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The map label for this gene is prfC [H]

Identifier: 91789652

GI number: 91789652

Start: 3995559

End: 3997175

Strand: Direct

Name: prfC [H]

Synonym: Bpro_3808

Alternate gene names: 91789652

Gene position: 3995559-3997175 (Clockwise)

Preceding gene: 91789651

Following gene: 91789653

Centisome position: 76.83

GC content: 63.2

Gene sequence:

>1617_bases
ATGTCCGAAACCACCGAAATCGCAAAACAGGTCAAGCGCCGCCGCACGTTTGCCATCATTTCCCACCCTGACGCCGGCAA
GACCACGCTGACCGAGAAGCTGCTGCTGTTTTCGGGTGCGATCCAGATCGCCGGCAGCGTCAAGGCCCGCAAGGCCGCGC
GCCATGCCACGTCGGACTGGATGGAGATTGAAAAGCAGCGCGGCATCTCGGTGGCCAGCTCGGTCATGCAGATGGAATAC
CGCGACTGCGTGATCAACCTGCTCGACACCCCCGGCCACCAGGACTTTTCGGAAGATACCTACCGCGTGTTGACGGCAGT
CGATGCCGCGCTGATGGTGATTGACGCGGCCAACGGCGTCGAGCCGCAGACGCGCCGCCTGCTGCAGGTCTGCCGCGCAC
GCAACACGCCCATCCTCACGTTCGTCAACAAGATGGACCGCGAGGTGCAGGACCCGATGAGCGTGATGGACGAGATCGAG
CGTGAACTTGGCATGGCGGTGGTGCCCTTCACCTGGCCGGTGGGCATGGGCAAACTCTTTCACGGCGTTTATGACCGGCG
TGAAGACCGCATGCGCGTCTTCAGCCCGGGTGAAGAAAAAGCGGGCGGCGACGATGAAATCCTGGCCGGCCTGGACAACG
CCGAAGCCGCGAAACGCTTTGGCGCCGAATACAAGCAGGCGCAGGAAGAGATTGAGCTGGTTGCCGGCGCCTCGCACGAA
TTTGACCGCGCCCAATTCCTCAGCGGCAAACAGACGCCCATGTTCTTTGGCTCGGCCATCAACAACTTTGGTGTGCAGGA
GGTGCTGGACGCGCTGGTGGACCTGGCCCCCGCCCCAGCCGAGCGCGAAGCCATCCAGCGCGTGGTGCAGCCTGACGAAA
AGAAATTCTCCGGCGTGGTGTTCAAGATCCAGGCCAATATGGACCCGGCACACCGCGACCGCATTGCGTTTTTGCGCGTG
GCCAGCGGCGAGTTCACGCGCGGCATGCGCCTGAAGGTGGTGCGCAGCGGCAAGGAGTTGCGGCCCAACACGGTGGTGAG
CTTCATGAGCCAGCGCAGGGAATTACTGGATACTGCGTTCGCCGGTGACATCATCGGTATTCCCAACCACGGCGTGCTGC
AGTTGGGCGACACGCTCACCGAAGGCGAAGCGCTGCAATTCACCGGCCTGCCCTTCTTCGCGCCCGAGATGTTCCGCTCC
GTTGAAGTGGCCGATCCGCTGCGCAGCAAGCAGCTGCGTGCCGGCCTCACGCAGCTGGGTGAAGAAGGTGCGATCCAGGT
GTTCCGGCCCATTGCCGGCTCCGTGCTGCTGCTGGGCGCCGTCGGCCAGCTGCAGTTTGAAGTGGTGGCACACCGCCTGG
AGCACGAGTACGGCGTCAAGGCCCGCATCATGGGCAGCAACTTCAACCTGGCCCGCTGGGTCACCAGCGACGACGCCAAT
GAGTTGAAAAAATTCATGGATGCCAACGCGCACCGCGTCGCGCTCGATGCGGTCGATGCGCCCACGCTGCTGGTGGACCA
CAGCGCCACCTTGCGCGCGGTCGAGCAGCAATGGCCCAAGATCCGGTTCCATGCGCTGCGCGAGCATGCCGGGCTGGTGT
TTCAGTCAAAGATGTAA

Upstream 100 bases:

>100_bases
GCGCCGGGCCGCCCCAAGCAAGGCCAGCCCCCTCGGGAGCAGCGCATTACACGCAGTAAAAAGCGTGGGGGCCATGCCAC
GTCGCCGATAATCATGGGTT

Downstream 100 bases:

>100_bases
ATCGTTCACTGGCCTCGTTCACTGACCGCGCGGCCAGTTTCGCCGCATTTGCACGCCCCAGGATTGCAGCCGGCGACCTG
ACCTGCATCTCCGGCCGGCT

Product: peptide chain release factor 3

Products: NA

Alternate protein names: RF-3 [H]

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MSETTEIAKQVKRRRTFAIISHPDAGKTTLTEKLLLFSGAIQIAGSVKARKAARHATSDWMEIEKQRGISVASSVMQMEY
RDCVINLLDTPGHQDFSEDTYRVLTAVDAALMVIDAANGVEPQTRRLLQVCRARNTPILTFVNKMDREVQDPMSVMDEIE
RELGMAVVPFTWPVGMGKLFHGVYDRREDRMRVFSPGEEKAGGDDEILAGLDNAEAAKRFGAEYKQAQEEIELVAGASHE
FDRAQFLSGKQTPMFFGSAINNFGVQEVLDALVDLAPAPAEREAIQRVVQPDEKKFSGVVFKIQANMDPAHRDRIAFLRV
ASGEFTRGMRLKVVRSGKELRPNTVVSFMSQRRELLDTAFAGDIIGIPNHGVLQLGDTLTEGEALQFTGLPFFAPEMFRS
VEVADPLRSKQLRAGLTQLGEEGAIQVFRPIAGSVLLLGAVGQLQFEVVAHRLEHEYGVKARIMGSNFNLARWVTSDDAN
ELKKFMDANAHRVALDAVDAPTLLVDHSATLRAVEQQWPKIRFHALREHAGLVFQSKM

Sequences:

>Translated_538_residues
MSETTEIAKQVKRRRTFAIISHPDAGKTTLTEKLLLFSGAIQIAGSVKARKAARHATSDWMEIEKQRGISVASSVMQMEY
RDCVINLLDTPGHQDFSEDTYRVLTAVDAALMVIDAANGVEPQTRRLLQVCRARNTPILTFVNKMDREVQDPMSVMDEIE
RELGMAVVPFTWPVGMGKLFHGVYDRREDRMRVFSPGEEKAGGDDEILAGLDNAEAAKRFGAEYKQAQEEIELVAGASHE
FDRAQFLSGKQTPMFFGSAINNFGVQEVLDALVDLAPAPAEREAIQRVVQPDEKKFSGVVFKIQANMDPAHRDRIAFLRV
ASGEFTRGMRLKVVRSGKELRPNTVVSFMSQRRELLDTAFAGDIIGIPNHGVLQLGDTLTEGEALQFTGLPFFAPEMFRS
VEVADPLRSKQLRAGLTQLGEEGAIQVFRPIAGSVLLLGAVGQLQFEVVAHRLEHEYGVKARIMGSNFNLARWVTSDDAN
ELKKFMDANAHRVALDAVDAPTLLVDHSATLRAVEQQWPKIRFHALREHAGLVFQSKM
>Mature_537_residues
SETTEIAKQVKRRRTFAIISHPDAGKTTLTEKLLLFSGAIQIAGSVKARKAARHATSDWMEIEKQRGISVASSVMQMEYR
DCVINLLDTPGHQDFSEDTYRVLTAVDAALMVIDAANGVEPQTRRLLQVCRARNTPILTFVNKMDREVQDPMSVMDEIER
ELGMAVVPFTWPVGMGKLFHGVYDRREDRMRVFSPGEEKAGGDDEILAGLDNAEAAKRFGAEYKQAQEEIELVAGASHEF
DRAQFLSGKQTPMFFGSAINNFGVQEVLDALVDLAPAPAEREAIQRVVQPDEKKFSGVVFKIQANMDPAHRDRIAFLRVA
SGEFTRGMRLKVVRSGKELRPNTVVSFMSQRRELLDTAFAGDIIGIPNHGVLQLGDTLTEGEALQFTGLPFFAPEMFRSV
EVADPLRSKQLRAGLTQLGEEGAIQVFRPIAGSVLLLGAVGQLQFEVVAHRLEHEYGVKARIMGSNFNLARWVTSDDANE
LKKFMDANAHRVALDAVDAPTLLVDHSATLRAVEQQWPKIRFHALREHAGLVFQSKM

Specific function: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-

COG id: COG4108

COG function: function code J; Peptide chain release factor RF-3

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. PrfC subfamily [H]

Homologues:

Organism=Homo sapiens, GI18390331, Length=489, Percent_Identity=27.8118609406953, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI19923640, Length=514, Percent_Identity=25.2918287937743, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI25306283, Length=343, Percent_Identity=27.9883381924198, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI25306287, Length=316, Percent_Identity=29.1139240506329, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI157426893, Length=155, Percent_Identity=32.9032258064516, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI94966754, Length=151, Percent_Identity=31.7880794701987, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI310132016, Length=131, Percent_Identity=32.824427480916, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI310110807, Length=131, Percent_Identity=32.824427480916, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI310123363, Length=131, Percent_Identity=32.824427480916, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI4503483, Length=150, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790835, Length=522, Percent_Identity=52.8735632183908, Blast_Score=592, Evalue=1e-170,
Organism=Escherichia coli, GI1789738, Length=504, Percent_Identity=29.9603174603175, Blast_Score=173, Evalue=3e-44,
Organism=Escherichia coli, GI48994988, Length=382, Percent_Identity=25.3926701570681, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788922, Length=160, Percent_Identity=34.375, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17533571, Length=492, Percent_Identity=27.2357723577236, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17556745, Length=187, Percent_Identity=35.2941176470588, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17557151, Length=146, Percent_Identity=32.1917808219178, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17506493, Length=162, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71988819, Length=134, Percent_Identity=35.0746268656716, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71988811, Length=134, Percent_Identity=35.0746268656716, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323098, Length=489, Percent_Identity=26.9938650306748, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6322359, Length=512, Percent_Identity=24.609375, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323320, Length=151, Percent_Identity=29.1390728476821, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324707, Length=154, Percent_Identity=32.4675324675325, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320593, Length=154, Percent_Identity=32.4675324675325, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24582462, Length=492, Percent_Identity=28.4552845528455, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI221458488, Length=404, Percent_Identity=28.2178217821782, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI78706572, Length=159, Percent_Identity=33.9622641509434, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24585711, Length=154, Percent_Identity=34.4155844155844, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585713, Length=154, Percent_Identity=34.4155844155844, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585709, Length=154, Percent_Identity=34.4155844155844, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574573, Length=143, Percent_Identity=35.6643356643357, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR004548
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 59786; Mature: 59655

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETTEIAKQVKRRRTFAIISHPDAGKTTLTEKLLLFSGAIQIAGSVKARKAARHATSDW
CCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
MEIEKQRGISVASSVMQMEYRDCVINLLDTPGHQDFSEDTYRVLTAVDAALMVIDAANGV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCC
EPQTRRLLQVCRARNTPILTFVNKMDREVQDPMSVMDEIERELGMAVVPFTWPVGMGKLF
CHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHH
HGVYDRREDRMRVFSPGEEKAGGDDEILAGLDNAEAAKRFGAEYKQAQEEIELVAGASHE
HHHHHCCCCCEEEECCCCCCCCCCHHHHCCCCCHHHHHHHCHHHHHHHHHHHHHHCCCCC
FDRAQFLSGKQTPMFFGSAINNFGVQEVLDALVDLAPAPAEREAIQRVVQPDEKKFSGVV
HHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEE
FKIQANMDPAHRDRIAFLRVASGEFTRGMRLKVVRSGKELRPNTVVSFMSQRRELLDTAF
EEEECCCCHHHHCCEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
AGDIIGIPNHGVLQLGDTLTEGEALQFTGLPFFAPEMFRSVEVADPLRSKQLRAGLTQLG
CCCEEECCCCCCEEECCCCCCCCEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHC
EEGAIQVFRPIAGSVLLLGAVGQLQFEVVAHRLEHEYGVKARIMGSNFNLARWVTSDDAN
CCCCHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCHH
ELKKFMDANAHRVALDAVDAPTLLVDHSATLRAVEQQWPKIRFHALREHAGLVFQSKM
HHHHHHCCCCCEEEEECCCCCEEEECCCHHHHHHHHHCCHHHHHHHHHHCCCEEECCC
>Mature Secondary Structure 
SETTEIAKQVKRRRTFAIISHPDAGKTTLTEKLLLFSGAIQIAGSVKARKAARHATSDW
CCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
MEIEKQRGISVASSVMQMEYRDCVINLLDTPGHQDFSEDTYRVLTAVDAALMVIDAANGV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCC
EPQTRRLLQVCRARNTPILTFVNKMDREVQDPMSVMDEIERELGMAVVPFTWPVGMGKLF
CHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHH
HGVYDRREDRMRVFSPGEEKAGGDDEILAGLDNAEAAKRFGAEYKQAQEEIELVAGASHE
HHHHHCCCCCEEEECCCCCCCCCCHHHHCCCCCHHHHHHHCHHHHHHHHHHHHHHCCCCC
FDRAQFLSGKQTPMFFGSAINNFGVQEVLDALVDLAPAPAEREAIQRVVQPDEKKFSGVV
HHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEE
FKIQANMDPAHRDRIAFLRVASGEFTRGMRLKVVRSGKELRPNTVVSFMSQRRELLDTAF
EEEECCCCHHHHCCEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
AGDIIGIPNHGVLQLGDTLTEGEALQFTGLPFFAPEMFRSVEVADPLRSKQLRAGLTQLG
CCCEEECCCCCCEEECCCCCCCCEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHC
EEGAIQVFRPIAGSVLLLGAVGQLQFEVVAHRLEHEYGVKARIMGSNFNLARWVTSDDAN
CCCCHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCHH
ELKKFMDANAHRVALDAVDAPTLLVDHSATLRAVEQQWPKIRFHALREHAGLVFQSKM
HHHHHHCCCCCEEEEECCCCCEEEECCCHHHHHHHHHCCHHHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA