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The map label for this gene is ahcY [H]

Identifier: 91789971

GI number: 91789971

Start: 4337432

End: 4338871

Strand: Reverse

Name: ahcY [H]

Synonym: Bpro_4132

Alternate gene names: 91789971

Gene position: 4338871-4337432 (Counterclockwise)

Preceding gene: 91789973

Following gene: 91789970

Centisome position: 83.44

GC content: 61.53

Gene sequence:

>1440_bases
ATGAGCGCTGTCCTGAAACCCGTATCTGCCGCCGCCGACCACATCATTGCCGACCTGTCGCTCGCCGACTGGGGCCGCAA
GGAACTGAACATTGCCCAGACCGAGATGCCCGGCCTGATGGCCATTCGCGAAGAATTCGCCAAGGCACAGCCCCTGAAGG
GCGCGCGCATCACCGGCTCACTGCACATGACCATCCAGACCGGCGTGCTGATCGAGACGCTGCAGGCGCTGGGCGCCGAC
GTGCGCTGGGCTTCGTGCAACATTTTCTCGACGCAGGACCATGCCGCCGCCGCGATTGCCGCCAAGGGCACGCCGGTGTT
TGCCATCAAGGGCGAGACCCTGGCCGACTACTGGGACTACACCCACAGGATCTTCGAATTCAGCGGTGCCAAGGGCACGC
CTGAAGAAGGCCCGAACATGATCCTGGACGACGGCGGCGATGCCACGCTGCTGATGCACCTGGGCACCAAGGCCGAAAAA
GACGCCAGCCTGATCTCCAAGCCGACCAGCGAAGAAGAAATCTGCCTGTTCAACTCGATCAAGGCCAAACTGGCGCAAGA
TCCGACCTGGTACAGCCGCCGCCTGAAGAACATCATCGGCGTGACCGAAGAAACCACCACCGGCGTGCTGCGCCTCAATG
AAATGTCGGCCAAGGGCACGCTGGCCCTGCGCGCCATCAACGTCAACGACTCGGTCACCAAGTCCAAGTTCGACAACCTC
TACGGTTGCCGCGAGTCGCTGGTCGACGCCATCAAGCGCGCCACCGACGTGATGGTGGCCGGCAAGGTGGCTTGCGTGGC
CGGTTACGGCGACGTGGGCAAGGGCTCGGCCCAGGCCCTGCGTGCCCTGAGCGCCCAGGTGTGGGTGACCGAGATCGATC
CGATCAACGCCCTGCAGGCCGCGATGGAAGGCTACAAGGTCGTGACCATGGAATACGCCGCCGACAAGGCCGACATCTTT
GTGTCCGCCACCGGCAACAAGAACGTCATCACCTACGAGCACATGGCGAAGATGAAAGATCAGGCCATCGTCTGCAACAT
CGGCCATTTCGACAATGAAATCGACGTCGCCTCGCTGGAAAAATGCACCTGGGAAGAGATCAAGCCGCAAGTCGATCACG
TGATCTTCCCCGATGGCAAACGCATCATCCTGCTGGCCAAGGGCCGCCTGGTGAACCTGGGCTGCGGCACCGGCCACCCC
AGCTTCGTGATGTCGTCCAGCTTTGCCAACCAGACCATTGCGCAGATCGAGTTGTTCACCAAGCAGGCCGACTACGAAGT
GGGCAAGGTCTATGTGCTGCCCAAGCACCTCGATGAAAAGGTCGCGCGTTTGCACCTCAAGAAGGTCGGCGCGATGCTGA
CCGAGTTGAGCGACGAGCAGGCGGCTTATATCGGTGTGTCGAAGGCAGGCCCGTACAAGGCCAACACCTACCGCTATTGA

Upstream 100 bases:

>100_bases
ATGTGCTCTCAAGCCGGGTGAATGACTGAATTCTCCCGCCCCCGAAAGCCCCATGCCCGTGGCGATTTTGCCCAGTTGAC
GTTTGAATTTGGAGAACCGT

Downstream 100 bases:

>100_bases
TCAAGCGGCGGGTATTCCTCCCTCTCCCCCTGGGAGAGGGCAGGGGTGAGGGCTGGCGGCGTCAGTTGTCAAGCGAGCTT
TTTTAAGGCCGCTGGCCTTC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MSAVLKPVSAAADHIIADLSLADWGRKELNIAQTEMPGLMAIREEFAKAQPLKGARITGSLHMTIQTGVLIETLQALGAD
VRWASCNIFSTQDHAAAAIAAKGTPVFAIKGETLADYWDYTHRIFEFSGAKGTPEEGPNMILDDGGDATLLMHLGTKAEK
DASLISKPTSEEEICLFNSIKAKLAQDPTWYSRRLKNIIGVTEETTTGVLRLNEMSAKGTLALRAINVNDSVTKSKFDNL
YGCRESLVDAIKRATDVMVAGKVACVAGYGDVGKGSAQALRALSAQVWVTEIDPINALQAAMEGYKVVTMEYAADKADIF
VSATGNKNVITYEHMAKMKDQAIVCNIGHFDNEIDVASLEKCTWEEIKPQVDHVIFPDGKRIILLAKGRLVNLGCGTGHP
SFVMSSSFANQTIAQIELFTKQADYEVGKVYVLPKHLDEKVARLHLKKVGAMLTELSDEQAAYIGVSKAGPYKANTYRY

Sequences:

>Translated_479_residues
MSAVLKPVSAAADHIIADLSLADWGRKELNIAQTEMPGLMAIREEFAKAQPLKGARITGSLHMTIQTGVLIETLQALGAD
VRWASCNIFSTQDHAAAAIAAKGTPVFAIKGETLADYWDYTHRIFEFSGAKGTPEEGPNMILDDGGDATLLMHLGTKAEK
DASLISKPTSEEEICLFNSIKAKLAQDPTWYSRRLKNIIGVTEETTTGVLRLNEMSAKGTLALRAINVNDSVTKSKFDNL
YGCRESLVDAIKRATDVMVAGKVACVAGYGDVGKGSAQALRALSAQVWVTEIDPINALQAAMEGYKVVTMEYAADKADIF
VSATGNKNVITYEHMAKMKDQAIVCNIGHFDNEIDVASLEKCTWEEIKPQVDHVIFPDGKRIILLAKGRLVNLGCGTGHP
SFVMSSSFANQTIAQIELFTKQADYEVGKVYVLPKHLDEKVARLHLKKVGAMLTELSDEQAAYIGVSKAGPYKANTYRY
>Mature_478_residues
SAVLKPVSAAADHIIADLSLADWGRKELNIAQTEMPGLMAIREEFAKAQPLKGARITGSLHMTIQTGVLIETLQALGADV
RWASCNIFSTQDHAAAAIAAKGTPVFAIKGETLADYWDYTHRIFEFSGAKGTPEEGPNMILDDGGDATLLMHLGTKAEKD
ASLISKPTSEEEICLFNSIKAKLAQDPTWYSRRLKNIIGVTEETTTGVLRLNEMSAKGTLALRAINVNDSVTKSKFDNLY
GCRESLVDAIKRATDVMVAGKVACVAGYGDVGKGSAQALRALSAQVWVTEIDPINALQAAMEGYKVVTMEYAADKADIFV
SATGNKNVITYEHMAKMKDQAIVCNIGHFDNEIDVASLEKCTWEEIKPQVDHVIFPDGKRIILLAKGRLVNLGCGTGHPS
FVMSSSFANQTIAQIELFTKQADYEVGKVYVLPKHLDEKVARLHLKKVGAMLTELSDEQAAYIGVSKAGPYKANTYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=467, Percent_Identity=57.3875802997859, Blast_Score=496, Evalue=1e-140,
Organism=Homo sapiens, GI239937451, Length=447, Percent_Identity=57.2706935123042, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI24308043, Length=471, Percent_Identity=47.9830148619958, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI298286489, Length=476, Percent_Identity=47.6890756302521, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI195539337, Length=471, Percent_Identity=47.9830148619958, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI195539349, Length=476, Percent_Identity=47.6890756302521, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI21361647, Length=472, Percent_Identity=46.8220338983051, Blast_Score=416, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17506425, Length=469, Percent_Identity=58.4221748400853, Blast_Score=509, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6320882, Length=488, Percent_Identity=56.1475409836066, Blast_Score=492, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24642172, Length=467, Percent_Identity=58.8865096359743, Blast_Score=510, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24656245, Length=458, Percent_Identity=50.4366812227074, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45553387, Length=473, Percent_Identity=47.568710359408, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI45553385, Length=472, Percent_Identity=47.4576271186441, Blast_Score=410, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52023; Mature: 51892

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVLKPVSAAADHIIADLSLADWGRKELNIAQTEMPGLMAIREEFAKAQPLKGARITGS
CCCHHHHHHHHHHHHHEECCHHCCCCCCCCEEHHCCCHHHHHHHHHHHCCCCCCCEEEEE
LHMTIQTGVLIETLQALGADVRWASCNIFSTQDHAAAAIAAKGTPVFAIKGETLADYWDY
EEEEEECCHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEECCCEEEEEECCHHHHHHHH
THRIFEFSGAKGTPEEGPNMILDDGGDATLLMHLGTKAEKDASLISKPTSEEEICLFNSI
HHHHEEECCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCCHHHHCCCCCCCCEEEHHHH
KAKLAQDPTWYSRRLKNIIGVTEETTTGVLRLNEMSAKGTLALRAINVNDSVTKSKFDNL
HHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCHHHHHHHHH
YGCRESLVDAIKRATDVMVAGKVACVAGYGDVGKGSAQALRALSAQVWVTEIDPINALQA
HHHHHHHHHHHHHHHHEEEECCEEEEECCCCCCCCHHHHHHHHHHEEEEEECCCHHHHHH
AMEGYKVVTMEYAADKADIFVSATGNKNVITYEHMAKMKDQAIVCNIGHFDNEIDVASLE
HHCCCEEEEEEECCCCCEEEEEECCCCCEEEHHHHHHCCCCEEEEEECCCCCCCCHHHHH
KCTWEEIKPQVDHVIFPDGKRIILLAKGRLVNLGCGTGHPSFVMSSSFANQTIAQIELFT
HCCHHHCCCCCCEEECCCCCEEEEEECCCEEEEECCCCCCCCEEECHHHHHHHHHHEEEH
KQADYEVGKVYVLPKHLDEKVARLHLKKVGAMLTELSDEQAAYIGVSKAGPYKANTYRY
HHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SAVLKPVSAAADHIIADLSLADWGRKELNIAQTEMPGLMAIREEFAKAQPLKGARITGS
CCHHHHHHHHHHHHHEECCHHCCCCCCCCEEHHCCCHHHHHHHHHHHCCCCCCCEEEEE
LHMTIQTGVLIETLQALGADVRWASCNIFSTQDHAAAAIAAKGTPVFAIKGETLADYWDY
EEEEEECCHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEECCCEEEEEECCHHHHHHHH
THRIFEFSGAKGTPEEGPNMILDDGGDATLLMHLGTKAEKDASLISKPTSEEEICLFNSI
HHHHEEECCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCCHHHHCCCCCCCCEEEHHHH
KAKLAQDPTWYSRRLKNIIGVTEETTTGVLRLNEMSAKGTLALRAINVNDSVTKSKFDNL
HHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCHHHHHHHHH
YGCRESLVDAIKRATDVMVAGKVACVAGYGDVGKGSAQALRALSAQVWVTEIDPINALQA
HHHHHHHHHHHHHHHHEEEECCEEEEECCCCCCCCHHHHHHHHHHEEEEEECCCHHHHHH
AMEGYKVVTMEYAADKADIFVSATGNKNVITYEHMAKMKDQAIVCNIGHFDNEIDVASLE
HHCCCEEEEEEECCCCCEEEEEECCCCCEEEHHHHHHCCCCEEEEEECCCCCCCCHHHHH
KCTWEEIKPQVDHVIFPDGKRIILLAKGRLVNLGCGTGHPSFVMSSSFANQTIAQIELFT
HCCHHHCCCCCCEEECCCCCEEEEEECCCEEEEECCCCCCCCEEECHHHHHHHHHHEEEH
KQADYEVGKVYVLPKHLDEKVARLHLKKVGAMLTELSDEQAAYIGVSKAGPYKANTYRY
HHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA