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The map label for this gene is mrdA [H]

Identifier: 91781445

GI number: 91781445

Start: 76453

End: 78756

Strand: Reverse

Name: mrdA [H]

Synonym: Bxe_A4401

Alternate gene names: 91781445

Gene position: 78756-76453 (Counterclockwise)

Preceding gene: 91781446

Following gene: 91781444

Centisome position: 1.61

GC content: 65.67

Gene sequence:

>2304_bases
ATGACCGAATTCAAGGACACCCAGCAACAGCTCTCGAAGTTCCGCCTGCGCGTCGCGGCGGCGGGTCTGTTCGTGTTCGT
CTGCTTCGGGCTGATCGGCTTCCGGTTCCTGTTCCTGCAGGTCTGGCACTACAGCAAATACTCGCTGCAAGCCGATGAAA
ACCGCATTTCCGTCGCGCCGATCGTACCGAACCGCGGCATCATCACCGACCGCAACGGCGTGGTGCTGGCCAAGAACTAC
TCGGCCTACACGCTCGAAATTACGCCCTCGAAGCTGAACGACTCGCTCGAAAACGTGATCGACAACCTGGCCACCGTCGT
CTCGATCGACGCGCGCGACCGCCGCCGCTTCAAGAAGCTGCAGGAAGACTCGAAGAACTTCGAGAGCCTGCCCATCCGCA
CCCGCCTGACCGACGACGAAGTCGCGCGCTTCACCGCGCAGCGCTTCCGTTTTCCCGGCGTGGAAGTGCGCGCGCGCCTG
TTCCGCCAATATCCGCTCGGACCGACGGCGGCGCACGTGATCGGCTACATCGGCCGGATTTCGCAGCGCGATCAGGACCG
TATCGACGACGCCAGCGACCAGAACGACAGCGATCCCGACCACTACGATCCGCGGCTGGACGCGAACAACTACAAGGGCA
CCGACTACATCGGCAAGATCGGCGTCGAGCAGAGTTACGAGACCGAACTGCACGGCCAGACCGGTTTCGAGGAAGTGGAA
GTGACCGCCGGCGGCCGCCCGGTGCGCACCTTGTCGCGCACCCAGGCAACGCCGGGCAACAACCTCGTGCTGTCTTTGGA
TATCGGCTTGCAGCAGGTCGCCGAGCAGGCCTTCGCGGGACGGCGCGGCGCGCTGGTCGCCATCGAGCCATCGTCGGGCG
ACGTGCTCGCGTTCGTGTCCGCGCCGAGCTTCGATCCCAATTCGTTCGTCGACGGCATCGACCAGCAGACGTGGGACGAT
CTCAACAATTCGCCCGACCATCCGCTACTCAACCGGCCGCTGCACGGCACCTATCCGCCCGGCTCGACCTACAAGCCGTT
CATGGCGCTCGCCGCGCTCACACTGCATAAGCGCACGCCGGGCTGGGGCTTCCAGGATCCGGGCTCGTACACCTTCGGCG
GTCACACGTTCCGCAACGACGTGCGTTCGGGCCAGGGTTGGGTCGACATGAACCGCGCAATCGTGGTGTCGAACGACACG
TATTTCTACATGCTCGCGCACGATCTCGGCGTCAACAATATTGCCAACTTCATGAAGCCGTGGGGTTTCGGCCAGATCAC
CGGCATCGACATTTCGGGCGAGGCGCGCGGCATCCTGCCGTCCACCGAATGGAAGCGCAAGGCGTACCGCAAGCCCGAAC
AGCAACGGTGGTATGAAGGCGAGACGATCAGTCTCGGCATCGGCCAGGGCTACAACTCGTTCACCATTCTCCAGCTTGCT
CACGCCACGGCCACACTCGCGAACAACGGTGTCGTGATGAAGCCGCACCTCGTGCGCGACATCGAAAACCCGATCACCAA
AGAGACCCGGCCGGTCGTGCGCGATCCGAGCGACAGGATCGCGGTGAAGCAATCGGATATCGACATCATCAAGCGCGCAA
TGGTAGGCGTCGTGACCAATGGCACGGCGTCGAAACTATTCGTCGGCGCGCCGTACCAGGCGGCCGGCAAGACCGGCACG
GCGCAGGTCTACTCGCTGCAAGGCGCGAACTACAAGGGCCACGCGATCGCCGAACATCTGCGCGACCACGCGCTCTTCAT
CGCCTTCGCACCGGCCGAGCAGCCGAAGATCGCGCTCGCGCTGATCGTCGAAAACGGCGGCTGGGGTGCGGAAGCGGCGG
GCCCGATCGCGCGGAAGGTGCTCGACTACTACCTCGTCGGCAAGAACAAACCGGGCGCTCAGGCGGCGGCCATCGAGGCA
GCGGCATCGGCAACCGAAGACGCGTCCGCGCCCGAAGTCGGCGGCGCACCGGCGCCACAGGAGGCGGTGCAGCCGGTCAA
GGTCGCTGCGGGCTTCACTGCCCTGCCGATTCCCGGTGCGGCTTCGGCCGCAGAGGCGGCCTCCGCTGCGGCGGCTGCCT
CGGCGGCGAGCGCGGCATCGGCCTCGGCATCTGCTGCCGCGTCGGCGCCCGTGGCCGCCTCCACGTCCGCTGCCGCAAAG
AATCCGACGCCGCGTAAATCCGGCGCCCCGCATAAACCCCGTCCGGCCAGCGAGCCGGCGCCGAGCGCCGCGGCACCGTC
GCGCGATGACGGTATTCAGGCCACGTCGCCACGCCAGCCGGTTTCCGGCGGCATCGACGAGTAA

Upstream 100 bases:

>100_bases
TGCCGGCCCGCTCGACGCGCATCGCAGTTCATGCCTTCCGGTTCCGGCCGGAAAAGGCGCACACTCATCATGGCCGTCAT
CCGGCCTTTTGCAGAATCGC

Downstream 100 bases:

>100_bases
GGAGAAAGGCATGCAATTCGACAAGCGCGCCTGGCTCGATCGCATCAAGCGGATGTTCGCGGGCTTCGACCGTCCGCTCG
CACTGATCGTGTTTCTGCTT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 767; Mature: 766

Protein sequence:

>767_residues
MTEFKDTQQQLSKFRLRVAAAGLFVFVCFGLIGFRFLFLQVWHYSKYSLQADENRISVAPIVPNRGIITDRNGVVLAKNY
SAYTLEITPSKLNDSLENVIDNLATVVSIDARDRRRFKKLQEDSKNFESLPIRTRLTDDEVARFTAQRFRFPGVEVRARL
FRQYPLGPTAAHVIGYIGRISQRDQDRIDDASDQNDSDPDHYDPRLDANNYKGTDYIGKIGVEQSYETELHGQTGFEEVE
VTAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGRRGALVAIEPSSGDVLAFVSAPSFDPNSFVDGIDQQTWDD
LNNSPDHPLLNRPLHGTYPPGSTYKPFMALAALTLHKRTPGWGFQDPGSYTFGGHTFRNDVRSGQGWVDMNRAIVVSNDT
YFYMLAHDLGVNNIANFMKPWGFGQITGIDISGEARGILPSTEWKRKAYRKPEQQRWYEGETISLGIGQGYNSFTILQLA
HATATLANNGVVMKPHLVRDIENPITKETRPVVRDPSDRIAVKQSDIDIIKRAMVGVVTNGTASKLFVGAPYQAAGKTGT
AQVYSLQGANYKGHAIAEHLRDHALFIAFAPAEQPKIALALIVENGGWGAEAAGPIARKVLDYYLVGKNKPGAQAAAIEA
AASATEDASAPEVGGAPAPQEAVQPVKVAAGFTALPIPGAASAAEAASAAAAASAASAASASASAAASAPVAASTSAAAK
NPTPRKSGAPHKPRPASEPAPSAAAPSRDDGIQATSPRQPVSGGIDE

Sequences:

>Translated_767_residues
MTEFKDTQQQLSKFRLRVAAAGLFVFVCFGLIGFRFLFLQVWHYSKYSLQADENRISVAPIVPNRGIITDRNGVVLAKNY
SAYTLEITPSKLNDSLENVIDNLATVVSIDARDRRRFKKLQEDSKNFESLPIRTRLTDDEVARFTAQRFRFPGVEVRARL
FRQYPLGPTAAHVIGYIGRISQRDQDRIDDASDQNDSDPDHYDPRLDANNYKGTDYIGKIGVEQSYETELHGQTGFEEVE
VTAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGRRGALVAIEPSSGDVLAFVSAPSFDPNSFVDGIDQQTWDD
LNNSPDHPLLNRPLHGTYPPGSTYKPFMALAALTLHKRTPGWGFQDPGSYTFGGHTFRNDVRSGQGWVDMNRAIVVSNDT
YFYMLAHDLGVNNIANFMKPWGFGQITGIDISGEARGILPSTEWKRKAYRKPEQQRWYEGETISLGIGQGYNSFTILQLA
HATATLANNGVVMKPHLVRDIENPITKETRPVVRDPSDRIAVKQSDIDIIKRAMVGVVTNGTASKLFVGAPYQAAGKTGT
AQVYSLQGANYKGHAIAEHLRDHALFIAFAPAEQPKIALALIVENGGWGAEAAGPIARKVLDYYLVGKNKPGAQAAAIEA
AASATEDASAPEVGGAPAPQEAVQPVKVAAGFTALPIPGAASAAEAASAAAAASAASAASASASAAASAPVAASTSAAAK
NPTPRKSGAPHKPRPASEPAPSAAAPSRDDGIQATSPRQPVSGGIDE
>Mature_766_residues
TEFKDTQQQLSKFRLRVAAAGLFVFVCFGLIGFRFLFLQVWHYSKYSLQADENRISVAPIVPNRGIITDRNGVVLAKNYS
AYTLEITPSKLNDSLENVIDNLATVVSIDARDRRRFKKLQEDSKNFESLPIRTRLTDDEVARFTAQRFRFPGVEVRARLF
RQYPLGPTAAHVIGYIGRISQRDQDRIDDASDQNDSDPDHYDPRLDANNYKGTDYIGKIGVEQSYETELHGQTGFEEVEV
TAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGRRGALVAIEPSSGDVLAFVSAPSFDPNSFVDGIDQQTWDDL
NNSPDHPLLNRPLHGTYPPGSTYKPFMALAALTLHKRTPGWGFQDPGSYTFGGHTFRNDVRSGQGWVDMNRAIVVSNDTY
FYMLAHDLGVNNIANFMKPWGFGQITGIDISGEARGILPSTEWKRKAYRKPEQQRWYEGETISLGIGQGYNSFTILQLAH
ATATLANNGVVMKPHLVRDIENPITKETRPVVRDPSDRIAVKQSDIDIIKRAMVGVVTNGTASKLFVGAPYQAAGKTGTA
QVYSLQGANYKGHAIAEHLRDHALFIAFAPAEQPKIALALIVENGGWGAEAAGPIARKVLDYYLVGKNKPGAQAAAIEAA
ASATEDASAPEVGGAPAPQEAVQPVKVAAGFTALPIPGAASAAEAASAAAAASAASAASASASAAASAPVAASTSAAAKN
PTPRKSGAPHKPRPASEPAPSAAAPSRDDGIQATSPRQPVSGGIDE

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=654, Percent_Identity=39.6024464831804, Blast_Score=469, Evalue=1e-133,
Organism=Escherichia coli, GI1786272, Length=631, Percent_Identity=22.5039619651347, Blast_Score=118, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 82388; Mature: 82257

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFKDTQQQLSKFRLRVAAAGLFVFVCFGLIGFRFLFLQVWHYSKYSLQADENRISVAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEE
IVPNRGIITDRNGVVLAKNYSAYTLEITPSKLNDSLENVIDNLATVVSIDARDRRRFKKL
ECCCCCEEECCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHH
QEDSKNFESLPIRTRLTDDEVARFTAQRFRFPGVEVRARLFRQYPLGPTAAHVIGYIGRI
HHHCCCHHCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
SQRDQDRIDDASDQNDSDPDHYDPRLDANNYKGTDYIGKIGVEQSYETELHGQTGFEEVE
CCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCCHHCCCCCCCCEEE
VTAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGRRGALVAIEPSSGDVLAFVS
EECCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEEE
APSFDPNSFVDGIDQQTWDDLNNSPDHPLLNRPLHGTYPPGSTYKPFMALAALTLHKRTP
CCCCCCHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
GWGFQDPGSYTFGGHTFRNDVRSGQGWVDMNRAIVVSNDTYFYMLAHDLGVNNIANFMKP
CCCCCCCCCCCCCCHHHHHHHCCCCCEEECCCEEEEECCEEEEEEEECCCHHHHHHHHCC
WGFGQITGIDISGEARGILPSTEWKRKAYRKPEQQRWYEGETISLGIGQGYNSFTILQLA
CCCCEEEEEEECCCCCCCCCCCHHHHHHHCCCHHHHCCCCCEEEEECCCCCCCEEEEEEH
HATATLANNGVVMKPHLVRDIENPITKETRPVVRDPSDRIAVKQSDIDIIKRAMVGVVTN
HHHHHHCCCCEEECCHHHHHHHCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHEEEC
GTASKLFVGAPYQAAGKTGTAQVYSLQGANYKGHAIAEHLRDHALFIAFAPAEQPKIALA
CCCCEEEEECCCHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCEEEEEECCCCCCCEEEE
LIVENGGWGAEAAGPIARKVLDYYLVGKNKPGAQAAAIEAAASATEDASAPEVGGAPAPQ
EEEECCCCCCCCCCHHHHHHHHHHEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCH
EAVQPVKVAAGFTALPIPGAASAAEAASAAAAASAASAASASASAAASAPVAASTSAAAK
HHHCCHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCC
NPTPRKSGAPHKPRPASEPAPSAAAPSRDDGIQATSPRQPVSGGIDE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEFKDTQQQLSKFRLRVAAAGLFVFVCFGLIGFRFLFLQVWHYSKYSLQADENRISVAP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEE
IVPNRGIITDRNGVVLAKNYSAYTLEITPSKLNDSLENVIDNLATVVSIDARDRRRFKKL
ECCCCCEEECCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHH
QEDSKNFESLPIRTRLTDDEVARFTAQRFRFPGVEVRARLFRQYPLGPTAAHVIGYIGRI
HHHCCCHHCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
SQRDQDRIDDASDQNDSDPDHYDPRLDANNYKGTDYIGKIGVEQSYETELHGQTGFEEVE
CCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCCHHCCCCCCCCEEE
VTAGGRPVRTLSRTQATPGNNLVLSLDIGLQQVAEQAFAGRRGALVAIEPSSGDVLAFVS
EECCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEEE
APSFDPNSFVDGIDQQTWDDLNNSPDHPLLNRPLHGTYPPGSTYKPFMALAALTLHKRTP
CCCCCCHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
GWGFQDPGSYTFGGHTFRNDVRSGQGWVDMNRAIVVSNDTYFYMLAHDLGVNNIANFMKP
CCCCCCCCCCCCCCHHHHHHHCCCCCEEECCCEEEEECCEEEEEEEECCCHHHHHHHHCC
WGFGQITGIDISGEARGILPSTEWKRKAYRKPEQQRWYEGETISLGIGQGYNSFTILQLA
CCCCEEEEEEECCCCCCCCCCCHHHHHHHCCCHHHHCCCCCEEEEECCCCCCCEEEEEEH
HATATLANNGVVMKPHLVRDIENPITKETRPVVRDPSDRIAVKQSDIDIIKRAMVGVVTN
HHHHHHCCCCEEECCHHHHHHHCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHEEEC
GTASKLFVGAPYQAAGKTGTAQVYSLQGANYKGHAIAEHLRDHALFIAFAPAEQPKIALA
CCCCEEEEECCCHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCEEEEEECCCCCCCEEEE
LIVENGGWGAEAAGPIARKVLDYYLVGKNKPGAQAAAIEAAASATEDASAPEVGGAPAPQ
EEEECCCCCCCCCCHHHHHHHHHHEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCH
EAVQPVKVAAGFTALPIPGAASAAEAASAAAAASAASAASASASAAASAPVAASTSAAAK
HHHCCHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCC
NPTPRKSGAPHKPRPASEPAPSAAAPSRDDGIQATSPRQPVSGGIDE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]