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The map label for this gene is lysR [H]

Identifier: 91790244

GI number: 91790244

Start: 4657420

End: 4658331

Strand: Reverse

Name: lysR [H]

Synonym: Bpro_4411

Alternate gene names: 91790244

Gene position: 4658331-4657420 (Counterclockwise)

Preceding gene: 91790245

Following gene: 91790243

Centisome position: 89.58

GC content: 54.17

Gene sequence:

>912_bases
ATGATGAACCTCTCGCAGGTTGAAGCCTTTCGTGCGGTTGTGCTCTCCGGCTCCACCACGGCAGCGGCGCGCGTTCTTCA
CACTTCGCAGCCCAATGTCAGCCGGTTGATATCTCAGCTTGAAAAAGCCATCGGCCTCCTCCTTTTCGAAAGATCCCCAG
GCAAGTTGACCCCAACGGAGGAGGGGCTCACTTTTTTCACCGAGGTTCAACGCAGCTTCCTGGGTTTGGAGAGGCTAGAT
GAAACTGCAGACAAAATTAGGCGTTTTGGCACCGGCGAACTGAGAATTGCCGCGGTGTCCACGATTGCATTCGGACTTCT
GCCGCGCGCAATAAAGAGGTTCGCCCAAGATCATCCCGAAGTCGGCATCTCCATTCACATGGGCCACTCGTCGGTCATTT
CGCAGTGGGTGGATTCGCATTTCTGTGATTTGGGCATCGTTTCGCAGCTGTCACGCCAGGACATTTCAACTGAGCCGGAC
GTTTTATACCGGATAGATGGCGTTTGCCTGATGCCGGAAAACCACCGACTGGCGGAGAAGAAGCGTCTCACTCCGATGGA
TCTTGAAGGCGAGACCTTCATCTCGTCAGCCAAGCCTGACGAACTGCGTAAAAGCGTCGACCGAATTTTCGATCAAGCGG
GGGTGAAGCGAATAATAAATATCGAAACGTCCTACAGCTCCATCATCTGGTCGCTCGTGGGGCTGGGCATGGGCATAAGT
ATCGTCAATCCGCTTGCCGTACAGGATTACCGGTCGGCGCCTGTCGTGACACGGCCTTTTGATCCCGCACTGCCGTATGA
AGGCATTCTGATCATTCCGAAAGGTCGACCGGCCAACCGCCTGGTCGCGAAATTTTCAGAAGTATTACGTCAGATCGCAC
GCGAAGAGTGCGAAGCACTACAAGGAAAATGA

Upstream 100 bases:

>100_bases
CAGCCGTGTGGTGTAGCGACCTGCGGTTTCCCGGCTCCTCTTGATATTCATCCAATTAGGCGATTAAATTGCCTGTTGCA
CGTTACAAGGAGCCTACACA

Downstream 100 bases:

>100_bases
ACCTGCTCTGCGTTCTCGAGGTTAGGGTACACCCGCCCCCTTATATCGTCTTCGAATAGACCGATCTTATATTTCTATTT
GACCAGCCATTGACTCCCTC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MMNLSQVEAFRAVVLSGSTTAAARVLHTSQPNVSRLISQLEKAIGLLLFERSPGKLTPTEEGLTFFTEVQRSFLGLERLD
ETADKIRRFGTGELRIAAVSTIAFGLLPRAIKRFAQDHPEVGISIHMGHSSVISQWVDSHFCDLGIVSQLSRQDISTEPD
VLYRIDGVCLMPENHRLAEKKRLTPMDLEGETFISSAKPDELRKSVDRIFDQAGVKRIINIETSYSSIIWSLVGLGMGIS
IVNPLAVQDYRSAPVVTRPFDPALPYEGILIIPKGRPANRLVAKFSEVLRQIAREECEALQGK

Sequences:

>Translated_303_residues
MMNLSQVEAFRAVVLSGSTTAAARVLHTSQPNVSRLISQLEKAIGLLLFERSPGKLTPTEEGLTFFTEVQRSFLGLERLD
ETADKIRRFGTGELRIAAVSTIAFGLLPRAIKRFAQDHPEVGISIHMGHSSVISQWVDSHFCDLGIVSQLSRQDISTEPD
VLYRIDGVCLMPENHRLAEKKRLTPMDLEGETFISSAKPDELRKSVDRIFDQAGVKRIINIETSYSSIIWSLVGLGMGIS
IVNPLAVQDYRSAPVVTRPFDPALPYEGILIIPKGRPANRLVAKFSEVLRQIAREECEALQGK
>Mature_303_residues
MMNLSQVEAFRAVVLSGSTTAAARVLHTSQPNVSRLISQLEKAIGLLLFERSPGKLTPTEEGLTFFTEVQRSFLGLERLD
ETADKIRRFGTGELRIAAVSTIAFGLLPRAIKRFAQDHPEVGISIHMGHSSVISQWVDSHFCDLGIVSQLSRQDISTEPD
VLYRIDGVCLMPENHRLAEKKRLTPMDLEGETFISSAKPDELRKSVDRIFDQAGVKRIINIETSYSSIIWSLVGLGMGIS
IVNPLAVQDYRSAPVVTRPFDPALPYEGILIIPKGRPANRLVAKFSEVLRQIAREECEALQGK

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=285, Percent_Identity=41.4035087719298, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1787530, Length=252, Percent_Identity=26.984126984127, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788481, Length=249, Percent_Identity=28.1124497991968, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788887, Length=290, Percent_Identity=27.5862068965517, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI145693105, Length=281, Percent_Identity=26.3345195729537, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788296, Length=247, Percent_Identity=28.3400809716599, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790399, Length=291, Percent_Identity=24.0549828178694, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787601, Length=131, Percent_Identity=35.1145038167939, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788748, Length=308, Percent_Identity=23.7012987012987, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33594; Mature: 33594

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNLSQVEAFRAVVLSGSTTAAARVLHTSQPNVSRLISQLEKAIGLLLFERSPGKLTPTE
CCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCH
EGLTFFTEVQRSFLGLERLDETADKIRRFGTGELRIAAVSTIAFGLLPRAIKRFAQDHPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCC
VGISIHMGHSSVISQWVDSHFCDLGIVSQLSRQDISTEPDVLYRIDGVCLMPENHRLAEK
CCEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECCEEECCCCCCHHHH
KRLTPMDLEGETFISSAKPDELRKSVDRIFDQAGVKRIINIETSYSSIIWSLVGLGMGIS
HCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCHHHEEEECCHHHHHHHHHHHHCCCHH
IVNPLAVQDYRSAPVVTRPFDPALPYEGILIIPKGRPANRLVAKFSEVLRQIAREECEAL
HHCCHHHHHHCCCCCEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
QGK
CCC
>Mature Secondary Structure
MMNLSQVEAFRAVVLSGSTTAAARVLHTSQPNVSRLISQLEKAIGLLLFERSPGKLTPTE
CCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCH
EGLTFFTEVQRSFLGLERLDETADKIRRFGTGELRIAAVSTIAFGLLPRAIKRFAQDHPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCC
VGISIHMGHSSVISQWVDSHFCDLGIVSQLSRQDISTEPDVLYRIDGVCLMPENHRLAEK
CCEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECCEEECCCCCCHHHH
KRLTPMDLEGETFISSAKPDELRKSVDRIFDQAGVKRIINIETSYSSIIWSLVGLGMGIS
HCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCHHHEEEECCHHHHHHHHHHHHCCCHH
IVNPLAVQDYRSAPVVTRPFDPALPYEGILIIPKGRPANRLVAKFSEVLRQIAREECEAL
HHCCHHHHHHCCCCCEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
QGK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]