTGFEGH

Sequences:

>Translated_188_residues
MSNALPSAPLDAADYIKSHIRTVPDWPEPGVQFRDITPLLQEPKSLRVLIDLFVQRYIDAKLDYIAGLDARGFIIGPILA
YELNLGFIPIRKAGKLPYNRLAQSYELEYGCATVEIHEDACKPGDRVVIIDDLIATGGTMMAGKILLERLGAVVVEGAAI
IDLPELGGSKLLRDSGLALYTVTGFEGH
>Mature_187_residues
SNALPSAPLDAADYIKSHIRTVPDWPEPGVQFRDITPLLQEPKSLRVLIDLFVQRYIDAKLDYIAGLDARGFIIGPILAY
ELNLGFIPIRKAGKLPYNRLAQSYELEYGCATVEIHEDACKPGDRVVIIDDLIATGGTMMAGKILLERLGAVVVEGAAII
DLPELGGSKLLRDSGLALYTVTGFEGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=161, Percent_Identity=52.1739130434783, Blast_Score=156, Evalue=1e-38,
Organism=Homo sapiens, GI71773201, Length=126, Percent_Identity=54.7619047619048, Blast_Score=135, Evalue=3e-32,
Organism=Escherichia coli, GI1786675, Length=182, Percent_Identity=45.0549450549451, Blast_Score=176, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17509087, Length=165, Percent_Identity=44.2424242424242, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=164, Percent_Identity=40.8536585365854, Blast_Score=112, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=164, Percent_Identity=34.1463414634146, Blast_Score=85, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17136334, Length=164, Percent_Identity=43.2926829268293, Blast_Score=131, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 20476; Mature: 20345

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNALPSAPLDAADYIKSHIRTVPDWPEPGVQFRDITPLLQEPKSLRVLIDLFVQRYIDA
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEECCCCHHHHCCHHHHHHHHHHHHHHHHH
KLDYIAGLDARGFIIGPILAYELNLGFIPIRKAGKLPYNRLAQSYELEYGCATVEIHEDA
HHHHHHCCCCCCEEECCEEEEEECCCEEECCCCCCCCHHHHHHHHCCCCCEEEEEECCCC
CKPGDRVVIIDDLIATGGTMMAGKILLERLGAVVVEGAAIIDLPELGGSKLLRDSGLALY
CCCCCEEEEEECHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHCCCEEEE
TVTGFEGH
EECCCCCC
>Mature Secondary Structure 
SNALPSAPLDAADYIKSHIRTVPDWPEPGVQFRDITPLLQEPKSLRVLIDLFVQRYIDA
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEECCCCHHHHCCHHHHHHHHHHHHHHHHH
KLDYIAGLDARGFIIGPILAYELNLGFIPIRKAGKLPYNRLAQSYELEYGCATVEIHEDA
HHHHHHCCCCCCEEECCEEEEEECCCEEECCCCCCCCHHHHHHHHCCCCCEEEEEECCCC
CKPGDRVVIIDDLIATGGTMMAGKILLERLGAVVVEGAAIIDLPELGGSKLLRDSGLALY
CCCCCEEEEEECHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHCCCEEEE
TVTGFEGH
EECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA