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The map label for this gene is livM [H]

Identifier: 91788847

GI number: 91788847

Start: 3142349

End: 3143371

Strand: Direct

Name: livM [H]

Synonym: Bpro_2987

Alternate gene names: 91788847

Gene position: 3142349-3143371 (Clockwise)

Preceding gene: 91788846

Following gene: 91788848

Centisome position: 60.43

GC content: 64.81

Gene sequence:

>1023_bases
ATGAGCGCACAAAAATCCAACCTCGAAGTCCTGCCGCGCGGCGTGCAGGTGGCGCTCGTGCTGGGGCTGGTCGCCCTGCT
CGCCTTCCCCTTCGCCGGCACCGAGTTCTACACCCAGATGGTGACCCGCATGATGATCATGGCGATCTTTGCCATGAGCC
TGGACCTGCTGCAGGGCGTGACCGGCCTGGTCTCGCTGGGTCACGCCGCCTTCTTCGGCATTGCCGGCTACGCCCTGGCC
TTCCTCACCCCGCAGGGCGAGCCGGTGAGCCTGTGGTGGACCCTGCCCGTTGCGGTGCTGGCCTCGGGCCTGGCGGCGCT
GGTGATCGGCTTTTTTGTGGTGCGCACCCACGGCATCTACTTCATCATGGTCACCATGGCCTTTGCCCAGATGGTGTTTT
ACCTGTTCTTTGACAACAAGGTGCTGGGCGGCTCCGACGGGCTGTACATCAACTTCAAGCCCAGCGCCGAGCTCTTCGGC
TGGACGCCCTTTGATCTGGACGGCAAGCGCACGCTGTACTACTTCACGCTGGGCGTCCTGCTGGCCGTCTATGCCTTTTT
GCGGCGCCTGCTGTGGAGCCCGTTTGGCCGGGCGCTGGCCGGCATCCGCGTCAACGAGCACCGCATGCGGGCCATGGGCT
ATGGCACCTTCGGCTACAAGCTGGCGGCCTTCACGCTGGCCGGCAGCCTGGCCGGGCTGGCCGGCTACCTGTGGGGCGCG
CAGACCGGCTACATCAACCCGGAGCTGATGGGCTTTCACATGAGCGCGCACGCCATCATGATGGTGATCCTGGGCGGCAT
GGGCAACTTCGCGGGTGCCATCGTCGGCGCCTTTGCCTTTGAGTACCTGCTGCATGTGTTCAAGGACCTGCCCACCCTCG
AGGTATTGGGCAGCGTCAACCTGGGCAAGCACTGGCAACTCTGGATGGGGCTGTTCATCGTGGCGGTGGTGGTGTTCGCG
CCGCGCGGCCTGCTGGGCCTGGCGCAAAAGTTCATGAAGCGCAAGGAGGCCGACCATGGCTGA

Upstream 100 bases:

>100_bases
ATACCTTTGGCAAGGTCTTGCTGCCCTCGGTCGCCGGCATGCTGGTCTACATGCTGATGGCCGGCGTTCTGCTGTGGAAA
CCTGAAGGGCTGTTCAAGCA

Downstream 100 bases:

>100_bases
AATACTCCTGTCGGCAAGGAGTCTGACCAAACGCTTTGGCGGCCTGGCGGCGGTCAACGATGTTTCTGTCGATCTCTGGC
GCAACCACATCCATGCGGTG

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MSAQKSNLEVLPRGVQVALVLGLVALLAFPFAGTEFYTQMVTRMMIMAIFAMSLDLLQGVTGLVSLGHAAFFGIAGYALA
FLTPQGEPVSLWWTLPVAVLASGLAALVIGFFVVRTHGIYFIMVTMAFAQMVFYLFFDNKVLGGSDGLYINFKPSAELFG
WTPFDLDGKRTLYYFTLGVLLAVYAFLRRLLWSPFGRALAGIRVNEHRMRAMGYGTFGYKLAAFTLAGSLAGLAGYLWGA
QTGYINPELMGFHMSAHAIMMVILGGMGNFAGAIVGAFAFEYLLHVFKDLPTLEVLGSVNLGKHWQLWMGLFIVAVVVFA
PRGLLGLAQKFMKRKEADHG

Sequences:

>Translated_340_residues
MSAQKSNLEVLPRGVQVALVLGLVALLAFPFAGTEFYTQMVTRMMIMAIFAMSLDLLQGVTGLVSLGHAAFFGIAGYALA
FLTPQGEPVSLWWTLPVAVLASGLAALVIGFFVVRTHGIYFIMVTMAFAQMVFYLFFDNKVLGGSDGLYINFKPSAELFG
WTPFDLDGKRTLYYFTLGVLLAVYAFLRRLLWSPFGRALAGIRVNEHRMRAMGYGTFGYKLAAFTLAGSLAGLAGYLWGA
QTGYINPELMGFHMSAHAIMMVILGGMGNFAGAIVGAFAFEYLLHVFKDLPTLEVLGSVNLGKHWQLWMGLFIVAVVVFA
PRGLLGLAQKFMKRKEADHG
>Mature_339_residues
SAQKSNLEVLPRGVQVALVLGLVALLAFPFAGTEFYTQMVTRMMIMAIFAMSLDLLQGVTGLVSLGHAAFFGIAGYALAF
LTPQGEPVSLWWTLPVAVLASGLAALVIGFFVVRTHGIYFIMVTMAFAQMVFYLFFDNKVLGGSDGLYINFKPSAELFGW
TPFDLDGKRTLYYFTLGVLLAVYAFLRRLLWSPFGRALAGIRVNEHRMRAMGYGTFGYKLAAFTLAGSLAGLAGYLWGAQ
TGYINPELMGFHMSAHAIMMVILGGMGNFAGAIVGAFAFEYLLHVFKDLPTLEVLGSVNLGKHWQLWMGLFIVAVVVFAP
RGLLGLAQKFMKRKEADHG

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=326, Percent_Identity=29.4478527607362, Blast_Score=119, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 37152; Mature: 37021

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQKSNLEVLPRGVQVALVLGLVALLAFPFAGTEFYTQMVTRMMIMAIFAMSLDLLQGV
CCCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGLVSLGHAAFFGIAGYALAFLTPQGEPVSLWWTLPVAVLASGLAALVIGFFVVRTHGIY
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHH
FIMVTMAFAQMVFYLFFDNKVLGGSDGLYINFKPSAELFGWTPFDLDGKRTLYYFTLGVL
HHHHHHHHHHHHHHHHHCCEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHH
LAVYAFLRRLLWSPFGRALAGIRVNEHRMRAMGYGTFGYKLAAFTLAGSLAGLAGYLWGA
HHHHHHHHHHHHCHHHHHHHCCEECHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
QTGYINPELMGFHMSAHAIMMVILGGMGNFAGAIVGAFAFEYLLHVFKDLPTLEVLGSVN
CCCCCCHHHEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCC
LGKHWQLWMGLFIVAVVVFAPRGLLGLAQKFMKRKEADHG
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SAQKSNLEVLPRGVQVALVLGLVALLAFPFAGTEFYTQMVTRMMIMAIFAMSLDLLQGV
CCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGLVSLGHAAFFGIAGYALAFLTPQGEPVSLWWTLPVAVLASGLAALVIGFFVVRTHGIY
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHH
FIMVTMAFAQMVFYLFFDNKVLGGSDGLYINFKPSAELFGWTPFDLDGKRTLYYFTLGVL
HHHHHHHHHHHHHHHHHCCEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHH
LAVYAFLRRLLWSPFGRALAGIRVNEHRMRAMGYGTFGYKLAAFTLAGSLAGLAGYLWGA
HHHHHHHHHHHHCHHHHHHHCCEECHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
QTGYINPELMGFHMSAHAIMMVILGGMGNFAGAIVGAFAFEYLLHVFKDLPTLEVLGSVN
CCCCCCHHHEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCC
LGKHWQLWMGLFIVAVVVFAPRGLLGLAQKFMKRKEADHG
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]