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The map label for this gene is gyaR [H]

Identifier: 91781423

GI number: 91781423

Start: 52547

End: 53638

Strand: Reverse

Name: gyaR [H]

Synonym: Bxe_A4423

Alternate gene names: 91781423

Gene position: 53638-52547 (Counterclockwise)

Preceding gene: 91781425

Following gene: 91781414

Centisome position: 1.1

GC content: 61.36

Gene sequence:

>1092_bases
GTGACCTGGGTCACATGGTGGGACAGTCAGCATAACACTCCGTTCCGCACCACCGAGGTGCGGCGCAAGACACATACCAT
GAAGATTGCCATCCTCGACGATTACCAGGACGCCGTTCGCAAGCTCGACTGCTTTCAATTGCTGGCCGACCATGAGGTCA
AGGTTTTCAACAACACCGTCCGCGGTCTCGGCCAGCTGGCAAGCCGTCTTGCCGAAGTCGATGCTCTCGTCCTGATTCGC
GAACGTACCCGCATCAGCTCGCAACTGCTCGACAAATTGCCGCGTTTGCGCATGATCAGCCAGACCGGCAAGGTCTCGAG
CCACATCGATCTGGCGGCTTGTACCGAGCGCGGCATTGCGGTACTGGAAGGCACCGGTTCACCGTTCGCGCCCGCCGAGT
TGACGTGGGCTCTCATCATGGCGGCCCAGCGGCGGATTCCGCAATACGTAGCAAACCTTAAGCAGGGCGCCTGGCAGCAG
TCCGGTCTGAAGACATCCGCGTTGCCGCCGAACTTTGGTTTGGGCCAGGTGTTGCGCGGTCAGACGCTGGGAATCTGGGG
TTATGGCAAGATCGGCCGGCTGGTTGCCGGATACGGCAAGGCATTCGGCATGAACGTGCTGATCTGGGGCCGCGAGCATT
CGCGCGAAGCCGCTCGCGCCGACGGTTACGGCGTGGCGGAAAGCCGCGAGGCGCTGTTCGAGCAGAGCGACGTGCTGTCG
CTGCACTTGCGCCTGCACGACGACACGCGCGGCATCGTCAAACAGGAAGACCTGATGCGCATGAAGCCGACCGCGCTGCT
CGTGAACACGAGCCGGGCCGAACTGCTCGACGAAAACGCGCTGGTGAATGCGCTGTCGCACAATCGTCCGGGGATGGTCG
CCATCGACGTTTATGAAAGCGAGCCGATTCTGCAGGGCTACAGCCTGCTGCGTATGGAAAACGTGATCTGTACCCCGCAC
ATCGGCTATGTGGAACGGGAGAGCTACGAGCAGTATTTCACCGCCGCGTTCAATAACATTCTGGCTTTCGACGCCGGCGA
TCCGGCCAGCGTGGCCAATCCTGAAGCCTTGCAGGGTGGCCGCCGACGCTAA

Upstream 100 bases:

>100_bases
CGCAACAAACTGTTAAAAACGATGTCAATCGGCCTTGCCGTGCGCTGCCGTTCATTCTGTGCGGTAGCTGCTACGGTAAG
GCATTCAGCCAGACCGGCAT

Downstream 100 bases:

>100_bases
GCGCCCGGCTCTTTCTTTGGCGAGCGCGTTGCCGCGGGCGCGCCGCTCGTCGCCGTGTGGTTTCGCGCCGCGCCGTGTGC
GCGATTCAGCGCGCCGCTTC

Product: putative 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MTWVTWWDSQHNTPFRTTEVRRKTHTMKIAILDDYQDAVRKLDCFQLLADHEVKVFNNTVRGLGQLASRLAEVDALVLIR
ERTRISSQLLDKLPRLRMISQTGKVSSHIDLAACTERGIAVLEGTGSPFAPAELTWALIMAAQRRIPQYVANLKQGAWQQ
SGLKTSALPPNFGLGQVLRGQTLGIWGYGKIGRLVAGYGKAFGMNVLIWGREHSREAARADGYGVAESREALFEQSDVLS
LHLRLHDDTRGIVKQEDLMRMKPTALLVNTSRAELLDENALVNALSHNRPGMVAIDVYESEPILQGYSLLRMENVICTPH
IGYVERESYEQYFTAAFNNILAFDAGDPASVANPEALQGGRRR

Sequences:

>Translated_363_residues
MTWVTWWDSQHNTPFRTTEVRRKTHTMKIAILDDYQDAVRKLDCFQLLADHEVKVFNNTVRGLGQLASRLAEVDALVLIR
ERTRISSQLLDKLPRLRMISQTGKVSSHIDLAACTERGIAVLEGTGSPFAPAELTWALIMAAQRRIPQYVANLKQGAWQQ
SGLKTSALPPNFGLGQVLRGQTLGIWGYGKIGRLVAGYGKAFGMNVLIWGREHSREAARADGYGVAESREALFEQSDVLS
LHLRLHDDTRGIVKQEDLMRMKPTALLVNTSRAELLDENALVNALSHNRPGMVAIDVYESEPILQGYSLLRMENVICTPH
IGYVERESYEQYFTAAFNNILAFDAGDPASVANPEALQGGRRR
>Mature_362_residues
TWVTWWDSQHNTPFRTTEVRRKTHTMKIAILDDYQDAVRKLDCFQLLADHEVKVFNNTVRGLGQLASRLAEVDALVLIRE
RTRISSQLLDKLPRLRMISQTGKVSSHIDLAACTERGIAVLEGTGSPFAPAELTWALIMAAQRRIPQYVANLKQGAWQQS
GLKTSALPPNFGLGQVLRGQTLGIWGYGKIGRLVAGYGKAFGMNVLIWGREHSREAARADGYGVAESREALFEQSDVLSL
HLRLHDDTRGIVKQEDLMRMKPTALLVNTSRAELLDENALVNALSHNRPGMVAIDVYESEPILQGYSLLRMENVICTPHI
GYVERESYEQYFTAAFNNILAFDAGDPASVANPEALQGGRRR

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=303, Percent_Identity=29.042904290429, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI61743967, Length=262, Percent_Identity=32.824427480916, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI4557497, Length=262, Percent_Identity=32.824427480916, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI145580578, Length=267, Percent_Identity=31.8352059925094, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI4557499, Length=267, Percent_Identity=31.8352059925094, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI6912396, Length=260, Percent_Identity=27.6923076923077, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI145580575, Length=251, Percent_Identity=33.4661354581673, Blast_Score=101, Evalue=9e-22,
Organism=Escherichia coli, GI87082289, Length=303, Percent_Identity=29.7029702970297, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1789279, Length=297, Percent_Identity=28.956228956229, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1787645, Length=256, Percent_Identity=27.734375, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=328, Percent_Identity=27.4390243902439, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25147481, Length=255, Percent_Identity=28.6274509803922, Blast_Score=95, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6320925, Length=277, Percent_Identity=28.5198555956679, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=277, Percent_Identity=27.0758122743682, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=246, Percent_Identity=27.6422764227642, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324964, Length=253, Percent_Identity=26.4822134387352, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24646446, Length=247, Percent_Identity=32.7935222672065, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646448, Length=247, Percent_Identity=32.7935222672065, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646452, Length=247, Percent_Identity=32.7935222672065, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646450, Length=247, Percent_Identity=32.7935222672065, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI62472511, Length=250, Percent_Identity=32.8, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI19921140, Length=331, Percent_Identity=27.4924471299094, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI28574286, Length=273, Percent_Identity=28.2051282051282, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45552429, Length=257, Percent_Identity=28.4046692607004, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24585514, Length=257, Percent_Identity=28.4046692607004, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28574282, Length=257, Percent_Identity=28.4046692607004, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI45551003, Length=257, Percent_Identity=28.4046692607004, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28574284, Length=257, Percent_Identity=28.4046692607004, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI28571528, Length=274, Percent_Identity=28.4671532846715, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585516, Length=257, Percent_Identity=26.0700389105058, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 40541; Mature: 40410

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWVTWWDSQHNTPFRTTEVRRKTHTMKIAILDDYQDAVRKLDCFQLLADHEVKVFNNTV
CCEEEEECCCCCCCCCHHHHHHHHEEEEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHH
RGLGQLASRLAEVDALVLIRERTRISSQLLDKLPRLRMISQTGKVSSHIDLAACTERGIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEE
VLEGTGSPFAPAELTWALIMAAQRRIPQYVANLKQGAWQQSGLKTSALPPNFGLGQVLRG
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHCC
QTLGIWGYGKIGRLVAGYGKAFGMNVLIWGREHSREAARADGYGVAESREALFEQSDVLS
CEEEEECCCHHHHHHHHCCHHCCCEEEEECCCCCCHHHHCCCCCCHHHHHHHHCCCCEEE
LHLRLHDDTRGIVKQEDLMRMKPTALLVNTSRAELLDENALVNALSHNRPGMVAIDVYES
EEEEEECCCCCCHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
EPILQGYSLLRMENVICTPHIGYVERESYEQYFTAAFNNILAFDAGDPASVANPEALQGG
CCHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCHHHCCC
RRR
CCC
>Mature Secondary Structure 
TWVTWWDSQHNTPFRTTEVRRKTHTMKIAILDDYQDAVRKLDCFQLLADHEVKVFNNTV
CEEEEECCCCCCCCCHHHHHHHHEEEEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHH
RGLGQLASRLAEVDALVLIRERTRISSQLLDKLPRLRMISQTGKVSSHIDLAACTERGIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEE
VLEGTGSPFAPAELTWALIMAAQRRIPQYVANLKQGAWQQSGLKTSALPPNFGLGQVLRG
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHCC
QTLGIWGYGKIGRLVAGYGKAFGMNVLIWGREHSREAARADGYGVAESREALFEQSDVLS
CEEEEECCCHHHHHHHHCCHHCCCEEEEECCCCCCHHHHCCCCCCHHHHHHHHCCCCEEE
LHLRLHDDTRGIVKQEDLMRMKPTALLVNTSRAELLDENALVNALSHNRPGMVAIDVYES
EEEEEECCCCCCHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
EPILQGYSLLRMENVICTPHIGYVERESYEQYFTAAFNNILAFDAGDPASVANPEALQGG
CCHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCHHHCCC
RRR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]