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The map label for this gene is fabG2 [H]

Identifier: 91788953

GI number: 91788953

Start: 3261002

End: 3261781

Strand: Direct

Name: fabG2 [H]

Synonym: Bpro_3093

Alternate gene names: 91788953

Gene position: 3261002-3261781 (Clockwise)

Preceding gene: 91788952

Following gene: 91788954

Centisome position: 62.71

GC content: 64.23

Gene sequence:

>780_bases
ATGGATATCGCAGGCAAAGTATTTATCGTCACCGGCGGCGCATCAGGTCTGGGTGAAGGCACGGCACGCATGCTGGTCGC
CAACGGCGCCAAGGTGGTGATTGCCGACATGCAGGCCGACAAGGGCGAAGCCATCGTCTCCGAGTTGACCAAAGAACTCG
GGGAAGGCAAAGCCGCGTTTGTGCCCTGCGACGTCAGCCAGGAGGCCGACGGCCAGGCCGTGGTGGCCAAGGCCGTGTCC
ATGGGCAAGCTGATGGGCCTGGTCAATTGCGCCGGCATTGCGCCCGCCGAAAAAACCGTAGGCAAAAACGGCGCGCACGG
CCTGGCCCTGTTCAGCAAGACCATCACCGTCAACCTGATCGGCAGCTTCAACATGATCCGGCTGGCAGCCGACGCCATGT
GCAAGAACGAGCCGGAAGCCACCGGCGAGCGCGGTGTGCTGATTTCCACCGCCTCGGTCGCGGCCTATGACGGGCAGATC
GGCCAGGCCGCCTACAGCGCGTCCAAGGGCGGCATCGTCGGCATGACCCTGCCCATTGCCCGCGACCTGGCACGCAACGG
CATCCGAAACATGACCATCGCCCCCGGCATCTTCGGCACGCCCATGCTGTTTAGCATGCCGCAGGAAGTGCAGGACTCGC
TGGCCGCCGGCGTGCCCTTCCCTTCGCGCCTGGGTACGCCGCAAGACTATGCCAAGCTGGCCAAACACATCATCGAAAAC
GACATGCTCAATGGCGAGGTGATCCGCCTCGACGGCGCGATTCGGCTGGCGCCACGCTGA

Upstream 100 bases:

>100_bases
CGGGCTTTTTTCATGCGCCATAATTCACATCATTGACGTTTACGTCAACGTCAACATTCCCCCTCCTTTTCTCCCCTTCT
TTTATTTCAAGGAACAAGCC

Downstream 100 bases:

>100_bases
CATCATACGGCTCAGACGCTATTTAACTGATAGCTACTTGCGCCCTATTCTTAAGGGCTATAGGCCGATTTGACTAGTAA
CTCAGTCGAGTCGGTCCGAC

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MDIAGKVFIVTGGASGLGEGTARMLVANGAKVVIADMQADKGEAIVSELTKELGEGKAAFVPCDVSQEADGQAVVAKAVS
MGKLMGLVNCAGIAPAEKTVGKNGAHGLALFSKTITVNLIGSFNMIRLAADAMCKNEPEATGERGVLISTASVAAYDGQI
GQAAYSASKGGIVGMTLPIARDLARNGIRNMTIAPGIFGTPMLFSMPQEVQDSLAAGVPFPSRLGTPQDYAKLAKHIIEN
DMLNGEVIRLDGAIRLAPR

Sequences:

>Translated_259_residues
MDIAGKVFIVTGGASGLGEGTARMLVANGAKVVIADMQADKGEAIVSELTKELGEGKAAFVPCDVSQEADGQAVVAKAVS
MGKLMGLVNCAGIAPAEKTVGKNGAHGLALFSKTITVNLIGSFNMIRLAADAMCKNEPEATGERGVLISTASVAAYDGQI
GQAAYSASKGGIVGMTLPIARDLARNGIRNMTIAPGIFGTPMLFSMPQEVQDSLAAGVPFPSRLGTPQDYAKLAKHIIEN
DMLNGEVIRLDGAIRLAPR
>Mature_259_residues
MDIAGKVFIVTGGASGLGEGTARMLVANGAKVVIADMQADKGEAIVSELTKELGEGKAAFVPCDVSQEADGQAVVAKAVS
MGKLMGLVNCAGIAPAEKTVGKNGAHGLALFSKTITVNLIGSFNMIRLAADAMCKNEPEATGERGVLISTASVAAYDGQI
GQAAYSASKGGIVGMTLPIARDLARNGIRNMTIAPGIFGTPMLFSMPQEVQDSLAAGVPFPSRLGTPQDYAKLAKHIIEN
DMLNGEVIRLDGAIRLAPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=259, Percent_Identity=57.1428571428571, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI83715985, Length=259, Percent_Identity=54.0540540540541, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI15277342, Length=249, Percent_Identity=31.3253012048193, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI31542939, Length=261, Percent_Identity=29.8850574712644, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI40254992, Length=258, Percent_Identity=28.2945736434109, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI59889578, Length=200, Percent_Identity=31, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI5031737, Length=257, Percent_Identity=29.9610894941634, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI224922801, Length=191, Percent_Identity=31.413612565445, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI33667109, Length=200, Percent_Identity=31.5, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI32483357, Length=256, Percent_Identity=27.734375, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4504505, Length=220, Percent_Identity=28.6363636363636, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI19923817, Length=263, Percent_Identity=25.8555133079848, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=259, Percent_Identity=27.7992277992278, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87082160, Length=264, Percent_Identity=30.3030303030303, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787905, Length=239, Percent_Identity=31.3807531380753, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1789057, Length=209, Percent_Identity=31.5789473684211, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87082100, Length=269, Percent_Identity=27.5092936802974, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1790717, Length=267, Percent_Identity=28.0898876404494, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786812, Length=262, Percent_Identity=26.7175572519084, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI2367175, Length=254, Percent_Identity=29.9212598425197, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=255, Percent_Identity=51.3725490196078, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI25147288, Length=229, Percent_Identity=30.1310043668122, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17555706, Length=234, Percent_Identity=32.9059829059829, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17561402, Length=259, Percent_Identity=30.8880308880309, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=247, Percent_Identity=29.1497975708502, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=244, Percent_Identity=27.0491803278689, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=249, Percent_Identity=28.5140562248996, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=270, Percent_Identity=25.1851851851852, Blast_Score=64, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=203, Percent_Identity=29.5566502463054, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=200, Percent_Identity=29.5, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322227, Length=200, Percent_Identity=25.5, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737361, Length=259, Percent_Identity=54.8262548262548, Blast_Score=267, Evalue=5e-72,
Organism=Drosophila melanogaster, GI24639444, Length=261, Percent_Identity=30.2681992337165, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21355319, Length=250, Percent_Identity=28.8, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24644339, Length=240, Percent_Identity=27.5, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18859837, Length=201, Percent_Identity=30.3482587064677, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 26614; Mature: 26614

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIAGKVFIVTGGASGLGEGTARMLVANGAKVVIADMQADKGEAIVSELTKELGEGKAAF
CCCCCEEEEEECCCCCCCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEE
VPCDVSQEADGQAVVAKAVSMGKLMGLVNCAGIAPAEKTVGKNGAHGLALFSKTITVNLI
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCEEEEEEEEEEEEE
GSFNMIRLAADAMCKNEPEATGERGVLISTASVAAYDGQIGQAAYSASKGGIVGMTLPIA
CCCHHHHHHHHHHHCCCCCCCCCCCEEEEECEEEEECCCCCHHHHHCCCCCEEEEEHHHH
RDLARNGIRNMTIAPGIFGTPMLFSMPQEVQDSLAAGVPFPSRLGTPQDYAKLAKHIIEN
HHHHHCCCCCCEECCCCCCCCHHHCCCHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHH
DMLNGEVIRLDGAIRLAPR
CCCCCEEEEECCEEEECCC
>Mature Secondary Structure
MDIAGKVFIVTGGASGLGEGTARMLVANGAKVVIADMQADKGEAIVSELTKELGEGKAAF
CCCCCEEEEEECCCCCCCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEE
VPCDVSQEADGQAVVAKAVSMGKLMGLVNCAGIAPAEKTVGKNGAHGLALFSKTITVNLI
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCEEEEEEEEEEEEE
GSFNMIRLAADAMCKNEPEATGERGVLISTASVAAYDGQIGQAAYSASKGGIVGMTLPIA
CCCHHHHHHHHHHHCCCCCCCCCCCEEEEECEEEEECCCCCHHHHHCCCCCEEEEEHHHH
RDLARNGIRNMTIAPGIFGTPMLFSMPQEVQDSLAAGVPFPSRLGTPQDYAKLAKHIIEN
HHHHHCCCCCCEECCCCCCCCHHHCCCHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHH
DMLNGEVIRLDGAIRLAPR
CCCCCEEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]