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The map label for this gene is aceK [H]

Identifier: 91781593

GI number: 91781593

Start: 242240

End: 244078

Strand: Reverse

Name: aceK [H]

Synonym: Bxe_A4253

Alternate gene names: 91781593

Gene position: 244078-242240 (Counterclockwise)

Preceding gene: 91781594

Following gene: 91781592

Centisome position: 4.99

GC content: 58.24

Gene sequence:

>1839_bases
ATGAATCACTTTCCCAAATTGCTGTCGTCGCAAATCGGCTTTGACGTCGCACAGACGATGCTCGAAGGATTCGACCGGCA
TTACCGGATTTTTCGCGACGCCGCGATCCACGCCAAGACGCTCTTTGAACAGGCCGACTGGCATGGTCTGCAAAAGCTCG
CGCGCGACCGCATTACCTCGTACGACGAACGCGTCGAGGAATGCGTCGAACTGCTCGAAGACGAATACGACGCGGAAAAT
ATCGACGACGAAGTGTGGCAGCAGATCAAGCTGCACTATATCGGCCTTTTGACCACGCACCGCCAGCCCGAATGCGCGGA
GACGTTTTTCAATTCGGTGTGCTGCAAGATCCTGCACCGCTCGTACTTCAGCAACGATTTCATTTTCGTGCGCCCGGCCA
TCTCGACCGAATACATCGAGAACGACGAACCGGCCGCGAAGCCGACCTACCGTGCGTACTATCCCGGCAAGGATGGGCTC
GCGGCAACGCTCGAACGCATTGTCACGAACTTCCAGTTGGAGCCGCCGTTTGAAGACCTGACACGCGACGTCGGCTGCGT
GATGCAGGCAATCCAGGACGCGTTCGGCGTGTTCGACGAAGCGCCCAACTTTCAGATTCACGTGCTCTCGTCGCTGTTCT
ACCGGAACAAGTCGGCGTATATCATCGGGCGGATCATCAACGGCGATCTGCTGATGCCGTTCGCGGTGCCGCTGCGGCAT
GTGAAACCGGGCGTGCTCGCGCTCGACACGGTACTGCTCAAGCGCGACCAGTTGCTGATCATTTTCAGCTTTTCGCATTC
GTACTTCCTCGTAGATATGGAAGTGCCGTCCGCTTATGTCGAGTTTCTCGGCACCATCATGCAGGGCAAACCGAAAGCGG
AAATCTATACGTCGGTGGGTTTGCAGAAGCAGGGCAAGAATCTGTTCTATCGCGACCTGCTGCATCACCTGTCGCATTCG
AGCGATCAGTTCATCATCGCGCCCGGCATCAAGGGGCTCGTGATGCTGGTGTTCACGCTGCCCTCGTTTCCGTACGTGTT
CAAGCTGATCAAGGACAGCTTCCCGCCGCCGAAGGAAACCACGCGCGCGCAGATCAAGGAAAAGTATCAGCTCGTCAAAC
GGCACGACCGCCTGGGCCGCATGGCCGACACACTCGAATATTCGAGCGTCGCGTTGCCGGTCTCGCGGCTCGATGAAGCG
CTGGTGCGTGAACTCGAAAAGGAAGTGCCGTCGCTGATCGAATACGACGGCGACAGCCTGGTGATTCGCCATATGTATAT
CGAACGCCGCATGGTGCCGCTGAATCTGTTCCTCCAGAACGGCAACGACGAGGACATCGAACACGGCATCAAGGAATACG
GCAATGCAATCAAGGAACTGATGCAGGCGAACATCTTTCCGGGCGACATGCTGTACAAGAACTTCGGCGTCACGCGTCAC
GGCCGCGTGGTGTTCTACGACTACGATGAAATCGAATATCTGACCGACTGCAACGTGCGCGCGGTGCCGGCGCCACGCAA
CGAGGAAGACGAAATGTCCGGCGAGCCGTGGTACTCGGTCGGCCCGCACGATATTTTCCCGGAGACGTACGGCACATTTC
TGCTCGGCGACCCACGCGTGCGCCGTTCCTTCATGCAGCATCACGCGGACTTCTTCGATCCTGCGCTATGGCAACGGCAC
AAGGATCATCTATTGAAAGGCGAACTGGCCGATTTTTTCCCGTACGACGGCAGCGTGCGCTTCTGCATGCGCTATCCGGA
GCGCTTTGCCGATGCCGCCGGAGCCGCATCAAACGAGCAGGACGCGCCGGACGCCGGGCGCAGCGTGCGGGCAGCGTGA

Upstream 100 bases:

>100_bases
GCCAGGCCGGCATGAACAAGGGCGGCGCGACGCGTCGCGGGCGCACCCGGGCGATACAATCACGGGTGTCTTCACGACAT
GAGACGAATGCACGGTCGAC

Downstream 100 bases:

>100_bases
GACTCATACGCTGCTCGCCGTGTTGAATGCCTCGTCCTAACCTTATGTAACGACATCGACCGGTCAAGCGGTCGAGCAAC
CACTCAGACGCACCATGAAC

Product: bifunctional isocitrate dehydrogenase kinase/phosphatase protein

Products: NA

Alternate protein names: IDH kinase/phosphatase; IDHK/P [H]

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MNHFPKLLSSQIGFDVAQTMLEGFDRHYRIFRDAAIHAKTLFEQADWHGLQKLARDRITSYDERVEECVELLEDEYDAEN
IDDEVWQQIKLHYIGLLTTHRQPECAETFFNSVCCKILHRSYFSNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGKDGL
AATLERIVTNFQLEPPFEDLTRDVGCVMQAIQDAFGVFDEAPNFQIHVLSSLFYRNKSAYIIGRIINGDLLMPFAVPLRH
VKPGVLALDTVLLKRDQLLIIFSFSHSYFLVDMEVPSAYVEFLGTIMQGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHS
SDQFIIAPGIKGLVMLVFTLPSFPYVFKLIKDSFPPPKETTRAQIKEKYQLVKRHDRLGRMADTLEYSSVALPVSRLDEA
LVRELEKEVPSLIEYDGDSLVIRHMYIERRMVPLNLFLQNGNDEDIEHGIKEYGNAIKELMQANIFPGDMLYKNFGVTRH
GRVVFYDYDEIEYLTDCNVRAVPAPRNEEDEMSGEPWYSVGPHDIFPETYGTFLLGDPRVRRSFMQHHADFFDPALWQRH
KDHLLKGELADFFPYDGSVRFCMRYPERFADAAGAASNEQDAPDAGRSVRAA

Sequences:

>Translated_612_residues
MNHFPKLLSSQIGFDVAQTMLEGFDRHYRIFRDAAIHAKTLFEQADWHGLQKLARDRITSYDERVEECVELLEDEYDAEN
IDDEVWQQIKLHYIGLLTTHRQPECAETFFNSVCCKILHRSYFSNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGKDGL
AATLERIVTNFQLEPPFEDLTRDVGCVMQAIQDAFGVFDEAPNFQIHVLSSLFYRNKSAYIIGRIINGDLLMPFAVPLRH
VKPGVLALDTVLLKRDQLLIIFSFSHSYFLVDMEVPSAYVEFLGTIMQGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHS
SDQFIIAPGIKGLVMLVFTLPSFPYVFKLIKDSFPPPKETTRAQIKEKYQLVKRHDRLGRMADTLEYSSVALPVSRLDEA
LVRELEKEVPSLIEYDGDSLVIRHMYIERRMVPLNLFLQNGNDEDIEHGIKEYGNAIKELMQANIFPGDMLYKNFGVTRH
GRVVFYDYDEIEYLTDCNVRAVPAPRNEEDEMSGEPWYSVGPHDIFPETYGTFLLGDPRVRRSFMQHHADFFDPALWQRH
KDHLLKGELADFFPYDGSVRFCMRYPERFADAAGAASNEQDAPDAGRSVRAA
>Mature_612_residues
MNHFPKLLSSQIGFDVAQTMLEGFDRHYRIFRDAAIHAKTLFEQADWHGLQKLARDRITSYDERVEECVELLEDEYDAEN
IDDEVWQQIKLHYIGLLTTHRQPECAETFFNSVCCKILHRSYFSNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGKDGL
AATLERIVTNFQLEPPFEDLTRDVGCVMQAIQDAFGVFDEAPNFQIHVLSSLFYRNKSAYIIGRIINGDLLMPFAVPLRH
VKPGVLALDTVLLKRDQLLIIFSFSHSYFLVDMEVPSAYVEFLGTIMQGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHS
SDQFIIAPGIKGLVMLVFTLPSFPYVFKLIKDSFPPPKETTRAQIKEKYQLVKRHDRLGRMADTLEYSSVALPVSRLDEA
LVRELEKEVPSLIEYDGDSLVIRHMYIERRMVPLNLFLQNGNDEDIEHGIKEYGNAIKELMQANIFPGDMLYKNFGVTRH
GRVVFYDYDEIEYLTDCNVRAVPAPRNEEDEMSGEPWYSVGPHDIFPETYGTFLLGDPRVRRSFMQHHADFFDPALWQRH
KDHLLKGELADFFPYDGSVRFCMRYPERFADAAGAASNEQDAPDAGRSVRAA

Specific function: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source

COG id: COG4579

COG function: function code T; Isocitrate dehydrogenase kinase/phosphatase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AceK family [H]

Homologues:

Organism=Escherichia coli, GI1790446, Length=572, Percent_Identity=41.4335664335664, Blast_Score=461, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010452
- ProDom:   PD043552 [H]

Pfam domain/function: PF06315 AceK [H]

EC number: =2.7.11.5 [H]

Molecular weight: Translated: 70543; Mature: 70543

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHFPKLLSSQIGFDVAQTMLEGFDRHYRIFRDAAIHAKTLFEQADWHGLQKLARDRITS
CCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YDERVEECVELLEDEYDAENIDDEVWQQIKLHYIGLLTTHRQPECAETFFNSVCCKILHR
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHH
SYFSNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGKDGLAATLERIVTNFQLEPPFEDL
HHCCCCEEEEECCCCHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCHHHH
TRDVGCVMQAIQDAFGVFDEAPNFQIHVLSSLFYRNKSAYIIGRIINGDLLMPFAVPLRH
HHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCCCEEEEEEECCCEEHHHHHHHHH
VKPGVLALDTVLLKRDQLLIIFSFSHSYFLVDMEVPSAYVEFLGTIMQGKPKAEIYTSVG
CCCCHHHHHHHHHCCCCEEEEEEECCCEEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCC
LQKQGKNLFYRDLLHHLSHSSDQFIIAPGIKGLVMLVFTLPSFPYVFKLIKDSFPPPKET
CHHCCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHH
TRAQIKEKYQLVKRHDRLGRMADTLEYSSVALPVSRLDEALVRELEKEVPSLIEYDGDSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
VIRHMYIERRMVPLNLFLQNGNDEDIEHGIKEYGNAIKELMQANIFPGDMLYKNFGVTRH
EHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCC
GRVVFYDYDEIEYLTDCNVRAVPAPRNEEDEMSGEPWYSVGPHDIFPETYGTFLLGDPRV
CEEEEEECCCHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHH
RRSFMQHHADFFDPALWQRHKDHLLKGELADFFPYDGSVRFCMRYPERFADAAGAASNEQ
HHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCC
DAPDAGRSVRAA
CCCCCCCCCCCC
>Mature Secondary Structure
MNHFPKLLSSQIGFDVAQTMLEGFDRHYRIFRDAAIHAKTLFEQADWHGLQKLARDRITS
CCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YDERVEECVELLEDEYDAENIDDEVWQQIKLHYIGLLTTHRQPECAETFFNSVCCKILHR
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHH
SYFSNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGKDGLAATLERIVTNFQLEPPFEDL
HHCCCCEEEEECCCCHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCHHHH
TRDVGCVMQAIQDAFGVFDEAPNFQIHVLSSLFYRNKSAYIIGRIINGDLLMPFAVPLRH
HHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCCCEEEEEEECCCEEHHHHHHHHH
VKPGVLALDTVLLKRDQLLIIFSFSHSYFLVDMEVPSAYVEFLGTIMQGKPKAEIYTSVG
CCCCHHHHHHHHHCCCCEEEEEEECCCEEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCC
LQKQGKNLFYRDLLHHLSHSSDQFIIAPGIKGLVMLVFTLPSFPYVFKLIKDSFPPPKET
CHHCCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHH
TRAQIKEKYQLVKRHDRLGRMADTLEYSSVALPVSRLDEALVRELEKEVPSLIEYDGDSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
VIRHMYIERRMVPLNLFLQNGNDEDIEHGIKEYGNAIKELMQANIFPGDMLYKNFGVTRH
EHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCC
GRVVFYDYDEIEYLTDCNVRAVPAPRNEEDEMSGEPWYSVGPHDIFPETYGTFLLGDPRV
CEEEEEECCCHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHH
RRSFMQHHADFFDPALWQRHKDHLLKGELADFFPYDGSVRFCMRYPERFADAAGAASNEQ
HHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCC
DAPDAGRSVRAA
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA