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The map label for this gene is yhcA [H]

Identifier: 91790370

GI number: 91790370

Start: 4799499

End: 4800995

Strand: Direct

Name: yhcA [H]

Synonym: Bpro_4538

Alternate gene names: 91790370

Gene position: 4799499-4800995 (Clockwise)

Preceding gene: 91790369

Following gene: 91790371

Centisome position: 92.29

GC content: 69.47

Gene sequence:

>1497_bases
GTGACCGCCCCCGCCGCCCCCTCCTCGCTCGCCGACATGCAGGCGCGCTACGGCCCGCGTTACCGCTGGCTGTTGCTGCT
GTCGGTGATGATAGGCACCATGGCCTCGATCATGTCGTCGACCATCGTCAATGTGGCGATTCCCGACATGAGCCAGCATT
TCACGCTGGGGCAGGAGCGTGCGCAATGGGTCAGTTCCGGCTTCATGGCGGCCATGACGGTCTCCATGCTCACCACGCCG
TGGCTGCTGGCGCGCTATGGCTACCGCCGCACCTACGCCGGCACCATGCTGCTGCTGATGGCCGGCGGCATGGTCGGCGG
CCTGGCCAACAGCTTTGGCCTGGTGCTGGGTGCGCGCGTGGCCGAGGGGCTGGCCGCCGGCATCGTGCAGCCGATTCCGG
CCATCATCATCATGCGCGCCTTCGGTCCGCACGAGCAGGGCCGCGCCAGCGGCCTCTTCGGCATGGGCGTGGTGCTGGCC
CCGGCCCTGGGGCCCAGCATCGGCGGCATCCTCGTCGACCTGTTTGGCTGGCGCTCGATTTTCTTCATGGTGGTGCCGCT
GTGCCTGGTGTCGCTGTGGATGGCCTGGCGCTATGTGCCGGTCACCGCACCCGGCGGCGTGGCGGCCAACCGCAACGGCG
TCATGATTGACTGGCGCGGCCTGCTGCTGGCCGCCGTCGGCACGCTGAGCCTGCTCAACGGCATGGTGGAACTGCATGGC
GGCAACCGGCTGGCGGCGCTGGGGCTGCTGGGCGCAGCCGCAGCCGCGCTGCTGGTATTTGTGGGGTGGCAGCGCCGCCT
GGCCGCCGCGGGCGGCGCGCCGCTGATGAACCTGGCCCTCTTCGGCTACCGCCCCTTCGCCATGGGCAGCATCGTGGCCT
TTATTTACGGCACGGCGCTGTTCGGCTCCACCTACCTGCTGCCGGTATACATGCAGCTGGGCCTGAACCTGTCGGCCTCG
CATGTGGGCACCATCCTGTTGCCCGCCGGCCTGGTGCTGGCCGCCACCATCGCCGGCGTGGGCCGGCTGGCCGACCGGCA
CCCGACCTGGCTGCTGGTCAGCATCGGTCTGGCGCTGCTGGCTGCGTCGTTCGCGCTGATGCTGAGCGTGACCCTGGCGT
CGGCGCTGTGGCTGCTGATGCTCTGGGCAACACTGGGGCGCATCGGGCTGGGCTTCATCCTGCCCTCGCTGAACCTCGGC
TCGCTGCGGCCCCTGCATGAACACCTGCTGTCCCAGGGTGCCAGCGCCATCAATTTCCTGCGCATGCTGGGCGGTGCGAT
CGGCGTGAGCCTGTGCGGCATTGTGCTGGAGTCGCGGCTGGCCGCGCATGGCGATTCACTGGCCAACCCAGTCGGCAGCG
CCGCGCGACTGGCGGCCTTTAACGAGGCATTCCTGATGCTGGCTGCCCTGTGCGCGCTGGCCATGGTGGCGGCCTGGCAA
CTCAAGGCGCCGGCACCTGTGCCAGCGCCCTTGCCCCAGCCCTCGAAGGCGGATTGA

Upstream 100 bases:

>100_bases
ACCCATGACATAAGAGTCGCAGGCCTCCTCCGTCCCGGAACCCGGACAGCGACGCAGGCAGCTGGCACAATCGGCTGGCA
TACATCCGACGGATCTTTTT

Downstream 100 bases:

>100_bases
CCATGTGCCAATTGCTGGGAATGAACTGCAACACGCCGACGGACGTGACCTTCAGCTTTCGTGGTTTTGCGCAGCGTGGC
GGGCACACCGACCAGCACGC

Product: major facilitator transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MTAPAAPSSLADMQARYGPRYRWLLLLSVMIGTMASIMSSTIVNVAIPDMSQHFTLGQERAQWVSSGFMAAMTVSMLTTP
WLLARYGYRRTYAGTMLLLMAGGMVGGLANSFGLVLGARVAEGLAAGIVQPIPAIIIMRAFGPHEQGRASGLFGMGVVLA
PALGPSIGGILVDLFGWRSIFFMVVPLCLVSLWMAWRYVPVTAPGGVAANRNGVMIDWRGLLLAAVGTLSLLNGMVELHG
GNRLAALGLLGAAAAALLVFVGWQRRLAAAGGAPLMNLALFGYRPFAMGSIVAFIYGTALFGSTYLLPVYMQLGLNLSAS
HVGTILLPAGLVLAATIAGVGRLADRHPTWLLVSIGLALLAASFALMLSVTLASALWLLMLWATLGRIGLGFILPSLNLG
SLRPLHEHLLSQGASAINFLRMLGGAIGVSLCGIVLESRLAAHGDSLANPVGSAARLAAFNEAFLMLAALCALAMVAAWQ
LKAPAPVPAPLPQPSKAD

Sequences:

>Translated_498_residues
MTAPAAPSSLADMQARYGPRYRWLLLLSVMIGTMASIMSSTIVNVAIPDMSQHFTLGQERAQWVSSGFMAAMTVSMLTTP
WLLARYGYRRTYAGTMLLLMAGGMVGGLANSFGLVLGARVAEGLAAGIVQPIPAIIIMRAFGPHEQGRASGLFGMGVVLA
PALGPSIGGILVDLFGWRSIFFMVVPLCLVSLWMAWRYVPVTAPGGVAANRNGVMIDWRGLLLAAVGTLSLLNGMVELHG
GNRLAALGLLGAAAAALLVFVGWQRRLAAAGGAPLMNLALFGYRPFAMGSIVAFIYGTALFGSTYLLPVYMQLGLNLSAS
HVGTILLPAGLVLAATIAGVGRLADRHPTWLLVSIGLALLAASFALMLSVTLASALWLLMLWATLGRIGLGFILPSLNLG
SLRPLHEHLLSQGASAINFLRMLGGAIGVSLCGIVLESRLAAHGDSLANPVGSAARLAAFNEAFLMLAALCALAMVAAWQ
LKAPAPVPAPLPQPSKAD
>Mature_497_residues
TAPAAPSSLADMQARYGPRYRWLLLLSVMIGTMASIMSSTIVNVAIPDMSQHFTLGQERAQWVSSGFMAAMTVSMLTTPW
LLARYGYRRTYAGTMLLLMAGGMVGGLANSFGLVLGARVAEGLAAGIVQPIPAIIIMRAFGPHEQGRASGLFGMGVVLAP
ALGPSIGGILVDLFGWRSIFFMVVPLCLVSLWMAWRYVPVTAPGGVAANRNGVMIDWRGLLLAAVGTLSLLNGMVELHGG
NRLAALGLLGAAAAALLVFVGWQRRLAAAGGAPLMNLALFGYRPFAMGSIVAFIYGTALFGSTYLLPVYMQLGLNLSASH
VGTILLPAGLVLAATIAGVGRLADRHPTWLLVSIGLALLAASFALMLSVTLASALWLLMLWATLGRIGLGFILPSLNLGS
LRPLHEHLLSQGASAINFLRMLGGAIGVSLCGIVLESRLAAHGDSLANPVGSAARLAAFNEAFLMLAALCALAMVAAWQL
KAPAPVPAPLPQPSKAD

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=435, Percent_Identity=23.6781609195402, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788710, Length=450, Percent_Identity=24.8888888888889, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1790195, Length=420, Percent_Identity=25.952380952381, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87081983, Length=348, Percent_Identity=24.7126436781609, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788392, Length=428, Percent_Identity=25.9345794392523, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51917; Mature: 51786

Theoretical pI: Translated: 10.66; Mature: 10.66

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPAAPSSLADMQARYGPRYRWLLLLSVMIGTMASIMSSTIVNVAIPDMSQHFTLGQER
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHCCHHHH
AQWVSSGFMAAMTVSMLTTPWLLARYGYRRTYAGTMLLLMAGGMVGGLANSFGLVLGARV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
AEGLAAGIVQPIPAIIIMRAFGPHEQGRASGLFGMGVVLAPALGPSIGGILVDLFGWRSI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FFMVVPLCLVSLWMAWRYVPVTAPGGVAANRNGVMIDWRGLLLAAVGTLSLLNGMVELHG
HHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCC
GNRLAALGLLGAAAAALLVFVGWQRRLAAAGGAPLMNLALFGYRPFAMGSIVAFIYGTAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
FGSTYLLPVYMQLGLNLSASHVGTILLPAGLVLAATIAGVGRLADRHPTWLLVSIGLALL
HCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AASFALMLSVTLASALWLLMLWATLGRIGLGFILPSLNLGSLRPLHEHLLSQGASAINFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHH
RMLGGAIGVSLCGIVLESRLAAHGDSLANPVGSAARLAAFNEAFLMLAALCALAMVAAWQ
HHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKAPAPVPAPLPQPSKAD
CCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAPAAPSSLADMQARYGPRYRWLLLLSVMIGTMASIMSSTIVNVAIPDMSQHFTLGQER
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHCCHHHH
AQWVSSGFMAAMTVSMLTTPWLLARYGYRRTYAGTMLLLMAGGMVGGLANSFGLVLGARV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
AEGLAAGIVQPIPAIIIMRAFGPHEQGRASGLFGMGVVLAPALGPSIGGILVDLFGWRSI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FFMVVPLCLVSLWMAWRYVPVTAPGGVAANRNGVMIDWRGLLLAAVGTLSLLNGMVELHG
HHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCC
GNRLAALGLLGAAAAALLVFVGWQRRLAAAGGAPLMNLALFGYRPFAMGSIVAFIYGTAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
FGSTYLLPVYMQLGLNLSASHVGTILLPAGLVLAATIAGVGRLADRHPTWLLVSIGLALL
HCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AASFALMLSVTLASALWLLMLWATLGRIGLGFILPSLNLGSLRPLHEHLLSQGASAINFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHH
RMLGGAIGVSLCGIVLESRLAAHGDSLANPVGSAARLAAFNEAFLMLAALCALAMVAAWQ
HHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKAPAPVPAPLPQPSKAD
CCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]