Click here to switch to the map view.

The map label for this gene is ilvD [H]

Identifier: 91789386

GI number: 91789386

Start: 3734783

End: 3736522

Strand: Direct

Name: ilvD [H]

Synonym: Bpro_3532

Alternate gene names: 91789386

Gene position: 3734783-3736522 (Clockwise)

Preceding gene: 91789375

Following gene: 91789388

Centisome position: 71.82

GC content: 63.97

Gene sequence:

>1740_bases
ATGAGCAACCAGACACCCAAAAAGAAACCCGAAGAACTACGCAGCCAGCAATGGTTTGGGCGGCAGGACCGCGACGGCTT
TGCCTACCGCAGCTGGGTCAAGGGCAAGGGCGTGCCGCATGACCAGTTCGACGGACGCCCCGTCATCGGCATCTGCAACA
CCTTCAGCGAACTCACCCCCTGCAACAGCCACTTCCGCACCATTGCGGAGCAGGTCAAGATCGGCGTGTACGAGGCCGGC
GGTTTTCCGCTGGAGTTCCCCGTGATGTCGCTGGGCGAGACCCTGTTGCGCCCGACTGCCATGCTCTACCGCAACCTGGC
CAGCATGGACGTGGAAGAAAGCATTCGCGGCAACCCGATTGACGGCGTGGTGCTGCTGATGGGCTGCGACAAGACCACGC
CCTCGCTGGTGATGGGCGCGTCCAGCGTGGACCTGCCGACGGTGGGCGTCAGCGGCGGCCCCATGCTCAGCGGCAAGTGG
CGCGGCCAGGAGCTCGGCTCCGGCACCGGCGTGTGGAGCATGAGCGAGCAGGTGCGCGCCGGCACACTCAAGCTGCAGGA
TTTCTTTGAGGCCGAAAGCTGCATGCACCGCAGCCATGGCCACTGCATGACCATGGGCACGGCCTCCACCATGGCCAGCA
TGGTGGAAGCGCTGGGCATTGGCCTGCCGGGCAATGCAGCCTATCCCGCGGTGGACGGCCGGCGCAATGTGCTGGCCCGC
CTGGCCGGACGGCGGGCGGTCGAGATGGTGCATGAAGACCTCACGCTCTCCAAAATCCTGACACGCGAGGCATTTGAAAA
CGCCATCAAGACGCTGGCGGCCATTGGCGGCTCCACCAACGCCGTGATTCACCTGATTGCCATTGCCGGGCGCATTGGCG
TGAAGCTGACGGTGGACGACTTTGACCGGCTGGCCAGCGAACTGCCCTGCCTCGTCAACCTGCAGCCTTCCGGCAAATAC
CTGATGGAAGACTTCTGCTATGCCGGCGGCCTGCCGGTGGTGATGAAGGAAATTGCGCAGCACCTGCACACGGACGCCAT
CACCGCCAACGGCAAGACCATAGGCGAGAACATTGCCGACGCCGAGAACTACAACACCGACGTGATCATGCCGCTAAGCA
CGCCATTCAAGGACAAGGCGGGCATTGCGGTGCTGCGCGGCAACCTCTCGCCGCGCGGCGCCGTCATCAAGCCCAGTGCC
GCCACACCTGAGCTGATGGTGCACAAAGGCCGGGCCGTGGTGTTTGAAACCATCGAGGACTTTCACGCCCGCATCGATGA
CGAAGACCTCGACATCGACGAAACCTGCGTGATGGTGCTAAAAAATTGCGGACCCAAGGGCTACCCCGGCATGGCCGAGG
TGGGCAACATGCCGCTGCCGCCCAAAGTGCTGCGCAAGGGCATTACCGACATGGTGCGCATCAGCGACGCCCGCATGAGC
GGCACCGCTTACGGCACCGTGGTGCTGCACACGGCGCCCGAGGCGGCGGCGGGCGGCCCGCTGGCGCTGGTGCAAAACGG
CGACATCATTGAACTCGACGTACCCAACCGCCGCCTGCACCTGCACGTGAGCGACGAAGAACTCGCCAAACGCATGGCCG
ACTGGAAGGCACCGGCGCCGCCGTTGACGTCCGGCTACTGGAAACTCTACATTGACCATGTGCTGCAGGCCGACGAGGGC
GTGGACCTGGACTTTCTGGTGGGCAAGCGCGGCGCTTTTGTCCCGAGGGATAATCACTGA

Upstream 100 bases:

>100_bases
ATGGGCCACTATTGTCTTATCATCATATGATTGAGCCTCGATTGGCATCCATGCAAACCCTGAATCCTTGACGGAAACTT
TTACGGAAACGCAGCACACC

Downstream 100 bases:

>100_bases
CTTTTGCCCGCAAGGCAATCACCGCATTGCCTTGCGCCGCAAGCACCGGCTGGCGCCACGCTGGCAGTTACCATGGGTGC
AGCTGGCGCGTCCCGGCCCC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 579; Mature: 578

Protein sequence:

>579_residues
MSNQTPKKKPEELRSQQWFGRQDRDGFAYRSWVKGKGVPHDQFDGRPVIGICNTFSELTPCNSHFRTIAEQVKIGVYEAG
GFPLEFPVMSLGETLLRPTAMLYRNLASMDVEESIRGNPIDGVVLLMGCDKTTPSLVMGASSVDLPTVGVSGGPMLSGKW
RGQELGSGTGVWSMSEQVRAGTLKLQDFFEAESCMHRSHGHCMTMGTASTMASMVEALGIGLPGNAAYPAVDGRRNVLAR
LAGRRAVEMVHEDLTLSKILTREAFENAIKTLAAIGGSTNAVIHLIAIAGRIGVKLTVDDFDRLASELPCLVNLQPSGKY
LMEDFCYAGGLPVVMKEIAQHLHTDAITANGKTIGENIADAENYNTDVIMPLSTPFKDKAGIAVLRGNLSPRGAVIKPSA
ATPELMVHKGRAVVFETIEDFHARIDDEDLDIDETCVMVLKNCGPKGYPGMAEVGNMPLPPKVLRKGITDMVRISDARMS
GTAYGTVVLHTAPEAAAGGPLALVQNGDIIELDVPNRRLHLHVSDEELAKRMADWKAPAPPLTSGYWKLYIDHVLQADEG
VDLDFLVGKRGAFVPRDNH

Sequences:

>Translated_579_residues
MSNQTPKKKPEELRSQQWFGRQDRDGFAYRSWVKGKGVPHDQFDGRPVIGICNTFSELTPCNSHFRTIAEQVKIGVYEAG
GFPLEFPVMSLGETLLRPTAMLYRNLASMDVEESIRGNPIDGVVLLMGCDKTTPSLVMGASSVDLPTVGVSGGPMLSGKW
RGQELGSGTGVWSMSEQVRAGTLKLQDFFEAESCMHRSHGHCMTMGTASTMASMVEALGIGLPGNAAYPAVDGRRNVLAR
LAGRRAVEMVHEDLTLSKILTREAFENAIKTLAAIGGSTNAVIHLIAIAGRIGVKLTVDDFDRLASELPCLVNLQPSGKY
LMEDFCYAGGLPVVMKEIAQHLHTDAITANGKTIGENIADAENYNTDVIMPLSTPFKDKAGIAVLRGNLSPRGAVIKPSA
ATPELMVHKGRAVVFETIEDFHARIDDEDLDIDETCVMVLKNCGPKGYPGMAEVGNMPLPPKVLRKGITDMVRISDARMS
GTAYGTVVLHTAPEAAAGGPLALVQNGDIIELDVPNRRLHLHVSDEELAKRMADWKAPAPPLTSGYWKLYIDHVLQADEG
VDLDFLVGKRGAFVPRDNH
>Mature_578_residues
SNQTPKKKPEELRSQQWFGRQDRDGFAYRSWVKGKGVPHDQFDGRPVIGICNTFSELTPCNSHFRTIAEQVKIGVYEAGG
FPLEFPVMSLGETLLRPTAMLYRNLASMDVEESIRGNPIDGVVLLMGCDKTTPSLVMGASSVDLPTVGVSGGPMLSGKWR
GQELGSGTGVWSMSEQVRAGTLKLQDFFEAESCMHRSHGHCMTMGTASTMASMVEALGIGLPGNAAYPAVDGRRNVLARL
AGRRAVEMVHEDLTLSKILTREAFENAIKTLAAIGGSTNAVIHLIAIAGRIGVKLTVDDFDRLASELPCLVNLQPSGKYL
MEDFCYAGGLPVVMKEIAQHLHTDAITANGKTIGENIADAENYNTDVIMPLSTPFKDKAGIAVLRGNLSPRGAVIKPSAA
TPELMVHKGRAVVFETIEDFHARIDDEDLDIDETCVMVLKNCGPKGYPGMAEVGNMPLPPKVLRKGITDMVRISDARMSG
TAYGTVVLHTAPEAAAGGPLALVQNGDIIELDVPNRRLHLHVSDEELAKRMADWKAPAPPLTSGYWKLYIDHVLQADEGV
DLDFLVGKRGAFVPRDNH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=559, Percent_Identity=30.4114490161002, Blast_Score=218, Evalue=9e-58,
Organism=Escherichia coli, GI1788157, Length=515, Percent_Identity=30.2912621359223, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI2367371, Length=469, Percent_Identity=33.9019189765458, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1786464, Length=449, Percent_Identity=32.0712694877506, Blast_Score=152, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6322476, Length=554, Percent_Identity=31.7689530685921, Blast_Score=257, Evalue=3e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 62668; Mature: 62537

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQTPKKKPEELRSQQWFGRQDRDGFAYRSWVKGKGVPHDQFDGRPVIGICNTFSELTP
CCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHCCC
CNSHFRTIAEQVKIGVYEAGGFPLEFPVMSLGETLLRPTAMLYRNLASMDVEESIRGNPI
CHHHHHHHHHHHHEEEEECCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCC
DGVVLLMGCDKTTPSLVMGASSVDLPTVGVSGGPMLSGKWRGQELGSGTGVWSMSEQVRA
CCEEEEEECCCCCCHHEECCCCCCCCEECCCCCCEECCCCCCCCCCCCCCCCCCHHHHHH
GTLKLQDFFEAESCMHRSHGHCMTMGTASTMASMVEALGIGLPGNAAYPAVDGRRNVLAR
CEEHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
LAGRRAVEMVHEDLTLSKILTREAFENAIKTLAAIGGSTNAVIHLIAIAGRIGVKLTVDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEHEEHHCCCCEEEEHHH
FDRLASELPCLVNLQPSGKYLMEDFCYAGGLPVVMKEIAQHLHTDAITANGKTIGENIAD
HHHHHHHCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCEECCCCCCCCCCCC
AENYNTDVIMPLSTPFKDKAGIAVLRGNLSPRGAVIKPSAATPELMVHKGRAVVFETIED
CCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCEECCCCCCCHHEEECCCEEEHHHHHH
FHARIDDEDLDIDETCVMVLKNCGPKGYPGMAEVGNMPLPPKVLRKGITDMVRISDARMS
HHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC
GTAYGTVVLHTAPEAAAGGPLALVQNGDIIELDVPNRRLHLHVSDEELAKRMADWKAPAP
CCEEEEEEEEECCCCCCCCCEEEEECCCEEEEECCCCEEEEEECHHHHHHHHHHCCCCCC
PLTSGYWKLYIDHVLQADEGVDLDFLVGKRGAFVPRDNH
CCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SNQTPKKKPEELRSQQWFGRQDRDGFAYRSWVKGKGVPHDQFDGRPVIGICNTFSELTP
CCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHCCC
CNSHFRTIAEQVKIGVYEAGGFPLEFPVMSLGETLLRPTAMLYRNLASMDVEESIRGNPI
CHHHHHHHHHHHHEEEEECCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCC
DGVVLLMGCDKTTPSLVMGASSVDLPTVGVSGGPMLSGKWRGQELGSGTGVWSMSEQVRA
CCEEEEEECCCCCCHHEECCCCCCCCEECCCCCCEECCCCCCCCCCCCCCCCCCHHHHHH
GTLKLQDFFEAESCMHRSHGHCMTMGTASTMASMVEALGIGLPGNAAYPAVDGRRNVLAR
CEEHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
LAGRRAVEMVHEDLTLSKILTREAFENAIKTLAAIGGSTNAVIHLIAIAGRIGVKLTVDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEHEEHHCCCCEEEEHHH
FDRLASELPCLVNLQPSGKYLMEDFCYAGGLPVVMKEIAQHLHTDAITANGKTIGENIAD
HHHHHHHCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCEECCCCCCCCCCCC
AENYNTDVIMPLSTPFKDKAGIAVLRGNLSPRGAVIKPSAATPELMVHKGRAVVFETIED
CCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCEECCCCCCCHHEEECCCEEEHHHHHH
FHARIDDEDLDIDETCVMVLKNCGPKGYPGMAEVGNMPLPPKVLRKGITDMVRISDARMS
HHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC
GTAYGTVVLHTAPEAAAGGPLALVQNGDIIELDVPNRRLHLHVSDEELAKRMADWKAPAP
CCEEEEEEEEECCCCCCCCCEEEEECCCEEEEECCCCEEEEEECHHHHHHHHHHCCCCCC
PLTSGYWKLYIDHVLQADEGVDLDFLVGKRGAFVPRDNH
CCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA