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The map label for this gene is fadA [H]

Identifier: 91789793

GI number: 91789793

Start: 4143883

End: 4145079

Strand: Reverse

Name: fadA [H]

Synonym: Bpro_3953

Alternate gene names: 91789793

Gene position: 4145079-4143883 (Counterclockwise)

Preceding gene: 91789794

Following gene: 91789789

Centisome position: 79.71

GC content: 65.25

Gene sequence:

>1197_bases
ATGAAACAAGTCCAGGAAGCCTACATCGTTGCCGCCACGCGCACGCCCATCGGCCGTTCGCACCGGGGGTTTTTCCGCAA
TACGCGTCCCGACGACCTGCTGGTCAAGGCGCTGCAGGCCGCGCTGGCCCAGGTGCCCACGCTGGACCCCAAGGCCATTG
AAGACATCATCTGCGGCTGCGCGATTCCCGAAGGCCCGCAGGGTTTGAACATCGCCCGCATCGGTGCGGTGCTGGCGGGC
TTGCCCACCAGTGTGGGTGGCATCACCGTCAACCGCTTTTGTGCCTCGGGCCTGTCCGCCGTGCAGATGGCGGCGGACCG
CATCCGTGTCGGCGAAGCCGATGTGATGATTGCCGCCGGCACCGAGAGCATGAGCATGGTGCCCATGTCGGGCAACTCGC
CGTCGCTGTCGCCGGAAATGTTTGCCAACGACGAGAACGTCGGCATCGCCTACGGCATGGGCCTGACGGCCGAGAAGGTT
GCGCAGCAGTGGAAGGTCTCGCGTGATGCGCAGGACCAGTTCGCCTACGAGTCCCACATGAAGGCACTCAAGGCGCAGCA
GGCCGGCGAGTTCACGAATGAAATCACGCCGGTGGAAGTGACCGACCGAACCGCCAACCTGGAAACCGGCGAAGTCATCG
CCACCACCCGCACCGTGAGCCTGGACGAGGGCGCGCGCCCCGACACCACGGTGGAAGGCCTGGCCAAACTGAAAACCGTG
TTTGCTGCGCGCGGCTCGGTCACGGCCGGCAACAGCTCACAAACTTCCGATGGCGCGGGCGCGCTGATTCTGGCCAGCGA
AAAAGCCGTCAAGGAATTCGGCCTGAAACCGCTGGCGCGTTTCGTCAGTTACGCCGCCAAGGGCGTGCCGCCGCACATCA
TGGGCGTAGGCCCGATCGAAGCCATTCCCGCAGCGCTGCGTTACGCCGGCCTGAAGCAGGATGACATCGACTGGTTCGAA
CTCAACGAGGCGTTTGCCGCGCAGTCGCTGGCGGTCATCAACACGCTGGGCCTGAACGCGGCCAAAGTCAACCCGATGGG
CGGCGCGATTGCACTGGGTCACCCGCTGGGCGCCACGGGCGCGATTCGCGCGGCCACCGTGATCCATGCGCTGCAGCGCC
ATCAGCTGAAGTACGGCATGGTGACCATGTGTGTCGGCATGGGGCAAGGCGCCGCCGGCATTTTCGAGCGGGTGTAG

Upstream 100 bases:

>100_bases
CCTGTACCCAGTCCCCTCTCCCGCTGGCGGGAGAGGGTTAGGGTGAGGGCAGCAGCCTTTGTCCTACCAAGCCAACTTAT
TGAGAAACAAGGAACTACCC

Downstream 100 bases:

>100_bases
GGTGGTACTGCCGACCTGACCTCCGCAGTGCTGTGCGCGGCGGGGCCGGCGCTTAAATCTCGAAACGAATCCCCTGCGCC
AGCGGCAGGCTGGATCCGTA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MKQVQEAYIVAATRTPIGRSHRGFFRNTRPDDLLVKALQAALAQVPTLDPKAIEDIICGCAIPEGPQGLNIARIGAVLAG
LPTSVGGITVNRFCASGLSAVQMAADRIRVGEADVMIAAGTESMSMVPMSGNSPSLSPEMFANDENVGIAYGMGLTAEKV
AQQWKVSRDAQDQFAYESHMKALKAQQAGEFTNEITPVEVTDRTANLETGEVIATTRTVSLDEGARPDTTVEGLAKLKTV
FAARGSVTAGNSSQTSDGAGALILASEKAVKEFGLKPLARFVSYAAKGVPPHIMGVGPIEAIPAALRYAGLKQDDIDWFE
LNEAFAAQSLAVINTLGLNAAKVNPMGGAIALGHPLGATGAIRAATVIHALQRHQLKYGMVTMCVGMGQGAAGIFERV

Sequences:

>Translated_398_residues
MKQVQEAYIVAATRTPIGRSHRGFFRNTRPDDLLVKALQAALAQVPTLDPKAIEDIICGCAIPEGPQGLNIARIGAVLAG
LPTSVGGITVNRFCASGLSAVQMAADRIRVGEADVMIAAGTESMSMVPMSGNSPSLSPEMFANDENVGIAYGMGLTAEKV
AQQWKVSRDAQDQFAYESHMKALKAQQAGEFTNEITPVEVTDRTANLETGEVIATTRTVSLDEGARPDTTVEGLAKLKTV
FAARGSVTAGNSSQTSDGAGALILASEKAVKEFGLKPLARFVSYAAKGVPPHIMGVGPIEAIPAALRYAGLKQDDIDWFE
LNEAFAAQSLAVINTLGLNAAKVNPMGGAIALGHPLGATGAIRAATVIHALQRHQLKYGMVTMCVGMGQGAAGIFERV
>Mature_398_residues
MKQVQEAYIVAATRTPIGRSHRGFFRNTRPDDLLVKALQAALAQVPTLDPKAIEDIICGCAIPEGPQGLNIARIGAVLAG
LPTSVGGITVNRFCASGLSAVQMAADRIRVGEADVMIAAGTESMSMVPMSGNSPSLSPEMFANDENVGIAYGMGLTAEKV
AQQWKVSRDAQDQFAYESHMKALKAQQAGEFTNEITPVEVTDRTANLETGEVIATTRTVSLDEGARPDTTVEGLAKLKTV
FAARGSVTAGNSSQTSDGAGALILASEKAVKEFGLKPLARFVSYAAKGVPPHIMGVGPIEAIPAALRYAGLKQDDIDWFE
LNEAFAAQSLAVINTLGLNAAKVNPMGGAIALGHPLGATGAIRAATVIHALQRHQLKYGMVTMCVGMGQGAAGIFERV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=45.1530612244898, Blast_Score=305, Evalue=6e-83,
Organism=Homo sapiens, GI167614485, Length=406, Percent_Identity=38.1773399014778, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI148539872, Length=400, Percent_Identity=38.5, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI4557237, Length=405, Percent_Identity=34.8148148148148, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI4504327, Length=442, Percent_Identity=31.9004524886878, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI194353979, Length=245, Percent_Identity=36.734693877551, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI1787663, Length=413, Percent_Identity=44.0677966101695, Blast_Score=307, Evalue=9e-85,
Organism=Escherichia coli, GI48994986, Length=403, Percent_Identity=45.1612903225806, Blast_Score=301, Evalue=6e-83,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=40.1477832512315, Blast_Score=254, Evalue=5e-69,
Organism=Escherichia coli, GI87082165, Length=406, Percent_Identity=37.6847290640394, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1788683, Length=430, Percent_Identity=29.0697674418605, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI133906874, Length=401, Percent_Identity=42.3940149625935, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI25147385, Length=402, Percent_Identity=34.5771144278607, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17535921, Length=406, Percent_Identity=34.4827586206897, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=442, Percent_Identity=31.2217194570136, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17535917, Length=401, Percent_Identity=29.925187032419, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322031, Length=400, Percent_Identity=41, Blast_Score=286, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6325229, Length=415, Percent_Identity=37.5903614457831, Blast_Score=226, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24655093, Length=408, Percent_Identity=39.7058823529412, Blast_Score=271, Evalue=6e-73,
Organism=Drosophila melanogaster, GI17648125, Length=402, Percent_Identity=39.0547263681592, Blast_Score=254, Evalue=8e-68,
Organism=Drosophila melanogaster, GI24640423, Length=405, Percent_Identity=33.8271604938272, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI17137578, Length=442, Percent_Identity=31.9004524886878, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41614; Mature: 41614

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQVQEAYIVAATRTPIGRSHRGFFRNTRPDDLLVKALQAALAQVPTLDPKAIEDIICGC
CCCHHCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
AIPEGPQGLNIARIGAVLAGLPTSVGGITVNRFCASGLSAVQMAADRIRVGEADVMIAAG
CCCCCCCCCCHHHHHHHHHCCCCCCCCEEHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEC
TESMSMVPMSGNSPSLSPEMFANDENVGIAYGMGLTAEKVAQQWKVSRDAQDQFAYESHM
CCCCEEEEECCCCCCCCHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHH
KALKAQQAGEFTNEITPVEVTDRTANLETGEVIATTRTVSLDEGARPDTTVEGLAKLKTV
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHH
FAARGSVTAGNSSQTSDGAGALILASEKAVKEFGLKPLARFVSYAAKGVPPHIMGVGPIE
HHHCCCCCCCCCCCCCCCCCEEEEECHHHHHHHCHHHHHHHHHHHHCCCCCCEECCCCHH
AIPAALRYAGLKQDDIDWFELNEAFAAQSLAVINTLGLNAAKVNPMGGAIALGHPLGATG
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEECCCCCCCH
AIRAATVIHALQRHQLKYGMVTMCVGMGQGAAGIFERV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCC
>Mature Secondary Structure
MKQVQEAYIVAATRTPIGRSHRGFFRNTRPDDLLVKALQAALAQVPTLDPKAIEDIICGC
CCCHHCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
AIPEGPQGLNIARIGAVLAGLPTSVGGITVNRFCASGLSAVQMAADRIRVGEADVMIAAG
CCCCCCCCCCHHHHHHHHHCCCCCCCCEEHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEC
TESMSMVPMSGNSPSLSPEMFANDENVGIAYGMGLTAEKVAQQWKVSRDAQDQFAYESHM
CCCCEEEEECCCCCCCCHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHH
KALKAQQAGEFTNEITPVEVTDRTANLETGEVIATTRTVSLDEGARPDTTVEGLAKLKTV
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHH
FAARGSVTAGNSSQTSDGAGALILASEKAVKEFGLKPLARFVSYAAKGVPPHIMGVGPIE
HHHCCCCCCCCCCCCCCCCCEEEEECHHHHHHHCHHHHHHHHHHHHCCCCCCEECCCCHH
AIPAALRYAGLKQDDIDWFELNEAFAAQSLAVINTLGLNAAKVNPMGGAIALGHPLGATG
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEECCCCCCCH
AIRAATVIHALQRHQLKYGMVTMCVGMGQGAAGIFERV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]