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The map label for this gene is rmlA1 [H]

Identifier: 91789858

GI number: 91789858

Start: 4217376

End: 4218293

Strand: Reverse

Name: rmlA1 [H]

Synonym: Bpro_4018

Alternate gene names: 91789858

Gene position: 4218293-4217376 (Counterclockwise)

Preceding gene: 91789859

Following gene: 91789857

Centisome position: 81.12

GC content: 57.95

Gene sequence:

>918_bases
ATGACCTCTTCCCCACTCACCACTAGCCACTCACCACTAGCCAGGAAGGGCATCATCCTCGCCGGCGGCTCAGGCACCCG
CCTGCACCCGGCCACGCTGGCCATCAGCAAACAGCTGCTCCCGGTGTACGACAAGCCCATGATCTACTACCCGCTCAGCA
CTCTCATGCTCGCGGGCATGCGCGACATCCTCGTCATCAGCACCCCGCAAGACACACCGCGTTTTCAGCAACTGCTGGGC
GACGGCAGCCAGTGGGGCCTGAACCTGCAGTATGCCGTGCAGCCCAGCCCAGACGGCCTGGCGCAGGCTTTCATCATCGG
TGAGCCGTTCATTGGCAACTCGCCCAGTGCACTGGTGCTTGGTGACAATATTTTTTATGGTCATGACTTTCACCAATTGC
TGGGCAGCGCCATGGCCAGAACTGAGGGTGCCAGCGTTTTCGCCTACCATGTGCACAACCCGGAGCGCTATGGCGTGGCG
GAGTTCGACGCGCGCGGCAAAGTGCTGTCGCTGGAAGAAAAGCCAAAACAACCCAAGTCAAACTACGCCGTAACGGGCCT
GTATTTTTACGACAATCAGGTGGTTGACTTGGCCAAAAGCCTGAAGCCATCCCTGCGCGGCGAGCTTGAAATAACTGACC
TTAACCGCTTGTATCTTGAGCGCGGCCAACTCGATGTTGAAATCATGGGCCGGGGCTATGCCTGGCTTGACACCGGTACC
CACGAATCGTTGCTGGAGGCCGGCCAGTTCATTGCCACCCTGGAAAACCGCCAAGGCCTGAAGGTAGCCTGCCCCGAAGA
AATCGCTTATCGCCAGCACTGGATTGATGCCTCCCAGCTGGAAAAGCTTGCACAGCCCCTCGCCAAAAACGGCTATGGGC
AGTACCTGCTTCGCATCCTCAAAGAAAAAGTATTTTGA

Upstream 100 bases:

>100_bases
TAGAAACGGTGCAAAAGAATATCTGCACTTCATCGGCATTGCGCGTGGCTCACTGGCAGAACTCGAAACGCAGCTCGGCC
TTTAAATAACTAAGCCTCTC

Downstream 100 bases:

>100_bases
TGAAAGCCACACCCCTCGCCATTCCTGATGTGATCCTGCTTGAACCCCAAGTGTTTGGAGACGCGCGGGGCTTCTTTTTT
GAGAGCTTTAATCAGGCAAA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MTSSPLTTSHSPLARKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGMRDILVISTPQDTPRFQQLLG
DGSQWGLNLQYAVQPSPDGLAQAFIIGEPFIGNSPSALVLGDNIFYGHDFHQLLGSAMARTEGASVFAYHVHNPERYGVA
EFDARGKVLSLEEKPKQPKSNYAVTGLYFYDNQVVDLAKSLKPSLRGELEITDLNRLYLERGQLDVEIMGRGYAWLDTGT
HESLLEAGQFIATLENRQGLKVACPEEIAYRQHWIDASQLEKLAQPLAKNGYGQYLLRILKEKVF

Sequences:

>Translated_305_residues
MTSSPLTTSHSPLARKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGMRDILVISTPQDTPRFQQLLG
DGSQWGLNLQYAVQPSPDGLAQAFIIGEPFIGNSPSALVLGDNIFYGHDFHQLLGSAMARTEGASVFAYHVHNPERYGVA
EFDARGKVLSLEEKPKQPKSNYAVTGLYFYDNQVVDLAKSLKPSLRGELEITDLNRLYLERGQLDVEIMGRGYAWLDTGT
HESLLEAGQFIATLENRQGLKVACPEEIAYRQHWIDASQLEKLAQPLAKNGYGQYLLRILKEKVF
>Mature_304_residues
TSSPLTTSHSPLARKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGMRDILVISTPQDTPRFQQLLGD
GSQWGLNLQYAVQPSPDGLAQAFIIGEPFIGNSPSALVLGDNIFYGHDFHQLLGSAMARTEGASVFAYHVHNPERYGVAE
FDARGKVLSLEEKPKQPKSNYAVTGLYFYDNQVVDLAKSLKPSLRGELEITDLNRLYLERGQLDVEIMGRGYAWLDTGTH
ESLLEAGQFIATLENRQGLKVACPEEIAYRQHWIDASQLEKLAQPLAKNGYGQYLLRILKEKVF

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=288, Percent_Identity=75.6944444444444, Blast_Score=469, Evalue=1e-133,
Organism=Escherichia coli, GI1790224, Length=288, Percent_Identity=65.9722222222222, Blast_Score=407, Evalue=1e-115,
Organism=Escherichia coli, GI1787488, Length=296, Percent_Identity=26.0135135135135, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI133931050, Length=190, Percent_Identity=25.7894736842105, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=259, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355443, Length=251, Percent_Identity=25.0996015936255, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24644084, Length=251, Percent_Identity=25.0996015936255, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 33778; Mature: 33647

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSPLTTSHSPLARKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGM
CCCCCCCCCCCCHHHCCEEEECCCCCEECHHHHHHHHHHCCCCCCCEEEECHHHHHHHCC
RDILVISTPQDTPRFQQLLGDGSQWGLNLQYAVQPSPDGLAQAFIIGEPFIGNSPSALVL
CEEEEEECCCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCEEEE
GDNIFYGHDFHQLLGSAMARTEGASVFAYHVHNPERYGVAEFDARGKVLSLEEKPKQPKS
ECCEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEECCCCCEEECCCCCCCCCC
NYAVTGLYFYDNQVVDLAKSLKPSLRGELEITDLNRLYLERGQLDVEIMGRGYAWLDTGT
CEEEEEEEEECCHHHHHHHHCCHHHCCCEEEEHHHHHHHHCCCEEEEEECCCEEEEECCC
HESLLEAGQFIATLENRQGLKVACPEEIAYRQHWIDASQLEKLAQPLAKNGYGQYLLRIL
HHHHHHHHHHEEECCCCCCCEEECHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHH
KEKVF
HHHCC
>Mature Secondary Structure 
TSSPLTTSHSPLARKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGM
CCCCCCCCCCCHHHCCEEEECCCCCEECHHHHHHHHHHCCCCCCCEEEECHHHHHHHCC
RDILVISTPQDTPRFQQLLGDGSQWGLNLQYAVQPSPDGLAQAFIIGEPFIGNSPSALVL
CEEEEEECCCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCEEEE
GDNIFYGHDFHQLLGSAMARTEGASVFAYHVHNPERYGVAEFDARGKVLSLEEKPKQPKS
ECCEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEECCCCCEEECCCCCCCCCC
NYAVTGLYFYDNQVVDLAKSLKPSLRGELEITDLNRLYLERGQLDVEIMGRGYAWLDTGT
CEEEEEEEEECCHHHHHHHHCCHHHCCCEEEEHHHHHHHHCCCEEEEEECCCEEEEECCC
HESLLEAGQFIATLENRQGLKVACPEEIAYRQHWIDASQLEKLAQPLAKNGYGQYLLRIL
HHHHHHHHHHEEECCCCCCCEEECHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHH
KEKVF
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]