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The map label for this gene is pdhR [H]

Identifier: 91781400

GI number: 91781400

Start: 20900

End: 21616

Strand: Direct

Name: pdhR [H]

Synonym: Bxe_A4447

Alternate gene names: 91781400

Gene position: 20900-21616 (Clockwise)

Preceding gene: 91781393

Following gene: 91781402

Centisome position: 0.43

GC content: 66.53

Gene sequence:

>717_bases
ATGGCGAGCATCCAACCCACCCGCAGCGTGCTGGAACATACGGTGCGGGAACTCGAACGTCACATGCTTGACGGCAGTTG
GGGCGACGGTGCGCGGCTGCCGGCCGAGCGCGCGCTGGCCGAACAGTTCGGCGTGTCCCGCGCGACGGTGCGCGAGGCCA
TTCAACGGCTGGTGTCGCGCGGCCTGCTGCAGACACGGCGCGGAAGCGGGGTGTTTCTGGTTGGCCGCCATCCGGCCCGC
CTCGCGGCGCCGTGGCTGCAGTTGATCGCCGAACATCCGCCGCTGCGCGCGGATACGCTCGAATTCCGGCTCGTGTTCGA
GTGTGCCGCCGCCGGTCTGGCGGCAAGGCGCGCCAGCGAGGACGAACGCGGGCAATTACGCGAGATCGTCACGCGAATGC
GCGACGCCGTGCTCACCCACGACCTCGCTGCCGAAGCCGCCGCCGACGCGCAATTCCACGCCACGCTCGCGCTTGCGTCG
CACAACCGCATGTTCGACCATTTCTATTCGAGCGTGATCGTGATGCTGCGCGAACATATCACCAGCAATACGTACGAAGC
CACGCTCAATCACGCGCAGGCCGCCGAACGTGCGCATGCGCGGTTGCTGCAACACGAGCGCATCTGCGACGCGATCTGCC
GGCAAGTGCCGGAAGACGCTACGCACGCAATGCGTGCGCACATCGAATTCGTCGGGCATCAATTCGAGGCGGAATAG

Upstream 100 bases:

>100_bases
GCCGCGTCGTGCGCCGCTTGATCGCATCATGGATAATCGAAACCACCCGGACAAATTGGTCTGACTACTTTTTGGCGGCT
TTCGAACCGCTTTCGAGGTT

Downstream 100 bases:

>100_bases
GCTGCAATAGGCTAAGCGGCGAACCAGTGCCGCGTGATTCTGCTACGCCGCGCCTGTCGAGTTATCCACAGCGTCCTCTG
GACAACTTTTGTACAAGCCA

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MASIQPTRSVLEHTVRELERHMLDGSWGDGARLPAERALAEQFGVSRATVREAIQRLVSRGLLQTRRGSGVFLVGRHPAR
LAAPWLQLIAEHPPLRADTLEFRLVFECAAAGLAARRASEDERGQLREIVTRMRDAVLTHDLAAEAAADAQFHATLALAS
HNRMFDHFYSSVIVMLREHITSNTYEATLNHAQAAERAHARLLQHERICDAICRQVPEDATHAMRAHIEFVGHQFEAE

Sequences:

>Translated_238_residues
MASIQPTRSVLEHTVRELERHMLDGSWGDGARLPAERALAEQFGVSRATVREAIQRLVSRGLLQTRRGSGVFLVGRHPAR
LAAPWLQLIAEHPPLRADTLEFRLVFECAAAGLAARRASEDERGQLREIVTRMRDAVLTHDLAAEAAADAQFHATLALAS
HNRMFDHFYSSVIVMLREHITSNTYEATLNHAQAAERAHARLLQHERICDAICRQVPEDATHAMRAHIEFVGHQFEAE
>Mature_237_residues
ASIQPTRSVLEHTVRELERHMLDGSWGDGARLPAERALAEQFGVSRATVREAIQRLVSRGLLQTRRGSGVFLVGRHPARL
AAPWLQLIAEHPPLRADTLEFRLVFECAAAGLAARRASEDERGQLREIVTRMRDAVLTHDLAAEAAADAQFHATLALASH
NRMFDHFYSSVIVMLREHITSNTYEATLNHAQAAERAHARLLQHERICDAICRQVPEDATHAMRAHIEFVGHQFEAE

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=216, Percent_Identity=32.8703703703704, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790032, Length=214, Percent_Identity=35.5140186915888, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1789353, Length=241, Percent_Identity=26.5560165975104, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI87082208, Length=227, Percent_Identity=27.3127753303965, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1790780, Length=238, Percent_Identity=26.0504201680672, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1789621, Length=228, Percent_Identity=29.3859649122807, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 26669; Mature: 26537

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASIQPTRSVLEHTVRELERHMLDGSWGDGARLPAERALAEQFGVSRATVREAIQRLVSR
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
GLLQTRRGSGVFLVGRHPARLAAPWLQLIAEHPPLRADTLEFRLVFECAAAGLAARRASE
HHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
DERGQLREIVTRMRDAVLTHDLAAEAAADAQFHATLALASHNRMFDHFYSSVIVMLREHI
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSNTYEATLNHAQAAERAHARLLQHERICDAICRQVPEDATHAMRAHIEFVGHQFEAE
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASIQPTRSVLEHTVRELERHMLDGSWGDGARLPAERALAEQFGVSRATVREAIQRLVSR
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
GLLQTRRGSGVFLVGRHPARLAAPWLQLIAEHPPLRADTLEFRLVFECAAAGLAARRASE
HHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
DERGQLREIVTRMRDAVLTHDLAAEAAADAQFHATLALASHNRMFDHFYSSVIVMLREHI
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSNTYEATLNHAQAAERAHARLLQHERICDAICRQVPEDATHAMRAHIEFVGHQFEAE
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]