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The map label for this gene is tyrS [H]

Identifier: 91789945

GI number: 91789945

Start: 4312568

End: 4313812

Strand: Reverse

Name: tyrS [H]

Synonym: Bpro_4106

Alternate gene names: 91789945

Gene position: 4313812-4312568 (Counterclockwise)

Preceding gene: 91789948

Following gene: 91789944

Centisome position: 82.95

GC content: 62.49

Gene sequence:

>1245_bases
ATGAATCAAGAACTTGTTACAAATATCCCGCTGTCTGACCGTGTCAAGACGGCCCTGGCCGTTTCCTTGCGCGGATGCGA
TGAACTGATTCCGCAGGACGAATGGGTCAAAAAACTGGTCCGAAGCGAGTCCACGGGCGTGCCGTTGCGCATCAAACTGG
GCCTGGACCCGACCGCACCTGACATTCATGTCGGACATACGGTGGTTTTGAACAAAATGCGGCAGCTCCAGGATCTGGGC
CATTCGGTGATTTTCCTGATCGGCGACTTCACCACCATGATTGGCGACCCGTCGGGCCGCAACAGCACCCGCCCGCCGCT
GACCCGCGAGCAGATCGAGGTCAACGCCCAGACCTACTACAGGCAGGCCAGCCTGGTGCTGGACCCGGCCCGGACCGAGA
TCCGCTACAACAGCGAATGGAGCGATCCACTGGGTGCCCGCGGCATGATCCAGCTGGCCTCGCGCTACACCGTGGCCCGC
ATGATGGAGCGCAACGATTTCCACGACCGCTTCAAGGCCGGCCAGTCGATCAGTGTCCACGAATTTTTATACCCGCTGAT
GCAGGGCTATGACTCGGTCGCGCTCAAGTCCGACCTGGAACTCGGCGGCACCGACCAGAAGTTCAACCTGCTGATGGGCC
GCCACCTGCAGGTCGAGTACGGCCAGGATCCCCAGTGCGTCCTGACCATGCCGCTGCTGGAGGGGCTTGATGGCATCGAG
AAGATGTCCAAGAGCAAGAACAACTACATTGGTATTTCGGAAGATGCCAACACCATGTTTGCCAAGGTGCTGAGCATTTC
GGATGTGCTGATGTGGCGCTGGTATACCCTGCTGTCGTTCAGGAGCGAGGCCGAGATTGCCGCGCTCCGGGCTGAGGTCC
TGGCCGGCCGCAACCCGAAGGATGCCAAGGTGGCGCTGGCCAAGGAAATTACCGCCCGCTTCCATAGCGCGGCCGCCGCC
GATGCGGCCGAGCAGGATTTCATCAACCGCAGCAAGGGCGGGGTTCCCGACGAGATTCCCGAGGTGGCGCTGACGCTGGC
CGAGGGCGGTGCGCCGCTCGGCATCGGCGCCCTGCTCCGGCAGGCCGGGCTCGCCCCCTCAGGCAGTGAAGCCAACCGCC
TGATTGATGGCGGCGGCGTGCGCGTGGACTCCAGCGTGGTCAGTGACAAGGCCTTGAAGCTGGGCGCCGGCACCTATGTT
CTCCAGGTGGGCAAGCGCAAGTTTGCGCGGGTGACGCTGACCTGA

Upstream 100 bases:

>100_bases
TATCCTGATCAGCAAGTTGCGGGCCAACTAAAATGGCAGCCTGACGCAGGAGAGCACGAATTATATCTGTCGGATAAAGC
CCCGCATCTGAAAAACCCTT

Downstream 100 bases:

>100_bases
ATAACCAGGTTACGGATTGCGGTGAAGGGGTATAAATTGTACAAAGACTGTACAATTTATACCCATGATCACCAACATCG
ACATTGATGAAGTCGTCGTG

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MNQELVTNIPLSDRVKTALAVSLRGCDELIPQDEWVKKLVRSESTGVPLRIKLGLDPTAPDIHVGHTVVLNKMRQLQDLG
HSVIFLIGDFTTMIGDPSGRNSTRPPLTREQIEVNAQTYYRQASLVLDPARTEIRYNSEWSDPLGARGMIQLASRYTVAR
MMERNDFHDRFKAGQSISVHEFLYPLMQGYDSVALKSDLELGGTDQKFNLLMGRHLQVEYGQDPQCVLTMPLLEGLDGIE
KMSKSKNNYIGISEDANTMFAKVLSISDVLMWRWYTLLSFRSEAEIAALRAEVLAGRNPKDAKVALAKEITARFHSAAAA
DAAEQDFINRSKGGVPDEIPEVALTLAEGGAPLGIGALLRQAGLAPSGSEANRLIDGGGVRVDSSVVSDKALKLGAGTYV
LQVGKRKFARVTLT

Sequences:

>Translated_414_residues
MNQELVTNIPLSDRVKTALAVSLRGCDELIPQDEWVKKLVRSESTGVPLRIKLGLDPTAPDIHVGHTVVLNKMRQLQDLG
HSVIFLIGDFTTMIGDPSGRNSTRPPLTREQIEVNAQTYYRQASLVLDPARTEIRYNSEWSDPLGARGMIQLASRYTVAR
MMERNDFHDRFKAGQSISVHEFLYPLMQGYDSVALKSDLELGGTDQKFNLLMGRHLQVEYGQDPQCVLTMPLLEGLDGIE
KMSKSKNNYIGISEDANTMFAKVLSISDVLMWRWYTLLSFRSEAEIAALRAEVLAGRNPKDAKVALAKEITARFHSAAAA
DAAEQDFINRSKGGVPDEIPEVALTLAEGGAPLGIGALLRQAGLAPSGSEANRLIDGGGVRVDSSVVSDKALKLGAGTYV
LQVGKRKFARVTLT
>Mature_414_residues
MNQELVTNIPLSDRVKTALAVSLRGCDELIPQDEWVKKLVRSESTGVPLRIKLGLDPTAPDIHVGHTVVLNKMRQLQDLG
HSVIFLIGDFTTMIGDPSGRNSTRPPLTREQIEVNAQTYYRQASLVLDPARTEIRYNSEWSDPLGARGMIQLASRYTVAR
MMERNDFHDRFKAGQSISVHEFLYPLMQGYDSVALKSDLELGGTDQKFNLLMGRHLQVEYGQDPQCVLTMPLLEGLDGIE
KMSKSKNNYIGISEDANTMFAKVLSISDVLMWRWYTLLSFRSEAEIAALRAEVLAGRNPKDAKVALAKEITARFHSAAAA
DAAEQDFINRSKGGVPDEIPEVALTLAEGGAPLGIGALLRQAGLAPSGSEANRLIDGGGVRVDSSVVSDKALKLGAGTYV
LQVGKRKFARVTLT

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=410, Percent_Identity=25.609756097561, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1787925, Length=396, Percent_Identity=26.7676767676768, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25145802, Length=178, Percent_Identity=31.4606741573034, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325160, Length=326, Percent_Identity=23.3128834355828, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20130383, Length=403, Percent_Identity=26.5508684863524, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 45378; Mature: 45378

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS50889 S4 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQELVTNIPLSDRVKTALAVSLRGCDELIPQDEWVKKLVRSESTGVPLRIKLGLDPTAP
CCCCEEECCCCHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHCCCCCCCEEEEECCCCCCC
DIHVGHTVVLNKMRQLQDLGHSVIFLIGDFTTMIGDPSGRNSTRPPLTREQIEVNAQTYY
CCCCCHHHHHHHHHHHHHCCCEEEEEEECHHHHHCCCCCCCCCCCCCCHHHEEECHHHHH
RQASLVLDPARTEIRYNSEWSDPLGARGMIQLASRYTVARMMERNDFHDRFKAGQSISVH
HHHHEEECCCHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHH
EFLYPLMQGYDSVALKSDLELGGTDQKFNLLMGRHLQVEYGQDPQCVLTMPLLEGLDGIE
HHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHCCEEEEECCCCCCEEEECHHHHCCHHHH
KMSKSKNNYIGISEDANTMFAKVLSISDVLMWRWYTLLSFRSEAEIAALRAEVLAGRNPK
HHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
DAKVALAKEITARFHSAAAADAAEQDFINRSKGGVPDEIPEVALTLAEGGAPLGIGALLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHH
QAGLAPSGSEANRLIDGGGVRVDSSVVSDKALKLGAGTYVLQVGKRKFARVTLT
HHCCCCCCCCCCCEECCCCEEECHHHHHHHHHEECCCCEEEEECCCEEEEEECC
>Mature Secondary Structure
MNQELVTNIPLSDRVKTALAVSLRGCDELIPQDEWVKKLVRSESTGVPLRIKLGLDPTAP
CCCCEEECCCCHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHCCCCCCCEEEEECCCCCCC
DIHVGHTVVLNKMRQLQDLGHSVIFLIGDFTTMIGDPSGRNSTRPPLTREQIEVNAQTYY
CCCCCHHHHHHHHHHHHHCCCEEEEEEECHHHHHCCCCCCCCCCCCCCHHHEEECHHHHH
RQASLVLDPARTEIRYNSEWSDPLGARGMIQLASRYTVARMMERNDFHDRFKAGQSISVH
HHHHEEECCCHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHH
EFLYPLMQGYDSVALKSDLELGGTDQKFNLLMGRHLQVEYGQDPQCVLTMPLLEGLDGIE
HHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHCCEEEEECCCCCCEEEECHHHHCCHHHH
KMSKSKNNYIGISEDANTMFAKVLSISDVLMWRWYTLLSFRSEAEIAALRAEVLAGRNPK
HHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
DAKVALAKEITARFHSAAAADAAEQDFINRSKGGVPDEIPEVALTLAEGGAPLGIGALLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHH
QAGLAPSGSEANRLIDGGGVRVDSSVVSDKALKLGAGTYVLQVGKRKFARVTLT
HHCCCCCCCCCCCEECCCCEEECHHHHHHHHHEECCCCEEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA