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The map label for this gene is cqsS [H]

Identifier: 91789885

GI number: 91789885

Start: 4247037

End: 4248341

Strand: Direct

Name: cqsS [H]

Synonym: Bpro_4046

Alternate gene names: 91789885

Gene position: 4247037-4248341 (Clockwise)

Preceding gene: 91789882

Following gene: 91789886

Centisome position: 81.67

GC content: 62.45

Gene sequence:

>1305_bases
TTGAGAAAAGCTCGCGTCCCGCCATGGCTTTCCCGGCATCTTATTGCGCACGGGGTGCCCTCGCCCCTGGAGCCGATTCT
GCACCCATCGCCGTGGCGGCTGCGCCTGATCGGCCTGTCACTGCTGCTCGGCAACCCGCTGTTTGGCTGGATCTGGTCCA
GCTGGCTGGTCCAGCCCTACGAGAGTCCCTGGCTGCGCGGTTTGATGAGCGCGCTGGGCGGGGTCCTGATGCTCCCGCCG
GTGATCAGCGATCTTTCCAGTCCGGTCACGCGCGTGATCGTTCCGGTGATCACCTGGATTGAACTTCCCTTCTTCTTCAG
CTGGATGTACCTCAACAATGCCGGCGGCGCGGCCTGGCTGTCGAGCATGTGCGCGATGATTCTGATTTATTACCACCTGA
CCGACTGGCGAATCGCGACGGCGGGAACCGTCAGCGGCGCGCTGGTGGCCTGGGGCCTGCTCAACTGGCTGCCCCACCAG
AGCGTTCCCCTCGCCGGCCTCGCCAACCTCGCCAACCTCGGCGCCGTTGATGCCGTGGTGATCGCCTTCAGCTGGGGCTG
CGCCATATTGCTCGGGCTGTCGTCGGCCAACCTGCGACGTGAACATCTGGCCCACACACTGACCACCATTGGCATCATGG
CGCATGAGCTGCGCACGCCGCTTTCGACAGCGGCGCTGATCGGGGACGCGATCCAGCTGGAGATCGAGCGCCAGCCAGAT
CTCCCAAGAGCCCAGCAATTCGAAAAACTGGCCGTGCGCCTGCATGGCCTGGTGCGTCACATGAACCACCAGATCGACAC
CCAGATCGCCAACGCCAAGCTGCTGCAGCTGCCACGCTACGACCAGCGCATTCTGGCCAGCAAGCTGGTCAACGAGGTCA
CCAGCAACTACCCCTTTCAGTCCACACGCCAGCGGGAATGCGTGCAGGTACTGATACGCACCGACTTCGTATTCCGCGCT
TCCTTCACGCAGTTTTCCCAGGTGCTCGACAACATGATCAAGAATGCGCTGCACTCCCTGATGGCGGCCGACTCCAAATA
CCCCCTTGGCGCGCTGCGCATCGAGGTCGGCGTGGCGCGCAACCGCGGCCGTATCGTGGTGGCCGACGATGGCATGGGCA
TTGACCCCGCCTTGCAGGCGAAGATATTCAAGCCTTTTTTCTCCAGCAACCGCGGCACCGGCCATGGCCTTGGACTGGCT
TTTTGCCAACAGGTGGTGCAAAGTGCAGGCGGCAGGATTCAGGTGAAATCAGAGTTTGCCGTCGGCGCGATTTTTACCAT
TGACTTACCGCTGGCAGGCAGCTGA

Upstream 100 bases:

>100_bases
GTAGTTGCATTCGCTCGCCTAAAACAAAACAGGGACAATACAGGCAAATGCCAAACGCATTCCTGGTCAGCCCGCAAGTT
TCGCCGGAGATCTTCTGCTC

Downstream 100 bases:

>100_bases
TACAGGGCTGAATTTGACAACACCAAGAAACCCGACAACCATGACCTTTGCACTCTATCGCCGCCCGGGCGGCGTTGTCT
TTCTGGATGATGATCCGGAC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Cholerae quorum-sensing sensor [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MRKARVPPWLSRHLIAHGVPSPLEPILHPSPWRLRLIGLSLLLGNPLFGWIWSSWLVQPYESPWLRGLMSALGGVLMLPP
VISDLSSPVTRVIVPVITWIELPFFFSWMYLNNAGGAAWLSSMCAMILIYYHLTDWRIATAGTVSGALVAWGLLNWLPHQ
SVPLAGLANLANLGAVDAVVIAFSWGCAILLGLSSANLRREHLAHTLTTIGIMAHELRTPLSTAALIGDAIQLEIERQPD
LPRAQQFEKLAVRLHGLVRHMNHQIDTQIANAKLLQLPRYDQRILASKLVNEVTSNYPFQSTRQRECVQVLIRTDFVFRA
SFTQFSQVLDNMIKNALHSLMAADSKYPLGALRIEVGVARNRGRIVVADDGMGIDPALQAKIFKPFFSSNRGTGHGLGLA
FCQQVVQSAGGRIQVKSEFAVGAIFTIDLPLAGS

Sequences:

>Translated_434_residues
MRKARVPPWLSRHLIAHGVPSPLEPILHPSPWRLRLIGLSLLLGNPLFGWIWSSWLVQPYESPWLRGLMSALGGVLMLPP
VISDLSSPVTRVIVPVITWIELPFFFSWMYLNNAGGAAWLSSMCAMILIYYHLTDWRIATAGTVSGALVAWGLLNWLPHQ
SVPLAGLANLANLGAVDAVVIAFSWGCAILLGLSSANLRREHLAHTLTTIGIMAHELRTPLSTAALIGDAIQLEIERQPD
LPRAQQFEKLAVRLHGLVRHMNHQIDTQIANAKLLQLPRYDQRILASKLVNEVTSNYPFQSTRQRECVQVLIRTDFVFRA
SFTQFSQVLDNMIKNALHSLMAADSKYPLGALRIEVGVARNRGRIVVADDGMGIDPALQAKIFKPFFSSNRGTGHGLGLA
FCQQVVQSAGGRIQVKSEFAVGAIFTIDLPLAGS
>Mature_434_residues
MRKARVPPWLSRHLIAHGVPSPLEPILHPSPWRLRLIGLSLLLGNPLFGWIWSSWLVQPYESPWLRGLMSALGGVLMLPP
VISDLSSPVTRVIVPVITWIELPFFFSWMYLNNAGGAAWLSSMCAMILIYYHLTDWRIATAGTVSGALVAWGLLNWLPHQ
SVPLAGLANLANLGAVDAVVIAFSWGCAILLGLSSANLRREHLAHTLTTIGIMAHELRTPLSTAALIGDAIQLEIERQPD
LPRAQQFEKLAVRLHGLVRHMNHQIDTQIANAKLLQLPRYDQRILASKLVNEVTSNYPFQSTRQRECVQVLIRTDFVFRA
SFTQFSQVLDNMIKNALHSLMAADSKYPLGALRIEVGVARNRGRIVVADDGMGIDPALQAKIFKPFFSSNRGTGHGLGLA
FCQQVVQSAGGRIQVKSEFAVGAIFTIDLPLAGS

Specific function: Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to luxU and luxO [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=249, Percent_Identity=29.718875502008, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI145693157, Length=237, Percent_Identity=26.5822784810127, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47811; Mature: 47811

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKARVPPWLSRHLIAHGVPSPLEPILHPSPWRLRLIGLSLLLGNPLFGWIWSSWLVQPY
CCCCCCCHHHHHHHHHCCCCCCHHHCCCCCCCEEEHHHHHHHHCCCHHHHHHHHHHCCCC
ESPWLRGLMSALGGVLMLPPVISDLSSPVTRVIVPVITWIELPFFFSWMYLNNAGGAAWL
CCHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHH
SSMCAMILIYYHLTDWRIATAGTVSGALVAWGLLNWLPHQSVPLAGLANLANLGAVDAVV
HHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHH
IAFSWGCAILLGLSSANLRREHLAHTLTTIGIMAHELRTPLSTAALIGDAIQLEIERQPD
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEEECCCC
LPRAQQFEKLAVRLHGLVRHMNHQIDTQIANAKLLQLPRYDQRILASKLVNEVTSNYPFQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHCCCCCC
STRQRECVQVLIRTDFVFRASFTQFSQVLDNMIKNALHSLMAADSKYPLGALRIEVGVAR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEC
NRGRIVVADDGMGIDPALQAKIFKPFFSSNRGTGHGLGLAFCQQVVQSAGGRIQVKSEFA
CCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCC
VGAIFTIDLPLAGS
EEEEEEEECCCCCC
>Mature Secondary Structure
MRKARVPPWLSRHLIAHGVPSPLEPILHPSPWRLRLIGLSLLLGNPLFGWIWSSWLVQPY
CCCCCCCHHHHHHHHHCCCCCCHHHCCCCCCCEEEHHHHHHHHCCCHHHHHHHHHHCCCC
ESPWLRGLMSALGGVLMLPPVISDLSSPVTRVIVPVITWIELPFFFSWMYLNNAGGAAWL
CCHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHH
SSMCAMILIYYHLTDWRIATAGTVSGALVAWGLLNWLPHQSVPLAGLANLANLGAVDAVV
HHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHH
IAFSWGCAILLGLSSANLRREHLAHTLTTIGIMAHELRTPLSTAALIGDAIQLEIERQPD
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEEECCCC
LPRAQQFEKLAVRLHGLVRHMNHQIDTQIANAKLLQLPRYDQRILASKLVNEVTSNYPFQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHCCCCCC
STRQRECVQVLIRTDFVFRASFTQFSQVLDNMIKNALHSLMAADSKYPLGALRIEVGVAR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEC
NRGRIVVADDGMGIDPALQAKIFKPFFSSNRGTGHGLGLAFCQQVVQSAGGRIQVKSEFA
CCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCC
VGAIFTIDLPLAGS
EEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA