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The map label for this gene is livM [H]

Identifier: 91789902

GI number: 91789902

Start: 4270470

End: 4272368

Strand: Reverse

Name: livM [H]

Synonym: Bpro_4063

Alternate gene names: 91789902

Gene position: 4272368-4270470 (Counterclockwise)

Preceding gene: 91789903

Following gene: 91789901

Centisome position: 82.16

GC content: 63.51

Gene sequence:

>1899_bases
ATGAGCTTTTCAGGCTTTATCGTCCAGCTGCTCAACGGCCTTGCCGGTGCGTCGTCGCTGTTTCTGGTGGCGGCCGGGCT
GTCGCTGATCTTTGGTGTCACGCGCATCGTCAATTTCGCGCATGGCTCGTTTTTCATGGTCGGCATTTATGTCGCCTATT
CGCTGGTGGCCACCCTGGGCAGCACCCTGGGGTTCTGGCCGGCCTTGCTGCTCGCGGCCCTGGCCGTGGGCGTCCTCGGT
GCGCTGGTGGAAGTCTTGCTGCTGCGCCGCATTTACCATGCACCGGAGCTGTTTCAGCTGCTCGCCACGTTTGCGCTCGG
CCTGGTGATCAAGGACGGGGTGCTCTGGTTCTGGGGTGCGGAAGAACTGCTGGGCCCCAGGGCGCCCGGTTTGACCGGCT
CGGTCTCCATTCTCGGACGGCAATTTCCCTCGTACGACCTGTTCCTGATCGTTGCCGGACCCGTCGTCCTCGGTTTGCTC
TGGTTGCTGCTGACGAAAACCCGTTGGGGAACCCTGGTGCGTGCCGCCACCCAGGACCGGGAGATGGTGAGTGCGCTCGG
GGTCAACCAGGCCTGGCTGTTCACCGCCGTCTTTGCGCTGGGTGCGCTTCTGGCCGGCCTGGGGGGGGCGCTGCAGCTTC
CGCGCGAGCCTGCCAATCTGGAGATGGACCTGAACATCATAGGCGCCGCATTTGTGGTGGTGGTGGTCGGCGGCATGGGC
TCCCTTCCGGGGGCGTATGTGGCGGCACTGCTGATCGCTGAACTCAAGGCCATCTGTATCTGGCTCGGCCTGGTTGAAAT
TGCCGGCATCAGCATTTCCTTTTCCAAGCTCACCCTGGTGGTGGAATTTCTGGTGATGGCCGCCGTGCTGGTCGCCCGGC
CATGGGGCCTGTTCGGCAAAGCGCAGGCGGCTAGCCACCATGCCGGCACGGCCGAGGAGCCGCTGCGTCCGCCGGAACGC
CTTTACAAGTACGGCGGCGCAGCCCTGTTGGCGCTGCTGATCCTGATGCCTGCGCTCACCGCGCAGTCGCCCTATGTCAC
CGTCCTGCTGATTGATTTGCTGGTTGCCGTGCTGTTTGCGGCCAGCCTGCATTTCATCATGGGGCCGGCCGGCATGCACT
CGTTCGGGCATGCGGCCTACTTTGGCCTGGGTGCCTACGGTGCCGCGCTGCTGGTGCGCAGCCTGAACCTGCCGATGGAG
GTGGCGCTGCTCGTCGCCCCTGCGCTGGCGGCGCTGGGTGCCTTCGTCTACGGCTGGTTCTGCGTCCGGCTGTCCGGCGT
TTACCTGGCGATGCTGACCCTGGCATTTGCGCAAATTACCTGGGCGATCTGCTACCAATGGGATGCGTTCACCGGCGGCA
GCAACGGGCTGACCGGCGTGTGGCCGGCCGGCTGGCTGGCGGACAAACGGATCTACTACTACCTGACCCTGGTGCTGGTG
GTGGGCGGAGTACTTTTGATGCACAGGATGTTGTATTCACCCTTTGGCTACGCAATGCGCGCCGCGCGCGACTCCGTACT
TCGGTCTGACGCGATTGGTATCAACGTCAAGCGCATGCAATGGGTGGCTTTTGTCATGGCGGGCTCTTTCGCGGGCCTGG
CCGGCGCGCTCTACGCATTTTCAAAAGGCAGCATCTCCCCGGAAAGCCTGCACGTGGGCAAATCCATCGACGGTCTGGTG
ATGGTCCTGCTGGGCGGTGTGCAGACGCTGCTGGGCCCGGTGGTCGGCGCAGTCACCTTCACCTGGCTGCACGACACGGT
GGCACGGAACACCGATTACTGGCGCGCCATGCTGGGGGCCATCATCCTGATGCTGGTGCTGCTGTTTCCCCAGGGTATCG
CAGGCTTTGTCAAACAGCTGGTGTCGAATCGGCGCGATGCAAAAAAGGTGCAATCATGA

Upstream 100 bases:

>100_bases
GGTGTCAGCCGCCAGGTTTGCCGTCGTCCGTTTCGCAAAGTCATCATGTTCGTCGTAGCGCTTGCCGGTCGTCCATATCT
TCCGCAGTAAAAGGTTATCC

Downstream 100 bases:

>100_bases
GTTTGCTCAAAGTGTCTAGCCTGGGTAAATCGTTCGGCGGTGTCAAGGCGGTCGATGGCATCAGTTTTGAGCTGGCGGCG
GGTGAACTGCTGGCCCTGAT

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 632; Mature: 631

Protein sequence:

>632_residues
MSFSGFIVQLLNGLAGASSLFLVAAGLSLIFGVTRIVNFAHGSFFMVGIYVAYSLVATLGSTLGFWPALLLAALAVGVLG
ALVEVLLLRRIYHAPELFQLLATFALGLVIKDGVLWFWGAEELLGPRAPGLTGSVSILGRQFPSYDLFLIVAGPVVLGLL
WLLLTKTRWGTLVRAATQDREMVSALGVNQAWLFTAVFALGALLAGLGGALQLPREPANLEMDLNIIGAAFVVVVVGGMG
SLPGAYVAALLIAELKAICIWLGLVEIAGISISFSKLTLVVEFLVMAAVLVARPWGLFGKAQAASHHAGTAEEPLRPPER
LYKYGGAALLALLILMPALTAQSPYVTVLLIDLLVAVLFAASLHFIMGPAGMHSFGHAAYFGLGAYGAALLVRSLNLPME
VALLVAPALAALGAFVYGWFCVRLSGVYLAMLTLAFAQITWAICYQWDAFTGGSNGLTGVWPAGWLADKRIYYYLTLVLV
VGGVLLMHRMLYSPFGYAMRAARDSVLRSDAIGINVKRMQWVAFVMAGSFAGLAGALYAFSKGSISPESLHVGKSIDGLV
MVLLGGVQTLLGPVVGAVTFTWLHDTVARNTDYWRAMLGAIILMLVLLFPQGIAGFVKQLVSNRRDAKKVQS

Sequences:

>Translated_632_residues
MSFSGFIVQLLNGLAGASSLFLVAAGLSLIFGVTRIVNFAHGSFFMVGIYVAYSLVATLGSTLGFWPALLLAALAVGVLG
ALVEVLLLRRIYHAPELFQLLATFALGLVIKDGVLWFWGAEELLGPRAPGLTGSVSILGRQFPSYDLFLIVAGPVVLGLL
WLLLTKTRWGTLVRAATQDREMVSALGVNQAWLFTAVFALGALLAGLGGALQLPREPANLEMDLNIIGAAFVVVVVGGMG
SLPGAYVAALLIAELKAICIWLGLVEIAGISISFSKLTLVVEFLVMAAVLVARPWGLFGKAQAASHHAGTAEEPLRPPER
LYKYGGAALLALLILMPALTAQSPYVTVLLIDLLVAVLFAASLHFIMGPAGMHSFGHAAYFGLGAYGAALLVRSLNLPME
VALLVAPALAALGAFVYGWFCVRLSGVYLAMLTLAFAQITWAICYQWDAFTGGSNGLTGVWPAGWLADKRIYYYLTLVLV
VGGVLLMHRMLYSPFGYAMRAARDSVLRSDAIGINVKRMQWVAFVMAGSFAGLAGALYAFSKGSISPESLHVGKSIDGLV
MVLLGGVQTLLGPVVGAVTFTWLHDTVARNTDYWRAMLGAIILMLVLLFPQGIAGFVKQLVSNRRDAKKVQS
>Mature_631_residues
SFSGFIVQLLNGLAGASSLFLVAAGLSLIFGVTRIVNFAHGSFFMVGIYVAYSLVATLGSTLGFWPALLLAALAVGVLGA
LVEVLLLRRIYHAPELFQLLATFALGLVIKDGVLWFWGAEELLGPRAPGLTGSVSILGRQFPSYDLFLIVAGPVVLGLLW
LLLTKTRWGTLVRAATQDREMVSALGVNQAWLFTAVFALGALLAGLGGALQLPREPANLEMDLNIIGAAFVVVVVGGMGS
LPGAYVAALLIAELKAICIWLGLVEIAGISISFSKLTLVVEFLVMAAVLVARPWGLFGKAQAASHHAGTAEEPLRPPERL
YKYGGAALLALLILMPALTAQSPYVTVLLIDLLVAVLFAASLHFIMGPAGMHSFGHAAYFGLGAYGAALLVRSLNLPMEV
ALLVAPALAALGAFVYGWFCVRLSGVYLAMLTLAFAQITWAICYQWDAFTGGSNGLTGVWPAGWLADKRIYYYLTLVLVV
GGVLLMHRMLYSPFGYAMRAARDSVLRSDAIGINVKRMQWVAFVMAGSFAGLAGALYAFSKGSISPESLHVGKSIDGLVM
VLLGGVQTLLGPVVGAVTFTWLHDTVARNTDYWRAMLGAIILMLVLLFPQGIAGFVKQLVSNRRDAKKVQS

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=303, Percent_Identity=26.4026402640264, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789866, Length=317, Percent_Identity=23.9747634069401, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 67165; Mature: 67034

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSGFIVQLLNGLAGASSLFLVAAGLSLIFGVTRIVNFAHGSFFMVGIYVAYSLVATLG
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
STLGFWPALLLAALAVGVLGALVEVLLLRRIYHAPELFQLLATFALGLVIKDGVLWFWGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEECC
EELLGPRAPGLTGSVSILGRQFPSYDLFLIVAGPVVLGLLWLLLTKTRWGTLVRAATQDR
HHHCCCCCCCCCCHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMVSALGVNQAWLFTAVFALGALLAGLGGALQLPREPANLEMDLNIIGAAFVVVVVGGMG
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECHHHHHHHHHHHHHCCCC
SLPGAYVAALLIAELKAICIWLGLVEIAGISISFSKLTLVVEFLVMAAVLVARPWGLFGK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AQAASHHAGTAEEPLRPPERLYKYGGAALLALLILMPALTAQSPYVTVLLIDLLVAVLFA
CHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
ASLHFIMGPAGMHSFGHAAYFGLGAYGAALLVRSLNLPMEVALLVAPALAALGAFVYGWF
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
CVRLSGVYLAMLTLAFAQITWAICYQWDAFTGGSNGLTGVWPAGWLADKRIYYYLTLVLV
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
VGGVLLMHRMLYSPFGYAMRAARDSVLRSDAIGINVKRMQWVAFVMAGSFAGLAGALYAF
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SKGSISPESLHVGKSIDGLVMVLLGGVQTLLGPVVGAVTFTWLHDTVARNTDYWRAMLGA
CCCCCCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
IILMLVLLFPQGIAGFVKQLVSNRRDAKKVQS
HHHHHHHHHCCCHHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure 
SFSGFIVQLLNGLAGASSLFLVAAGLSLIFGVTRIVNFAHGSFFMVGIYVAYSLVATLG
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
STLGFWPALLLAALAVGVLGALVEVLLLRRIYHAPELFQLLATFALGLVIKDGVLWFWGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEECC
EELLGPRAPGLTGSVSILGRQFPSYDLFLIVAGPVVLGLLWLLLTKTRWGTLVRAATQDR
HHHCCCCCCCCCCHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMVSALGVNQAWLFTAVFALGALLAGLGGALQLPREPANLEMDLNIIGAAFVVVVVGGMG
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECHHHHHHHHHHHHHCCCC
SLPGAYVAALLIAELKAICIWLGLVEIAGISISFSKLTLVVEFLVMAAVLVARPWGLFGK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
AQAASHHAGTAEEPLRPPERLYKYGGAALLALLILMPALTAQSPYVTVLLIDLLVAVLFA
CHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
ASLHFIMGPAGMHSFGHAAYFGLGAYGAALLVRSLNLPMEVALLVAPALAALGAFVYGWF
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
CVRLSGVYLAMLTLAFAQITWAICYQWDAFTGGSNGLTGVWPAGWLADKRIYYYLTLVLV
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
VGGVLLMHRMLYSPFGYAMRAARDSVLRSDAIGINVKRMQWVAFVMAGSFAGLAGALYAF
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SKGSISPESLHVGKSIDGLVMVLLGGVQTLLGPVVGAVTFTWLHDTVARNTDYWRAMLGA
CCCCCCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
IILMLVLLFPQGIAGFVKQLVSNRRDAKKVQS
HHHHHHHHHCCCHHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]